J C Cross
Affiliation: University of Calgary
Liu Y, Fan X, Wang R, Lu X, Dang Y, Wang H, et al
. Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018;28:819-832 pubmed publisher
..These results document human placental trophoblast differentiation at single-cell resolution and thus advance our understanding of human placentation during the early stage of pregnancy. ..
Rai A, Cross J. Three-dimensional cultures of trophoblast stem cells autonomously develop vascular-like spaces lined by trophoblast giant cells. Dev Biol. 2015;398:110-9 pubmed publisher
..The trophosphere system will be valuable for assessing mechanisms that regulate specification of different TGC subtypes and their morphogenesis into vascular spaces. ..
Cross J, Coan P, Fundele R, Hemberger M, Kibschull M, Ferguson Smith A. Genes and development--a workshop report. Placenta. 2004;25 Suppl A:S39-41 pubmed
Cross J. Gene Amplification: Trophoblast Giant Cells Use All the Tricks. Curr Biol. 2016;26:R177-9 pubmed publisher
..When these processes occur together, things get really interesting, and new work shows that is the lifestyle of cells in the placenta. ..
Simmons D, Rawn S, Davies A, Hughes M, Cross J. Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus. BMC Genomics. 2008;9:352 pubmed publisher
..Fourth, further diversification of gene products from the PRL/PL locus occurs through alternative splice isoforms for several genes. ..
Cross J, Nakano H, Natale D, Simmons D, Watson E. Branching morphogenesis during development of placental villi. Differentiation. 2006;74:393-401 pubmed
Rawn S, Huang C, Hughes M, Shaykhutdinov R, Vogel H, Cross J. Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis. Biol Reprod. 2015;93:75 pubmed publisher
..These data suggest that the placenta has a sophisticated endocrine system that regulates maternal glucose metabolism during pregnancy. ..
Lu X, Wang R, Zhu C, Wang H, Lin H, Gu Y, et al
. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. 2017;21:1150-1159 pubmed publisher
..These findings demonstrate that G0-restricted Syncytin-2 expression is a prerequisite for development of functional post-mitotic syncytia. ..