Juanita Crook

..Routine use of MRI-CT fusion reveals significant prostate edema may persist several weeks. This study evaluates the effect of edema, and its subsequent resolution, on dosimetry...

..8 months of neoadjuvant hormonal therapy before conventional dose radiotherapy (RT) on disease-free survival using prostate-specific antigen PSA and biopsies as end points for clinically localized prostate cancer...

..Outcome depends on implant quality, but perceived implant quality depends on accurate prostate contouring. This study documents inter observer variation in prostate contouring on post implant CT scans...

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..To report the incidence, timing, and magnitude of the benign prostate-specific antigen (PSA) bounce after 125I prostate brachytherapy and correlate the bounce with clinical and/or dosimetric factors...

..We hypothesized that a cyclooxygenase-2 (COX-2) inhibitor regimen started 1 week prior to seed implant might diminish the inflammatory response, thus reducing edema, retention rates, and symptom severity...

..We have used primary penile brachytherapy as the treatment of choice for T1, T2 and selected T3 patients since 1989 and present updated results for 67 patients...

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..To evaluate the effect of 3 vs. 8 months of neoadjuvant hormonal therapy before conventional-dose radiotherapy (RT) on disease-free survival for localized prostate cancer...

..To report the genitourinary (GU) and gastrointestinal (GI) toxicity rates, erectile function preservation, and biochemical outcome (bNED) in men aged<or=55 years treated with 125iodine (125I) brachytherapy (BT)...

..Critical-organ dose reporting and guidelines for minimizing toxicity must take into account the time of the assessment...

..To assess in a prospective trial the feasibility and late toxicity of hypofractionated radiotherapy (RT) for prostate cancer...

..Dose coverage of the prostate was good for all patients during Days 1-30. Our data indicate that postimplant dosimetry on the day of implant is sufficient for patients with good dose coverage (Day 1 V(100) >93%)...

..To report outcomes for 1,111 men treated with iodine-125 brachytherapy (BT) at a single institution...

..CONCLUSIONS: 75.6 Gy caused modest levels of acute and late toxicity. Three-year biopsies predicted subsequent biochemical outcome...

..To present the mature experience of a phase II trial of intermittent androgen suppression (IAS)...

..We calculated implant quality parameters, D90 and V100, for the magnetic resonance imaging (MRI)-defined prostate plus 2, 3, and 5 mm...

..To compare stranded seeds (SSs) with loose seeds (LSs) in terms of prostate edema, dosimetry, and seed loss after (125)I brachytherapy...

..Prostate size was the major determinant of AUR. For any given prostate size, prior androgen ablation increased the risk of AUR. Men with larger prostates should be aware of the increased risk when contemplating brachytherapy...

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..We hypothesized that men with higher BMI will have a lower dose to the rectal wall and less rectal toxicity after permanent prostate implant...

..We examined the clinical outcomes and toxicity profile of men receiving a D(90) (isodose enclosing 90% of the prostate) of ≥180 Gy...

..HP(5), as determined in this study, should adequately discriminate among patients with prostate cancer and allow the independent prognostic significance of oxygenation to be evaluated once the study matures...

..To assess the feasibility and tolerability of intermittent androgen suppression therapy (IAS) in prostate cancer...

..To determine the reduction of prostate motion during a typical radiotherapy (RT) fraction from a bowel regimen comprising an antiflatulent diet and daily milk of magnesia...

..Supine positioning has been adopted as the standard for conformal prostatic irradiation at our centre...

..In the absence of a randomized clinical trial, such a comparison can be helpful both in counseling patients as to what to expect from either treatment and in facilitating their treatment decision process...

..This may reduce the incidence of erectile dysfunction and urinary toxicity after permanent seed prostate brachytherapy...

..TZ index, initial prostate volume, and use of neoadjuvant hormones are interrelated and are all predictive of AUR in univariate analysis, but in multivariate analysis, TZ index is not an independent prognostic factor...

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..The IPAs receive a low but calculable dose from permanent-seed (125)I brachytherapy. Further research is needed to determine if this outcome has any correlation with subsequent potency...

..Current clinical practice in localized prostate cancer reflects the evolving information in the published medical literature...

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..To examine effects of a teaching intervention on precise delineation of the prostate and rectum during planning of three-dimensional conformal radiotherapy (3D-CRT) for prostate cancer...

..CONCLUSIONS: There have been significant changes in the way that prostate cancer is managed with radiotherapy in Ontario between 2002 and 2005. Dose escalation and more complex treatment planning is widely evident...

..CONCLUSIONS: Pretreatment IPS questionnaire and urinary flow studies assist in predicting risk of urinary morbidity and retention post-125I brachytherapy for prostate cancer...

..Hyperbaric oxygen therapy (HBO) has a well-defined role in the treatment of late radiation toxicities. We present experience with HBO for medically refractory soft tissue necrosis after penile brachytherapy...

..Aside from notable gynecomastia, he remained asymptomatic. He has a strong family history of breast cancer with multiple sisters affected...

..We recommend planned staging superficial inguinal node dissection 3 months after implantation for moderately and/or poorly differentiated tumors with clinically negative groins...

..We describe long-term urinary function in men treated with 125iodine brachytherapy without supplemental beam irradiation...

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..The single-seed DVH calculated by VariSeed fell below the hand calculation by up to 50% at low doses (30 Gy), and above it by over 50% at high doses (>250 Gy)...

..We report our technique that has been developed and refined over the past 20 years...

..are biochemical freedom from failure (bNED) rates, clinical recurrence-free survival, disease-specific survival and acute and late toxicity; (b) what is the appropriate dose and fractionation prescription in this clinical setting?..

..This may explain the poorer success in the external beam radiation patients. The success of sildenafil in both groups of patients was lower than has previously been reported...

..We determined the effects of prostatic brachytherapy on semen parameters and sperm DNA integrity, and the potential impact on fertility...

..Ideal tumors for brachytherapy should be less than 4 cm without extension onto the shaft. More advanced cases can be considered for external radiotherapy...

..We set out to examine the existing data and propose a uniform method of reporting such that results from different centers can more easily be compared...

..The literature, which consists mainly of retrospective studies of patients treated over several decades, is not conclusive. We undertook a literature review to address this issue and to propose...

..A history of remote HPV infection should increase the index of suspicion for any nonhealing penile lesion, despite a history of neonatal circumcision...

..For multiple painful sites on both sides of the diaphragm, radiopharmaceuticals can be considered but will not treat adjacent soft tissue disease or neurologic compromise...

..This study investigates whether the location and dose of urethral radiation received during transperineal interstitial permanent prostate brachytherapy determine the degree and type of urinary symptoms experienced subsequently...

..To compare the critical organ dosimetry and toxicity of loose seeds (LS) with stranded seeds (SS) in (125)I permanent implant for low-risk prostate cancer...