Ann Craig

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc NMDA receptors mediate synaptic competition in culture
    Kevin She
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 6:e24423. 2011
  2. pmc Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development
    Florentina Soto
    Department of Biological Structure, University of Washington, 1950 Pacific Ave, Seattle, WA 98195, USA
    Neural Dev 6:31. 2011
  3. pmc Neurexin-neuroligin signaling in synapse development
    Ann Marie Craig
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, Canada
    Curr Opin Neurobiol 17:43-52. 2007
  4. pmc How to build a central synapse: clues from cell culture
    Ann Marie Craig
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, Canada V6T 2B5
    Trends Neurosci 29:8-20. 2006
  5. pmc Induction of GABAergic postsynaptic differentiation by alpha-neurexins
    Yunhee Kang
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 283:2323-34. 2008
  6. pmc LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development
    Tabrez J Siddiqui
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 30:7495-506. 2010
  7. pmc An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers
    Michael W Linhoff
    The Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Neuron 61:734-49. 2009
  8. pmc Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II
    Jacqueline Rose
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Neuron 61:351-8. 2009
  9. pmc A fight for neurotransmission: SCRAPPER trashes RIM
    Frederick Dobie
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Cell 130:775-7. 2007
  10. doi request reprint ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms
    Daria Krivosheya
    Department of Psychiatry, the Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 283:32944-56. 2008

Collaborators

  • Matti S Airaksinen
  • Shernaz X Bamji
  • Juha Lauren
  • Sabine Levi
  • Kamal Sharma
  • Craig C Garner
  • RONALD GRADY
  • Clarissa L Waites
  • David Holtzman
  • J E Huettner
  • Joshua N Levinson
  • W B Huttner
  • Yunhee Kang
  • Fernanda Laezza
  • Michelle L Schlief
  • Kimberly J Harms
  • Ethan R Graf
  • Frederick Dobie
  • Michael W Linhoff
  • Florentina Soto
  • Kevin She
  • Tabrez J Siddiqui
  • Jacqueline Rose
  • Amanda Rooyakkers
  • Daria Krivosheya
  • Yitao Liu
  • Shan Xue Jin
  • XueZhao Zhang
  • Jonathan D Gitlin
  • Xiaozhong Wang
  • Dan K Fong
  • Renate Lewis
  • Daniel Kerschensteiner
  • Adam Bleckert
  • Rachel O L Wong
  • Raika Pancaroglu
  • Haakon B Nygaard
  • Robert M Cassidy
  • Hideto Takahashi
  • Frederick A Dobie
  • Stephen M Strittmatter
  • Rochelle Hines
  • Lucia Tapia
  • Alaa El-Husseini
  • Kun Huang
  • Lin Mei
  • Annie K Ting
  • Huaiyang Wu
  • Tak Pan Wong
  • Marie A Kozel
  • Fran├žoise Coussen
  • Yu Tian Wang
  • Benjamin R Gerber
  • Michelle Aarts
  • Christophe Mulle
  • Xue Zhao Zhang
  • Jun Yang Lou
  • Hali Hartman
  • Rona Hill-Robinson
  • Jeanne M Nerbonne
  • Michael Tymianski
  • Ted Weita Lai
  • Sunitha Sequeira
  • Lidong Liu
  • Dong Chuan Wu
  • David M Ornitz
  • Timothy J Wilding
  • Jie Lu
  • Tim West
  • Anna M Hauner
  • Kenneth R Tovar
  • Anuradha Rao
  • Joshua R Sanes
  • Joshua A Weiner
  • Allan Bradley
  • F Thomas Crump

Detail Information

Publications26

  1. pmc NMDA receptors mediate synaptic competition in culture
    Kevin She
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 6:e24423. 2011
    ..Here, we develop a model of NMDA-receptor dependent synaptic competition in dissociated cultured hippocampal neurons...
  2. pmc Coordinated increase in inhibitory and excitatory synapses onto retinal ganglion cells during development
    Florentina Soto
    Department of Biological Structure, University of Washington, 1950 Pacific Ave, Seattle, WA 98195, USA
    Neural Dev 6:31. 2011
    ..By labeling RGC dendrites biolistically in YFP-NL2-expressing retinas, we were able to map the spatial distribution and thus densities of inhibitory postsynaptic sites on the dendritic arbors of individual large-field RGCs across ages...
  3. pmc Neurexin-neuroligin signaling in synapse development
    Ann Marie Craig
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, Canada
    Curr Opin Neurobiol 17:43-52. 2007
    ....
  4. pmc How to build a central synapse: clues from cell culture
    Ann Marie Craig
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, Canada V6T 2B5
    Trends Neurosci 29:8-20. 2006
    ..Taking into account these data, we consider here how basic parameters of synapses--competence, placement, composition, size and longevity--might be determined...
  5. pmc Induction of GABAergic postsynaptic differentiation by alpha-neurexins
    Yunhee Kang
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 283:2323-34. 2008
    ..Thus, +S4 beta-neurexins and, even more selectively, alpha-neurexins may be mediators of GABAergic synaptic protein recruitment and stabilization...
  6. pmc LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development
    Tabrez J Siddiqui
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 30:7495-506. 2010
    ..Thus, we propose a synaptic code hypothesis suggesting that neurexins are master regulators of the cooperative activities of LRRTMs and neuroligins...
  7. pmc An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers
    Michael W Linhoff
    The Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Neuron 61:734-49. 2009
    ..These results suggest a prevalence of LRR domain proteins in trans-synaptic signaling and provide a cellular basis for the reported linkage of LRRTM1 to handedness and schizophrenia...
  8. pmc Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II
    Jacqueline Rose
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Neuron 61:351-8. 2009
    ..L-IPS translocation of CaMKII alters biochemical signaling and is associated with an increase in AMPA receptor GluR1 at both stimulated and nonstimulated synapses and thus provides a molecular mechanism for heterosynaptic plasticity...
  9. pmc A fight for neurotransmission: SCRAPPER trashes RIM
    Frederick Dobie
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Cell 130:775-7. 2007
    ..Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check...
  10. doi request reprint ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms
    Daria Krivosheya
    Department of Psychiatry, the Brain Research Center, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 283:32944-56. 2008
    ..These findings demonstrate that NRG1/ErbB4 signaling differentially regulates synapse maturation and dendritic morphology via two distinct mechanisms involving trans-synaptic signaling and tyrosine kinase activity, respectively...
  11. ncbi request reprint NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
    Yitao Liu
    Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    J Neurosci 27:2846-57. 2007
    ....
  12. ncbi request reprint Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II
    Dan K Fong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:2153-64. 2002
    ..These results reveal a surprisingly dynamic nature to the molecular composition and functional properties of glutamatergic postsynaptic specializations...
  13. pmc Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain
    Ethan R Graf
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:4256-65. 2006
    ..These results suggest that differential neurexin-neuroligin binding affinities and splice variations may play an instructive role in postsynaptic differentiation...
  14. ncbi request reprint Postsynaptic protein mobility in dendritic spines: long-term regulation by synaptic NMDA receptor activation
    Kamal Sharma
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 31:702-12. 2006
    ..Such lasting changes in protein mobility may contribute to maintaining alterations in synaptic efficacy...
  15. ncbi request reprint Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons
    Kimberly J Harms
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 490:72-84. 2005
    ..Subcellular enrichment of synaptic proteins into specialized domains also appears intact. These data indicate that global activity inhibition is insufficient to disrupt central synapse formation or organization...
  16. ncbi request reprint Mechanisms of vertebrate synaptogenesis
    Clarissa L Waites
    Department of Psychiatry and Behavioral Science, Nancy Pritzker Laboratory, Stanford University, Palo Alto, CA 94304 5485, USA
    Annu Rev Neurosci 28:251-74. 2005
    ..Although synapse formation and elimination are hallmarks of early development, these processes are also fundamental to learning, memory, and cognition in the mature brain...
  17. ncbi request reprint Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation
    Sabine Levi
    Washington University, Department of Anatomy and Neurobiology, St Louis, Missouri 63110, USA
    J Neurosci 22:4274-85. 2002
    ..Thus the DGC is not essential for GABAergic synaptogenesis but is likely to function in modulating inhibitory synapses or conferring specialized properties on a subset of them...
  18. ncbi request reprint Gamma protocadherins are required for survival of spinal interneurons
    Xiaozhong Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 36:843-54. 2002
    ..In cultures from mutant spinal cord, neurons differentiate and form synapses but then die. Thus, Pcdh-gamma genes are dispensable for at least some aspects of connectivity but required for survival of specific neuronal types...
  19. ncbi request reprint Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons
    Sabine Levi
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 24:207-17. 2004
    ..This clustered gephyrin may then recruit glycine receptors, additional GABA(A)Rs, and other signal-transducing components...
  20. pmc Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins
    Ethan R Graf
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:1013-26. 2004
    ....
  21. pmc Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity
    Michelle L Schlief
    Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:14919-24. 2006
    ..Taken together, these data reveal a unique connection between copper homeostasis and NMDA receptor activity that is of broad relevance to the processes of synaptic plasticity and excitotoxic cell death...
  22. ncbi request reprint NMDA receptor activation mediates copper homeostasis in hippocampal neurons
    Michelle L Schlief
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:239-46. 2005
    ....
  23. pmc Neuronal and glial cell biology
    Ann Marie Craig
    Curr Opin Neurobiol 17:505-6. 2007
  24. ncbi request reprint Synapse-specific regulation of AMPA receptor subunit composition by activity
    Kimberly J Harms
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:6379-88. 2005
    ..These results demonstrate precise input specificity of postsynaptic receptor composition via differential activity among neighbor synapses...
  25. ncbi request reprint The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability
    Fernanda Laezza
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 27:12033-44. 2007
    ....
  26. pmc KRIP6: a novel BTB/kelch protein regulating function of kainate receptors
    Fernanda Laezza
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Neurosci 34:539-50. 2007
    ..Taken together, these results suggest that KRIP6 can directly regulate native kainate receptors and provide the first evidence for a BTB/kelch protein in direct functional regulation of a mammalian glutamate receptor...

Research Grants16

  1. Mechanisms of Central Neuron Synaptogenesis
    ANN M CRAIG; Fiscal Year: 2011
    ....
  2. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 2000
    ....
  3. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 1999
    ....
  4. Mechanisms of Central Neuron Synaptogenesis
    Ann Craig; Fiscal Year: 2009
    ..These experiments address fundamental mechanisms of brain development with implications for therapeutic approaches to regeneration following neurological disorders or trauma. ..
  5. Mechanisms of Central Neuron Synaptogenesis
    Ann Craig; Fiscal Year: 2007
    ..These experiments address fundamental mechanisms of brain development with implications for therapeutic approaches to regeneration following neurological disorders or trauma. ..
  6. Mechanisms of Central Neuron Synaptogenesis
    Ann Craig; Fiscal Year: 2006
    ..These experiments address fundamental mechanisms of brain development with implications for therapeutic approaches to regeneration following neurological disorders or trauma. ..
  7. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 2004
    ..This research on the cellular and molecular mechanisms of activity regulation of synaptic NMDA and GABA receptors is likely to lead to better therapeutic approaches to these neurological disorders. ..
  8. MOLECULAR ANALYSIS OF NEURONAL POLARIZATION
    Ann Craig; Fiscal Year: 2004
    ..abstract_text> ..
  9. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 2003
    ..This research on the cellular and molecular mechanisms of activity regulation of synaptic NMDA and GABA receptors is likely to lead to better therapeutic approaches to these neurological disorders. ..
  10. MOLECULAR ANALYSIS OF NEURONAL POLARIZATION
    Ann Craig; Fiscal Year: 2003
    ..abstract_text> ..
  11. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 2002
    ..This research on the cellular and molecular mechanisms of activity regulation of synaptic NMDA and GABA receptors is likely to lead to better therapeutic approaches to these neurological disorders. ..
  12. MOLECULAR ANALYSIS OF NEURONAL POLARIZATION
    Ann Craig; Fiscal Year: 2002
    ..abstract_text> ..
  13. SUBCELLULAR TARGETING OF NEUROTRANSMITTER RECEPTORS
    Ann Craig; Fiscal Year: 2001
    ..This research on the cellular and molecular mechanisms of activity regulation of synaptic NMDA and GABA receptors is likely to lead to better therapeutic approaches to these neurological disorders. ..
  14. MOLECULAR ANALYSIS OF NEURONAL POLARIZATION
    Ann Craig; Fiscal Year: 2001
    ..abstract_text> ..
  15. MOLECULAR ANALYSIS OF NEURONAL POLARIZATION
    Ann Craig; Fiscal Year: 2000
    ..abstract_text> ..