Helene C F Cote

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Mechanisms of antiretroviral therapy-induced mitochondrial dysfunction
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Curr Opin HIV AIDS 2:253-60. 2007
  2. pmc Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 7:e39266. 2012
  3. pmc Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Mitochondrion 11:520-7. 2011
  4. pmc Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada V6T 2B5
    Crit Care 11:R88. 2007
  5. ncbi request reprint Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, Providence Health Care, Vancouver, BC, Canada
    Antivir Ther 11:79-86. 2006
  6. ncbi request reprint Possible ways nucleoside analogues can affect mitochondrial DNA content and gene expression during HIV therapy
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, Department of Pathology, Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    Antivir Ther 10:M3-11. 2005
  7. doi request reprint Perinatal exposure to antiretroviral therapy is associated with increased blood mitochondrial DNA levels and decreased mitochondrial gene expression in infants
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 198:851-9. 2008
  8. ncbi request reprint Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants
    Tuhina Imam
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 60:495-502. 2012
  9. ncbi request reprint Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens
    Helene C F Cote
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 187:1972-6. 2003
  10. ncbi request reprint Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial DNA
    Julio S G Montaner
    BC Centre for Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 38:S73-9. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Mechanisms of antiretroviral therapy-induced mitochondrial dysfunction
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Curr Opin HIV AIDS 2:253-60. 2007
    ....
  2. pmc Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    PLoS ONE 7:e39266. 2012
    ..We therefore investigated whether in utero or childhood exposure to NRTIs affects leukocyte telomere length (LTL), a marker of cellular aging...
  3. pmc Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Mitochondrion 11:520-7. 2011
    ..However, within laboratory and relative mtDNA/nDNA comparisons between laboratories should be reliable...
  4. pmc Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada V6T 2B5
    Crit Care 11:R88. 2007
    ..Decreased mitochondrial DNA (mtDNA) levels have been associated with mitochondrial dysfunction and were investigated here in relation to short-term (31-day) survival...
  5. ncbi request reprint Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, Providence Health Care, Vancouver, BC, Canada
    Antivir Ther 11:79-86. 2006
    ..Mitochondrial nephrotoxicity was investigated as an underlying mechanism. Given the interaction between TDF and didanosine (ddl), their concurrent use was also investigated...
  6. ncbi request reprint Possible ways nucleoside analogues can affect mitochondrial DNA content and gene expression during HIV therapy
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, Department of Pathology, Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    Antivir Ther 10:M3-11. 2005
    ....
  7. doi request reprint Perinatal exposure to antiretroviral therapy is associated with increased blood mitochondrial DNA levels and decreased mitochondrial gene expression in infants
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 198:851-9. 2008
    ....
  8. ncbi request reprint Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants
    Tuhina Imam
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 60:495-502. 2012
    ..This could in turn lead to shorter telomeres. We hypothesized that HIV and ART exposure would be associated with shorter leukocyte telomere length (TL) in exposed mother/infant pairs compared with controls...
  9. ncbi request reprint Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens
    Helene C F Cote
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 187:1972-6. 2003
    ..24 months; P<.01). Because of survivor-bias effect, these results may represent a conservative estimate of these nucleosides' effect on mtDNA...
  10. ncbi request reprint Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial DNA
    Julio S G Montaner
    BC Centre for Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 38:S73-9. 2004
    ..A statistically significant increase in the mtDNA : nDNA ratio was observed after the discontinuation of antiretroviral therapy. Full validation of monitoring the mtDNA : nDNA ratio is currently under way...
  11. ncbi request reprint Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, St Paul s Hospital, Providence Health Care, Vancouver, BC, Canada
    N Engl J Med 346:811-20. 2002
    ..We studied changes in mitochondrial DNA relative to nuclear DNA in the peripheral-blood cells of patients with symptomatic, nucleoside-induced hyperlactatemia...
  12. doi request reprint Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy
    Marissa H J Jitratkosol
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    AIDS 26:675-83. 2012
    ..We hypothesized that HAART-exposed/HIV-uninfected infants may show higher blood mtDNA mutation burden than controls born to HIV-uninfected mothers...
  13. pmc In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs
    Kyle R Hukezalie
    Genetics Graduate Program, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e47505. 2012
    ....
  14. ncbi request reprint Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy
    Julio S G Montaner
    British Columbia Centrefor Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 34:S85-90. 2003
    ..These results suggest that measurement of this parameter should be investigated as a potential clinical management tool...
  15. doi request reprint Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells
    Eszter Papp
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Antimicrob Chemother 61:1048-52. 2008
    ....
  16. doi request reprint Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy
    Motoi Matsukura
    Department of Pathology and Laboratory Medicine, University of British Columbia, Canada
    AIDS 22:1226-9. 2008
    ..We found no evidence of increased mitochondrial toxicity in individuals currently on HAART, suggesting that concomitant HAART should not delay HCV therapy...
  17. pmc Blood and dried blood spot telomere length measurement by qPCR: assay considerations
    Deanna L Zanet
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e57787. 2013
    ..This suggests that DNA from cells blotted on paper is not equivalent to that collected from venipuncture whole blood, and caution should be taken when comparing between blood sample types...
  18. doi request reprint Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes
    Mario A Jardon
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Biotechnol Bioeng 109:1228-38. 2012
    ..Monitoring or genetic engineering of autophagy provides novel avenues to improve the performance of cell culture-based recombinant protein production...