Brenda L Coomber
Affiliation: University of Guelph
Coomber B, Mitchell G, Starr A, Minhas K, Tamblyn A, Shewen P, et al
. Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia. Vet J. 2006;171:126-34 pubmed
Ho N, Coomber B. Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Exp Cell Res. 2015;331:73-81 pubmed publisher
..However, these effects did not lead to significant changes in cellular metabolism nor growth. In conclusion, DCA may only be beneficial in treating a subset of tumor types based on their molecular profiles of different PDK isoforms. ..
Farias N, Ho N, Butler S, Delaney L, Morrison J, Shahrzad S, et al
. The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines. J Nutr Biochem. 2015;26:818-26 pubmed publisher
..Taken together, these results demonstrate an interaction between FA metabolism and CSC phenotype in vitro and help elucidate a connection between supplemental FA intake and CRC development. ..
Thompson J, Morrison J, Pearl D, Boston S, Wood G, Foster R, et al
. Receptor Tyrosine Kinase Expression Profiles in Canine Cutaneous and Subcutaneous Mast Cell Tumors. Vet Pathol. 2016;53:545-58 pubmed publisher
Ho N, Morrison J, Silva A, Coomber B. The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. Biosci Rep. 2016;36:e00299 pubmed publisher
..These results emphasize the importance of the tumour microenvironment and glucose availability when considering therapeutic approaches involving metabolic modulation. ..
Nguyen V, Chen S, Trinh J, Kim H, Coomber B, Dumont D. Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell Biol. 2007;8:10 pubmed
..Our results suggest that although both Ang1 and Ang2 can activate the Tie-2 receptor in bmLECs, Ang1 and Ang2 may have distinct roles in mesenteric lymphatic endothelial cells. ..
Patten S, Adamcic U, Lacombe K, Minhas K, Skowronski K, Coomber B. VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment. BMC Cancer. 2010;10:683 pubmed publisher
..It remains to be seen whether this heterogeneity is partly responsible for the variable clinical success seen to date with targeted anti-VEGFR2 therapy. ..
Montanholi Y, Haas L, Swanson K, Coomber B, Yamashiro S, Miller S. Liver morphometrics and metabolic blood profile across divergent phenotypes for feed efficiency in the bovine. Acta Vet Scand. 2017;59:24 pubmed publisher
..These metabolic discrepancies between feed efficient and inefficient cattle may be determinants of productive performance. ..
Crozier C, Wood G, Foster R, Stasi S, Liu J, Bartlett J, et al
. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. J Comp Pathol. 2016;155:24-8 pubmed publisher
..Due to the similarity of the clinical disease in dogs and cats to that of man, this study confirms that companion animals offer potential as a suitable model for investigating this rare subtype of pancreatic carcinoma. ..