Richard J Cook

Summary

Affiliation: University of Waterloo
Country: Canada

Publications

  1. ncbi request reprint The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia
    Kathryn Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 91:1530-7. 2006
  2. ncbi request reprint Multistate analysis of skeletal events in patients with bone metastases
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Clin Cancer Res 12:6264s-6269s. 2006
  3. doi request reprint Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 53:1843-55. 2013
  4. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
  5. pmc Prediction of falls using a risk assessment tool in the acute care setting
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Med 2:1. 2004
  6. ncbi request reprint Conditional analysis of mixed Poisson processes with baseline counts: implications for trial design and analysis
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Biostatistics 4:479-94. 2003
  7. doi request reprint Information in the sample covariate distribution in prevalent cohorts
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ont, Canada N2L 3G1
    Stat Med 30:1397-409. 2011
  8. ncbi request reprint A conditional Markov model for clustered progressive multistate processes under incomplete observation
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Biometrics 60:436-43. 2004
  9. ncbi request reprint Marginal analysis of incomplete longitudinal binary data: a cautionary note on LOCF imputation
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Ontario N2L 3G1, Canada
    Biometrics 60:820-8. 2004
  10. doi request reprint A copula-based mixed Poisson model for bivariate recurrent events under event-dependent censoring
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
    Stat Med 29:694-707. 2010

Detail Information

Publications95

  1. ncbi request reprint The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia
    Kathryn Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Haematologica 91:1530-7. 2006
    ..Patients with acute myeloid leukemia are at risk of bleeding. The risk factors for different severities of bleeding are poorly studied...
  2. ncbi request reprint Multistate analysis of skeletal events in patients with bone metastases
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Clin Cancer Res 12:6264s-6269s. 2006
    ..The relation between the multistate approach and previously used methods is highlighted...
  3. doi request reprint Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 53:1843-55. 2013
    ..The purpose of this article is to discuss methodologic issues in the design and analysis of PLT transfusion trials evaluating pathogen reduction technology and make recommendations for the conduct of future trials...
  4. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  5. pmc Prediction of falls using a risk assessment tool in the acute care setting
    Alexandra Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    BMC Med 2:1. 2004
    ..Although the tool has several strengths, certain limitations exist which may not allow generalizability to a Canadian setting. Thus, we tested the STRATIFY tool with some modification and re-weighting of items in Canadian hospitals...
  6. ncbi request reprint Conditional analysis of mixed Poisson processes with baseline counts: implications for trial design and analysis
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Biostatistics 4:479-94. 2003
    ..We show that designs based on this approach are more efficient than those proposed by McMahon et al. (1994)...
  7. doi request reprint Information in the sample covariate distribution in prevalent cohorts
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ont, Canada N2L 3G1
    Stat Med 30:1397-409. 2011
    ..The various methods considered are applied in an illustrative analysis of risk factors for death following onset of dementia using data collected in the Canadian Study of Health and Aging...
  8. ncbi request reprint A conditional Markov model for clustered progressive multistate processes under incomplete observation
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Biometrics 60:436-43. 2004
    ..A generalization to accommodate a subpopulation of "stayers" and extensions which facilitate regression are indicated and illustrated...
  9. ncbi request reprint Marginal analysis of incomplete longitudinal binary data: a cautionary note on LOCF imputation
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Ontario N2L 3G1, Canada
    Biometrics 60:820-8. 2004
    ..We illustrate the differences between various methods of dealing with drop-outs using data from a study of smoking behavior...
  10. doi request reprint A copula-based mixed Poisson model for bivariate recurrent events under event-dependent censoring
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
    Stat Med 29:694-707. 2010
    ....
  11. ncbi request reprint Robust tests for treatment effects based on censored recurrent event data observed over multiple periods
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Biometrics 61:692-701. 2005
    ..Adaptations to handle recurrent events arising in crossover trials are described and these methods are applied to data from a two-period crossover trial of patients with bronchial asthma...
  12. doi request reprint Second-order estimating equations for the analysis of clustered current status data
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada N2L 3G1
    Biostatistics 10:756-72. 2009
    ....
  13. doi request reprint Two-stage design of clinical trials involving recurrent events
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada
    Stat Med 28:2617-38. 2009
    ..The work is motivated by the design of a study involving patients with immune thrombocytopenic purpura where the aim is to reduce bleeding episodes and an illustrative application is given using data from a cardiovascular trial...
  14. ncbi request reprint Analysis of a nonsusceptible fraction with current status data
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
    Stat Med 27:2715-30. 2008
    ..The methods are applied to motivating studies examining an immunological response to low molecular weight heparin in patients undergoing orthopedic surgery...
  15. ncbi request reprint A mixed model for two-state Markov processes under panel observation
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Ontario, Canada
    Biometrics 55:915-20. 1999
    ..We focus on a particular random effects formulation that generates a closed-form expression for the marginal likelihood. The methodology is illustrated by application to a data set from a parasitic field infection survey...
  16. ncbi request reprint Synthesis of evidence from epidemiological studies with interval-censored exposure due to grouping
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Ontario, Canada
    Biometrics 57:671-80. 2001
    ..The methods are applied to the motivating study of the relationship between chorionic villus sampling and the occurrence of terminal transverse limb reduction...
  17. ncbi request reprint Estimation of operating characteristics for dependent diagnostic tests based on latent Markov models
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
    Biometrics 56:1109-17. 2000
    ..The methods are illustrated by application to a study of diffuse bilateral infiltrates among patients in intensive care wards in which the objective was to assess aspects of validity and clinical agreement...
  18. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1740-5. 2007
    ..To determine whether the assessments of peripheral joints and enthesitis were reproducible for both AS and PsA with axial disease, and whether dactylitis assessment is reproducible in patients with PsA...
  19. doi request reprint The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial
    Nancy M Heddle
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Transfusion 52:1203-12. 2012
    ..The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality...
  20. doi request reprint Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis
    Janice A Husted
    University of Waterloo, Waterloo, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:1729-35. 2011
    ..To determine whether the presence of psoriatic arthritis (PsA) is associated with greater comorbidity, in particular cardiovascular morbidity, compared to psoriasis without arthritis...
  21. ncbi request reprint A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation
    Kathryn E Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:81-91. 2008
    ..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia...
  22. doi request reprint A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia
    Donald M Arnold
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood 119:1356-62. 2012
    ..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)...
  23. ncbi request reprint Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    Donald M Arnold
    McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Ann Intern Med 146:25-33. 2007
    ..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)...
  24. ncbi request reprint Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1286-91. 2006
    ..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...
  25. ncbi request reprint A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemia
    Nancy M Heddle
    Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
    Transfusion 46:903-11. 2006
    ..The purpose of this study was to provide a descriptive summary of data from PLT studies conducted in four countries and exploratory analyses to determine the relationship between bleeding and PLT count...
  26. ncbi request reprint Non-inferiority trial design for recurrent events
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
    Stat Med 26:4563-77. 2007
    ..When the between-patient heterogeneity in the event rate is small, there may be a considerable reduction in sample size with recurrent event outcomes...
  27. doi request reprint The association between smoking and the development of psoriatic arthritis among psoriasis patients
    Lihi Eder
    Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, ON, Canada
    Ann Rheum Dis 71:219-24. 2012
    ..To investigate the association between smoking and psoriatic arthritis (PsA) among patients with psoriasis and its interaction with the HLA-C*06 allele...
  28. doi request reprint Studies of the immune response in heparin-induced thrombocytopenia
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 113:4963-9. 2009
    ..Compared with seropositive non-HIT controls, HIT patients develop significantly higher anti-PF4/heparin IgG levels that are detectable before the onset of thrombocytopenia...
  29. ncbi request reprint An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts
    Catherine P M Hayward
    McMaster University and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada, L8N 3Z5
    Thromb Haemost 100:134-45. 2008
    ..The derived limits for thrombocytopenic samples provide guidance for evaluating thrombocytopenic platelet function disorders, including which agonists to test, based on the sample platelet count...
  30. doi request reprint A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 113:1564-73. 2009
    ..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914...
  31. doi request reprint Association between environmental factors and onset of psoriatic arthritis in patients with psoriasis
    Lihi Eder
    Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:1091-7. 2011
    ..To investigate the association between potential environmental exposures and the development of psoriatic arthritis (PsA) in patients with psoriasis...
  32. ncbi request reprint Anterior optic nerve capillary blood flow response to diurnal variation of mean ocular perfusion pressure in early untreated primary open-angle glaucoma
    Mitra Sehi
    School of Optometry, University of Waterloo, Waterloo, Canada
    Invest Ophthalmol Vis Sci 46:4581-7. 2005
    ....
  33. doi request reprint Time and predictors of response to tumour necrosis factor-alpha blockers in psoriatic arthritis: an analysis of a longitudinal observational cohort
    Lihi Eder
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada
    Rheumatology (Oxford) 49:1361-6. 2010
    ..To determine predictors and time to response to treatment with TNF-alpha blockers in patients with PsA in a longitudinal observational cohort...
  34. doi request reprint Regression with incomplete covariates and left-truncated time-to-event data
    Hua Shen
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada, N2L 3G1
    Stat Med 32:1004-15. 2013
    ..We describe an extension to deal with subgroup analyses in clinical trials for the case in which the stratification variable is incompletely observed...
  35. doi request reprint The Spondyloarthritis Research Consortium of Canada registry for spondyloarthritis
    Dafna D Gladman
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 38:1343-8. 2011
    ..This article describes the SPARCC database and outlines difficulties and possible solutions for maintaining such a database...
  36. ncbi request reprint Tests for multivariate recurrent events in the presence of a terminal event
    Bingshu Eric Chen
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    Biostatistics 5:129-43. 2004
    ..The global test suggests that bisphosphonate therapy significantly reduces the overall number of skeletal complications...
  37. doi request reprint Risk factors for axial inflammatory arthritis in patients with psoriatic arthritis
    Vinod Chandran
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 37:809-15. 2010
    ..Axial involvement is an important manifestation of psoriatic arthritis (PsA). We aimed to identify risk factors associated with the presence of axial PsA (AxPsA) in patients with PsA...
  38. doi request reprint Regression analysis with a misclassified covariate from a current status observation scheme
    Leilei Zeng
    Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Biometrics 66:415-25. 2010
    ..The method is shown to reduce the bias resulting from naive analyses in simulation studies and an application to the data from the orthopedic studies provides further illustration...
  39. ncbi request reprint Regression modeling with recurrent events and time-dependent interval-censored marker data
    Eric Bingshu Chen
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West Waterloo, Ontario, Canada N2L 3G1
    Lifetime Data Anal 9:275-91. 2003
    ..A modified EM algorithm is used to deal with this incomplete data problem...
  40. doi request reprint Rehabilitation in home care is associated with functional improvement and preferred discharge
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Arch Phys Med Rehabil 94:1038-47. 2013
    ..To investigate the impact of physiotherapy (PT) and occupational therapy (OT) services on long-stay home care patients with musculoskeletal disorders...
  41. pmc Misspecification of Cox regression models with composite endpoints
    Longyang Wu
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Stat Med 31:3545-62. 2012
    ..We illustrate the methods by application to a recent asthma study...
  42. ncbi request reprint Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Clin Cancer Res 12:3361-7. 2006
    ..To evaluate the relative prognostic value for specific markers of osteoblast and osteoclast activity while controlling for previously reported prognostic variables among men with hormone-refractory metastatic prostate cancer...
  43. pmc Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity
    Pierre P Major
    McMaster University, Juravinski Cancer Centre, Hamilton, Ontario, Canada
    BMC Cancer 9:272. 2009
    ..Because many patients with cancer die before trial completion, there is a need for survival-adjusted methods to accurately assess the effects of treatment on skeletal morbidity...
  44. ncbi request reprint Methodologic issues in the use of bleeding as an outcome in transfusion medicine studies
    Nancy M Heddle
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 43:742-52. 2003
    ....
  45. doi request reprint Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease?
    Dafna D Gladman
    Department of Medicine, University of Toronto, Ontario, Canada
    Ann Rheum Dis 70:2152-4. 2011
    ....
  46. ncbi request reprint Seasonal variation in vitamin D levels in psoriatic arthritis patients from different latitudes and its association with clinical outcomes
    Zahi Touma
    Centre for Prognosis Studiesin the Rheumatic Diseases, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 63:1440-7. 2011
    ..There was no seasonal variation in 25(OH)D levels among PsA patients in the southern and northern sites. No association could be established between disease activity and vitamin D level...
  47. doi request reprint Predictors of response to intra-articular steroid injection in psoriatic arthritis
    Lihi Eder
    Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Rheumatology (Oxford) 49:1367-73. 2010
    ..To assess the effectiveness of IA corticosteroid (IAS) injections in PsA and to determine the association between macrophage migration inhibition factor (MIF) gene polymorphism and response to IAS injections...
  48. doi request reprint A multistate model for bivariate interval-censored failure time data
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Biometrics 64:1100-9. 2008
    ..The method is illustrated by application to data from a trial of HIV patients where the events are the onset of viral shedding in the blood and urine among individuals infected with cytomegalovirus...
  49. doi request reprint Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis
    Vinod Chandran
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada
    Rheumatology (Oxford) 49:1399-405. 2010
    ..Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA...
  50. ncbi request reprint International spondyloarthritis interobserver reliability exercise--the INSPIRE study: I. Assessment of spinal measures
    Dafna D Gladman
    Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1733-9. 2007
    ..To determine whether the axial measures used in primary ankylosing spondylitis (AS) were reproducible for both AS and psoriatic arthritis (PsA) with axial disease...
  51. doi request reprint Soluble biomarkers associated with response to treatment with tumor necrosis factor inhibitors in psoriatic arthritis
    Vinod Chandran
    Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Canada
    J Rheumatol 40:866-71. 2013
    ..To identify soluble biomarkers associated with response to therapy with tumor necrosis factor inhibitors (TNFi) in patients with psoriatic arthritis (PsA)...
  52. ncbi request reprint The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of Canada
    Dafna D Gladman
    The Psoriatic Arthritis Program, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 31:1126-31. 2004
    ..To evaluate whether rheumatologists experienced in psoriatic arthritis (PsA) assess peripheral and axial involvement in the same way and to consider core clinical measurements that should be included in clinical trials in PsA...
  53. doi request reprint Duration of red cell storage before transfusion and in-hospital mortality
    John W Eikelboom
    Department of Medicine, McMaster University, Ontario, Canada
    Am Heart J 159:737-743.e1. 2010
    ..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality...
  54. doi request reprint Is ASDAS better than BASDAI as a measure of disease activity in axial psoriatic arthritis?
    Lihi Eder
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Psoriatic Arthritis Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Rheum Dis 69:2160-4. 2010
    ....
  55. pmc Risk factors for hip fracture in older home care clients
    Paul Stolee
    Department of Health Studies and Gerontology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    J Gerontol A Biol Sci Med Sci 64:403-10. 2009
    ..Little information is available on hip fracture risks among community-dwelling persons receiving home care. Our aim was to identify risk factors for hip fracture from health information routinely collected for older home care clients...
  56. doi request reprint The association between diurnal variation of optic nerve head topography and intraocular pressure and ocular perfusion pressure in untreated primary open-angle glaucoma
    Mitra Sehi
    Department of Ophthalmology, University of Miami Miller School of Medicine, Palm Beach Gardens, FL, USA
    J Glaucoma 20:44-50. 2011
    ....
  57. ncbi request reprint Risk-adjusted monitoring of binary surgical outcomes
    S H Steiner
    Department of Statistics and Actuarial Sciences, University of Waterloo, Ontario, Canada
    Med Decis Making 21:163-9. 2001
    ..Signals of the chart lead to investigations of the cause and to the timely introduction of remedial measures designed to avoid unnecessary future failures...
  58. ncbi request reprint Monitoring paired binary surgical outcomes using cumulative sum charts
    S H Steiner
    Department of Statistics and Actuarial Sciences, University of Waterloo, Ontario, Canada
    Stat Med 18:69-86. 1999
    ..This procedure is illustrated using bivariate outcome data arising from a series of paediatric surgeries. The methodology is sufficiently general that it may be adapted for multivariate normal, binomial or Poisson responses...
  59. ncbi request reprint The utility of mixed-form likelihoods
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Canada
    Biometrics 55:284-8. 1999
    ..The advantages of constructing overall likelihoods in this way are illustrated by applications involving the analysis of 2 x 2 x K tables and left-censored water quality data...
  60. ncbi request reprint Reliability of electrocardiogram interpretation in critically ill patients
    Wendy Lim
    Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1338-43. 2006
    ..To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates...
  61. ncbi request reprint Designing laboratory-based research studies: is it time for a change?
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
    Transfusion 47:2336-7. 2007
  62. doi request reprint International multicenter psoriasis and psoriatic arthritis reliability trial for the assessment of skin, joints, nails, and dactylitis
    Vinod Chandran
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 61:1235-42. 2009
    ..This study aimed to determine whether assessment of the skin and joints in patients with PsA by rheumatologists and dermatologists is reproducible...
  63. ncbi request reprint A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptoms
    Kathryn E Webert
    McMaster University, Hamilton, Ontario, Canada
    Transfusion 46:1926-33. 2006
    ..These assessments are commonly performed by study personnel and can be time-consuming. The purpose of this study was to assess whether patients were able to reliably assess their bleeding status on a daily basis...
  64. ncbi request reprint Selection effects in randomized trials with count data
    Richard J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, N2L 3G1, Canada
    Stat Med 21:515-31. 2002
    ..Applications involving data from an epilepsy trial and a study of transient myocardial ischaemia illustrate the effect of ignoring the selection mechanism...
  65. doi request reprint A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia
    Vishwanath K Mahabir
    Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Eur J Haematol 90:121-6. 2013
    ..The objectives of this study were to determine the inter-rater reliability of bone marrow examinations and to identify distinguishing morphological features of ITP bone marrows under controlled conditions...
  66. doi request reprint Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients
    Janet E Brown
    Cancer Research UK Experimental Cancer Medicine Centres at Leeds and Sheffield, Cancer Research Centre, Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, United Kingdom
    Clin Cancer Res 18:6348-55. 2012
    ..We analyzed data from a phase III trial comparing zoledronic acid (ZOL) with pamidronate in patients with breast cancer and bone metastases to identify variables prognostic for overall survival...
  67. pmc Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Blood 106:3791-6. 2005
    ..We conclude that despite similar immunogenicity of fondaparinux and LMWH, PF4/fondaparinux, but not PF4/LMWH, is recognized poorly by the antibodies generated, suggesting that the risk of HIT with fondaparinux likely is very low...
  68. doi request reprint The role of noninferiority designs in clinical research
    Lora Giangregorio
    Kinesiology and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
    Transfusion 48:1050-2. 2008
  69. doi request reprint Whole stimulated salivary flow: correlation with the pathology of inflammation and damage in minor salivary gland biopsy specimens from patients with primary Sjögren's syndrome but not patients with sicca
    Arthur A M Bookman
    University of Toronto, Toronto, Ontario, Canada
    Arthritis Rheum 63:2014-20. 2011
    ....
  70. ncbi request reprint Prevalence of vertebral fractures among patients with chronic obstructive pulmonary disease in Canada
    A Papaioannou
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Osteoporos Int 14:913-7. 2003
    ..The primary objective of this case-control study was to determine the prevalence of vertebral fractures among patients with COPD admitted to acute care compared with a gender- and age-matched control group...
  71. doi request reprint A copula model for marked point processes
    Liqun Diao
    Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, N2L 3G1, Canada
    Lifetime Data Anal 19:463-89. 2013
    ..An application to data from a recent trial in transfusion medicine is given for illustration. ..
  72. ncbi request reprint Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin
    Donald M Arnold
    Canadian Blood Services, Hamilton, Ontario, Canada
    Anesth Analg 102:731-7. 2006
    ..Further high-quality trials with clinically important outcomes may be warranted before aprotinin can be routinely recommended in this population...
  73. ncbi request reprint Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucoma
    Mitra Sehi
    School of Optometry, University of Waterloo, ON N2I 3G1, Canada
    Invest Ophthalmol Vis Sci 46:561-7. 2005
    ....
  74. ncbi request reprint Implications of model misspecification in robust tests for recurrent events
    J Boher
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
    Lifetime Data Anal 12:69-95. 2006
    ..Methods based on marginal or partially conditional rate functions perform well in situations where treatment effects persist or in settings where the aim is to summarizee long-term data on efficacy...
  75. ncbi request reprint Predictive factors for symptomatic osteonecrosis in patients with systemic lupus erythematosus
    D D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 28:761-5. 2001
    ..CONCLUSION: Glucocorticosteroid therapy, the presence of arthritis, and use of cytotoxic medication are independent risk factors for development of ON in patients with SLE...
  76. ncbi request reprint Using inverse-weighting in cost-effectiveness analysis with censored data
    A R Willan
    Program in Population Health Sciences, Research Centre, Hospital for Sick Children, Toronto, ON, Canada
    Stat Methods Med Res 11:539-51. 2002
    ..The method of inverse-weighting is used for censored cost and quality of life data. The methods are illustrated in an example using an incremental net benefit analysis...
  77. ncbi request reprint When should an effective treatment be used? Derivation of the threshold number needed to treat and the minimum event rate for treatment
    J C Sinclair
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 3N11F, 1200 Main Street West, Hamilton, L8N 3Z5, Ontario, Canada
    J Clin Epidemiol 54:253-62. 2001
    ..Quantification of the determinants of the threshold NNT and of the minimum event rate to justify treatment can assist clinicians and patients in the explicit use of underlying values when making treatment decisions...
  78. ncbi request reprint Health-related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritis
    J A Husted
    Department of Health Studies and Gerontology, University of Waterloo, Ontario, Canada
    Arthritis Rheum 45:151-8. 2001
    ..Further, it appeared that there may be unique disabilities associated with the psoriasis dimension of PsA...
  79. doi request reprint Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments
    C P M Hayward
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 7:676-84. 2009
    ..Light transmission aggregometry (LTA) is commonly performed to assess individuals for bleeding disorders...
  80. ncbi request reprint Agreement between alternative classifications of acute respiratory distress syndrome
    M O Meade
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:490-3. 2001
    ..These discordant classifications had no prognostic importance...
  81. ncbi request reprint Analysis of repeated events
    R J Cook
    Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
    Stat Methods Med Res 11:141-66. 2002
    ..Most of the methodology considered can be implemented with existing software...
  82. doi request reprint Anti-PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization
    T E Warkentin
    Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:504-12. 2010
    ..Heparin-induced thrombocytopenia is an antibody-mediated disorder exhibiting variable frequency in different clinical settings. Antibodies recognize PF4/heparin complexes formed at optimal stoichiometric molar ratios...
  83. ncbi request reprint Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients
    D J Cook
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 129:433-40. 1998
    ..Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies...
  84. ncbi request reprint Incremental net benefit in randomized clinical trials with quality-adjusted survival
    Andrew R Willan
    Program in Population Health Sciences, Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, Canada
    Stat Med 22:353-62. 2003
    ..The methods are illustrated in an example using an incremental net benefit analysis...
  85. ncbi request reprint Statistical methods for multivariate interval-censored recurrent events
    Bingshu E Chen
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852 7244, USA
    Stat Med 24:671-91. 2005
    ..The application of these methods to data from a trial of women with advanced breast cancer provides insight into the clinical course of bone metastases in this population...
  86. ncbi request reprint Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
    Janet E Brown
    Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield, England, United Kingdom
    J Natl Cancer Inst 97:59-69. 2005
    ..We investigated this question in patients with bone metastases secondary to prostate cancer and to non-small-cell lung cancer (NSCLC) and other solid tumors assigned to the placebo arms of two phase III trials of zoledronic acid...
  87. ncbi request reprint Regression analysis of multivariate panel count data
    Xin He
    Department of Statistics, University of Missouri, 146 Middlebush Hall, Columbia, MO 65211 6100, USA
    Biostatistics 9:234-48. 2008
    ..The methodology is applied to a motivating study of patients with psoriatic arthritis in which the events of interest are the onset of joint damage according to 2 different criteria...
  88. ncbi request reprint Monitoring the evolutionary process of quality: risk-adjusted charting to track outcomes in intensive care
    David A Cook
    Intensive Care Unit, Princess Alexandra Hospital, Brisbane, Australia
    Crit Care Med 31:1676-82. 2003
    ..To present graphical procedures for prospectively monitoring outcomes in the intensive care unit...
  89. pmc Predictors of skeletal complications in men with hormone-refractory metastatic prostate cancer
    Matthew R Smith
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Urology 70:315-9. 2007
    ..Skeletal complications are a major cause of morbidity in men with hormone-refractory metastatic prostate cancer. These analyses were designed to identify the variables associated with a greater risk of skeletal complications...
  90. ncbi request reprint Changing pattern of sputum cell counts during successive exacerbations of airway disease
    Liesel D'silva
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Respir Med 101:2217-20. 2007
    ..We examined changes in the cellular nature of airway inflammation between consecutive exacerbations and their predictors in individual patients...
  91. ncbi request reprint Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity
    Allan Lipton
    Milton S Hershey Medical Center, Penn State Cancer Institute, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Oncologist 12:1035-43. 2007
    ....
  92. ncbi request reprint Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma
    Allan Lipton
    Division of Oncology, Penn State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Clin Lymphoma Myeloma 7:346-53. 2007
    ..The aim of this review is to improve our understanding of bone markers as a clinical tool for the management of malignant bone disease in patients with MM...
  93. ncbi request reprint Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency
    Christian G Rabbat
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:357-63. 2005
    ....
  94. doi request reprint Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity
    Vera Hirsh
    McGill University Health Centre, Montreal, Quebec, Canada
    J Thorac Oncol 3:228-36. 2008
    ..Zoledronic acid (ZOL) reduces SRE risk and NTX levels...
  95. pmc Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
    Allan Lipton
    Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 12:6209s-6212s. 2006
    ..The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings...