Research Topics
| Richard J CookSummaryAffiliation: University of Waterloo Country: Canada Publications
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Detail Information
Publications
The risk of bleeding in thrombocytopenic patients with acute myeloid leukemiaKathryn Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Haematologica 91:1530-7. 2006..Patients with acute myeloid leukemia are at risk of bleeding. The risk factors for different severities of bleeding are poorly studied...
Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working GroupLehana Thabane
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
Trials 12:48. 2011..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
Prediction of falls using a risk assessment tool in the acute care settingAlexandra Papaioannou
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
BMC Med 2:1. 2004..Although the tool has several strengths, certain limitations exist which may not allow generalizability to a Canadian setting. Thus, we tested the STRATIFY tool with some modification and re-weighting of items in Canadian hospitals...- Multistate analysis of skeletal events in patients with bone metastasesRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Clin Cancer Res 12:6264s-6269s. 2006..The relation between the multistate approach and previously used methods is highlighted... 
Two-stage design of clinical trials involving recurrent eventsRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada
Stat Med 28:2617-38. 2009..The work is motivated by the design of a study involving patients with immune thrombocytopenic purpura where the aim is to reduce bleeding episodes and an illustrative application is given using data from a cardiovascular trial...- Marginal analysis of incomplete longitudinal binary data: a cautionary note on LOCF imputationRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Ontario N2L 3G1, Canada
Biometrics 60:820-8. 2004..We illustrate the differences between various methods of dealing with drop-outs using data from a study of smoking behavior... - A conditional Markov model for clustered progressive multistate processes under incomplete observationRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
Biometrics 60:436-43. 2004..A generalization to accommodate a subpopulation of "stayers" and extensions which facilitate regression are indicated and illustrated... - Conditional analysis of mixed Poisson processes with baseline counts: implications for trial design and analysisRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
Biostatistics 4:479-94. 2003..We show that designs based on this approach are more efficient than those proposed by McMahon et al. (1994)... - A copula-based mixed Poisson model for bivariate recurrent events under event-dependent censoringRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
Stat Med 29:694-707. 2010.... - Information in the sample covariate distribution in prevalent cohortsRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ont, Canada N2L 3G1
Stat Med 30:1397-409. 2011..The various methods considered are applied in an illustrative analysis of risk factors for death following onset of dementia using data collected in the Canadian Study of Health and Aging... - Synthesis of evidence from epidemiological studies with interval-censored exposure due to groupingR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Ontario, Canada
Biometrics 57:671-80. 2001..The methods are applied to the motivating study of the relationship between chorionic villus sampling and the occurrence of terminal transverse limb reduction... - Second-order estimating equations for the analysis of clustered current status dataRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada N2L 3G1
Biostatistics 10:756-72. 2009.... - Analysis of a nonsusceptible fraction with current status dataRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Stat Med 27:2715-30. 2008..The methods are applied to motivating studies examining an immunological response to low molecular weight heparin in patients undergoing orthopedic surgery... - Estimation of operating characteristics for dependent diagnostic tests based on latent Markov modelsR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
Biometrics 56:1109-17. 2000..The methods are illustrated by application to a study of diffuse bilateral infiltrates among patients in intensive care wards in which the objective was to assess aspects of validity and clinical agreement... - Robust tests for treatment effects based on censored recurrent event data observed over multiple periodsRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
Biometrics 61:692-701. 2005..Adaptations to handle recurrent events arising in crossover trials are described and these methods are applied to data from a two-period crossover trial of patients with bronchial asthma... - A mixed model for two-state Markov processes under panel observationR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Ontario, Canada
Biometrics 55:915-20. 1999..We focus on a particular random effects formulation that generates a closed-form expression for the marginal likelihood. The methodology is illustrated by application to a data set from a parasitic field infection survey... - International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitisDafna D Gladman
Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 34:1740-5. 2007..To determine whether the assessments of peripheral joints and enthesitis were reproducible for both AS and PsA with axial disease, and whether dactylitis assessment is reproducible in patients with PsA... - The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trialNancy M Heddle
Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Transfusion 52:1203-12. 2012..The objective was to determine feasibility of a comparative effectiveness trial to evaluate duration of storage of blood before transfusion on in-hospital mortality... - A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantationKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:81-91. 2008..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia... - Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasisJanice A Husted
University of Waterloo, Waterloo, Ontario, Canada
Arthritis Care Res (Hoboken) 63:1729-35. 2011..To determine whether the presence of psoriatic arthritis (PsA) is associated with greater comorbidity, in particular cardiovascular morbidity, compared to psoriasis without arthritis... - A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Blood 119:1356-62. 2012..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)... - Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpuraDonald M Arnold
McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada
Ann Intern Med 146:25-33. 2007..Rituximab, a monoclonal anti-CD20 antibody, is increasingly used to treat idiopathic thrombocytopenic purpura (ITP)... - Non-inferiority trial design for recurrent eventsRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
Stat Med 26:4563-77. 2007..When the between-patient heterogeneity in the event rate is small, there may be a considerable reduction in sample size with recurrent event outcomes... - Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responsesDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1286-91. 2006..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed... - The association between smoking and the development of psoriatic arthritis among psoriasis patientsLihi Eder
Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, ON, Canada
Ann Rheum Dis 71:219-24. 2012..To investigate the association between smoking and psoriatic arthritis (PsA) among patients with psoriasis and its interaction with the HLA-C*06 allele... - A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemiaNancy M Heddle
Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
Transfusion 46:903-11. 2006..The purpose of this study was to provide a descriptive summary of data from PLT studies conducted in four countries and exploratory analyses to determine the relationship between bleeding and PLT count... - Association between environmental factors and onset of psoriatic arthritis in patients with psoriasisLihi Eder
Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
Arthritis Care Res (Hoboken) 63:1091-7. 2011..To investigate the association between potential environmental exposures and the development of psoriatic arthritis (PsA) in patients with psoriasis... - A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopeniaNancy M Heddle
Department of Medicine, McMaster University, Hamilton, ON, Canada
Blood 113:1564-73. 2009..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914... - An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet countsCatherine P M Hayward
McMaster University and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada, L8N 3Z5
Thromb Haemost 100:134-45. 2008..The derived limits for thrombocytopenic samples provide guidance for evaluating thrombocytopenic platelet function disorders, including which agonists to test, based on the sample platelet count... - Time and predictors of response to tumour necrosis factor-alpha blockers in psoriatic arthritis: an analysis of a longitudinal observational cohortLihi Eder
Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada
Rheumatology (Oxford) 49:1361-6. 2010..To determine predictors and time to response to treatment with TNF-alpha blockers in patients with PsA in a longitudinal observational cohort... - Studies of the immune response in heparin-induced thrombocytopeniaTheodore E Warkentin
Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Blood 113:4963-9. 2009..Compared with seropositive non-HIT controls, HIT patients develop significantly higher anti-PF4/heparin IgG levels that are detectable before the onset of thrombocytopenia... - Anterior optic nerve capillary blood flow response to diurnal variation of mean ocular perfusion pressure in early untreated primary open-angle glaucomaMitra Sehi
School of Optometry, University of Waterloo, Waterloo, Canada
Invest Ophthalmol Vis Sci 46:4581-7. 2005.... - Risk factors for axial inflammatory arthritis in patients with psoriatic arthritisVinod Chandran
Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
J Rheumatol 37:809-15. 2010..Axial involvement is an important manifestation of psoriatic arthritis (PsA). We aimed to identify risk factors associated with the presence of axial PsA (AxPsA) in patients with PsA... - Tests for multivariate recurrent events in the presence of a terminal eventBingshu Eric Chen
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
Biostatistics 5:129-43. 2004..The global test suggests that bisphosphonate therapy significantly reduces the overall number of skeletal complications... - Regression analysis with a misclassified covariate from a current status observation schemeLeilei Zeng
Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
Biometrics 66:415-25. 2010..The method is shown to reduce the bias resulting from naive analyses in simulation studies and an application to the data from the orthopedic studies provides further illustration... - Regression modeling with recurrent events and time-dependent interval-censored marker dataEric Bingshu Chen
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West Waterloo, Ontario, Canada N2L 3G1
Lifetime Data Anal 9:275-91. 2003..A modified EM algorithm is used to deal with this incomplete data problem... - The Spondyloarthritis Research Consortium of Canada registry for spondyloarthritisDafna D Gladman
Toronto Western Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 38:1343-8. 2011..This article describes the SPARCC database and outlines difficulties and possible solutions for maintaining such a database... - Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancerRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Clin Cancer Res 12:3361-7. 2006..In multivariate models, higher levels of serum BAP but not urinary N-telopeptide are associated with shorter overall survival... - Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidityPierre P Major
McMaster University, Juravinski Cancer Centre, Hamilton, Ontario, Canada
BMC Cancer 9:272. 2009..Because many patients with cancer die before trial completion, there is a need for survival-adjusted methods to accurately assess the effects of treatment on skeletal morbidity... - International spondyloarthritis interobserver reliability exercise--the INSPIRE study: I. Assessment of spinal measuresDafna D Gladman
Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 34:1733-9. 2007..To determine whether the axial measures used in primary ankylosing spondylitis (AS) were reproducible for both AS and psoriatic arthritis (PsA) with axial disease... - A multistate model for bivariate interval-censored failure time dataRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Biometrics 64:1100-9. 2008..The method is illustrated by application to data from a trial of HIV patients where the events are the onset of viral shedding in the blood and urine among individuals infected with cytomegalovirus... - Seasonal variation in vitamin D levels in psoriatic arthritis patients from different latitudes and its association with clinical outcomesZahi Touma
Centre for Prognosis Studiesin the Rheumatic Diseases, Toronto, Ontario, Canada
Arthritis Care Res (Hoboken) 63:1440-7. 2011..There was no seasonal variation in 25(OH)D levels among PsA patients in the southern and northern sites. No association could be established between disease activity and vitamin D level... - Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease?Dafna D Gladman
Department of Medicine, University of Toronto, Ontario, Canada
Ann Rheum Dis 70:2152-4. 2011.... - Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritisVinod Chandran
Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada
Rheumatology (Oxford) 49:1399-405. 2010..Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA... - Predictors of response to intra-articular steroid injection in psoriatic arthritisLihi Eder
Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
Rheumatology (Oxford) 49:1367-73. 2010..To assess the effectiveness of IA corticosteroid (IAS) injections in PsA and to determine the association between macrophage migration inhibition factor (MIF) gene polymorphism and response to IAS injections... - Duration of red cell storage before transfusion and in-hospital mortalityJohn W Eikelboom
Department of Medicine, McMaster University, Ontario, Canada
Am Heart J 159:737-743.e1. 2010..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality... - The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of CanadaDafna D Gladman
The Psoriatic Arthritis Program, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 31:1126-31. 2004..To evaluate whether rheumatologists experienced in psoriatic arthritis (PsA) assess peripheral and axial involvement in the same way and to consider core clinical measurements that should be included in clinical trials in PsA... - Is ASDAS better than BASDAI as a measure of disease activity in axial psoriatic arthritis?Lihi Eder
Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto Psoriatic Arthritis Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
Ann Rheum Dis 69:2160-4. 2010.... - Risk factors for hip fracture in older home care clientsPaul Stolee
Department of Health Studies and Gerontology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
J Gerontol A Biol Sci Med Sci 64:403-10. 2009..Little information is available on hip fracture risks among community-dwelling persons receiving home care. Our aim was to identify risk factors for hip fracture from health information routinely collected for older home care clients... - The association between diurnal variation of optic nerve head topography and intraocular pressure and ocular perfusion pressure in untreated primary open-angle glaucomaMitra Sehi
Department of Ophthalmology, University of Miami Miller School of Medicine, Palm Beach Gardens, FL, USA
J Glaucoma 20:44-50. 2011.... - Risk-adjusted monitoring of binary surgical outcomesS H Steiner
Department of Statistics and Actuarial Sciences, University of Waterloo, Ontario, Canada
Med Decis Making 21:163-9. 2001..Signals of the chart lead to investigations of the cause and to the timely introduction of remedial measures designed to avoid unnecessary future failures... - Monitoring paired binary surgical outcomes using cumulative sum chartsS H Steiner
Department of Statistics and Actuarial Sciences, University of Waterloo, Ontario, Canada
Stat Med 18:69-86. 1999..This procedure is illustrated using bivariate outcome data arising from a series of paediatric surgeries. The methodology is sufficiently general that it may be adapted for multivariate normal, binomial or Poisson responses... - The utility of mixed-form likelihoodsR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Canada
Biometrics 55:284-8. 1999..The advantages of constructing overall likelihoods in this way are illustrated by applications involving the analysis of 2 x 2 x K tables and left-censored water quality data... - International multicenter psoriasis and psoriatic arthritis reliability trial for the assessment of skin, joints, nails, and dactylitisVinod Chandran
Toronto Western Hospital, Toronto, Ontario, Canada
Arthritis Rheum 61:1235-42. 2009..This study aimed to determine whether assessment of the skin and joints in patients with PsA by rheumatologists and dermatologists is reproducible... - Designing laboratory-based research studies: is it time for a change?Richard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Transfusion 47:2336-7. 2007 - Reliability of electrocardiogram interpretation in critically ill patientsWendy Lim
Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 34:1338-43. 2006..Additional studies assessing the appropriate methods of diagnosing myocardial ischemia and infarction and assessing the reliability of these diagnostic tests in critically ill patients are required... - A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptomsKathryn E Webert
McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1926-33. 2006..These assessments are commonly performed by study personnel and can be time-consuming. The purpose of this study was to assess whether patients were able to reliably assess their bleeding status on a daily basis... - Selection effects in randomized trials with count dataRichard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, N2L 3G1, Canada
Stat Med 21:515-31. 2002..Applications involving data from an epilepsy trial and a study of transient myocardial ischaemia illustrate the effect of ignoring the selection mechanism... - Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patientsJanet E Brown
Authors Affiliations Cancer Research UK Experimental Cancer Medicine Centres at Leeds and Sheffield Cancer Research Centre, Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield University of Waterloo, Waterloo, Ontario, Canada and Milton S Hershey Medical Center, Penn State University, Hershey, Pennsylvania
Clin Cancer Res 18:6348-55. 2012..We analyzed data from a phase III trial comparing zoledronic acid (ZOL) with pamidronate in patients with breast cancer and bone metastases to identify variables prognostic for overall survival... - Whole stimulated salivary flow: correlation with the pathology of inflammation and damage in minor salivary gland biopsy specimens from patients with primary Sjögren's syndrome but not patients with siccaArthur A M Bookman
University of Toronto, Toronto, Ontario, Canada
Arthritis Rheum 63:2014-20. 2011.... - Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparinTheodore E Warkentin
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Blood 106:3791-6. 2005..We conclude that despite similar immunogenicity of fondaparinux and LMWH, PF4/fondaparinux, but not PF4/LMWH, is recognized poorly by the antibodies generated, suggesting that the risk of HIT with fondaparinux likely is very low... - The role of noninferiority designs in clinical researchLora Giangregorio
Kinesiology and the Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Transfusion 48:1050-2. 2008 - Methodologic issues in the use of bleeding as an outcome in transfusion medicine studiesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 43:742-52. 2003.... - Prevalence of vertebral fractures among patients with chronic obstructive pulmonary disease in CanadaA Papaioannou
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Osteoporos Int 14:913-7. 2003..The primary objective of this case-control study was to determine the prevalence of vertebral fractures among patients with COPD admitted to acute care compared with a gender- and age-matched control group... - Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucomaMitra Sehi
School of Optometry, University of Waterloo, ON N2I 3G1, Canada
Invest Ophthalmol Vis Sci 46:561-7. 2005.... - Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotininDonald M Arnold
Canadian Blood Services, Hamilton, Ontario, Canada
Anesth Analg 102:731-7. 2006..Further high-quality trials with clinically important outcomes may be warranted before aprotinin can be routinely recommended in this population... - Implications of model misspecification in robust tests for recurrent eventsJ Boher
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
Lifetime Data Anal 12:69-95. 2006..Methods based on marginal or partially conditional rate functions perform well in situations where treatment effects persist or in settings where the aim is to summarizee long-term data on efficacy... - Using inverse-weighting in cost-effectiveness analysis with censored dataA R Willan
Program in Population Health Sciences, Research Centre, Hospital for Sick Children, Toronto, ON, Canada
Stat Methods Med Res 11:539-51. 2002..The method of inverse-weighting is used for censored cost and quality of life data. The methods are illustrated in an example using an incremental net benefit analysis... - Predictive factors for symptomatic osteonecrosis in patients with systemic lupus erythematosusD D Gladman
Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
J Rheumatol 28:761-5. 2001..CONCLUSION: Glucocorticosteroid therapy, the presence of arthritis, and use of cytotoxic medication are independent risk factors for development of ON in patients with SLE... - Analysis of repeated eventsR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
Stat Methods Med Res 11:141-66. 2002..Most of the methodology considered can be implemented with existing software... - Health-related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritisJ A Husted
Department of Health Studies and Gerontology, University of Waterloo, Ontario, Canada
Arthritis Rheum 45:151-8. 2001..Further, it appeared that there may be unique disabilities associated with the psoriasis dimension of PsA... - When should an effective treatment be used? Derivation of the threshold number needed to treat and the minimum event rate for treatmentJ C Sinclair
Department of Clinical Epidemiology and Biostatistics, McMaster University, Room 3N11F, 1200 Main Street West, Hamilton, L8N 3Z5, Ontario, Canada
J Clin Epidemiol 54:253-62. 2001..Quantification of the determinants of the threshold NNT and of the minimum event rate to justify treatment can assist clinicians and patients in the explicit use of underlying values when making treatment decisions... - Agreement between alternative classifications of acute respiratory distress syndromeM O Meade
Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 163:490-3. 2001..These discordant classifications had no prognostic importance... - Incidence of and risk factors for ventilator-associated pneumonia in critically ill patientsD J Cook
McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 129:433-40. 1998..Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies... - Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessmentsC P M Hayward
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
J Thromb Haemost 7:676-84. 2009..Light transmission aggregometry (LTA) is commonly performed to assess individuals for bleeding disorders... - Anti-PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunizationT E Warkentin
Department of Pathology and Molecular Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
J Thromb Haemost 8:504-12. 2010..Heparin-induced thrombocytopenia is an antibody-mediated disorder exhibiting variable frequency in different clinical settings. Antibodies recognize PF4/heparin complexes formed at optimal stoichiometric molar ratios... - Statistical methods for multivariate interval-censored recurrent eventsBingshu E Chen
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852 7244, USA
Stat Med 24:671-91. 2005..The application of these methods to data from a trial of women with advanced breast cancer provides insight into the clinical course of bone metastases in this population... - Monitoring the evolutionary process of quality: risk-adjusted charting to track outcomes in intensive careDavid A Cook
Intensive Care Unit, Princess Alexandra Hospital, Brisbane, Australia
Crit Care Med 31:1676-82. 2003..This was temporally related to increased senior staffing levels and enhanced ongoing multidisciplinary review of practice, quality improvement, and educational activities. Formulas and analyses are provided as appendices... - Regression analysis of multivariate panel count dataXin He
Department of Statistics, University of Missouri, 146 Middlebush Hall, Columbia, MO 65211 6100, USA
Biostatistics 9:234-48. 2008..The methodology is applied to a motivating study of patients with psoriatic arthritis in which the events of interest are the onset of joint damage according to 2 different criteria... - Incremental net benefit in randomized clinical trials with quality-adjusted survivalAndrew R Willan
Program in Population Health Sciences, Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, Canada
Stat Med 22:353-62. 2003..The methods are illustrated in an example using an incremental net benefit analysis... - Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumorsJanet E Brown
Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield, England, United Kingdom
J Natl Cancer Inst 97:59-69. 2005..N-telopeptide levels were more consistent prognostic indicators than bone-specific alkaline phosphatase for all tumor types, reflecting the key role of osteolysis in the development of skeletal complications... - Changing pattern of sputum cell counts during successive exacerbations of airway diseaseLiesel D'silva
Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
Respir Med 101:2217-20. 2007..We examined changes in the cellular nature of airway inflammation between consecutive exacerbations and their predictors in individual patients... - Predictors of skeletal complications in men with hormone-refractory metastatic prostate cancerMatthew R Smith
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Urology 70:315-9. 2007..Skeletal complications are a major cause of morbidity in men with hormone-refractory metastatic prostate cancer. These analyses were designed to identify the variables associated with a greater risk of skeletal complications... - Advances in treating metastatic bone cancer: summary statement for the First Cambridge ConferenceAllan Lipton
Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
Clin Cancer Res 12:6209s-6212s. 2006..The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings... - Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activityAllan Lipton
Milton S Hershey Medical Center, Penn State Cancer Institute, 500 University Drive, Hershey, Pennsylvania 17033, USA
Oncologist 12:1035-43. 2007.... - Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiencyChristian G Rabbat
Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Crit Care 20:357-63. 2005..If dalteparin does not bioaccumulate, it may be an attractive alternative agent for thromboprophylaxis... - Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activityVera Hirsh
McGill University Health Centre, Montreal, Quebec, Canada
J Thorac Oncol 3:228-36. 2008..Zoledronic acid (ZOL) reduces SRE risk and NTX levels... - Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myelomaAllan Lipton
Division of Oncology, Penn State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
Clin Lymphoma Myeloma 7:346-53. 2007..The aim of this review is to improve our understanding of bone markers as a clinical tool for the management of malignant bone disease in patients with MM...