P W Connelly

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi The prevalence of hyperlipidemia in women and its association with use of oral contraceptives, sex hormone replacement therapy and nonlipid coronary artery disease risk factors. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:419-27. 1999
  2. ncbi Reference values of plasma apolipoproteins A-I and B, and association with nonlipid risk factors in the populations of two Canadian provinces: Quebec and Saskatchewan. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:409-18. 1999
  3. ncbi Prevalence of high plasma triglyceride combined with low HDL-C levels and its association with smoking, hypertension, obesity, diabetes, sedentariness and LDL-C levels in the Canadian population. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:428-33. 1999
  4. ncbi Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1060-6. 1997
  5. ncbi Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 48:993-1001. 2005
  6. ncbi Cross-sectional and prospective associations between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition
    A J Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 24:1240-7. 2001
  7. ncbi Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, J Alick Little Core Lipid Laboratory, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 65:1524-33. 1997
  8. ncbi Plasmodium falciparum-infected erythrocytes and oxidized low-density lipoprotein bind to separate domains of CD36
    I Crandall
    Tropical Disease Unit, The Toronto Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 180:473-9. 1999
  9. pmc Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada
    Diabetologia 53:268-76. 2010
  10. doi The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy
    R Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:706-12. 2011

Detail Information

Publications40

  1. ncbi The prevalence of hyperlipidemia in women and its association with use of oral contraceptives, sex hormone replacement therapy and nonlipid coronary artery disease risk factors. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:419-27. 1999
    ..To report the prevalence of lipid and nonlipid coronary artery disease risk factors in women classified by use of oral contraceptives or sex hormone replacement therapy...
  2. ncbi Reference values of plasma apolipoproteins A-I and B, and association with nonlipid risk factors in the populations of two Canadian provinces: Quebec and Saskatchewan. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:409-18. 1999
    ..To determine the population distribution of apolipoproteins A-I and B, and the relationship of apolipoprotein B to lipid risk factors for coronary artery disease...
  3. ncbi Prevalence of high plasma triglyceride combined with low HDL-C levels and its association with smoking, hypertension, obesity, diabetes, sedentariness and LDL-C levels in the Canadian population. Canadian Heart Health Surveys Research Group
    P W Connelly
    St Michael s Hospital and University of Toronto, Toronto, Canada
    Can J Cardiol 15:428-33. 1999
    ..In particular, the associations for persons with high triglyceride and low HDL-C levels were examined...
  4. ncbi Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1060-6. 1997
    ..045, and P = .047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprotein phenotypes in this study sample...
  5. ncbi Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 48:993-1001. 2005
    ..We conducted the current investigation to determine whether adiponectin is associated with beta cell dysfunction in GDM...
  6. ncbi Cross-sectional and prospective associations between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition
    A J Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 24:1240-7. 2001
    ..CONCLUSIONS: These results confirm previously reported cross-sectional associations between proinsulin and lipid concentrations. In addition, an unexpected association between baseline lipids and proinsulin change was documented...
  7. ncbi Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, J Alick Little Core Lipid Laboratory, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 65:1524-33. 1997
    ..We conclude that psyllium lowered LDL- and HDL-cholesterol concentrations similarly at both MUFA intakes. However, there may be some advantage in combining soluble fiber and MUFA to reduce the ratio of LDL to HDL cholesterol...
  8. ncbi Plasmodium falciparum-infected erythrocytes and oxidized low-density lipoprotein bind to separate domains of CD36
    I Crandall
    Tropical Disease Unit, The Toronto Hospital, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 180:473-9. 1999
    ..These results suggest that, although oxLDL competitively inhibits the adherence of pRBCs, these ligands interact with distinct domains on the CD36 receptor...
  9. pmc Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada
    Diabetologia 53:268-76. 2010
    ..Thus, we sought to determine whether adiponectin, leptin and CRP levels during pregnancy relate to the postpartum metabolic defects linking GDM with type 2 diabetes...
  10. doi The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy
    R Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:706-12. 2011
    ....
  11. ncbi Angiotensinogen gene variation associated with variation in blood pressure in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Centre, Toronto, Ontario, Canada
    Hypertension 29:1073-7. 1997
    ..The high frequency of the angiotensinogen T235 variant suggests that subjects in this young, essentially normotensive population might be predisposed to hypertension, which may become more apparent in the presence of secondary factors...
  12. ncbi Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Diabet Med 24:245-52. 2007
    ..e. representing an early stage in the natural history of the disease), we sought to determine if decreased HMW adiponectin is a feature of GDM...
  13. ncbi -6A promoter variant of angiotensinogen and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    St Michael s Hospital, Toronto, Ontario, Canada
    J Hum Genet 43:37-41. 1998
    ..Our findings are consistent with a marginally deleterious effect of the AGT -6A allele on blood pressure, but linkage disequilibrium with another causative variant cannot be ruled out in this sample of aboriginal Canadians...
  14. ncbi Interaction between variant apolipoproteins C-II and E that affects plasma lipoprotein concentrations
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Arterioscler Thromb 11:1303-9. 1991
    ....
  15. ncbi Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 82:3373-7. 1997
    ....
  16. ncbi Elevated C-reactive protein in Native Canadian children: an ominous early complication of childhood obesity
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:483-91. 2006
    ..Thus, we sought to determine whether subclinical inflammation is an early complication of obesity in Native children...
  17. doi Utility of non-high-density lipoprotein cholesterol in assessing incident type 2 diabetes risk
    S H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Diabetes Obes Metab 14:821-5. 2012
    ....
  18. ncbi Hypoadiponectinaemia in South Asian women during pregnancy: evidence of ethnic variation in adiponectin concentration
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabet Med 21:388-92. 2004
    ..Here, we report the impact of ethnicity on plasma adiponectin concentration in that study...
  19. ncbi Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
    R A Guy
    Department of Medicine, Institute of Medical Science, University of Toronto, Rm. 7202 Medical Sciences Building, 8 Taddle Creek Road, Ont, M5S 1A8, Toronto, Canada
    Atherosclerosis 155:19-28. 2001
    ....
  20. ncbi Genetic variation in factor VII associated with variation in plasma lipoprotein(a) concentration
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1701-6. 1997
    ..71 micrograms/mL and to increase by 0.301 microgram/mL plasma Lp(a) concentration from the sample mean. This suggests that common genomic variation in F7 is associated with variation in plasma Lp(a) concentration...
  21. doi Altering source or amount of dietary carbohydrate has acute and chronic effects on postprandial glucose and triglycerides in type 2 diabetes: Canadian trial of Carbohydrates in Diabetes (CCD)
    T M S Wolever
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:227-34. 2013
    ..We aimed to explore whether long-term changes in postprandial responses on low-glycemic-index (GI) or low-CHO diets were due to acute or chronic effects in T2DM...
  22. ncbi Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor
    Z Ahmed
    J. Alick Little Lipid Research Laboratory, St. Michael's Hospital, University of Toronto, 38 Shuter Street, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 276:24473-81. 2001
    ..We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1...
  23. ncbi Genetic and biochemical factors associated with variation in blood pressure in a genetic isolate
    R A Hegele
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Hypertension 27:308-12. 1996
    ..The association between plasma apo B concentration and diastolic blood pressure suggests that these traits may share some determinants...
  24. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis...
  25. ncbi Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Center, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:4334-7. 1996
    ..These findings suggest that the T54 variant of the intestinal fatty acid-binding protein is associated with differences in fat metabolism in this aboriginal population...
  26. ncbi Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center, Department of Medicine, Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Quebec, Canada
    Metabolism 50:494-503. 2001
    ..We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation...
  27. ncbi Human hepatic lipase mutations and polymorphisms
    R A Hegele
    DNA and Lipid Research Laboratories, St Michael s Hospital, Toronto, Ontario, Canada
    Hum Mutat 1:320-4. 1992
    ..Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia...
  28. ncbi High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function
    D J Jenkins
    Clinical Nutrition and Risk Factor Modification Center and the Department of Medicine, The Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Canada
    Am J Clin Nutr 74:57-63. 2001
    ..Further studies are required to assess the longer-term effects on renal function...
  29. pmc Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease
    P W Connelly
    Lipid Research Clinic, St Michael s Hospital, Toronto, Canada
    J Clin Invest 80:1597-606. 1987
    ..Both siblings and several relatives had premature ischemic vascular disease, in contrast with its apparent absence in other apoCII-deficient families...
  30. ncbi Direct comparison of dietary portfolio vs statin on C-reactive protein
    D J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    Eur J Clin Nutr 59:851-60. 2005
    ..3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known...
  31. ncbi Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
    P W Connelly
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Int J Obes Relat Metab Disord 27:347-54. 2003
    ....
  32. ncbi Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Department of Medicine, Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, 406 100 Perth Drive, Ont, N6A 5K8, London, Canada
    Atherosclerosis 154:579-87. 2001
    ..The inconsistencies could be due to differences in genetic background or to unspecified environmental or genetic factors...
  33. ncbi Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate
    A H Lichtman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1938-44. 1999
    ..This study shows that sodium cholate is not necessary for the formation of atherosclerosis in LDLR(-/-) mice and that precisely defined semipurified diets are a valuable tool for the examination of diet-gene interactions...
  34. ncbi Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Québec population
    A M Madore
    University of Montreal Community Genomic Medicine Center, Chicoutimi University Hospital, Chicoutimi, Canada
    Community Genet 10:218-26. 2007
    ..e. differences in allele frequency in subpopulations, such as the 15 public health regions of the province of Québec (Canada)...
  35. ncbi ABCC6 gene polymorphism associated with variation in plasma lipoproteins
    J Wang
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, ON, Canada
    J Hum Genet 46:699-705. 2001
    ..The results suggest that ABCC6 may be a determinant of plasma lipoproteins...
  36. ncbi A hepatic lipase gene mutation associated with heritable lipolytic deficiency
    R A Hegele
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 72:730-2. 1991
    ..We propose that T383M is specific to families with heritable HL deficiency. Furthermore, structural variation at the HL gene, possibly in combination with other factors, appears to be etiologic in HL deficiency...
  37. ncbi An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia
    R A Hegele
    Department of Medicine, University of Toronto, Canada
    Dis Markers 9:73-80. 1991
    ....
  38. doi Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors
    B A Nassar
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Scand J Clin Lab Invest 68:286-91. 2008
    ..Two CX3CR1 mutations, V249I and T280M, reportedly decrease coronary artery disease (CAD) risk independent of established risk factors. An I249 protective effect is attributed to reducing CX3CR1 binding to fractalkine, its ligand...
  39. ncbi Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency
    R A Hegele
    Department of Medicine, University of Toronto, Ontario, Canada
    Biochem Biophys Res Commun 179:78-84. 1991
    ..We now report the identification of three more hepatic lipase gene mutations in this family and demonstrate that compound heterozygosity for two hepatic lipase mutations (designated S267F and T383M) underlies hepatic lipase deficiency...
  40. ncbi Common and rare ABCA1 variants affecting plasma HDL cholesterol
    J Wang
    John P Robarts Research Institute, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 20:1983-9. 2000
    ....