Carla S Coffin

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. doi request reprint Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
    Liver Transpl 17:955-62. 2011
  2. doi request reprint Virology and clinical sequelae of long-term antiviral therapy in a North American cohort of hepatitis B virus (HBV)/human immunodeficiency virus type 1 (HIV-1) co-infected patients
    C S Coffin
    Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4Z6, Canada
    J Clin Virol 57:103-8. 2013
  3. pmc Improving rates of pneumococcal vaccination on discharge from a tertiary center medical teaching unit: a prospective intervention
    Chandra M Thomas
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Public Health 5:110. 2005
  4. doi request reprint Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy
    C S Coffin
    Liver Unit, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, AB, Canada
    J Viral Hepat 18:415-23. 2011
  5. doi request reprint Liver diseases associated with anti-tumor necrosis factor-alpha (TNF-α) use for inflammatory bowel disease
    Carla S Coffin
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Inflamm Bowel Dis 17:479-84. 2011
  6. doi request reprint Management of patients co-infected with HBV and HCV
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Canada
    Expert Rev Anti Infect Ther 7:549-58. 2009
  7. ncbi request reprint Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Liver Int 27:722-6. 2007
  8. doi request reprint Occult hepatitis C virus infection: what does it mean?
    Tram N Q Pham
    Molecular Virology and Hepatology Research Group, Division of Biomedical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University, St John s, Newfoundland and Labrador, Canada
    Liver Int 30:502-11. 2010
  9. pmc Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection
    Laura M Stinton
    Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada
    BMC Gastroenterol 13:50. 2013
  10. pmc Management of chronic hepatitis B: Canadian Association for the Study of the Liver consensus guidelines
    Carla S Coffin
    Department of Medicine, University of Calgary, Alberta
    Can J Gastroenterol 26:917-38. 2012

Collaborators

Detail Information

Publications23

  1. doi request reprint Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
    Liver Transpl 17:955-62. 2011
    ..Antiviral drug-resistant variants are more frequent in the liver versus PBMCs, but both compartments are potential sources of reinfection...
  2. doi request reprint Virology and clinical sequelae of long-term antiviral therapy in a North American cohort of hepatitis B virus (HBV)/human immunodeficiency virus type 1 (HIV-1) co-infected patients
    C S Coffin
    Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB T2N 4Z6, Canada
    J Clin Virol 57:103-8. 2013
    ..There are limited recent data worldwide on clinical and virological outcomes in hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfected patients on dual active antiretroviral therapy (ART)...
  3. pmc Improving rates of pneumococcal vaccination on discharge from a tertiary center medical teaching unit: a prospective intervention
    Chandra M Thomas
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Public Health 5:110. 2005
    ....
  4. doi request reprint Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy
    C S Coffin
    Liver Unit, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, AB, Canada
    J Viral Hepat 18:415-23. 2011
    ..PBMC may be a sanctuary for wt virus during antiviral therapy, while the liver harbours more drug-resistant viruses. Drug resistance correlates with intrahepatic viral diversity...
  5. doi request reprint Liver diseases associated with anti-tumor necrosis factor-alpha (TNF-α) use for inflammatory bowel disease
    Carla S Coffin
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Inflamm Bowel Dis 17:479-84. 2011
    ..Often treatment may be complicated by preexisting chronic liver disease. Clinicians should be aware of potential hepatic side effects and appropriate management options...
  6. doi request reprint Management of patients co-infected with HBV and HCV
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Canada
    Expert Rev Anti Infect Ther 7:549-58. 2009
    ..For patients unresponsive to these initial treatments, there are no specific guidelines, and additional studies to define the treatment algorithms for nonresponders or relapsers are needed...
  7. ncbi request reprint Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Liver Int 27:722-6. 2007
    ..Hepatitis B virus (HBV) and hepatitis C virus (HCV) share similar transmission routes; thus, coinfection is frequent. The consequences of acute HBV infection in patients with chronic hepatitis C are unknown...
  8. doi request reprint Occult hepatitis C virus infection: what does it mean?
    Tram N Q Pham
    Molecular Virology and Hepatology Research Group, Division of Biomedical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University, St John s, Newfoundland and Labrador, Canada
    Liver Int 30:502-11. 2010
    ..The current understanding of the nature and characteristics of OCI, methods and pitfalls of its detection, as well as the documented and expected pathological consequences of OCI will be summarized in this review...
  9. pmc Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection
    Laura M Stinton
    Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada
    BMC Gastroenterol 13:50. 2013
    ..Our objectives were to determine the prevalence and clinical associations of RR autoantibodies in HCV patients, and identify related novel autoantibody targets...
  10. pmc Management of chronic hepatitis B: Canadian Association for the Study of the Liver consensus guidelines
    Carla S Coffin
    Department of Medicine, University of Calgary, Alberta
    Can J Gastroenterol 26:917-38. 2012
    ..The proceedings of the consensus conference are summarized and provide updated clinical practice guidelines to assist Canadian health care providers in the prevention, diagnosis, assessment and treatment of CHB...
  11. doi request reprint Entecavir for the treatment of patients with hepatitis B virus-related decompensated cirrhosis
    Matthew D Sadler
    University of Calgary Liver Unit, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada
    Expert Opin Pharmacother 14:1363-9. 2013
    ..Several studies have now shown nucleot(s)ide analogs to be safe and effective in decompensated cirrhosis due to CHB...
  12. pmc Rituximab for the treatment of patients with autoimmune hepatitis who are refractory or intolerant to standard therapy
    Kelly W Burak
    Liver Unit, Division of Gastroenterologyand Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Can J Gastroenterol 27:273-80. 2013
    ..Rituximab is an anti-CD20 monoclonal antibody that depletes B cells and has demonstrated efficacy in other autoimmune conditions...
  13. doi request reprint Treatment of HBeAg-positive patients with nucleos/tide analogues
    Carla S Coffin
    Liver Unit, University of Calgary, Calgary, AB, Canada
    Liver Int 29:116-24. 2009
    ..This review includes the range of treatment options and criteria for determining when and how to most effectively intervene with antiviral therapy for chronically infected patients positive for the HBeAg...
  14. doi request reprint Hepatitis B immunoglobulin for prevention of hepatitis B virus infection and recurrence after liver transplantation
    Stephen E Congly
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Alberta, Canada
    Expert Rev Clin Immunol 7:429-36. 2011
    ..This article summarizes the main indications and the recommendations for use of intravenous HBIG, as well as the usage of intramuscular HBIG in the liver transplant setting...
  15. doi request reprint Characterization of hepatitis B virus genotypes and quantitative hepatitis B surface antigen titres in North American tertiary referral liver centres
    Stephen E Congly
    Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB, Canada
    Liver Int 33:1363-9. 2013
    ..In this nationwide cross-sectional study, we aimed to investigate the epidemiology and clinical significance of HBV genotype and qHBsAg in patients with chronic hepatitis B (CHB)...
  16. pmc Pregnancy following liver transplantation: review of outcomes and recommendations for management
    Kuljit S Parhar
    Division of General Internal Medicine, University of Calgary, Calgary, Alberta
    Can J Gastroenterol 26:621-6. 2012
    ..Subsequently, the authors provide recommendations for counselling prospective mothers and the management of the pregnant liver transplant recipient...
  17. pmc Venous thromboembolism in cirrhosis: a review of the literature
    Michelle Buresi
    Division of Gastroenterology and Hepatology, University of Calgary, Alberta
    Can J Gastroenterol 26:905-8. 2012
    ..Finally, the available evidence is assessed for prophylaxis and therapy of VTE in chronic liver disease, and the role it may play in decreasing clinical decompensation and improving survival...
  18. ncbi request reprint The impact of pathologist experience on liver transplant biopsy interpretation
    Carla S Coffin
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Mod Pathol 19:832-8. 2006
    ....
  19. pmc Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver
    Tomasz I Michalak
    Molecular Virology and Hepatology Research, Division of Basic Medical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    J Virol 78:1730-8. 2004
    ..Our study documents that the lymphatic system is the primary target of WHV infection when small quantities of virions invade a susceptible host...
  20. doi request reprint Pregnancy outcomes among liver transplant recipients in the United States: a nationwide case-control analysis
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Liver Transpl 16:56-63. 2010
    ..Additional studies evaluating mechanisms aimed at reducing these complications are necessary...
  21. pmc Chronic hepatitis B--who should be treated?
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
    MedGenMed 8:75. 2006
    ..This review includes criteria for determining when and how to most effectively intervene with antiviral therapy for chronically infected patients...
  22. doi request reprint Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract
    Gary R Martin
    Inflammation Research Network, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dig Liver Dis 42:103-9. 2010
    ..Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study was to characterize H2S synthesis throughout the gastrointestinal tract...
  23. pmc The hot air and cold facts of dietary fibre
    Carla S Coffin
    Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, Canada
    Can J Gastroenterol 20:255-6. 2006