Donald Cockcroft

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint Mechanisms of airway hyperresponsiveness
    Donald W Cockcroft
    Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    J Allergy Clin Immunol 118:551-9; quiz 560-1. 2006
  2. doi request reprint Are inhaled longacting β2 agonists detrimental to asthma?
    Donald W Cockcroft
    University of Saskatchewan, Royal University Hospital, Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Saskatoon, SK, Canada Electronic address
    Lancet Respir Med 1:339-46. 2013
  3. doi request reprint Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    Donald W Cockcroft
    Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
    Chest 138:18S-24S. 2010
  4. pmc Understanding allergic asthma from allergen inhalation tests
    Donald W Cockcroft
    University of Saskatchewan, Saskatoon, Canada
    Can Respir J 14:414-8. 2007
  5. doi request reprint Direct and indirect challenges in the clinical assessment of asthma
    Donald Cockcroft
    Department of Medicine, Division of Respirology, Critical Care, and Sleep Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 103:363-9; quiz 369-72, 400. 2009
  6. ncbi request reprint Diagnostic and therapeutic value of airway challenges in asthma
    Donald W Cockcroft
    Division of Respirology, Critical Care, and Sleep Medicine, Royal University Hospital, 103 Hospital Drive, Ellis Hall, 5th Floor, Saskatoon, Saskatchewan S7N0W8, Canada
    Curr Allergy Asthma Rep 9:247-53. 2009
  7. ncbi request reprint The effect of ipratropium nasal spray on bronchial methacholine challenge
    John K Reid
    Division of Respiratory, Critical Care, and Sleep Medicine, University of Saskatchewan, 5th Floor, Ellis Hall, 103 Hospital Dr, Saskatoon, SK, Canada S7N 0W8
    Chest 128:1245-7. 2005
  8. ncbi request reprint Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations
    David C Todd
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, SK S7N 0W8, Canada
    J Allergy Clin Immunol 114:517-9. 2004
  9. ncbi request reprint Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection
    Nathan D Allen
    Royal University Hospital, Department of Physiology, Division of Respirology, Critical Care and Sleep Medicine, 103 Hospital Dr, Ellis Hall, Room 551, Saskatoon, SK, S7N 0W8 Canada
    Chest 128:4018-23. 2005
  10. ncbi request reprint Seasonal fluctuations in airway responsiveness in elite endurance athletes
    Howard B Hemingson
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Can Respir J 11:399-401. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Mechanisms of airway hyperresponsiveness
    Donald W Cockcroft
    Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    J Allergy Clin Immunol 118:551-9; quiz 560-1. 2006
    ..The mechanisms are also uncertain, but reduced airway caliber, increased airway wall thickness, increased airway smooth muscle mass, and perhaps contractility likely all play a role...
  2. doi request reprint Are inhaled longacting β2 agonists detrimental to asthma?
    Donald W Cockcroft
    University of Saskatchewan, Royal University Hospital, Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Saskatoon, SK, Canada Electronic address
    Lancet Respir Med 1:339-46. 2013
    ..When used for appropriate indications, LABAs should be combined with ICS in one inhaler so that monotherapy is not possible. ..
  3. doi request reprint Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    Donald W Cockcroft
    Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
    Chest 138:18S-24S. 2010
    ..Direct challenges are more sensitive and less specific than indirect challenges (exercise, adenosine monophosphate, mannitol, etc)...
  4. pmc Understanding allergic asthma from allergen inhalation tests
    Donald W Cockcroft
    University of Saskatchewan, Saskatoon, Canada
    Can Respir J 14:414-8. 2007
    ....
  5. doi request reprint Direct and indirect challenges in the clinical assessment of asthma
    Donald Cockcroft
    Department of Medicine, Division of Respirology, Critical Care, and Sleep Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 103:363-9; quiz 369-72, 400. 2009
    ..To compare direct and indirect bronchoprovocation challenges in the clinical assessment of asthma...
  6. ncbi request reprint Diagnostic and therapeutic value of airway challenges in asthma
    Donald W Cockcroft
    Division of Respirology, Critical Care, and Sleep Medicine, Royal University Hospital, 103 Hospital Drive, Ellis Hall, 5th Floor, Saskatoon, Saskatchewan S7N0W8, Canada
    Curr Allergy Asthma Rep 9:247-53. 2009
    ..The indirect stimuli are the challenges of choice for evaluating exercise-induced bronchoconstriction...
  7. ncbi request reprint The effect of ipratropium nasal spray on bronchial methacholine challenge
    John K Reid
    Division of Respiratory, Critical Care, and Sleep Medicine, University of Saskatchewan, 5th Floor, Ellis Hall, 103 Hospital Dr, Saskatoon, SK, Canada S7N 0W8
    Chest 128:1245-7. 2005
    ..To determine the effect ipratropium bromide nasal spray has on methacholine challenge testing for airway hyperresponsiveness...
  8. ncbi request reprint Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations
    David C Todd
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, SK S7N 0W8, Canada
    J Allergy Clin Immunol 114:517-9. 2004
    ..We have anecdotally observed that the 5 breath to total lung capacity (TLC) dosimeter method reduced the response to methacholine in some subjects with mild AHR...
  9. ncbi request reprint Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection
    Nathan D Allen
    Royal University Hospital, Department of Physiology, Division of Respirology, Critical Care and Sleep Medicine, 103 Hospital Dr, Ellis Hall, Room 551, Saskatoon, SK, S7N 0W8 Canada
    Chest 128:4018-23. 2005
    ..Both the lower dose and the bronchoprotective deep inhalations contribute to the lesser airway response of the dosimeter...
  10. ncbi request reprint Seasonal fluctuations in airway responsiveness in elite endurance athletes
    Howard B Hemingson
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Can Respir J 11:399-401. 2004
    ..It has been suggested that exposure to winter training conditions (irritants in indoor facilities and/or cold, dry air in the outdoors) can increase airway responsiveness in elite endurance athletes...
  11. doi request reprint Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 124:1217-21. 2009
    ..Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved...
  12. ncbi request reprint Formoterol thrice weekly does not result in the development of tolerance to bronchoprotection
    Beth E Davis
    Division of Respiratory Medicine, Department of Medicine, Royal University Hospital, Saskatoon, Saskatchewan
    Can Respir J 10:23-6. 2003
    ..Loss of bronchoprotection routinely follows regular treatment with beta2-agonists. There are no data on the effects on bronchoprotection for thrice weekly use of a beta2-agonist...
  13. pmc The American Thoracic Society's spirometric criteria alone is inadequate in asthma diagnosis
    John A Gjevre
    Division of Respirology, Royal University Hospital, University of Saskatchewan, Saskatoon
    Can Respir J 13:433-7. 2006
    ....
  14. doi request reprint Occurrence of new-onset wheeze in a 3-year follow-up study of schoolchildren
    Joshua A Lawson
    Institute of Agricultural, Rural and Environmental Health, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    Ann Allergy Asthma Immunol 99:502-8. 2007
    ..Different wheeze phenotypes have been identified, primarily in preschool children...
  15. ncbi request reprint The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result
    Donald W Cockcroft
    Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan Royal University Hospital, Saskatoon, Canada
    J Allergy Clin Immunol 117:1244-8. 2006
    ..We recommend that the dosimeter method not be performed as outlined by the American Thoracic Society and that methacholine should be administered by means of submaximal inhalations or tidal breathing...
  16. ncbi request reprint A comparison of 2 methods of continuous aerosol administration during methacholine challenge testing
    Thomas S Hurst
    Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada
    Respir Care 51:46-8. 2006
    ..The methacholine can be inhaled using one of several methods. The loosely-fitting-mask method is likely to produce more contamination of the local environment than a filtered exhalation system...
  17. doi request reprint Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 177:952-8. 2008
    ....
  18. ncbi request reprint Regional variations in risk factors for asthma in school children
    Joshua A Lawson
    Institute of Agricultural, Rural and Environmental Health, University of Saskatchewan, Saskatoon
    Can Respir J 12:321-6. 2005
    ..The authors have previously reported an increased prevalence of asthma in Estevan, Saskatchewan (21.4%) compared with Swift Current, Saskatchewan (16.2%)...
  19. ncbi request reprint Lack of tachyphylaxis to methacholine at 24 h
    Donald W Cockcroft
    Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, 103 Hospital Dr, Ellis Hall, Fifth Floor, Saskatoon, SK, S7N 0W8 Canada
    Chest 128:1248-51. 2005
    ....
  20. ncbi request reprint Sex differences in asthma, atopy, and airway hyperresponsiveness in a university population
    Elizabeth S PausJenssen
    Division of Pulmonary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 91:34-7. 2003
    ..A male predominance in atopy, a preadolescent male predominance in asthma, and a female predominance in airway hyperresponsiveness (AHR) have been previously documented, mostly in separate populations...
  21. ncbi request reprint Bronchoprovocation methods: direct challenges
    Donald W Cockcroft
    Department of Medicine, Royal University Hospital, Saskatoon, Canada
    Clin Rev Allergy Immunol 24:19-26. 2003
    ..A PC(20) < 16 mg/mL is highly sensitive for current symptoms of asthma. Interpretation of methacholine or histamine inhalation test requires that symptoms be current (within a few days) and that FEV(1) be normal...
  22. ncbi request reprint As-needed inhaled beta2-adrenoceptor agonists in moderate-to-severe asthma: current recommendations
    Donald W Cockcroft
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada
    Treat Respir Med 4:169-74. 2005
    ..On the basis of the available evidence, the as-needed intermediate-acting inhaled beta2-agonist therapeutic strategy appears appropriate for patients with moderate-to-severe asthma...
  23. ncbi request reprint Effect of a single dose of montelukast sodium on methacholine chloride PC20
    Beth E Davis
    University of Saskatchewan, Royal University Hospital, Saskatoon, Canada
    Can Respir J 12:26-8. 2005
    ..It is currently recommended that leukotriene modifiers (receptor antagonists and synthesis inhibitors) be withheld for a minimum of 24 h before direct bronchoprovocation testing, but there is little evidence to support this recommendation...
  24. ncbi request reprint Methacholine challenge: comparison of two methods
    Donald W Cockcroft
    Division of Respiratory Medicine, Department of Medicine, Royal University Hospital, University of Saskatchewan, Ellis Hall, Fifth Floor, Saskatoon, SK, S7N 0W8 Canada
    Chest 127:839-44. 2005
    ..Although subjects are exposed to twice as much aerosol at any given concentration during the tidal-breathing method compared to the dosimeter method, they were thought to give equivalent results...
  25. ncbi request reprint Differences in respiratory symptoms and pulmonary function in children in 2 Saskatchewan communities
    Donna C Rennie
    College of Nursing, Institute of Agricultural, Rural and Environmental Health, University of Saskatchewan, Saskatoon, Canada
    Ann Allergy Asthma Immunol 92:52-9. 2004
    ..Asthma prevalence is known to vary among different geographical regions both nationally and internationally. However, there is limited understanding of the nature of differences within geographical regions...
  26. ncbi request reprint Development of a methacholine challenge method to minimize methacholine waste
    Donald W Cockcroft
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada
    Chest 124:1522-5. 2003
    ..The standard 2-min tidal breathing methacholine challenge utilizes 3 mL to produce an output of 0.26 mL per 2 min, resulting in a substantial amount of methacholine being discarded...
  27. ncbi request reprint The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    J Allergy Clin Immunol 112:331-8. 2003
    ..Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes...
  28. ncbi request reprint Effect of combined montelukast and desloratadine on the early asthmatic response to inhaled allergen
    Beth E Davis
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada
    J Allergy Clin Immunol 116:768-72. 2005
    ..Combination therapy directed at blocking the effects of both mediators might protect against the EAR better than either therapy alone...
  29. doi request reprint Correlation between airway inflammation and loss of deep-inhalation bronchoprotection in asthma
    Nathan D Allen
    Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 101:413-8. 2008
    ..One of the characteristic features of the hyperresponsive airway smooth muscle in asthma is the loss of deep-inhalation bronchoprotection and bronchodilation. The airway of individuals with asthma is also characterized by inflammation...
  30. ncbi request reprint Importance of dosimeter calibration method on nebulizer output
    David C Todd
    Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada
    Ann Allergy Asthma Immunol 94:45-7. 2005
    ..We have observed that dosimeter-run nebulizers have a much smaller output when manually activated than when breath activated; however, this has not been adequately investigated...
  31. ncbi request reprint Hypersensitivity pneumonitis as a cause of airway-centered interstitial fibrosis
    Mark E Fenton
    Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Ann Allergy Asthma Immunol 99:465-6. 2007
    ..Airway-centered interstitial fibrosis (ACIF) has been postulated to be related to environmental exposures...
  32. pmc Nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia: report of a case
    Mark E Fenton
    Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Can Respir J 15:311-2. 2008
    ..A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented...
  33. ncbi request reprint Deep inspiration avoidance and methacholine response in normal subjects and patients with asthma
    Barbara Simard
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City, QC, Canada
    Chest 127:135-42. 2005
    ..Deep inspiration (DI) avoidance and time intervals between inhalation and measurement of FEV1 may influence methacholine challenges...
  34. ncbi request reprint Extrapolation of methacholine PC(20)
    Beth E Davis
    Chest 122:1499-500. 2002
  35. ncbi request reprint Nebulizer output for methacholine challenges with the KoKo Digidoser
    Yasmeen R Khan
    J Allergy Clin Immunol 116:924-6. 2005
  36. ncbi request reprint Deep inhalation bronchoprotection in asthma: correlation with airway responsiveness
    Donald W Cockcroft
    J Allergy Clin Immunol 117:951-2. 2006
  37. doi request reprint Methacholine challenge methods
    Donald W Cockcroft
    Chest 134:678-80. 2008
  38. ncbi request reprint Levalbuterol has not been established to have therapeutic advantage over racemic albuterol
    Michael J Asmus
    J Allergy Clin Immunol 110:325; author reply 325-8. 2002
  39. doi request reprint Extrapolation of allergen PC15
    Donald W Cockcroft
    Ann Allergy Asthma Immunol 100:619-20. 2008
  40. pmc Examining asthma quality of care using a population-based approach
    Helena Klomp
    Health Quality Council, Saskatoon, Sask
    CMAJ 178:1013-21. 2008
    ..Quality-of-care indicators would aid in monitoring asthma management. We describe the quality of asthma care using a set of proposed quality indicators...
  41. ncbi request reprint Magnitude of bronchoprotection of albuterol vs methacholine: relationship to baseline airway caliber
    Donald W Cockcroft
    Chest 130:622-3. 2006
  42. ncbi request reprint Efficacy and safety of mometasone furoate dry powder inhaler vs fluticasone propionate metered-dose inhaler in asthma subjects previously using fluticasone propionate
    Andy Wardlaw
    Institute for Lung Health, Glenfield Hospital NHS Trust, Leicester, England
    Ann Allergy Asthma Immunol 93:49-55. 2004
    ..To compare the efficacy and safety of mometasone furoate dry powder inhaler (DPI) administered once daily in the evening with fluticasone propionate metered-dose inhaler (MDI) administered twice daily...
  43. ncbi request reprint Deep inhalation bronchodilation and oral corticosteroids in asthma
    Donald W Cockcroft
    Chest 130:7-8. 2006
  44. ncbi request reprint Methacholine PC20: 1-point formula
    Donald W Cockcroft
    Ann Allergy Asthma Immunol 98:498-9. 2007
  45. ncbi request reprint Method of nebulizer calibration and methacholine airway responsiveness
    Beth E Davis
    J Allergy Clin Immunol 114:1474-5. 2004