Sean P Cleary

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk
    Sean P Cleary
    Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 172:1000-14. 2010
  2. pmc Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk
    Sean P Cleary
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dis Colon Rectum 51:1467-73; discussion 1473-4. 2008
  3. ncbi request reprint Prognosis and results after resection of very large (>or=10 cm) hepatocellular carcinoma
    Shimul A Shah
    Department of Surgery, Multi Organ Transplantation Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    J Gastrointest Surg 11:589-95. 2007
  4. ncbi request reprint Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients
    Marina E Croitoru
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Surg Oncol 95:499-506. 2007
  5. doi request reprint Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk
    Ji Hyun Jang
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
    Mol Carcinog 52:E103-9. 2013
  6. pmc Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study
    Sean P Cleary
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 136:1251-60. 2009
  7. pmc Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada
    Laura N Anderson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e66768. 2013
  8. ncbi request reprint Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk
    Marina E Croitoru
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    J Natl Cancer Inst 96:1631-4. 2004
  9. ncbi request reprint An analysis of resection vs transplantation for early hepatocellular carcinoma: defining the optimal therapy at a single institution
    Shimul A Shah
    Department of Surgery, University Health Network, University of Toronto, Toronto, Canada
    Ann Surg Oncol 14:2608-14. 2007
  10. pmc Predictors of peri-opertative morbidity and liver dysfunction after hepatic resection in patients with chronic liver disease
    Elisa Greco
    Department of Surgery, University Health Network, University of Toronto, Toronto, Canada
    HPB (Oxford) 13:559-65. 2011

Collaborators

Detail Information

Publications24

  1. pmc Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk
    Sean P Cleary
    Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 172:1000-14. 2010
    ..03) status. These findings support the hypothesis that prolonged cigarette smoking is associated with increased risk of colorectal cancer and that this risk may be modified by variation in carcinogen metabolism genes...
  2. pmc Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk
    Sean P Cleary
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dis Colon Rectum 51:1467-73; discussion 1473-4. 2008
    ..Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer...
  3. ncbi request reprint Prognosis and results after resection of very large (>or=10 cm) hepatocellular carcinoma
    Shimul A Shah
    Department of Surgery, Multi Organ Transplantation Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    J Gastrointest Surg 11:589-95. 2007
    ..We sought to examine the outcomes and risk factors for recurrence after resection of >or=10 cm HCC...
  4. ncbi request reprint Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients
    Marina E Croitoru
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Surg Oncol 95:499-506. 2007
    ..Our objective was to determine the significance of MYH mutations in a series of Canadian patients with multiple adenomas...
  5. doi request reprint Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk
    Ji Hyun Jang
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
    Mol Carcinog 52:E103-9. 2013
    ..77, 3.67). MCPH1-2550-C > T and TopBP1-3257-A > G modify the association between smoking and pancreatic cancer. These findings provide insights into the potential molecular mechanisms behind smoking-associated pancreatic cancer...
  6. pmc Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study
    Sean P Cleary
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 136:1251-60. 2009
    ..The objective of this study was to determine colorectal cancer (CRC) risk associated with mutations in the MYH gene...
  7. pmc Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada
    Laura N Anderson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e66768. 2013
    ..Vitamin D pathway gene variants may be associated with pancreas cancer risk and future studies are needed to understand the possible role of vitamin D in tumorigenesis and may have implications for cancer-prevention strategies. ..
  8. ncbi request reprint Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk
    Marina E Croitoru
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    J Natl Cancer Inst 96:1631-4. 2004
    ..These two MYH gene mutations may account for a substantial fraction of hereditary colorectal cancer...
  9. ncbi request reprint An analysis of resection vs transplantation for early hepatocellular carcinoma: defining the optimal therapy at a single institution
    Shimul A Shah
    Department of Surgery, University Health Network, University of Toronto, Toronto, Canada
    Ann Surg Oncol 14:2608-14. 2007
    ....
  10. pmc Predictors of peri-opertative morbidity and liver dysfunction after hepatic resection in patients with chronic liver disease
    Elisa Greco
    Department of Surgery, University Health Network, University of Toronto, Toronto, Canada
    HPB (Oxford) 13:559-65. 2011
    ..There is no universal risk stratification scheme for CLD patients undergoing resection...
  11. ncbi request reprint Impact of viral hepatitis on outcomes after liver resection for hepatocellular carcinoma: results from a north american center
    Jonghun J Lee
    Department of Surgery, 10EN216 Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Ann Surg Oncol 21:2708-16. 2014
    ..The characteristics and clinical outcomes of HCC arising from these conditions may differ. This study was conducted to compare the outcomes of HCC associated with HBV and HCV after liver resection...
  12. ncbi request reprint Surgery for gallbladder cancer: a population-based analysis
    Natalie G Coburn
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Surg 207:371-82. 2008
    ..Single institutional studies report an aggressive surgical approach improves survival. This analysis was performed to examine the components of surgical resection and resultant survival...
  13. pmc Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, University of Toronto, Toronto, Canada
    Cancer Epidemiol 37:424-7. 2013
    ..Data has suggested that HOXB13 expression levels are decreased in colorectal cancer (CRC) cell lines indicating this gene may be involved in colorectal tumourigenesis...
  14. pmc Aberrant right hepatic artery in pancreaticoduodenectomy for adenocarcinoma: impact on resectability and postoperative outcomes
    Peter T W Kim
    Department of Surgical Oncology, University Health Network, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada
    HPB (Oxford) 16:204-11. 2014
    ..The aim of this study was to assess the impact of an aRHA on resectability, and perioperative and oncologic outcomes after PD for PA...
  15. doi request reprint Clinical and economic comparison of laparoscopic to open liver resections using a 2-to-1 matched pair analysis: an institutional experience
    Faizal D Bhojani
    Division of General Surgery, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada
    J Am Coll Surg 214:184-95. 2012
    ..Our center has introduced a laparoscopic liver resection (LLR) program over the past 3 years. Our objective is to describe the initial clinical experience with LLR, including a detailed cost analysis...
  16. doi request reprint Neuroendocrine tumors of the gastrointestinal tract: a decade of experience at the Princess Margaret Hospital
    Jeff Rothenstein
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Clin Oncol 31:64-70. 2008
    ..Over the past decade, novel treatment approaches have been developed. The purpose of this study was to review the experience at the Princess Margaret Hospital in treating patients with NET over the past decade...
  17. pmc Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk
    Ji Hyun Jang
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada M5G 2L7
    Carcinogenesis 33:818-27. 2012
    ..04) and smoking status and N-acetyltransferase 2-857 (P = 0.03). Variants of carcinogen metabolism genes are independently associated with pancreatic cancer risk and may modify the risk posed by smoking...
  18. ncbi request reprint Heterozygosity for the BLM(Ash) mutation and cancer risk
    Sean P Cleary
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer Res 63:1769-71. 2003
    ....
  19. pmc Liver resection after chemotherapy and tumour downsizing in patients with initially unresectable colorectal cancer liver metastases
    Nicolas Devaud
    Toronto General Hospital, University Health Network UHN, Toronto, ON, Canada Department of Surgery, University of Toronto, Toronto, ON, Canada
    HPB (Oxford) 16:475-80. 2014
    ..This study reports the results achieved in liver resections performed at a single hepatobiliary referral centre after downsizing chemotherapy in patients with initially unresectable CLM...
  20. ncbi request reprint Recurrence after liver resection for hepatocellular carcinoma: risk factors, treatment, and outcomes
    Shimul A Shah
    Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Surgery 141:330-9. 2007
    ..The purpose of this study was to identify risk factors for the recurrence of HCC and to examine long-term outcomes after resection...
  21. pmc Identification of driver genes in hepatocellular carcinoma by exome sequencing
    Sean P Cleary
    Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Hepatology 58:1693-702. 2013
    ..In particular, the MLL family of methyltransferases for histone H3 lysine 4 were mutated in 20% of tumors. Conclusion: The NFE2L2-KEAP1 and MLL pathways are recurrently mutated in multiple cohorts of HCC...
  22. ncbi request reprint Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors
    Sean P Cleary
    Department of Surgery, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 2X5
    J Am Coll Surg 198:722-31. 2004
    ..We then sought to determine clinical and histopathologic features of 5-year survivors to determine factors associated with a favorable prognosis...
  23. ncbi request reprint Cancer of the gallbladder and extrahepatic bile ducts
    Sean P Cleary
    Department of Surgery, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Curr Probl Surg 44:396-482. 2007
  24. doi request reprint Association of hepatic hemangiomatosis with giant cavernous hemangioma in the adult population: prevalence, imaging appearance, and relevance
    Kartik S Jhaveri
    Department of Medical Imaging, University of Toronto, University Health Network and Mount Sinai Hospital, 610 University Ave, 3 957, Toronto, ON M5G2M9, Canada
    AJR Am J Roentgenol 196:809-15. 2011
    ..The purpose of our study was to evaluate the association of hepatic hemangiomatosis with giant cavernous hemangioma (GCH) and describe the imaging appearances and clinical relevance...