W F Clark

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial
    Michael Walsh
    Departments of Medicine and Clinical Epidemiology and Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St, Joseph s Hospital, 50 Charlton Ave East, Hamilton, ON L8S 4A6, Canada
    Trials 14:73. 2013
  2. pmc Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development and validation study
    Ainslie M Hildebrand
    Division of Nephrology, University of Western Ontario, London, Canada
    BMC Med Inform Decis Mak 12:49. 2012
  3. doi request reprint Plasma exchange for renal disease: evidence and use 2011
    W F Clark
    London Health Science Centre, Western University Canada
    J Clin Apher 27:112-6. 2012
  4. doi request reprint Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange
    William F Clark
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Semin Dial 25:214-9. 2012
  5. pmc Attending rounds: microangiopathic hemolytic anemia with renal insufficiency
    William F Clark
    University of Western Ontario, Department of Medicine, London, Ontario, Canada
    Clin J Am Soc Nephrol 7:342-7. 2012
  6. ncbi request reprint What have we learned about optimal induction therapy for lupus nephritis (III through V) from randomized, controlled trials?
    William F Clark
    London Health Sciences Centre, and Department of Medicine, University of Western Ontario, London, Canada, N6A 4G5
    Clin J Am Soc Nephrol 3:895-8. 2008
  7. pmc Excessive fluid intake as a novel cause of proteinuria
    William F Clark
    Department of Medicine Nephrology, London Health Sciences Centre, University of Western Ontario, London, Ont
    CMAJ 178:173-5. 2008
  8. ncbi request reprint Evaluation of GFR estimating equations in the general community: implications for screening
    William F Clark
    University of Western Ontario and London Health Sciences Centre, London, Ontario, Canada
    Clin J Am Soc Nephrol 1:787-95. 2006
  9. pmc Association between estimated glomerular filtration rate at initiation of dialysis and mortality
    William F Clark
    Division of Nephrology, University of Western Ontario, London Ont, Canada
    CMAJ 183:47-53. 2011
  10. pmc Dipstick proteinuria as a screening strategy to identify rapid renal decline
    William F Clark
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Soc Nephrol 22:1729-36. 2011

Collaborators

Detail Information

Publications54

  1. pmc Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial
    Michael Walsh
    Departments of Medicine and Clinical Epidemiology and Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St, Joseph s Hospital, 50 Charlton Ave East, Hamilton, ON L8S 4A6, Canada
    Trials 14:73. 2013
    ..A randomized study of both plasma exchange and glucocorticoids is required to evaluate plasma exchange and oral glucocorticoid dosing in patients with AAV...
  2. pmc Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development and validation study
    Ainslie M Hildebrand
    Division of Nephrology, University of Western Ontario, London, Canada
    BMC Med Inform Decis Mak 12:49. 2012
    ..Our objective was to develop and test search filters for PubMed, Ovid Medline, and Embase that allow physicians to search within a subset of the database to retrieve articles relevant to glomerular disease...
  3. doi request reprint Plasma exchange for renal disease: evidence and use 2011
    W F Clark
    London Health Science Centre, Western University Canada
    J Clin Apher 27:112-6. 2012
    ..This report describes the most common indications for plasma exchange in patient's with renal disease and the evidence that supports it's use in 2011...
  4. doi request reprint Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange
    William F Clark
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Semin Dial 25:214-9. 2012
    ..The advent of plasma therapy in the treatment of thrombotic microangiopathy has led to a clearer understanding of the role of ADAMTS13, both short- and long-term outcomes and the need for future surveillance and intervention...
  5. pmc Attending rounds: microangiopathic hemolytic anemia with renal insufficiency
    William F Clark
    University of Western Ontario, Department of Medicine, London, Ontario, Canada
    Clin J Am Soc Nephrol 7:342-7. 2012
    ..The discussion attempts to provide a simple clinical approach to the diagnosis, treatment options, and future course of adults and children suffering from a thrombotic microangiopathy...
  6. ncbi request reprint What have we learned about optimal induction therapy for lupus nephritis (III through V) from randomized, controlled trials?
    William F Clark
    London Health Sciences Centre, and Department of Medicine, University of Western Ontario, London, Canada, N6A 4G5
    Clin J Am Soc Nephrol 3:895-8. 2008
  7. pmc Excessive fluid intake as a novel cause of proteinuria
    William F Clark
    Department of Medicine Nephrology, London Health Sciences Centre, University of Western Ontario, London, Ont
    CMAJ 178:173-5. 2008
    ..We do not know at this time whether the proteinuria associated with excessive fluid intake in these otherwise healthy people will affect their kidney function in the long term...
  8. ncbi request reprint Evaluation of GFR estimating equations in the general community: implications for screening
    William F Clark
    University of Western Ontario and London Health Sciences Centre, London, Ontario, Canada
    Clin J Am Soc Nephrol 1:787-95. 2006
    ..The calibrated Rule equation seems to perform better than CG and MDRD (CKD 3 versus 11.3 to 12%) but lacks validation against gold standards for community-based screening...
  9. pmc Association between estimated glomerular filtration rate at initiation of dialysis and mortality
    William F Clark
    Division of Nephrology, University of Western Ontario, London Ont, Canada
    CMAJ 183:47-53. 2011
    ..We examined trends in initiation of hemodialysis within Canada and compared the risk of death between patients with early and late initiation of dialysis...
  10. pmc Dipstick proteinuria as a screening strategy to identify rapid renal decline
    William F Clark
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Soc Nephrol 22:1729-36. 2011
    ..In summary, inexpensive screening with urine dipstick should allow primary care physicians to follow fewer patients with serial eGFR assessment but still identify those with rapid decline of kidney function...
  11. pmc Urine volume and change in estimated GFR in a community-based cohort study
    William F Clark
    Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Clin J Am Soc Nephrol 6:2634-41. 2011
    ..The effect of increased fluid intake on kidney function is unclear. This study evaluates the relationship between urine volume and renal decline over 6 years in a large community-based cohort...
  12. pmc To pay or not to pay? A decision and cost-utility analysis of angiotensin-converting-enzyme inhibitor therapy for diabetic nephropathy
    W F Clark
    Division of Nephrology, London Health Sciences Centre, Ont
    CMAJ 162:195-8. 2000
    ....
  13. ncbi request reprint A novel treatment for lupus nephritis: lignan precursor derived from flax
    W F Clark
    Department of Medicine, London Health Sciences Centre and The University of Western Ontario, Canada
    Lupus 9:429-36. 2000
    ....
  14. ncbi request reprint Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study
    W F Clark
    London Health Sciences Centre, The University of Western Ontario, Canada
    J Am Coll Nutr 20:143-8. 2001
    ..The objective of this study was to determine the renoprotective effects of ground flaxseed in patients with lupus nephritis...
  15. pmc Long term risk for hypertension, renal impairment, and cardiovascular disease after gastroenteritis from drinking water contaminated with Escherichia coli O157:H7: a prospective cohort study
    William F Clark
    Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, ON, Canada
    BMJ 341:c6020. 2010
    ..To evaluate the risk for hypertension, renal impairment, and cardiovascular disease within eight years of gastroenteritis from drinking water contaminated with Escherichia coli O157:H7 and Campylobacter...
  16. doi request reprint Plasma exchange for myeloma kidney: cast(s) away?
    W F Clark
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Kidney Int 73:1211-3. 2008
    ..The analysis supports restitution of a better RCT of plasma exchange for myeloma kidney rather than off-label use...
  17. ncbi request reprint Absence of renal sequelae after childhood Escherichia coli O157:H7 gastroenteritis
    A X Garg
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 70:807-12. 2006
    ..With no existing data to support screening after self-limited E. coli O157:H7 gastroenteritis, we recommend that only those children who develop recognized features of hemolytic uremic syndrome be followed for long-term renal health...
  18. pmc Arthritis risk after acute bacterial gastroenteritis
    A X Garg
    London Kidney Research Unit, Division of Nephrology, London Health Sciences Centre, ON, Canada
    Rheumatology (Oxford) 47:200-4. 2008
    ....
  19. doi request reprint An outbreak of acute bacterial gastroenteritis is associated with an increased incidence of irritable bowel syndrome in children
    Marroon Thabane
    Division of Gastroenterology, Department of Medicine, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Am J Gastroenterol 105:933-9. 2010
    ..We assessed this association among a cohort of children enrolled in the Walkerton Health Study (WHS)...
  20. doi request reprint Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study
    Alexander C Ford
    Department of Medicine, Division of Gastroenterology, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 138:1727-36; quiz e12. 2010
    ..We assessed prevalence of uninvestigated dyspepsia in a cohort of individuals, some of whom were exposed to bacterial dysentery in May 2000, as well as risk factors for dyspepsia in exposed individuals...
  21. doi request reprint Elevated blood pressure in relation to overweight and obesity among children in a rural Canadian community
    Marina Salvadori
    Department of Pediatrics, Children s Hospital, London, Ontario, Canada
    Pediatrics 122:e821-7. 2008
    ..Rural populations in North America may be at increased risk for overweight. We evaluated whether overweight and obesity were associated with prehypertension and hypertension in a well-characterized population of children in rural Canada...
  22. doi request reprint Chronic renal disease is more prevalent in patients with hemolytic uremic syndrome who had a positive history of diarrhea
    Ajay P Sharma
    Division of Nephrology, Department of Pediatrics, Children s Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Kidney Int 78:598-604. 2010
    ..Prospective studies with appropriate controls are needed to completely resolve this issue...
  23. doi request reprint Risk of pregnancy-related hypertension within 5 years of exposure to drinking water contaminated with Escherichia coli O157:H7
    Louise Moist
    Division of Nephrology, Department of Medicine, Victoria Hospital London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada
    J Clin Hypertens (Greenwich) 12:613-20. 2010
    ..05-5.4). A trend toward higher chronic hypertension and mean arterial pressure in early pregnancy was observed among women who experienced gastroenteritis after exposure to bacterially-contaminated drinking water...
  24. pmc Hyperfiltration affects accuracy of creatinine eGFR measurement
    Shih Han S Huang
    Department of Pediatrics, Children s Hospital, London Health Sciences Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, 800 Commissioner s Road East, Room E6 104, London ON, Canada, N6A 5W9
    Clin J Am Soc Nephrol 6:274-80. 2011
    ..It is hypothesized that the accuracy of creatinine for eGFR may be affected by hyperfiltration and different effective renal plasma flow (ERPF)...
  25. pmc Opioid and benzodiazepine use in end-stage renal disease: a systematic review
    Ahraaz Wyne
    University of Western Ontario, London Kidney Clinical Research Unit, Room ELL 101 Victoria Hospital, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
    Clin J Am Soc Nephrol 6:326-33. 2011
    ..We conducted a systematic review to determine the: (1) prevalence of opioid and benzodiazepine use among dialysis patients; (2) reasons for use; (3) effectiveness of symptom control; and (4) incidence of adverse events...
  26. ncbi request reprint Optimal timing of initiation of chronic hemodialysis?
    Barbara Wilson
    London Health Sciences Centre, London, Ontario, Canada
    Hemodial Int 11:263-9. 2007
    ..Our survival benefit findings suggest the premorbid health condition is a more important determinant of 2 year survival than the timing of dialysis initiation...
  27. doi request reprint Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update
    Amit X Garg
    Division of Nephrology, University of Western Ontario, London, Canada
    Am J Kidney Dis 51:435-44. 2008
    ..Estimates in the literature are highly variable, and previous studies did not use a healthy control group to establish outcomes attributable to HUS...
  28. ncbi request reprint Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination
    Amit X Garg
    Division of Nephrology, University of Western Ontario, London, Ontario, London, Canada
    Kidney Int 67:1476-82. 2005
    ..However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group...
  29. ncbi request reprint Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery
    John K Marshall
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 131:445-50; quiz 660. 2006
    ..To better define its incidence and epidemiology, a large cohort study was initiated after the contamination of a municipal water supply led to a large outbreak of acute Escherichia coli 0157:H7 and Campylobacter jejuni gastroenteritis...
  30. ncbi request reprint Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression
    Amit X Garg
    Division of Adult and Pediatric Nephrology, University of Western Ontario, London, Canada
    JAMA 290:1360-70. 2003
    ..The long-term renal prognosis of patients with diarrhea-associated hemolytic uremic syndrome (HUS) remains controversial...
  31. pmc Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water
    Amit X Garg
    Division of Nephrology, University of Western Ontario, London, Ont
    CMAJ 173:261-8. 2005
    ..We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species...
  32. ncbi request reprint Diabetes during diarrhea-associated hemolytic uremic syndrome: a systematic review and meta-analysis
    Rita S Suri
    Kidney Clinical Research Unit, Division of Nephrology, London Health Sciences Center, University of Western Ontario, Room ELL 111 Victoria Hospital, 800 Commissioners Rd East, London, Ontario, Canada N6A 4G5
    Diabetes Care 28:2556-62. 2005
    ..To quantify the incidence of diabetes during the acute phase of diarrhea-associated hemolytic uremic syndrome (D + HUS) and to identify features associated with its development...
  33. ncbi request reprint ADAMTS-13 may not predict disease or outcome in patients with Thrombotic Thrombocytopenic Purpura
    G Rock
    Department of Pathology, University of Ottawa, Ottawa, ON, Canada
    Thromb Res 131:308-12. 2013
    ....
  34. doi request reprint Clustering and stability of functional lower gastrointestinal symptom after enteric infection
    M Thabane
    Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
    Neurogastroenterol Motil 24:546-52, e252. 2012
    ....
  35. ncbi request reprint Frequently relapsing thrombotic thrombocytopenic purpura treated with cytotoxic immunosuppressive therapy
    D S Allan
    Divison of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Haematologica 86:844-50. 2001
    ..Immunosuppression, thus, has a biologically plausible role in TTP. We describe three consecutive cases of relapsing TTP treated with cytotoxic therapy to highlight the potential role of immunosuppression...
  36. ncbi request reprint Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome: a new index predicting response to plasma exchange
    B F Wyllie
    Division of Nephrology, University of Western Ontario, London, Canada
    Br J Haematol 132:204-9. 2006
    ..5%, 14.0%, 31.3% and 61.5% respectively in our source population. This simple model may help identify those patients who would benefit from higher treatment intensity...
  37. ncbi request reprint Plasma exchange in rapidly progressive renal failure due to multiple myeloma. A retrospective case series
    L Moist
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ont, Canada
    Am J Nephrol 19:45-50. 1999
    ..To evaluate the effect of plasma exchange on renal function in patients with rapidly progressive renal failure secondary to multiple myeloma...
  38. doi request reprint Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
    John K Marshall
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada
    Gut 59:605-11. 2010
    ....
  39. ncbi request reprint Albuminuria and renal insufficiency prevalence guides population screening: results from the NHANES III
    Amit X Garg
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Kidney Int 61:2165-75. 2002
    ..S. non-institutionalized population. Such knowledge guides the utility of population screening to prevent ESRD...
  40. doi request reprint Plasma exchange for treating cryoglobulinemia: a descriptive analysis
    M A Rockx
    London Health Sciences Centre, London, ON, Canada
    Transfus Apher Sci 42:247-51. 2010
    ..The goal of this paper was to review over the past 20 years the medical literature for evidence supporting or refuting the reported use of plasmapheresis for cryoglobulinemia (January 1988 through June 2008)...
  41. ncbi request reprint Treatment of lupus nephritis
    Fayez F Hejaili
    Division of Nephrology, London Health Sciences Centre, Westminster Campus, The University of Western Ontario, Canada
    Drugs 63:257-74. 2003
    ....
  42. ncbi request reprint An operating cost comparison between conventional and home quotidian hemodialysis
    Andrew Kroeker
    Optimal Dialysis Research Unit, London Health Sciences Centre, London, Ontario, Canada
    Am J Kidney Dis 42:49-55. 2003
    ....
  43. doi request reprint Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis
    Alexandra Chloe Villani
    Division of Gastroenterology, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Gastroenterology 138:1502-13. 2010
    ..2% of these developed IBS. We used this cohort to study genetic susceptibility to post-infectious (PI)-IBS...
  44. ncbi request reprint Ustekinumab associated thrombotic thrombocytopenic purpura
    Shih Han S Huang
    The University of Western Ontario, Department of Medicine, Nephrology Division, and London Health Sciences Centre, London, Canada
    Transfus Apher Sci 47:185-8. 2012
    ..Although our patient experienced a prolonged course of TTP requiring 1 month of daily plasma exchange therapy, he recovered and remains in remission after 6 months...
  45. ncbi request reprint Causes of reversible nephrogenic diabetes insipidus: a systematic review
    Camelia G Garofeanu
    Division of Nephrology, Walkerton Health Study, London Health Science Centre, Westminster Campus, Canada
    Am J Kidney Dis 45:626-37. 2005
    ..The risk for conversion of reversible to irreversible NDI seems to be a potential complication. This review summarizes the reversible causes of acquired NDI to facilitate earlier recognition and more effective treatment by clinicians...
  46. ncbi request reprint Correction: Plasma exchange when myeloma presents as acute renal failure
    William F Clark
    University of Western Ontario, London, Ontario, Canada
    Ann Intern Med 146:471. 2007
  47. doi request reprint Treating TTP/HUS with plasma exchange: a single centre's 25-year experience
    Brian R Forzley
    London Health Sciences Centre, Victoria Hospital Division of Nephrology, Department of Medicine, London Health Sciences Centre, University of Western Ontario, Canada
    Br J Haematol 143:100-6. 2008
    ..Patient education, surveillance, and aggressive plasma exchange therapy are hypothesized to improve the likelihood of survival: these hypotheses should be tested in a randomized controlled trial...
  48. ncbi request reprint Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial
    William F Clark
    University of Western Ontario, London, Ontario, Canada
    Ann Intern Med 143:777-84. 2005
    ..Two small, randomized trials provide conflicting evidence about the benefits of plasma exchange for patients with acute renal failure at the onset of multiple myeloma...
  49. ncbi request reprint Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I
    Amit X Garg
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Kidney Int 61:1486-94. 2002
    ..S. general non-institutionalized population...
  50. doi request reprint Results of a randomized controlled trial on statin use in dialysis patients had no influence on statin prescription
    Ngan N Lam
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Canada
    Kidney Int 76:1172-9. 2009
    ..The use of a common cardiovascular medication in this patient population appears to be influenced by other factors...
  51. ncbi request reprint Ciprofloxacin-associated hemolytic-uremic syndrome
    David S Allan
    University of Western Ontario, London, Canada
    Ann Pharmacother 36:1000-2. 2002
    ..To report the first case of ciprofloxacin-associated hemolytic-uremic syndrome (HUS)...
  52. doi request reprint Environmental prevention of human disease from verocytotoxin-producing Escherichia coli
    Reena Khanna
    Nephrol Dial Transplant 23:1819-22. 2008
    ..Here, we review animal- and meat-handling strategies to reduce the burden of VTEC human disease...
  53. ncbi request reprint Effect of awareness of a randomized controlled trial on use of experimental therapy
    William F Clark
    Division of Nephrology, London Health Sciences Centre, University of Western Ontario, London, Canada
    JAMA 290:1351-5. 2003
    ..Use of experimental therapies during but outside of randomized controlled trials (RCTs) has not been studied...