Research Topics
| W F ClarkSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Detail Information
Publications
Plasma exchange for renal disease: evidence and use 2011W F Clark
London Health Science Centre, Western University Canada
J Clin Apher 27:112-6. 2012..This report describes the most common indications for plasma exchange in patient's with renal disease and the evidence that supports it's use in 2011...- Thrombotic microangiopathy: current knowledge and outcomes with plasma exchangeWilliam F Clark
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Semin Dial 25:214-9. 2012..The advent of plasma therapy in the treatment of thrombotic microangiopathy has led to a clearer understanding of the role of ADAMTS13, both short- and long-term outcomes and the need for future surveillance and intervention... 
Attending rounds: microangiopathic hemolytic anemia with renal insufficiencyWilliam F Clark
University of Western Ontario, Department of Medicine, London, Ontario, Canada
Clin J Am Soc Nephrol 7:342-7. 2012..The discussion attempts to provide a simple clinical approach to the diagnosis, treatment options, and future course of adults and children suffering from a thrombotic microangiopathy...
Evaluation of GFR estimating equations in the general community: implications for screeningWilliam F Clark
University of Western Ontario and London Health Sciences Centre, London, Ontario, Canada
Clin J Am Soc Nephrol 1:787-95. 2006..The calibrated Rule equation seems to perform better than CG and MDRD (CKD 3 versus 11.3 to 12%) but lacks validation against gold standards for community-based screening...- Excessive fluid intake as a novel cause of proteinuriaWilliam F Clark
Department of Medicine Nephrology, London Health Sciences Centre, University of Western Ontario, London, Ont
CMAJ 178:173-5. 2008..We do not know at this time whether the proteinuria associated with excessive fluid intake in these otherwise healthy people will affect their kidney function in the long term... - What have we learned about optimal induction therapy for lupus nephritis (III through V) from randomized, controlled trials?William F Clark
London Health Sciences Centre, and Department of Medicine, University of Western Ontario, London, Canada, N6A 4G5
Clin J Am Soc Nephrol 3:895-8. 2008 - Plasma exchange for myeloma kidney: cast(s) away?W F Clark
Division of Nephrology, University of Western Ontario, London, Ontario, Canada
Kidney Int 73:1211-3. 2008..The analysis supports restitution of a better RCT of plasma exchange for myeloma kidney rather than off-label use... - Dipstick proteinuria as a screening strategy to identify rapid renal declineWilliam F Clark
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
J Am Soc Nephrol 22:1729-36. 2011..In summary, inexpensive screening with urine dipstick should allow primary care physicians to follow fewer patients with serial eGFR assessment but still identify those with rapid decline of kidney function... - Long term risk for hypertension, renal impairment, and cardiovascular disease after gastroenteritis from drinking water contaminated with Escherichia coli O157:H7: a prospective cohort studyWilliam F Clark
Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, ON, Canada
BMJ 341:c6020. 2010..To evaluate the risk for hypertension, renal impairment, and cardiovascular disease within eight years of gastroenteritis from drinking water contaminated with Escherichia coli O157:H7 and Campylobacter... - Urine volume and change in estimated GFR in a community-based cohort studyWilliam F Clark
Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Clin J Am Soc Nephrol 6:2634-41. 2011..The effect of increased fluid intake on kidney function is unclear. This study evaluates the relationship between urine volume and renal decline over 6 years in a large community-based cohort... - To pay or not to pay? A decision and cost-utility analysis of angiotensin-converting-enzyme inhibitor therapy for diabetic nephropathyW F Clark
Division of Nephrology, London Health Sciences Centre, Ont
CMAJ 162:195-8. 2000.... - A novel treatment for lupus nephritis: lignan precursor derived from flaxW F Clark
Department of Medicine, London Health Sciences Centre and The University of Western Ontario, Canada
Lupus 9:429-36. 2000.... - Association between estimated glomerular filtration rate at initiation of dialysis and mortalityWilliam F Clark
Division of Nephrology, University of Western Ontario, London Ont, Canada
CMAJ 183:47-53. 2011..We examined trends in initiation of hemodialysis within Canada and compared the risk of death between patients with early and late initiation of dialysis... - Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover studyW F Clark
London Health Sciences Centre, The University of Western Ontario, Canada
J Am Coll Nutr 20:143-8. 2001..The objective of this study was to determine the renoprotective effects of ground flaxseed in patients with lupus nephritis... - Absence of renal sequelae after childhood Escherichia coli O157:H7 gastroenteritisA X Garg
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Kidney Int 70:807-12. 2006..With no existing data to support screening after self-limited E. coli O157:H7 gastroenteritis, we recommend that only those children who develop recognized features of hemolytic uremic syndrome be followed for long-term renal health... - Arthritis risk after acute bacterial gastroenteritisA X Garg
London Kidney Research Unit, Division of Nephrology, London Health Sciences Centre, ON, Canada
Rheumatology (Oxford) 47:200-4. 2008.... - An outbreak of acute bacterial gastroenteritis is associated with an increased incidence of irritable bowel syndrome in childrenMarroon Thabane
Division of Gastroenterology, Department of Medicine, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Am J Gastroenterol 105:933-9. 2010..We assessed this association among a cohort of children enrolled in the Walkerton Health Study (WHS)... - Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort studyAlexander C Ford
Department of Medicine, Division of Gastroenterology, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 138:1727-36; quiz e12. 2010..We assessed prevalence of uninvestigated dyspepsia in a cohort of individuals, some of whom were exposed to bacterial dysentery in May 2000, as well as risk factors for dyspepsia in exposed individuals... - Elevated blood pressure in relation to overweight and obesity among children in a rural Canadian communityMarina Salvadori
Department of Pediatrics, Children s Hospital, London, Ontario, Canada
Pediatrics 122:e821-7. 2008..Rural populations in North America may be at increased risk for overweight. We evaluated whether overweight and obesity were associated with prehypertension and hypertension in a well-characterized population of children in rural Canada... - Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an updateAmit X Garg
Division of Nephrology, University of Western Ontario, London, Canada
Am J Kidney Dis 51:435-44. 2008..Estimates in the literature are highly variable, and previous studies did not use a healthy control group to establish outcomes attributable to HUS... - Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysenteryJohn K Marshall
Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 131:445-50; quiz 660. 2006..To better define its incidence and epidemiology, a large cohort study was initiated after the contamination of a municipal water supply led to a large outbreak of acute Escherichia coli 0157:H7 and Campylobacter jejuni gastroenteritis... - Risk of pregnancy-related hypertension within 5 years of exposure to drinking water contaminated with Escherichia coli O157:H7Louise Moist
Division of Nephrology, Department of Medicine, Victoria Hospital London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada
J Clin Hypertens (Greenwich) 12:613-20. 2010..05-5.4). A trend toward higher chronic hypertension and mean arterial pressure in early pregnancy was observed among women who experienced gastroenteritis after exposure to bacterially-contaminated drinking water... - Hyperfiltration affects accuracy of creatinine eGFR measurementShih Han S Huang
Department of Pediatrics, Children s Hospital, London Health Sciences Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, 800 Commissioner s Road East, Room E6 104, London ON, Canada, N6A 5W9
Clin J Am Soc Nephrol 6:274-80. 2011..It is hypothesized that the accuracy of creatinine for eGFR may be affected by hyperfiltration and different effective renal plasma flow (ERPF)... - Opioid and benzodiazepine use in end-stage renal disease: a systematic reviewAhraaz Wyne
University of Western Ontario, London Kidney Clinical Research Unit, Room ELL 101 Victoria Hospital, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
Clin J Am Soc Nephrol 6:326-33. 2011..We conducted a systematic review to determine the: (1) prevalence of opioid and benzodiazepine use among dialysis patients; (2) reasons for use; (3) effectiveness of symptom control; and (4) incidence of adverse events... - Optimal timing of initiation of chronic hemodialysis?Barbara Wilson
London Health Sciences Centre, London, Ontario, Canada
Hemodial Int 11:263-9. 2007..Our survival benefit findings suggest the premorbid health condition is a more important determinant of 2 year survival than the timing of dialysis initiation... - Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking waterAmit X Garg
Division of Nephrology, University of Western Ontario, London, Ont
CMAJ 173:261-8. 2005..We studied the risk of hypertension and reduced kidney function after an outbreak of acute gastroenteritis due to contamination of a regional drinking water supply with Escherichia coli O157:H7 and Campylobacter species... - Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regressionAmit X Garg
Division of Adult and Pediatric Nephrology, University of Western Ontario, London, Canada
JAMA 290:1360-70. 2003..The long-term renal prognosis of patients with diarrhea-associated hemolytic uremic syndrome (HUS) remains controversial... - Diabetes during diarrhea-associated hemolytic uremic syndrome: a systematic review and meta-analysisRita S Suri
Kidney Clinical Research Unit, Division of Nephrology, London Health Sciences Center, University of Western Ontario, Room ELL 111 Victoria Hospital, 800 Commissioners Rd East, London, Ontario, Canada N6A 4G5
Diabetes Care 28:2556-62. 2005..To quantify the incidence of diabetes during the acute phase of diarrhea-associated hemolytic uremic syndrome (D + HUS) and to identify features associated with its development... - Chronic renal disease is more prevalent in patients with hemolytic uremic syndrome who had a positive history of diarrheaAjay P Sharma
Division of Nephrology, Department of Pediatrics, Children s Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
Kidney Int 78:598-604. 2010..Prospective studies with appropriate controls are needed to completely resolve this issue... - Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contaminationAmit X Garg
Division of Nephrology, University of Western Ontario, London, Ontario, London, Canada
Kidney Int 67:1476-82. 2005..However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group... - Clustering and stability of functional lower gastrointestinal symptom after enteric infectionM Thabane
Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Neurogastroenterol Motil 24:546-52, e252. 2012.... - Frequently relapsing thrombotic thrombocytopenic purpura treated with cytotoxic immunosuppressive therapyD S Allan
Divison of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Haematologica 86:844-50. 2001..Immunosuppression, thus, has a biologically plausible role in TTP. We describe three consecutive cases of relapsing TTP treated with cytotoxic therapy to highlight the potential role of immunosuppression... - Plasma exchange in rapidly progressive renal failure due to multiple myeloma. A retrospective case seriesL Moist
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ont, Canada
Am J Nephrol 19:45-50. 1999..To evaluate the effect of plasma exchange on renal function in patients with rapidly progressive renal failure secondary to multiple myeloma... - Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome: a new index predicting response to plasma exchangeB F Wyllie
Division of Nephrology, University of Western Ontario, London, Canada
Br J Haematol 132:204-9. 2006..5%, 14.0%, 31.3% and 61.5% respectively in our source population. This simple model may help identify those patients who would benefit from higher treatment intensity... - Albuminuria and renal insufficiency prevalence guides population screening: results from the NHANES IIIAmit X Garg
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Kidney Int 61:2165-75. 2002..S. non-institutionalized population. Such knowledge guides the utility of population screening to prevent ESRD... - Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysenteryJohn K Marshall
Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada
Gut 59:605-11. 2010.... - Plasma exchange for treating cryoglobulinemia: a descriptive analysisM A Rockx
London Health Sciences Centre, London, ON, Canada
Transfus Apher Sci 42:247-51. 2010..The goal of this paper was to review over the past 20 years the medical literature for evidence supporting or refuting the reported use of plasmapheresis for cryoglobulinemia (January 1988 through June 2008)... - Treatment of lupus nephritisFayez F Hejaili
Division of Nephrology, London Health Sciences Centre, Westminster Campus, The University of Western Ontario, Canada
Drugs 63:257-74. 2003.... - Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritisAlexandra Chloe Villani
Division of Gastroenterology, Department of Medicine, McGill University, Montreal, Quebec, Canada
Gastroenterology 138:1502-13. 2010..2% of these developed IBS. We used this cohort to study genetic susceptibility to post-infectious (PI)-IBS... - An operating cost comparison between conventional and home quotidian hemodialysisAndrew Kroeker
Optimal Dialysis Research Unit, London Health Sciences Centre, London, Ontario, Canada
Am J Kidney Dis 42:49-55. 2003..CONCLUSION: Substantial clinical benefits of home quotidian HD, combined with the economic advantage shown by this study, clearly justify its expansion... - Ustekinumab associated thrombotic thrombocytopenic purpuraShih Han S Huang
The University of Western Ontario, Department of Medicine, Nephrology Division, and London Health Sciences Centre, London, Canada
Transfus Apher Sci 47:185-8. 2012..Although our patient experienced a prolonged course of TTP requiring 1 month of daily plasma exchange therapy, he recovered and remains in remission after 6 months... - Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES IAmit X Garg
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Kidney Int 61:1486-94. 2002..S. general non-institutionalized population... - Causes of reversible nephrogenic diabetes insipidus: a systematic reviewCamelia G Garofeanu
Division of Nephrology, Walkerton Health Study, London Health Science Centre, Westminster Campus, Canada
Am J Kidney Dis 45:626-37. 2005..CONCLUSION: Most risk factors for reversible NDI were medications, and their identification and removal resulted in resolution of the condition. Long-term treatment with lithium seemed to result in irreversible NDI... - Results of a randomized controlled trial on statin use in dialysis patients had no influence on statin prescriptionNgan N Lam
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Canada
Kidney Int 76:1172-9. 2009..The use of a common cardiovascular medication in this patient population appears to be influenced by other factors... - Treating TTP/HUS with plasma exchange: a single centre's 25-year experienceBrian R Forzley
London Health Sciences Centre, Victoria Hospital Division of Nephrology, Department of Medicine, London Health Sciences Centre, University of Western Ontario, Canada
Br J Haematol 143:100-6. 2008..Patient education, surveillance, and aggressive plasma exchange therapy are hypothesized to improve the likelihood of survival: these hypotheses should be tested in a randomized controlled trial... - Correction: Plasma exchange when myeloma presents as acute renal failureWilliam F Clark
University of Western Ontario, London, Ontario, Canada
Ann Intern Med 146:471. 2007 - Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trialWilliam F Clark
University of Western Ontario, London, Ontario, Canada
Ann Intern Med 143:777-84. 2005..29 mL.s(-2).m(-2) (<30 mL/min per 1.73 m2) at 6 months... - Ciprofloxacin-associated hemolytic-uremic syndromeDavid S Allan
University of Western Ontario, London, Canada
Ann Pharmacother 36:1000-2. 2002..CONCLUSIONS: Ciprofloxacin use was followed by HUS in our patient and was possibly causally related. Early detection, discontinuation of the offending medication, and treatment of HUS/TTP is critical... - Environmental prevention of human disease from verocytotoxin-producing Escherichia coliReena Khanna
Nephrol Dial Transplant 23:1819-22. 2008..Here, we review animal- and meat-handling strategies to reduce the burden of VTEC human disease... - Effect of awareness of a randomized controlled trial on use of experimental therapyWilliam F Clark
Division of Nephrology, London Health Sciences Centre, University of Western Ontario, London, Canada
JAMA 290:1351-5. 2003..CONCLUSIONS: During 3 Canadian RCTs, apheresis increased, but most of the increase occurred outside the trials. This behavior during an RCT, in the absence of clear efficacy, can be termed jumping the gun...