Andrew Churg

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Airway wall remodeling induced by occupational mineral dusts and air pollutant particles
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:306S-309S. 2002
  2. ncbi Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
  3. ncbi Chronic exposure to high levels of particulate air pollution and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 111:714-8. 2003
  4. ncbi Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 37:144-51. 2007
  5. ncbi Recent advances in the diagnosis of Churg-Strauss syndrome
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Mod Pathol 14:1284-93. 2001
  6. ncbi Animal models of cigarette smoke-induced chronic obstructive lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, B C, Canada
    Contrib Microbiol 14:113-25. 2007
  7. ncbi Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 81:1119-31. 2001
  8. ncbi Ambient atmospheric particles in the airways of human lungs
    A Churg
    Department of Pathology and School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, Canada
    Ultrastruct Pathol 24:353-61. 2000
  9. ncbi The separation of benign and malignant mesothelial proliferations
    A Churg
    University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 24:1183-200. 2000
  10. ncbi Proteases and emphysema
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Pulm Med 11:153-9. 2005

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi Airway wall remodeling induced by occupational mineral dusts and air pollutant particles
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:306S-309S. 2002
    ..The studies here investigate the hypothesis that particulates, including air pollution particles, can induce airway wall fibrosis, a process that can lead to COPD...
  2. ncbi Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
    ..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
  3. ncbi Chronic exposure to high levels of particulate air pollution and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 111:714-8. 2003
    ..This process may produce chronic airflow obstruction...
  4. ncbi Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 37:144-51. 2007
    ....
  5. ncbi Recent advances in the diagnosis of Churg-Strauss syndrome
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Mod Pathol 14:1284-93. 2001
    ....
  6. ncbi Animal models of cigarette smoke-induced chronic obstructive lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, B C, Canada
    Contrib Microbiol 14:113-25. 2007
    ..There are no models of cigarette smoke-induced chronic bronchitis in animals and there are no models of acute exacerbations of COPD...
  7. ncbi Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 81:1119-31. 2001
    ..The antiproteolytic effects of these agents do not seem to be mediated by protection of endogenous alpha1AT...
  8. ncbi Ambient atmospheric particles in the airways of human lungs
    A Churg
    Department of Pathology and School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, Canada
    Ultrastruct Pathol 24:353-61. 2000
    ....
  9. ncbi The separation of benign and malignant mesothelial proliferations
    A Churg
    University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 24:1183-200. 2000
    ..Although both p53 and EMA staining have been proposed as markers of mesothelial malignancy, in our experience they are not helpful for the individual case...
  10. ncbi Proteases and emphysema
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Pulm Med 11:153-9. 2005
    ..The protease-antiprotease theory of emphysema is widely accepted, but exactly which cells/proteases play a role continues to be a controversial subject...
  11. ncbi Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    Thorax 62:706-13. 2007
    ..The role of MMPs in smoke-induced small airway remodelling is unknown...
  12. ncbi Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Am J Respir Crit Care Med 174:1327-34. 2006
    ..Small airway remodeling (SAR) is an important cause of airflow obstruction in cigarette smokers with chronic obstructive pulmonary disease, but the pathogenesis of SAR is not understood...
  13. ncbi Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 27:368-74. 2002
    ....
  14. ncbi Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:849-54. 2002
    ..The findings support the idea that TNF-alpha promoter polymorphisms may be of importance in determining who develops smoke-induced chronic obstructive pulmonary disease...
  15. ncbi Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 31:277-84. 2007
    ..Our data also imply that survival (of the acute episode) may be better than the literature suggests...
  16. ncbi Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 170:492-8. 2004
    ..These findings imply a second TNF-alpha-independent process, possibly related to direct MMP attack on matrix, that produces the remaining 30% of airspace enlargement...
  17. ncbi Paratesticular mesothelial proliferations
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Semin Diagn Pathol 20:272-8. 2003
    ..Peritesticular adenomatoid tumors are also very common; they are benign circumscribed cellular nodules with an appearance comparable to that of adenomatoid tumors in other body locations such as the uterine serosa...
  18. ncbi alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Am J Respir Crit Care Med 168:199-207. 2003
    ..We conclude that A1AT therapy ameliorates smoke-induced inflammation and matrix breakdown, possibly via an antiinflammatory mechanism related to tumor necrosis factor-alpha suppression, and provides partial protection against emphysema...
  19. ncbi Cellular vs fibrosing interstitial pneumonias and prognosis: a practical classification of the idiopathic interstitial pneumonias and pathologically/radiologically similar conditions
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Chest 130:1566-70. 2006
  20. ncbi Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 277:L975-82. 1999
    ..Differential upregulation of PDGF receptors does not appear to explain dust-induced fibrosis in this model...
  21. ncbi Chronic hypersensitivity pneumonitis
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Surg Pathol 30:201-8. 2006
    ..Despite the presence of extensive fibrosis, some patients responded to removal from exposure and steroid therapy...
  22. ncbi Testing drugs in animal models of cigarette smoke-induced chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC V6T 2B5 Canada
    Proc Am Thorac Soc 6:550-2. 2009
    ....
  23. ncbi Pathologic patterns and survival in chronic hypersensitivity pneumonitis
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 33:1765-70. 2009
    ..Most cases of chronic HP have distinctive pathologic features, but a small percentage of cases cannot be pathologically distinguished from UIP...
  24. ncbi Respiratory bronchiolitis/interstitial lung disease: fibrosis, pulmonary function, and evolving concepts
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Arch Pathol Lab Med 134:27-32. 2010
    ..Over time, the diagnostic criteria for RBILD have become progressively more confused...
  25. ncbi Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 167:1083-9. 2003
    ..TNF-alpha release may be a general mechanism whereby metalloproteases drive cigarette smoke-induced inflammation...
  26. ncbi Acute exacerbations of fibrotic interstitial lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 58:525-30. 2011
    ..The aetiology of acute exacerbations is unknown, and the prognosis is poor; however, some patients survive with high-dose steroid therapy...
  27. ncbi What's new in the pleura?
    Andrew Churg
    Department of Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Arch Pathol Lab Med 129:1405-6. 2005
  28. ncbi Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 45:1111-5. 2011
    ..This approach, combined with the realization that human COPD probably needs early rather than late treatment, may make development of treatments based on animal models more relevant...
  29. ncbi The fake fat phenomenon in organizing pleuritis: a source of confusion with desmoplastic malignant mesotheliomas
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 35:1823-9. 2011
    ..In contrast, in true desmoplastic mesotheliomas there is downward, rather than horizontal, growth of keratin-positive spindled cells running between clearly definable fat cells...
  30. ncbi Mechanisms of cigarette smoke-induced COPD: insights from animal models
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L612-31. 2008
    ..Emphysema, small airway remodeling, pulmonary hypertension, and mucus production appear to be at least partially independent processes that may require different therapeutic approaches...
  31. ncbi The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T2B5, Canada
    Am J Respir Cell Mol Biol 40:482-90. 2009
    ....
  32. ncbi Cigarette smoke causes small airway remodeling by direct growth factor induction and release
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC Canada V6T 2B5
    Proc Am Thorac Soc 3:493. 2006
  33. ncbi Expression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposure
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 40:268-76. 2009
    ..These observations support the idea that the parenchyma largely fails to repair smoke-induced matrix damage, but this phenomenon is a relatively late event...
  34. ncbi Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Toxicol Appl Pharmacol 208:37-45. 2005
    ..These findings imply that even brief contact of PM with a pulmonary epithelial cell surface may produce deleterious effects in vivo...
  35. ncbi Air pollution particles produce airway wall remodeling in rat tracheal explants
    Jin Dai
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 29:352-8. 2003
    ..PM-induced airway wall remodeling may play an important role in producing airflow obstruction in individuals living in high PM regions...
  36. ncbi Cigarette smoke produces airway wall remodeling in rat tracheal explants
    Rong D Wang
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Crit Care Med 168:1232-6. 2003
    ..Smoke-evoked inflammatory cells are not required for this process...
  37. ncbi Transforming growth factor-beta1 drives airway remodeling in cigarette smoke-exposed tracheal explants
    Rong D Wang
    Department of Pathology, University of British Columbia, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 33:387-93. 2005
    ....
  38. ncbi Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:954-60. 2002
    ..These data demonstrate that a serine elastase inhibitor ameliorates the inflammatory and destructive effects of cigarette smoke, and that these effects are mediated in part by neutrophils and by smoke-driven TNF-alpha production...
  39. ncbi Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 31:501-9. 2004
    ..These changes may be important in the development of smoke-induced pulmonary hypertension...
  40. ncbi Cigarette smoke induces rapid changes in gene expression in pulmonary arteries
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 82:1391-8. 2002
    ..These changes support the idea that pulmonary hypertension in cigarette smokers reflects a direct effect of smoke on the vasculature. The pattern of response in the vessels is distinctly different from that in the airways...
  41. ncbi Animal models of cigarette smoke-induced COPD
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Chest 122:301S-306S. 2002
    ..To review the animal models of COPD, and to compare these data to those found in humans...
  42. ncbi Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig
    Joanne L Wright
    Dept of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    J Appl Physiol 100:672-8. 2006
    ....
  43. ncbi Fibrosis with emphysema
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 58:517-24. 2011
    ..Care should be taken when describing these lesions in biopsies so as not to give the impression that a diffuse interstitial lung disease is present...
  44. ncbi Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 3350 950 W 10th Ave, Vancouver, BC, Canada V5Z 4E3
    Radiology 246:288-97. 2008
    ....
  45. ncbi Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 158:1907-13. 1998
    ..Different mineral dusts produce different patterns of reaction...
  46. ncbi Regional heterogeneity in murine lung fibroblasts from normal mice or mice exposed once to cigarette smoke
    Olena Preobrazhenska
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e39761. 2012
    ..However, PF still retain the ability to repair by producing new matrix after a single in vivo smoke exposure...
  47. ncbi Airway-centered interstitial fibrosis: a distinct form of aggressive diffuse lung disease
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Surg Pathol 28:62-8. 2004
    ..Two patients remained stable and 3 improved or healed. We propose that these findings represent a distinct airway-centered disease that mostly behaves as an interstitial lung disease and may exhibit a poor outcome...
  48. ncbi Hard metal lung disease: high resolution CT and histologic correlation of the initial findings and demonstration of interval improvement
    Patricia Dunlop
    Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC Canada
    J Thorac Imaging 20:301-4. 2005
    ..To our knowledge, this is the first described case of HMLD with follow-up CT examination...
  49. ncbi A model of tobacco smoke-induced airflow obstruction in the guinea pig
    Joanne L Wright
    Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada
    Chest 121:188S-191S. 2002
    ..Other animal models exist, however, and the investigator should select the model that is most suited to the hypothesis to be tested...
  50. ncbi Iron loading makes a nonfibrogenic model air pollutant particle fibrogenic in rat tracheal explants
    Jin Dai
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 26:685-93. 2002
    ..These findings suggest that air pollutant particles containing significant quantities of transition metals may produce airway wall fibrosis and lead to chronic obstructive pulmonary disease...
  51. ncbi Interactions of exogenous or evoked agents and particles: the role of reactive oxygen species
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Free Radic Biol Med 34:1230-5. 2003
    ..The small airways appear to be particular targets of coexposure to smoke or ozone and particles, a phenomenon that may produce chronic airflow obstruction...
  52. ncbi Animal models of cigarette smoke-induced chronic obstructive pulmonary disease
    Joanne L Wright
    Department of Pathology, University Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Expert Rev Respir Med 4:723-34. 2010
    ..The various different anatomic lesions induced by smoke appear to be largely independent effects and may require different therapeutic approaches...
  53. ncbi Idiopathic pulmonary fibrosis: spectrum of high-resolution CT findings
    Carolina Althoff Souza
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W. 12th Ave, Vancouver, BC V5Z 1M9, Canada
    AJR Am J Roentgenol 185:1531-9. 2005
    ....
  54. ncbi Acute exacerbation of chronic interstitial pneumonia: high-resolution computed tomography and pathologic findings
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
    J Thorac Imaging 22:221-9. 2007
    ..To review the high-resolution computed tomography (CT) and histologic findings of acute exacerbation of chronic interstitial pneumonia and to assess the potential value of CT and histologic findings in predicting prognosis...
  55. ncbi Malignant mesothelioma of the peritoneum presenting as an inflammatory lesion: a report of four cases
    Scott A J Kerrigan
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Surg Pathol 27:248-53. 2003
    ..We conclude that peritoneal mesotheliomas may occasionally present as inflammatory processes without grossly evident tumor and can be diagnosed by microscopic findings alone...
  56. ncbi Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 24:427-35. 2001
    ..Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism...
  57. ncbi Effects of cigarette smoke and asbestos on airway, vascular and mesothelial cell proliferation
    H Sekhon
    Department of Pathology, University of British Columbia, Canada
    Int J Exp Pathol 76:411-8. 1995
    ..However, the latter process does not correlate with local accumulation of asbestos fibres...
  58. ncbi Animal models of chronic obstructive pulmonary disease
    Joanne L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L1-15. 2008
    ....
  59. ncbi Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1M9
    AJR Am J Roentgenol 188:334-44. 2007
    ..Awareness of the various manifestations of HP is important for early diagnosis and management...
  60. ncbi Environmental, inhaled and ingested causes of pulmonary fibrosis
    Nasreen Khalil
    Department of Medicine, Respiratory Division, Vancouver General Hospital, V5Z 1M9, The University of British Columbia, Canada
    Toxicol Pathol 35:86-96. 2007
    ..Prevention or removal of the inciting agent is critical to the treatment of these disorders and in some instances corticosteroids may be of help...
  61. ncbi Airway remodeling in the smoke exposed guinea pig model
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Inhal Toxicol 19:915-23. 2007
    ..This model should prove useful in further investigations into the mechanisms of airway remodeling...
  62. ncbi Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices
    J L Wright
    Department of Pathology, University of British Columbia, University Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada
    J Appl Physiol 104:1462-9. 2008
    ..These changes may be important in the development of pulmonary hypertension...
  63. ncbi Advances in the pathology of COPD
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, BC, Canada
    Histopathology 49:1-9. 2006
    ..This review is designed to help surgical pathologists evaluate the lungs of subjects who have clinical manifestations of airflow obstruction so that appropriate clinical-pathological correlations can be performed...
  64. ncbi Current concepts in mechanisms of emphysema
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Toxicol Pathol 35:111-5. 2007
    ..Over the last 10 years, there has been a remarkable degree of progress in our understanding of the pathophysiological mechanisms involved in the genesis of emphysema. This review attempts to summarize these data...
  65. ncbi Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-alpha signaling
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5, USA
    Am J Physiol Lung Cell Mol Physiol 292:L125-33. 2007
    ..MMP production is largely TNF-alpha dependent, further supporting the importance of TNF-alpha in the pathogenesis of cigarette smoke-induced lung disease...
  66. ncbi Iron enhances uptake of mineral particles and increases lipid peroxidation in tracheal epithelial cells
    B Keeling
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 10:683-8. 1994
    ..These observations suggest that cationic iron may play a major role in particle uptake by tracheobronchial epithelia, and that particle uptake is also related to iron-mediated lipid peroxidation...
  67. ncbi Effects of cigarette smoke on the clearance of short asbestos fibres from the lung and a comparison with the clearance of long asbestos fibres
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Int J Exp Pathol 73:287-97. 1992
    ..These observations suggest that short asbestos fibres could play an important role in the pathogenesis of some types of asbestos-related disease in cigarette smokers...
  68. ncbi Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment
    J L Wright
    Department of Pathology, University of Columbia, Vancouver, BC, Canada
    Thorax 60:605-9. 2005
    ..These changes are in many ways similar to those seen in other forms of pulmonary hypertension and suggest that the treatments used for primary pulmonary hypertension may be beneficial in patients with COPD...
  69. ncbi Smoking cessation decreases the number of metaplastic secretory cells in the small airways of the Guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Inhal Toxicol 14:1153-9. 2002
    ..We conclude that, in a guinea pig model, smoking produces secretory-cell metaplasia in the airways and that smoking cessation allows partial recovery of normal structure...
  70. ncbi Cigarette smoke increases amosite asbestos fiber binding to the surface of tracheal epithelial cells
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 275:L502-8. 1998
    ....
  71. ncbi A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
    J L Wright
    Dept of Pathology, University of British Columbia, Vancouver, Canada
    Eur Respir J 22:77-81. 2003
    ..These data suggest that smoke-induced cell proliferation leads to pulmonary arterial muscularisation. Serine-elastase inhibitors appear to be able to reduce cell proliferation and vascular remodelling...
  72. ncbi Air pollution and retained particles in the lung
    M Brauer
    School of Occupational and Environmental Hygiene, Department of Medicine, The University of British Columbia, 2206 East Mall, Vancouver, BC, V6T 1Z3 Canada
    Environ Health Perspect 109:1039-43. 2001
    ....
  73. ncbi The separation of benign and malignant mesothelial proliferations
    Andrew Churg
    Department of Pathology, G227, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Arch Pathol Lab Med 136:1217-26. 2012
    ..The separation of benign from malignant mesothelial proliferations is crucial to patient management but is often a difficult problem for the pathologist...
  74. ncbi Commentary--Pathophysiology of airflow obstruction: could there really be an early test of prognostic significance?
    J L Wright
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Room GF164, VGT 2B5, Vancouver, British Columbia, Canada
    COPD 1:93-5. 2004
    ..Milic-Emili in this issue. The authors discuss the hyphothesis and suggest that a re-examination of longitudinal lung function data could prove or deny his suggestion...
  75. ncbi Animal models of COPD: Barriers, successes, and challenges
    Joanne L Wright
    Department of Pathology, University of British Columbia
    Pulm Pharmacol Ther 21:696-8. 2008
    ..Animal models have definite utility in the study of chronic obstructive pulmonary disease. However, choice of model must be determined with the full knowledge of their value, or potential limitations...
  76. ncbi Diffuse malignant epithelial mesotheliomas of the peritoneum in women: a clinicopathologic study of 25 patients
    Scott A J Kerrigan
    Department of Pathology, Vancouver Hospital and Health Sciences Center, British Columbia, Canada
    Cancer 94:378-85. 2002
    ..However, because there do not appear to be morphologic features that reliably identify favorable tumors versus unfavorable tumors, aggressive therapy for all women with diffuse peritoneal mesotheliomas may be warranted...
  77. ncbi Effects of cigarette smoke exposure on retention of asbestos fibers in various morphologic compartments of the guinea pig lung
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Pathol 129:385-93. 1987
    ....
  78. ncbi TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kappaB-dependent mechanism
    C Xie
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol Lung Cell Mol Physiol 279:L608-14. 2000
    ....
  79. ncbi Antioxidant gene expression in rat lung after exposure to cigarette smoke
    C B Gilks
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Am J Pathol 152:269-78. 1998
    ..MT expression is also transiently increased by smoke whereas GPX expression increases after prolonged (7 to 14 days) exposure to cigarette smoke...
  80. ncbi Mechanisms of mineral dust-induced emphysema
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Environ Health Perspect 105:1215-8. 1997
    ..These observations support our theory that dust-induced emphysema and smoke-induced emphysema occur through similar mechanisms...
  81. ncbi Active oxygen species mediate asbestos fiber uptake by tracheal epithelial cells
    J Hobson
    Department of Pathology, University of British Columbia, Vancouver, Canada
    FASEB J 4:3135-9. 1990
    ..We conclude that uptake of amosite asbestos fibers is mediated in part by active oxygen species (most likely OH.), but that other mechanisms of fiber uptake must also exist...
  82. ncbi Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Exp Lung Res 17:997-1009. 1991
    ..The etiology of this process may be smoke-induced inflammation with release of vasoactive substances as well as proteolytic enzymes...
  83. ncbi Role of neutrophils and alpha1-antitrypsin in coal- and silica-induced connective tissue breakdown
    K Zay
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
    Am J Physiol 276:L269-79. 1999
    ..G. Liou and E. J. Campbell. Biochemistry 34: 16171-16177, 1995). Macrophage-derived proteases may be of increasing importance over time, especially in coal-treated animals...
  84. ncbi Pulmonary alveolar proteinosis as a reaction to fentanyl patch smoke
    Erin Chapman
    Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
    Chest 141:1321-3. 2012
    ..Her symptoms disappeared and her chest imaging changes largely resolved when she stopped smoking the patches. Alveolar proteinosis is an uncommon drug reaction and in this case presented in a very unusual fashion as an inhalation injury...
  85. ncbi The distribution of amosite asbestos fibers in the lungs of workers with mesothelioma or carcinoma
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Exp Lung Res 15:771-83. 1989
    ..These differences may be a manifestation of individual handling of mineral particles because of structural variations in individual lungs...
  86. ncbi Enhanced retention of asbestos fibers in the airways of human smokers
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 151:1409-13. 1995
    ..These findings indicate that cigarette smoking causes enhanced accumulation of both amosite and chrysotile in the airway mucosa. This process may play a role in potentiating the pathologic effects of asbestos...
  87. ncbi Effects of cigarette smoke on nitric oxide synthase expression in the rat lung
    J L Wright
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Lab Invest 79:975-83. 1999
    ..These findings indicate that cigarette smoke can directly and rapidly affect NOS expression, and thus potentially affect the function of the pulmonary vasculature...
  88. ncbi Site of methacholine reactivity in the peripheral airways: analysis using lung explants
    J L Wright
    University of British Columbia, Vancouver, Canada
    Am J Physiol 272:L68-72. 1997
    ..They do not, however, completely rule out the possibility of in vivo species-dependent differences in airway-parenchymal interactions...
  89. ncbi Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 139:885-90. 1989
    ....
  90. ncbi Absence of amosite asbestos in airway mucosa of non-smoking long term workers with occupational exposure to asbestos
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Br J Ind Med 50:355-9. 1993
    ..These findings also call into question the idea that asbestos acts as a direct airway carcinogen in humans...
  91. ncbi The distribution of amosite asbestos in the periphery of the normal human lung
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Br J Ind Med 47:677-81. 1990
    ....
  92. ncbi Mineralogic parameters related to amosite asbestos-induced fibrosis in humans
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am Rev Respir Dis 142:1331-6. 1990
    ..Last, the concentration comparison data indicate that, fiber for fiber, amosite is more fibrogenic than is chrysotile or tremolite, and indirectly suggest that tremolite is more fibrogenic than is chrysotile...
  93. ncbi Fiber burden and patterns of asbestos-related disease in workers with heavy mixed amosite and chrysotile exposure
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 150:663-9. 1994
    ..abstract truncated at 250 words)..
  94. ncbi Review and update of uncommon primary pleural tumors: a practical approach to diagnosis
    Laura Granville
    Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    Arch Pathol Lab Med 129:1428-43. 2005
    ..Correct diagnosis is important because of different prognosis and treatment implications for the various neoplasms...
  95. ncbi Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies
    Philip T Cagle
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:1421-7. 2005
    ....
  96. ncbi Transbronchial biopsy and usual interstitial pneumonia: a new paradigm?
    Andrew Churg
    Chest 129:1117-8. 2006
  97. ncbi Churg-Strauss syndrome: high resolution CT and pathologic findings
    Cleonice Isabela S Silva
    Department of Diagnostic Imaging, , Brazil
    J Thorac Imaging 20:74-80. 2005
    ..These reflect the presence of eosinophilic infiltration of the airspaces, interstitium, and airways, and interstitial edema...
  98. ncbi Comparison of monoclonal versus polyclonal calretinin antibodies for immunohistochemical diagnosis of malignant mesothelioma
    Laura A Granville
    U T MD Anderson Cancer Center, Houston, TX, USA
    Appl Immunohistochem Mol Morphol 13:75-9. 2005
    ..Neither antibody performed well on sarcomatous malignant mesothelioma (Zymed=2/22; DAKO=1/22). Both antibodies are useful in the diagnosis of epithelial malignant mesothelioma, although monoclonal antibody is slightly less sensitive...
  99. ncbi Ferruginous bodies: implications in the mechanism of fiber and particle toxicity
    Andrew J Ghio
    United States Environmental Protection Agency, Research, Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 32:643-9. 2004
    ..It is recommended that an identification of ferruginous bodies in the lung be regarded as support for a metal-catalyzed oxidative stress in the mechanism of cell and tissue injury...
  100. ncbi The role of smoking and exposure to asbestos and man-made vitreous fibers in a questionable case of mesothelioma
    Gary M Marsh
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Ind Health 41:332-4. 2003
    ..S. cohort may have been caused by asbestos exposure...
  101. ncbi Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells
    Cynthia R Timblin
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Toxicol Appl Pharmacol 179:98-104. 2002
    ....