Deirdre Leigh Church

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc The distinct category of healthcare associated bloodstream infections
    Ryan Lenz
    Department of Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada
    BMC Infect Dis 12:85. 2012
  2. pmc Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection
    Guido van Marle
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Retrovirology 7:74. 2010
  3. pmc Compartmentalization of the gut viral reservoir in HIV-1 infected patients
    Guido van Marle
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Retrovirology 4:87. 2007
  4. pmc Intensive care unit-acquired urinary tract infections in a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, Center for Anti microbial Resistance, Calgary Health Region, Calgary Laboratory Services, and University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R60-5. 2005
  5. pmc Rationale for and protocol of a multi-national population-based bacteremia surveillance collaborative
    Kevin B Laupland
    Departments of Medicine and Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Res Notes 2:146. 2009
  6. pmc Clinical outcome of empiric antimicrobial therapy of bacteremia due to extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae
    Vikas P Chaubey
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Res Notes 3:116. 2010
  7. pmc Blood cultures in ambulatory outpatients
    Kevin B Laupland
    Department of Medicine, Centre for Anti microbial Resistance and Infectious Diseases Research Group, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 5:35. 2005
  8. pmc Population-based laboratory surveillance for Giardia sp. and Cryptosporidium sp. infections in a large Canadian health region
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Infect Dis 5:72. 2005
  9. pmc Population-based laboratory surveillance of Hafnia alvei isolates in a large Canadian health region
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary Alberta, Canada
    Ann Clin Microbiol Antimicrob 5:12. 2006
  10. pmc Comparison of the RealTime HIV-1, COBAS TaqMan 48 v1.0, Easy Q v1.2, and Versant v3.0 assays for determination of HIV-1 viral loads in a cohort of Canadian patients with diverse HIV subtype infections
    Deirdre Church
    Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada
    J Clin Microbiol 49:118-24. 2011

Detail Information

Publications59

  1. pmc The distinct category of healthcare associated bloodstream infections
    Ryan Lenz
    Department of Medicine, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada
    BMC Infect Dis 12:85. 2012
    ..However, a third category of healthcare-associated (HCA) community onset disease has been increasingly recognized. The objective of this study was to compare and contrast characteristics of HCA-BSI with CA-BSI and HA-BSI...
  2. pmc Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection
    Guido van Marle
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Retrovirology 7:74. 2010
    ..It serves as a viral reservoir and host-pathogen interface in infection. This study examined whether different parts of the gut and peripheral blood lymphocytes (PBL) contain different drug-resistant HIV-1 variants...
  3. pmc Compartmentalization of the gut viral reservoir in HIV-1 infected patients
    Guido van Marle
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Retrovirology 4:87. 2007
    ..The gut associated lymphoid tissue (GALT) is the largest lymphoid organ infected by HIV-1. In this study we examined if different HIV-1 quasispecies are found in different parts of the gut of HIV-1 infected individuals...
  4. pmc Intensive care unit-acquired urinary tract infections in a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, Center for Anti microbial Resistance, Calgary Health Region, Calgary Laboratory Services, and University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R60-5. 2005
    ..The objectives of this study were to describe the occurrence, microbiology, and risk factors for acquiring UTIs in the ICU and to determine whether these infections independently increase mortality...
  5. pmc Rationale for and protocol of a multi-national population-based bacteremia surveillance collaborative
    Kevin B Laupland
    Departments of Medicine and Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Res Notes 2:146. 2009
    ..CONCLUSION: Future studies from this collaborative should lead to a better understanding of the epidemiology of bloodstream infections...
  6. pmc Clinical outcome of empiric antimicrobial therapy of bacteremia due to extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae
    Vikas P Chaubey
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Res Notes 3:116. 2010
    ....
  7. pmc Blood cultures in ambulatory outpatients
    Kevin B Laupland
    Department of Medicine, Centre for Anti microbial Resistance and Infectious Diseases Research Group, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 5:35. 2005
    ..However, the low yield may limit their usefulness, particularly in low-risk populations. This study was conducted to assess the utility of blood cultures drawn from ambulatory outpatients...
  8. pmc Population-based laboratory surveillance for Giardia sp. and Cryptosporidium sp. infections in a large Canadian health region
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Infect Dis 5:72. 2005
    ..This study determined the incidence of and demographic risk factors for developing Giardia sp. and Cryptosporidium sp. infections in a general Canadian population...
  9. pmc Population-based laboratory surveillance of Hafnia alvei isolates in a large Canadian health region
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary Alberta, Canada
    Ann Clin Microbiol Antimicrob 5:12. 2006
    ..Hospital-based series have characterized Hafnia alvei primarily as an infrequent agent of polymicrobial nosocomial infections in males with underlying illness...
  10. pmc Comparison of the RealTime HIV-1, COBAS TaqMan 48 v1.0, Easy Q v1.2, and Versant v3.0 assays for determination of HIV-1 viral loads in a cohort of Canadian patients with diverse HIV subtype infections
    Deirdre Church
    Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada
    J Clin Microbiol 49:118-24. 2011
    ..Performance significantly varied between HIV VL platforms according to subtype. HIV viral diversity in the population being tested must be considered in selection of the viral load platform...
  11. pmc Burn wound infections
    Deirdre Church
    Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada T2L 2K8
    Clin Microbiol Rev 19:403-34. 2006
    ..Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices...
  12. ncbi request reprint Screening for Giardia/Cryptosporidium infections using an enzyme immunoassay in a centralized regional microbiology laboratory
    Deirdre Church
    Calgary Laboratory Services, Calgary, Alberta, Canada
    Arch Pathol Lab Med 129:754-9. 2005
    ..In April 1999, a microplate enzyme immunoassay (EIA) (ProSpecT G/C, Remel, Inc, Lenexa, Kan) for routine screening of all stool specimens was implemented...
  13. ncbi request reprint Clinical and economic evaluation of rapid influenza a virus testing in nursing homes in calgary, Canada
    Deirdre L Church
    Calgary Laboratory Services, Department of Pathology and Laboratory Medicine and Department of Medicine, University of Calgary, Calgary, Canada
    Clin Infect Dis 34:790-5. 2002
    ..03), and the cost of laboratory testing and the total cost (less the hospital cost) tended to be lower (P<.2). The rapid testing service also tended to lower the overall use of resources...
  14. pmc Identification by 16S rRNA gene sequencing of Negativicoccus succinicivorans recovered from the blood of a patient with hemochromatosis and pancreatitis
    D L Church
    Calgary Laboratory Services, 9 3535 Research Rd N W, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 49:3082-4. 2011
    ..This is the first published report of the recovery of this organism from a patient with invasive infection...
  15. pmc Evaluation of BBL CHROMagar O157 versus sorbitol-MacConkey medium for routine detection of Escherichia coli O157 in a centralized regional clinical microbiology laboratory
    D L Church
    Calgary Laboratory Services CLS, Calgary, Alberta T2N 4B8, Canada
    J Clin Microbiol 45:3098-100. 2007
    ..Results for 27/3,116 (0.9%) stool cultures were positive. CHROM had a higher sensitivity (96.30%) and negative predictive value (100%) and a better diagnostic efficiency than SMAC. Labor and material costs decreased when CHROM was used...
  16. ncbi request reprint Major factors affecting the emergence and re-emergence of infectious diseases
    Deirdre L Church
    Department of Pathology and Laboratory Medicine, University of Calgary, Faculty of Medicine, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Clin Lab Med 24:559-86, v. 2004
    ..A global strategy for dealing with infectious disease threats must be developed and implemented as soon as possible...
  17. doi request reprint Evaluation of automated repetitive-sequence-based PCR (DiversiLab) compared to PCR ribotyping for rapid molecular typing of community- and nosocomial-acquired Clostridium difficile
    Deirdre L Church
    Calgary Laboratory Services, Calgary, Alberta, Canada T2L 2K8
    Diagn Microbiol Infect Dis 70:183-90. 2011
    ..Routine use of rep-PCR for CD typing is limited by its lack of definitive separation of the hypertoxigenic 027 or 001 outbreak CD strains...
  18. pmc Evaluation of StrepB carrot broth versus Lim broth for detection of group B Streptococcus colonization status of near-term pregnant women
    D L Church
    Division of Microbiology, Calgary Laboratory Services, Calgary Health Region and the University of Calgary, Calgary, Alta T2L 2K8, Canada
    J Clin Microbiol 46:2780-2. 2008
    ..3%, respectively. Improved diagnostic efficiency due to direct reporting of GBS cases based on an orange color change in the SCB decreased overall labor and material costs...
  19. doi request reprint Evaluation of the Xpert® group B streptococcus real-time polymerase chain reaction assay compared to StrepB Carrot Broth™ for the rapid intrapartum detection of group B streptococcus colonization
    Deirdre Leigh Church
    Calgary Laboratory Services, Calgary Health Region and the University of Calgary, Calgary, T2L 2K8 Alberta, Canada
    Diagn Microbiol Infect Dis 69:460-2. 2011
    ..Xpert GBS detected all of the cases (45, 19.5%), but 4 were missed by SCB. A rapid Xpert GBS service for women in labor would increase costs by ∼$55.000 per annum in our region...
  20. ncbi request reprint A regional centralized microbiology service in Calgary for the rapid diagnosis of malaria
    Deirdre L Church
    Calgary Laboratory Services, Calgary, Alberta, Canada T3C 0J5
    Arch Pathol Lab Med 127:687-93. 2003
    ..A regional centralized laboratory service for the rapid diagnosis of malaria was implemented 3 years ago in May 1999 within the Division of Microbiology, Calgary Laboratory Services...
  21. doi request reprint Comparison of automated repetitive-sequence-based polymerase chain reaction and spa typing versus pulsed-field gel electrophoresis for molecular typing of methicillin-resistant Staphylococcus aureus
    Deirdre L Church
    Calgary Laboratory Services, Calgary, Alberta, Canada
    Diagn Microbiol Infect Dis 69:30-7. 2011
    ..10 full-time equivalents compared to PFGE. Repetitive PCR is a good method for rapid outbreak screening, but MRSA isolates that share the same repetitive PCR or PFGE patterns can be distinguished by spa typing...
  22. doi request reprint Clinical and economic evaluation of BBL CHROMagar Salmonella (CHROMSal) versus subculture after selenite broth enrichment to CHROMSal and Hektoen enteric agars to detect enteric Salmonella in a large regional microbiology laboratory
    Deirdre L Church
    Calgary Laboratory Services CLS, Calgary, Alberta, Canada
    Diagn Microbiol Infect Dis 68:13-9. 2010
    ..12%, 100% and 99.97%, 100% and 97.96%, and 100% and 99.90%, respectively. CHROMSal use would result in substantial cost and labor savings...
  23. pmc Quantitative gram stain interpretation criteria used by microbiology laboratories in Alberta, Canada
    D Church
    Laboratory Proficiency Testing Program, College of Physicians and Surgeons of Alberta
    J Clin Microbiol 38:4266-8. 2000
    ..Lack of standardized criteria not only poses a problem in the grading of proficiency testing results but may also impact the quality of patient care...
  24. ncbi request reprint Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum beta-lactamases: importance of community isolates with blaCTX-M genes
    Johann D D Pitout
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, and the Centre for Antimicrobial Resistance, Calgary, Alberta, Canada
    Clin Infect Dis 38:1736-41. 2004
    ..2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk...
  25. ncbi request reprint Population-based epidemiological study of infections caused by carbapenem-resistant Pseudomonas aeruginosa in the Calgary Health Region: importance of metallo-beta-lactamase (MBL)-producing strains
    Kevin B Laupland
    Department of Medicine, University of Calgary, Centre for Anti microbial Resistance, and Calgary Health Region, Calgary, Alberta, Canada
    J Infect Dis 192:1606-12. 2005
    ....
  26. ncbi request reprint Investigation of sources of potential bias in laboratory surveillance for anti-microbial resistance
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Clin Invest Med 30:E159-66. 2007
    ..Our objective was to evaluate the potential magnitude of bias in reporting of etiologic agents and their resistance rates associated with inclusion of multiple patient samples and non-random timing and location of sampling...
  27. doi request reprint Community-onset extended-spectrum beta-lactamase (ESBL) producing Escherichia coli: importance of international travel
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    J Infect 57:441-8. 2008
    ..Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli have emerged as significant causes of community-onset disease. We sought to identify risk factors for acquiring community-onset ESBL-producing E. coli...
  28. ncbi request reprint Validation of a rapid diagnostic strategy for determination of significant bacterial counts in bronchoalveolar lavage samples
    Kevin B Laupland
    Department of Critical Care Medicine, Centre for Antimicrobial Resistance, University of Calgary, Alberta, Canada
    Arch Pathol Lab Med 129:78-81. 2005
    ..We developed a rapid diagnostic testing strategy that is highly sensitive for screening bacteria in bronchoalveolar lavage (BAL) samples, with results available within hours of collection...
  29. doi request reprint Antimicrobial susceptibility of well-characterised multiresistant CTX-M-producing Escherichia coli: failure of automated systems to detect resistance to piperacillin/tazobactam
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Int J Antimicrob Agents 32:333-8. 2008
    ..coli. We recommend that laboratories using Vitek should employ alternative susceptibility testing methods for TZP before reporting the activity of this agent against ESBL-producing E. coli...
  30. pmc Using a commercial DiversiLab semiautomated repetitive sequence-based PCR typing technique for identification of Escherichia coli clone ST131 producing CTX-M-15
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    J Clin Microbiol 47:1212-5. 2009
    ..The DiversiLab system successfully identified E. coli clone ST131 producing CTX-M-15 and provides a simple standardized typing protocol for monitoring the spread of this clone...
  31. pmc Molecular characteristics of travel-related extended-spectrum-beta-lactamase-producing Escherichia coli isolates from the Calgary Health Region
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Antimicrob Agents Chemother 53:2539-43. 2009
    ..Our study suggested that clone ST131 coproducing CTX-M-15, OXA-1, TEM-1, and AAC(6')-Ib-cr and clonally unrelated CTX-M-14 producers have emerged as important causes of community-acquired, travel-related infections...
  32. pmc Salmonella enterica bacteraemia: a multi-national population-based cohort study
    Kevin B Laupland
    Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    BMC Infect Dis 10:95. 2010
    ..However, population-based data are limited. The objective of this study was to define the occurrence of S. enterica bacteremia in a large international population and to evaluate temporal and regional differences...
  33. ncbi request reprint Utility of Gram stain for the microbiological analysis of burn wound surfaces
    Sameer Elsayed
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada
    Arch Pathol Lab Med 127:1485-8. 2003
    ..To our knowledge, the utility of adding a Gram-stained slide in this context has not been evaluated previously...
  34. pmc Detection of Pseudomonas aeruginosa producing metallo-beta-lactamases in a large centralized laboratory
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 43:3129-35. 2005
    ..We recommend that all IPM-nonsusceptible P. aeruginosa isolates be routinely screened for MBL production using the EDTA disk screen test and that PCR confirmation be performed at a regional laboratory...
  35. ncbi request reprint A preliminary evaluation of the interaction between urine specific gravity and leukocyte esterase results using Bayer Multistix and the Clinitek 500
    Martha E Lyon
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Biochem 36:579-81. 2003
    ..To determine the sensitivity of the leukocyte esterase (LE) pad to predict microscopically quantified white blood cells in urine sediment and to assess the interaction of urine specific gravity (SG) on leukocyte esterase sensitivity...
  36. pmc Association between handling of pet treats and infection with Salmonella enterica serotype newport expressing the AmpC beta-lactamase, CMY-2
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services and Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Microbiol 41:4578-82. 2003
    ..enterica serotype Newport strains in Canada, this study illustrates the necessity of rapid and accurate laboratory-based surveillance in the identification of novel types of antimicrobial resistance...
  37. ncbi request reprint Comparison of direct selective versus nonselective agar media plus LIM broth enrichment for determination of group B streptococcus colonization status in pregnant women
    Sameer Elsayed
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta
    Arch Pathol Lab Med 127:718-20. 2003
    ....
  38. ncbi request reprint Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections
    Kevin B Laupland
    Department of Medicine, University of Calgary, Calgary Health Region, Calgary, Canada
    J Infect Dis 187:1452-9. 2003
    ..This study provides important data on the burden of ISA disease and identifies risk groups that may potentially benefit from preventive efforts...
  39. pmc Human case of lobomycosis
    Sameer Elsayed
    Calgary Laboratory Services, Calgary, Alberta, Canada
    Emerg Infect Dis 10:715-8. 2004
    ..Our case represents the first published report of imported human lobomycosis in Canada and the fifth in an industrialized country...
  40. pmc New quadriplex PCR assay for detection of methicillin and mupirocin resistance and simultaneous discrimination of Staphylococcus aureus from coagulase-negative staphylococci
    Kunyan Zhang
    Center for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 42:4947-55. 2004
    ....
  41. pmc Molecular epidemiology of CTX-M-producing Escherichia coli in the Calgary Health Region: emergence of CTX-M-15-producing isolates
    Johann D D Pitout
    Calgary Laboratory Services, Department of Pathology and Laboratory Medicine, University of Calgary, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    Antimicrob Agents Chemother 51:1281-6. 2007
    ..This study illustrates the importance of molecular surveillance in tracking CTX-M-producing E. coli strains in the community and investigating their influx into hospitals...
  42. ncbi request reprint Invasive Candida species infections: a 5 year population-based assessment
    Kevin B Laupland
    Department of Medicine, Calgary Health Region and University of Calgary, Calgary, Alberta, Canada
    J Antimicrob Chemother 56:532-7. 2005
    ..The objective of this study was to define the occurrence of, risk factors for, and antifungal susceptibilities of invasive Candida species infections in a large Canadian health region...
  43. pmc Virulence factors of Escherichia coli isolates that produce CTX-M-type extended-spectrum beta-lactamases
    Johann D D Pitout
    Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada
    Antimicrob Agents Chemother 49:4667-70. 2005
    ..Our results indicate that CTX-M type predicts phylogenetic background, and the virulence potential of ESBL-producing E. coli isolates is a complex issue, requiring further study and ongoing surveillance...
  44. pmc Population-based laboratory surveillance for AmpC beta-lactamase-producing Escherichia coli, Calgary
    Johann D D Pitout
    University of Calgary, Calgary, Alberta, Canada
    Emerg Infect Dis 13:443-8. 2007
    ..In this large Canadian region, AmpC beta-lactamase-producing E. coli is an emerging community pathogen that commonly causes urinary tract infections in older women...
  45. pmc Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa in the Calgary Health Region: emergence of VIM-2-producing isolates
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 45:294-8. 2007
    ..Our findings suggest that CR and dissemination of MBL clusters among P. aeruginosa populations in large geographic healthcare regions are dynamic processes that require continuous molecular surveillance...
  46. ncbi request reprint Emerging gram-negative enteric infections
    Johann D D Pitout
    Department of Pathology and Laboratory Medicine, University of Calgary, 11th Floor, Foothills Medical Centre, 1403 29 Street NW, Calgary, Alberta T2N 2T9, Canada
    Clin Lab Med 24:605-26, vi. 2004
    ..It concludes with suggestions for the implementation of molecular techniques to ensure rapid surveillance and enhanced patient care...
  47. pmc Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase-producing Escherichia coli strains in the Calgary health region
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd NW, Calgary, Alberta T2L 2K8, Canada
    J Clin Microbiol 43:2844-9. 2005
    ..Further studies are warranted to investigate whether community-onset diseases caused by ESBL-producing E. coli are related to a point source or transmission within the community...
  48. ncbi request reprint Development and validation of a molecular beacon probe-based real-time polymerase chain reaction assay for rapid detection of methicillin resistance in Staphylococcus aureus
    Sameer Elsayed
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
    Arch Pathol Lab Med 127:845-9. 2003
    ..A rapid, real-time, duplex, fluorescent molecular beacon probe-based polymerase chain reaction (PCR) assay was recently developed for the detection of methicillin-resistant Staphylococcus aureus...
  49. doi request reprint Surveillance for plasmid-mediated quinolone resistance determinants in Enterobacteriaceae within the Calgary Health Region, Canada: the emergence of aac(6')-Ib-cr
    Johann D D Pitout
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, 9, 3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8
    J Antimicrob Chemother 61:999-1002. 2008
    ..A study was designed to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among clinical isolates of Enterobacteriaceae from the Calgary Health Region (CHR)...
  50. pmc Species-level molecular identification of invasive "Streptococcus milleri" group clinical isolates by nucleic acid sequencing in a centralized regional microbiology laboratory
    Peter Daley
    Division of Microbiology, Calgary Laboratory Services, 9 3535 Research Rd NW, Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 43:2987-8. 2005
    ..A detailed understanding of their pathogenesis in human infection has only recently been facilitated by the use of molecular methods to study this group of organisms...
  51. doi request reprint Changing epidemiology of invasive pneumococcal disease in Canada, 1998-2007: update from the Calgary-area Streptococcus pneumoniae research (CASPER) study
    James D Kellner
    University of Calgary, Alberta Children s Hospital, Calgary Health Region, Calgary, Alberta, Canada
    Clin Infect Dis 49:205-12. 2009
    ..Routine infant vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) began in the Calgary Health Region (Alberta, Canada) in 2002. We measured the impact of this vaccine program on invasive pneumococcal disease (IPD)...
  52. ncbi request reprint Severe bloodstream infections: a population-based assessment
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Crit Care Med 32:992-7. 2004
    ..We sought to define the incidence and microbiology of severe bloodstream infection (bloodstream infection associated with intensive care unit admission within 48 hrs) and assess risk factors for acquisition and death...
  53. doi request reprint Effects of routine infant vaccination with the 7-valent pneumococcal conjugate vaccine on nasopharyngeal colonization with streptococcus pneumoniae in children in Calgary, Canada
    James D Kellner
    Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Pediatr Infect Dis J 27:526-32. 2008
    ..All Streptococcus pneumoniae disease is preceded by nasopharyngeal (NP) colonization. We studied the impact of 7-valent pneumococcal conjugate vaccine (PCV7) on colonization in healthy children...
  54. ncbi request reprint Selective testing of women based on age for genital Chlamydia trachomatis and Neisseria gonorrhoeae infection in a centralized regional microbiology laboratory
    Deirdre L Church
    Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada T2L 2K8
    Diagn Microbiol Infect Dis 57:379-85. 2007
    ..A 27.9% decrease in the total service costs resulted in a labor reduction of 0.2 FTE. Selective testing of women >35 years with a low prevalence of CT/GC infection is clinically relevant and cost-effective...
  55. ncbi request reprint Evaluation of a rapid bacterial ATP assay for screening BAL samples from ICU patients submitted for quantitative bacterial cultures
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Diagn Microbiol Infect Dis 47:465-9. 2003
    ..A combined negative rapid test consisting of Gram's stain/bacterial ATP assay rules out significant bacteria in BAL samples with a high degree of certainty. Future studies are needed to clinically validate these observations...
  56. doi request reprint Development of a novel electronic surveillance system for monitoring of bloodstream infections
    Jenine Leal
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Infect Control Hosp Epidemiol 31:740-7. 2010
    ..Electronic surveillance systems (ESSs) that utilize existing information in databases are more efficient than conventional infection surveillance methods...
  57. ncbi request reprint Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate
    Kevin B Laupland
    Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
    Crit Care Med 30:2462-7. 2002
    ..The study objective was to define the incidence, risk factors, microbiology, and clinical outcomes of intensive care unit-acquired bloodstream infections...
  58. ncbi request reprint Incidence and risk factors for acquiring nosocomial urinary tract infection in the critically ill
    Kevin B Laupland
    Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Canada
    J Crit Care 17:50-7. 2002
    ..However, the epidemiology of intensive care unit (ICU)-acquired UTIs is not well defined. The objective of this study was to describe the incidence, risk factors, and clinical outcomes of ICU-acquired UTIs...
  59. doi request reprint Epidemiology of Staphylococcus aureus nasal colonization and influence on outcome in the critically ill
    Daniel J Niven
    Department of Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
    J Crit Care 24:583-9. 2009
    ..To determine the rate of Staphylococcus aureus nasal colonization at admission to intensive care units (ICU) and assess its effect on the development of an ICU-acquired S aureus infection...