Eva W C Chow

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Neurocognitive profile in 22q11 deletion syndrome and schizophrenia
    Eva W C Chow
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 87:270-8. 2006
  2. ncbi request reprint Clinical characteristics and treatment response to SSRI in a female pedophile
    Eva W C Chow
    Law and Mental Health Program, Centre for Addiction and Mental Health, Clarke Site, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Arch Sex Behav 31:211-5. 2002
  3. pmc Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus
    Eva W C Chow
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Canada
    Am J Psychiatry 168:522-9. 2011
  4. pmc Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition
    Janice A Husted
    School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada
    Schizophr Res 137:166-8. 2012
  5. pmc Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene
    Janice A Husted
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Schizophr Res 121:187-92. 2010
  6. pmc Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome
    Anne S Bassett
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 61:1135-40. 2007
  7. pmc The schizophrenia phenotype in 22q11 deletion syndrome
    Anne S Bassett
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 Canada
    Am J Psychiatry 160:1580-6. 2003
  8. pmc Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome
    Anne S Bassett
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Hum Mol Genet 17:4045-53. 2008
  9. pmc Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays
    Gregory Costain
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada M5S 2S1
    Hum Mol Genet 22:4485-501. 2013
  10. doi request reprint Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications
    Nancy J Butcher
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada2Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    JAMA Neurol 70:1359-66. 2013

Collaborators

Detail Information

Publications29

  1. pmc Neurocognitive profile in 22q11 deletion syndrome and schizophrenia
    Eva W C Chow
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 87:270-8. 2006
    ..We hypothesized that in adults with 22qDS the neurocognitive profiles would differ between those with and without schizophrenia...
  2. ncbi request reprint Clinical characteristics and treatment response to SSRI in a female pedophile
    Eva W C Chow
    Law and Mental Health Program, Centre for Addiction and Mental Health, Clarke Site, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Arch Sex Behav 31:211-5. 2002
    ..This case adds to the limited literature on female pedophiles and suggests that SSRIs may be an effective treatment for paraphilic disorders in female sex offenders...
  3. pmc Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus
    Eva W C Chow
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Canada
    Am J Psychiatry 168:522-9. 2011
    ..2 deletion syndrome, as for schizophrenia in the general population, would be gray matter volumetric deficits, especially in the temporal lobes...
  4. pmc Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition
    Janice A Husted
    School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada
    Schizophr Res 137:166-8. 2012
    ..55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition...
  5. pmc Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene
    Janice A Husted
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Schizophr Res 121:187-92. 2010
    ..61, 11.91, respectively). The results suggest that childhood trauma is associated with expression of schizophrenia independent of measured genetic susceptibility and may be a candidate for gene-environment research using genetic variants...
  6. pmc Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome
    Anne S Bassett
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 61:1135-40. 2007
    ..COMT is within the region commonly deleted in 22q11 deletion syndrome (22q11DS), a syndrome with high prevalence of schizophrenia. We examined the role of COMT in schizophrenia-related expression in 22q11DS...
  7. pmc The schizophrenia phenotype in 22q11 deletion syndrome
    Anne S Bassett
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 1001 Queen Street West, Toronto, Ontario, M6J 1H4 Canada
    Am J Psychiatry 160:1580-6. 2003
    ..Individuals with 22qDS are at genetically high risk for schizophrenia...
  8. pmc Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome
    Anne S Bassett
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Hum Mol Genet 17:4045-53. 2008
    ..2DS. The results reinforce the need for further efforts to identify specific molecular mechanisms underlying this expression and to identify the 1% of patients with schizophrenia who carry 22q11.2 deletions...
  9. pmc Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays
    Gregory Costain
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada M5S 2S1
    Hum Mol Genet 22:4485-501. 2013
    ..7-fold increase, P = 0.0060). These findings suggest consideration of a potential role for clinical microarray testing in schizophrenia, as is now the suggested standard of care for related developmental disorders like autism. ..
  10. doi request reprint Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications
    Nancy J Butcher
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada2Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    JAMA Neurol 70:1359-66. 2013
    ..2 deletion syndrome (22q11.2DS), suggest that 22q11.2 deletions may lead to increased risk of early-onset Parkinson disease (PD). The frequency of PD and its neuropathological presentation remain unknown in this common genetic condition...
  11. doi request reprint Sex differences in reproductive fitness contribute to preferential maternal transmission of 22q11.2 deletions
    Gregory Costain
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Med Genet 48:819-24. 2011
    ..2 deletion is found to have been inherited, usually from an affected mother. Serious neuropsychiatric conditions that are commonly associated features of 22q11.2DS could disproportionately affect reproductive success in males...
  12. pmc Functional outcomes of adults with 22q11.2 deletion syndrome
    Nancy J Butcher
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Genet Med 14:836-43. 2012
    ..There are limited data on adult functioning in 22q11.2 deletion syndrome...
  13. pmc Clinical features of 78 adults with 22q11 Deletion Syndrome
    Anne S Bassett
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Med Genet A 138:307-13. 2005
    ..Many treatable conditions may be anticipated and features may accumulate over time. The results have implications for clinical assessment and management, genetic counseling and research into pathophysiological mechanisms...
  14. pmc Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report
    Gregory Costain
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 122:81-4. 2010
    ..These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype...
  15. pmc Heritability of neurocognitive traits in familial schizophrenia
    Janice A Husted
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:845-53. 2009
    ..Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition...
  16. pmc Schizophrenia and 22q11.2 deletion syndrome
    Anne S Bassett
    Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Curr Psychiatry Rep 10:148-57. 2008
    ..22qDS-schizophrenia is an important genetic subtype and a valuable model of neurodevelopmental mechanisms involved in the pathogenesis of schizophrenia...
  17. pmc Extracardiac features predicting 22q11.2 deletion syndrome in adult congenital heart disease
    Wai Lun Alan Fung
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Cardiol 131:51-8. 2008
    ..We aimed to determine an optimal combination of extracardiac features that could be clinically helpful in identifying adults with tetralogy of Fallot (TOF) and related conotruncal anomalies at highest risk for 22q11.2DS...
  18. pmc Clinically detectable copy number variations in a Canadian catchment population of schizophrenia
    Anne S Bassett
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychiatr Res 44:1005-9. 2010
    ..Identifying large, rare CNVs (particularly 22q11.2 deletions) can lead to significant changes in management, follow-up, and genetic counselling that are helpful to the patient, family, and clinicians...
  19. pmc Childhood head injury and expression of schizophrenia in multiply affected families
    Philip AbdelMalik
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M6J 1H4
    Arch Gen Psychiatry 60:231-6. 2003
    ..We investigated whether mild head injury during brain maturation plays a role in the expression of schizophrenia in multiply affected families...
  20. doi request reprint Premorbid adjustment and schizophrenia in individuals with 22q11.2 deletion syndrome
    Tracy Yuen
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 151:221-5. 2013
    ..2DS) are at heightened risk of developing schizophrenia. The present study examined the relationship between adult-onset schizophrenia and social and academic functioning across childhood and early adolescent development in 22q11.2DS...
  21. pmc A method for accurate detection of genomic microdeletions using real-time quantitative PCR
    Rosanna Weksberg
    Program in Genetics and Genomic Biology, The Research Institute, The Hospital for Sick Children, Toronto, Canada
    BMC Genomics 6:180. 2005
    ....
  22. pmc Complex congenital heart disease in unaffected relatives of adults with 22q11.2 deletion syndrome
    Jodi Ann M Swaby
    Toronto Congenital Cardiac Centre for Adults, University of Toronto, Peter Munk Cardiac Centre, University Health Network Toronto General Hospital, Ontario, Canada
    Am J Cardiol 107:466-71. 2011
    ..These findings have potential implications for the genetic counseling of families of those with 22q11DS and support the notion that interacting genetic variants might contribute to the variable expression of 22q11DS...
  23. doi request reprint Neonatal hypocalcemia, neonatal seizures, and intellectual disability in 22q11.2 deletion syndrome
    Evelyn Ning Man Cheung
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Genet Med 16:40-4. 2014
    ..2 deletion syndrome. Neonatal hypocalcemia may affect neurodevelopment. We hypothesized that neonatal hypocalcemia would be associated with rare, more severe forms of intellectual disability in 22q11.2 deletion syndrome...
  24. doi request reprint Mutations in MECP2 exon 1 in classical Rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2
    Peter J Gianakopoulos
    Molecular Neuropsychiatry and Development Lab, Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 159:210-6. 2012
    ..Altogether, our work further supports our hypothesis that MECP2_e1 is the predominant isoform involved in the neuropathology of Rett syndrome...
  25. pmc Is schizophrenia linked to chromosome 1q?
    Anne S Bassett
    Department of Psychiatry, University of Torontoand Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Science 298:2277; author reply 2277. 2002
  26. pmc Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome
    Eva W C Chow
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 51:208-15. 2002
    ..In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia...
  27. ncbi request reprint Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22
    Linda M Brzustowicz
    Department of Genetics, Rutgers University, Piscataway, NJ 08854 8095, USA
    Hum Hered 54:199-209. 2002
    ..This duplication may be involved in genomic instability, leading to gene deletion, and so presents an intriguing candidate locus for schizophrenia susceptibility...
  28. pmc Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22
    Linda M Brzustowicz
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Am J Hum Genet 74:1057-63. 2004
    ..Consistent with several recently identified candidate genes for schizophrenia, CAPON is involved in signal transduction in the NMDA receptor system, highlighting the potential importance of this pathway in the etiology of schizophrenia...
  29. pmc Sibship characteristics in a familial sample with genetic susceptibility to schizophrenia
    Janice A Husted
    Schizophr Res 95:248-9. 2007