Nickolay Y Chirgadze

Summary

Affiliation: University Health Network
Country: Canada

Publications

  1. pmc X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection
    Gera Kisselman
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr D Biol Crystallogr 67:533-9. 2011
  2. pmc Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family
    Teresa E Clarke
    Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    BMC Struct Biol 11:27. 2011
  3. doi request reprint Crystal structure of the CN-hydrolase SA0302 from the pathogenic bacterium Staphylococcus aureus belonging to the Nit and NitFhit Branch of the nitrilase superfamily
    Roni D Gordon
    a Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2C4, Canada
    J Biomol Struct Dyn 31:1057-65. 2013
  4. doi request reprint Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)
    Wei Qiu
    Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, M5G 2C4, Canada
    BMC Struct Biol 14:10. 2014
  5. pmc Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori
    Robert Lam
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Proteins 78:2839-48. 2010
  6. pmc Structure of Francisella tularensis peptidyl-tRNA hydrolase
    Teresa E Clarke
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, MBRC 5th Floor, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:446-9. 2011
  7. pmc Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP
    Shekeb Khan
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7
    J Mol Biol 413:985-1000. 2011
  8. pmc Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    Jack C C Liao
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C4, Canada
    Structure 19:418-29. 2011

Collaborators

  • Yuri N Chirgadze
  • Teresa E Clarke
  • Vaclav Brazda
  • Wei Qiu
  • Emil F Pai
  • Robert Lam
  • Vladimir Romanov
  • Kevin P Battaile
  • Roni D Gordon
  • Shekeb Khan
  • Jack C C Liao
  • Gera Kisselman
  • Kim Lam
  • Maria Soloveychik
  • Diana Benetteraj
  • Justin Ma
  • Shili Duan
  • Linda E Sandercock
  • Cheryl H Arrowsmith
  • Christine M Thompson
  • Wolfram Tempel
  • Yun Xing Wang
  • Hira S Mian
  • Mani Ravichandran
  • Xiaobing Zuo
  • Ting Xiao
  • Jennifer L Guthrie
  • Kathy Johns
  • Robert P Hausinger
  • Jean Wu-Brown

Detail Information

Publications8

  1. pmc X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection
    Gera Kisselman
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr D Biol Crystallogr 67:533-9. 2011
    ..It does not require any modification for most in-house and synchrotron beamline systems and offers a promising opportunity for full automation of the X-ray structure-determination process...
  2. pmc Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family
    Teresa E Clarke
    Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    BMC Struct Biol 11:27. 2011
    ..Alkyl hydroperoxidase activity provides an important antioxidant defense for bacterial cells. The catalytic mechanism requires two peroxidases, AhpC and AhpD, where AhpD plays the role of an essential adaptor protein...
  3. doi request reprint Crystal structure of the CN-hydrolase SA0302 from the pathogenic bacterium Staphylococcus aureus belonging to the Nit and NitFhit Branch of the nitrilase superfamily
    Roni D Gordon
    a Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2C4, Canada
    J Biomol Struct Dyn 31:1057-65. 2013
    ..An animated interactive 3D complement (I3DC) is available in Proteopedia at http://proteopedia.org/w/Journal:JBSD:19. ..
  4. doi request reprint Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)
    Wei Qiu
    Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, M5G 2C4, Canada
    BMC Struct Biol 14:10. 2014
    ..Consistent with the distinct pathogenesis of NS and LS, different types of PTPN11 mutations cause these disorders...
  5. pmc Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori
    Robert Lam
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Proteins 78:2839-48. 2010
    ..On the basis of evolutionary conservation analysis, the structure reveals a probable binding surface for interaction with other urease components as well as key conserved residues of potential functional relevance...
  6. pmc Structure of Francisella tularensis peptidyl-tRNA hydrolase
    Teresa E Clarke
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, MBRC 5th Floor, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:446-9. 2011
    ..The resultant reagents, structural data and analyses provide essential information for the structure-based design of novel inhibitors for this class of proteins...
  7. pmc Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP
    Shekeb Khan
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7
    J Mol Biol 413:985-1000. 2011
    ..We describe the structure of the EspP passenger domain in the context of previous results and provide an alternative hypothesis for the function of the β-helix within SPATEs...
  8. pmc Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    Jack C C Liao
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C4, Canada
    Structure 19:418-29. 2011
    ..Both interactions are compatible with the DNA-bound state of p53 and together contribute to the effect of full-length IFI16 on p53-DNA complex formation and transcriptional activation...