Nickolay Y Chirgadze

Summary

Affiliation: University Health Network
Country: Canada

Publications

  1. pmc Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family
    Teresa E Clarke
    Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    BMC Struct Biol 11:27. 2011
  2. pmc X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection
    Gera Kisselman
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr D Biol Crystallogr 67:533-9. 2011
  3. pmc Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori
    Robert Lam
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Proteins 78:2839-48. 2010
  4. pmc Structure of Francisella tularensis peptidyl-tRNA hydrolase
    Teresa E Clarke
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, MBRC 5th Floor, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:446-9. 2011
  5. pmc Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP
    Shekeb Khan
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7
    J Mol Biol 413:985-1000. 2011
  6. pmc Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    Jack C C Liao
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C4, Canada
    Structure 19:418-29. 2011

Collaborators

  • Vaclav Brazda
  • Yuri N Chirgadze
  • Robert Lam
  • Teresa E Clarke
  • Emil F Pai
  • Vladimir Romanov
  • Gera Kisselman
  • Shekeb Khan
  • Jack C C Liao
  • Kevin P Battaile
  • Jean Wu-Brown
  • Arthur A Branstrom
  • Srinivasa R Peddi
  • Justin Ma
  • Shili Duan
  • Scott A Gothe
  • Cheryl H Arrowsmith
  • Christine M Thompson
  • Chananat Klomsiri
  • Leslie B Poole
  • Richard S A Lipman
  • Linda E Sandercock
  • Ekaterina B Razumova
  • Wolfram Tempel
  • Yun Xing Wang
  • Wei Qiu
  • Hira S Mian
  • Mani Ravichandran
  • Xiaobing Zuo
  • Ting Xiao
  • Kathy Johns
  • Robert P Hausinger
  • Jennifer L Guthrie

Detail Information

Publications6

  1. pmc Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family
    Teresa E Clarke
    Campbell Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    BMC Struct Biol 11:27. 2011
    ..Alkyl hydroperoxidase activity provides an important antioxidant defense for bacterial cells. The catalytic mechanism requires two peroxidases, AhpC and AhpD, where AhpD plays the role of an essential adaptor protein...
  2. pmc X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection
    Gera Kisselman
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr D Biol Crystallogr 67:533-9. 2011
    ..It does not require any modification for most in-house and synchrotron beamline systems and offers a promising opportunity for full automation of the X-ray structure-determination process...
  3. pmc Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori
    Robert Lam
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    Proteins 78:2839-48. 2010
    ..On the basis of evolutionary conservation analysis, the structure reveals a probable binding surface for interaction with other urease components as well as key conserved residues of potential functional relevance...
  4. pmc Structure of Francisella tularensis peptidyl-tRNA hydrolase
    Teresa E Clarke
    Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, University Health Network, MBRC 5th Floor, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:446-9. 2011
    ..The resultant reagents, structural data and analyses provide essential information for the structure-based design of novel inhibitors for this class of proteins...
  5. pmc Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP
    Shekeb Khan
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto Medical Discovery Tower, Toronto, Ontario, Canada M5G 1L7
    J Mol Biol 413:985-1000. 2011
    ..We describe the structure of the EspP passenger domain in the context of previous results and provide an alternative hypothesis for the function of the β-helix within SPATEs...
  6. pmc Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    Jack C C Liao
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C4, Canada
    Structure 19:418-29. 2011
    ..Both interactions are compatible with the DNA-bound state of p53 and together contribute to the effect of full-length IFI16 on p53-DNA complex formation and transcriptional activation...