Peter Cheung

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand
    Vijender R Vaidyula
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 55:202-8. 2006
  2. ncbi request reprint Epigenetic regulation by histone methylation and histone variants
    Peter Cheung
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Room 10 516, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 19:563-73. 2005
  3. pmc Elucidating combinatorial histone modifications and crosstalks by coupling histone-modifying enzyme with biotin ligase activity
    Priscilla Nga Ieng Lau
    Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, Canada M5G 2M9, Canada
    Nucleic Acids Res 41:e49. 2013
  4. pmc A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation
    Ryan Draker
    Ontario Cancer Institute, Toronto, Canada
    PLoS Genet 8:e1003047. 2012
  5. pmc Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing
    Priscilla Nga Ieng Lau
    Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 108:2801-6. 2011
  6. pmc USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
    Ryan Draker
    Ontario Cancer Institute, 610 University Avenue, University of Toronto, Toronto, ON, Canada M5G 2M9
    Nucleic Acids Res 39:3529-42. 2011
  7. doi request reprint Transcriptional and epigenetic functions of histone variant H2A.Z
    Ryan Draker
    Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, ONM5G2M9, Canada
    Biochem Cell Biol 87:19-25. 2009
  8. pmc Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin
    Elizabeth Sarcinella
    Division of Signaling Biology, Ontario Cancer Institute, 610 University Ave, Rm 10 516, Toronto, Canada M5G 2M9
    Mol Cell Biol 27:6457-68. 2007
  9. ncbi request reprint Generation and characterization of antibodies directed against di-modified histones, and comments on antibody and epitope recognition
    Peter Cheung
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Canada
    Methods Enzymol 376:221-34. 2004
  10. ncbi request reprint Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
    Barbara A Boggs
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 30:73-6. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand
    Vijender R Vaidyula
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 55:202-8. 2006
    ....
  2. ncbi request reprint Epigenetic regulation by histone methylation and histone variants
    Peter Cheung
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Room 10 516, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 19:563-73. 2005
    ..We also highlight some of the enzymes that mediate histone methylation and discuss the stability and inheritance of this modification...
  3. pmc Elucidating combinatorial histone modifications and crosstalks by coupling histone-modifying enzyme with biotin ligase activity
    Priscilla Nga Ieng Lau
    Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, Canada M5G 2M9, Canada
    Nucleic Acids Res 41:e49. 2013
    ..These studies serve as proof-of-principle for this new technical approach, and demonstrate that BICON can be further adapted to study PTMs and crosstalks associated with other histone-modifying enzymes...
  4. pmc A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation
    Ryan Draker
    Ontario Cancer Institute, Toronto, Canada
    PLoS Genet 8:e1003047. 2012
    ..Moreover, this study validates the approach of using proteomics to identify nucleosome-interacting proteins in order to elucidate downstream mechanistic functions associated with the histone variant H2A.Z...
  5. pmc Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing
    Priscilla Nga Ieng Lau
    Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 108:2801-6. 2011
    ..Our findings show that signal transduction activation can directly regulate polycomb silencing through a specific histone code-mediated mechanism...
  6. pmc USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
    Ryan Draker
    Ontario Cancer Institute, 610 University Avenue, University of Toronto, Toronto, ON, Canada M5G 2M9
    Nucleic Acids Res 39:3529-42. 2011
    ..Zub1 is associated with transcriptional activation of these genes. Together, these data provide novel insights into how H2A.Z ubiquitylation/deubiquitylation and USP10 function in AR-regulated gene expression...
  7. doi request reprint Transcriptional and epigenetic functions of histone variant H2A.Z
    Ryan Draker
    Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, ONM5G2M9, Canada
    Biochem Cell Biol 87:19-25. 2009
    ..In this review, we discuss some of the recent findings related to this histone variant, how it associates with other histone epigenetic marks, and how post-translational modifications of H2A.Z further define its function...
  8. pmc Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin
    Elizabeth Sarcinella
    Division of Signaling Biology, Ontario Cancer Institute, 610 University Ave, Rm 10 516, Toronto, Canada M5G 2M9
    Mol Cell Biol 27:6457-68. 2007
    ..Z is associated with both euchromatin and facultative heterochromatin and that monoubiquitylation is a specific mark that distinguishes the H2A.Z associated with these different chromatin states...
  9. ncbi request reprint Generation and characterization of antibodies directed against di-modified histones, and comments on antibody and epitope recognition
    Peter Cheung
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Canada
    Methods Enzymol 376:221-34. 2004
  10. ncbi request reprint Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
    Barbara A Boggs
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 30:73-6. 2002
    ....
  11. ncbi request reprint The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved
    Cynthia M Barber
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Chromosoma 112:360-71. 2004
    ..The evolutionarily conserved phosphorylation of H4/H2A during the cell cycle suggests that they may have a dual purpose in chromatin condensation during mitosis and histone deposition during S-phase...
  12. ncbi request reprint Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
    Wang L Cheung
    Department of Microbiology, University of Virginia Health System, Charlottesville 22908, USA
    Cell 113:507-17. 2003
    ..Our data provide evidence for a potential apoptotic "histone code."..
  13. ncbi request reprint Chromatin immunoprecipitation assay for mammalian tissues
    Fiona B Turner
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, USA
    Methods Mol Biol 325:261-72. 2006
    ..ChIP, if applied globally, can also reveal how chromatin structures are dynamically changed when cells respond to certain stimuli. In this chapter, we describe this powerful technique in detail...