Runjan Chetty

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi E-cadherin in solid pseudopapillary tumors of the pancreas
    Runjan Chetty
    Hum Pathol 39:1407-8. 2008
  2. ncbi Metastatic clear cell renal cell carcinoma presenting as multiple colonic polyps
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
    Int J Surg Pathol 19:791-4. 2011
  3. ncbi Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant
    Runjan Chetty
    Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Surg Pathol 29:1668-72. 2005
  4. ncbi An incidental enterocolic lymphocytic phlebitis pattern is seen commonly in the rectal stump of patients with diversion colitis superimposed on inflammatory bowel disease
    R Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, Canada
    J Clin Pathol 62:464-7. 2009
  5. ncbi Plasmablastic lymphoma in HIV+ patients: an expanding spectrum
    R Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa and Department of Pathology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
    Histopathology 42:605-9. 2003
  6. ncbi Oncocytic rectal adenocarcinomas
    Runjan Chetty
    Department of Pathology, University Health Network and University of Toronto, Toronto, Canada
    Hum Pathol 40:478-83. 2009
  7. ncbi p27 Protein and cancers of the gastrointestinal tract and liver: an overview
    Runjan Chetty
    J Clin Gastroenterol 37:23-7. 2003
  8. ncbi Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Endocr Pathol 16:145-51. 2005
  9. ncbi Xanthelasma or xanthoma of the fallopian tube
    Runjan Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Arch Pathol Lab Med 127:e417-9. 2003
  10. ncbi Loss of membrane localization and aberrant nuclear E-cadherin expression correlates with invasion in pancreatic endocrine tumors
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Am J Surg Pathol 32:413-9. 2008

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi E-cadherin in solid pseudopapillary tumors of the pancreas
    Runjan Chetty
    Hum Pathol 39:1407-8. 2008
  2. ncbi Metastatic clear cell renal cell carcinoma presenting as multiple colonic polyps
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
    Int J Surg Pathol 19:791-4. 2011
    ..This case highlights an extremely unusual presentation of recurrent renal cell carcinoma as multiple, separate colonic polyps 17 years after resection of the primary tumor...
  3. ncbi Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant
    Runjan Chetty
    Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Surg Pathol 29:1668-72. 2005
    ..Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached...
  4. ncbi An incidental enterocolic lymphocytic phlebitis pattern is seen commonly in the rectal stump of patients with diversion colitis superimposed on inflammatory bowel disease
    R Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, Canada
    J Clin Pathol 62:464-7. 2009
    ..The present study examined the occurrence of ELP in the setting of diversion colitis and inflammatory bowel disease, as well as in random colectomy specimens...
  5. ncbi Plasmablastic lymphoma in HIV+ patients: an expanding spectrum
    R Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa and Department of Pathology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
    Histopathology 42:605-9. 2003
    ..Plasmablastic lymphoma is a distinctive HIV-associated tumour that was first described in the jaws and oral cavity. Only two cases (stomach and lung) have been documented in extra-oral sites...
  6. ncbi Oncocytic rectal adenocarcinomas
    Runjan Chetty
    Department of Pathology, University Health Network and University of Toronto, Toronto, Canada
    Hum Pathol 40:478-83. 2009
    ..All 8 cases appeared to have behaved aggressively with rapid local and/or distant spread over a short duration...
  7. ncbi p27 Protein and cancers of the gastrointestinal tract and liver: an overview
    Runjan Chetty
    J Clin Gastroenterol 37:23-7. 2003
    ..CONCLUSION: Therefore, in gastrointestinal and hepatic cancers, low p27 expression is regarded as an important adverse prognostic factor...
  8. ncbi Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Endocr Pathol 16:145-51. 2005
    ..ACTH-producing PET are usually aggressive lesions with metastases at the time of presentation and aggressive biological behavior. However, this case was characterized by an indolent clinical course...
  9. ncbi Xanthelasma or xanthoma of the fallopian tube
    Runjan Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Arch Pathol Lab Med 127:e417-9. 2003
    ..However, this lesion may share pathogenetic similarities with xanthogranulomatous salpingitis, since both processes are mediated by inflammation...
  10. ncbi Loss of membrane localization and aberrant nuclear E-cadherin expression correlates with invasion in pancreatic endocrine tumors
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Am J Surg Pathol 32:413-9. 2008
    ..Aberrant expression of both beta-catenin and E-cadherin correlated strongly with lymph node spread and liver metastases...
  11. ncbi Requiem for the term 'carcinoid tumour' in the gastrointestinal tract?
    Runjan Chetty
    Department of Pathology, University Health Network and University of Toronto, Toronto, Canada
    Can J Gastroenterol 22:357-8. 2008
    ..Thus, the term 'carcinoid' has served its purpose well, but its use should be phased out in favour of 'neuroendocrine tumour' or 'neuroendocrine carcinoma'...
  12. ncbi Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis
    R Chetty
    Department of Pathology, University of Toronto and University Health Network, Toronto, ON M5G 2M9, Canada
    J Clin Pathol 58:97-101. 2005
    ..Whether the heterotopic oxyntic gastric mucosa in the duodenum is also related is unclear, but it may represent a forme fruste of fundic gland polyps...
  13. ncbi p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas
    Runjan Chetty
    Departments of Pathology, University Health Network and University of Toronto, Toronto, Canada
    Am J Clin Pathol 130:71-6. 2008
    ..Aberrations and other alterations of the E-cadherin gene are unlikely to be responsible for the loss of E-cadherin in SPTs...
  14. ncbi Nuclear E-cadherin immunoexpression: from biology to potential applications in diagnostic pathology
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, Ontario, Canada
    Adv Anat Pathol 15:234-40. 2008
    ..The exact mechanism by which E-cadherin enters the nucleus is not known but it is likely that it is closely related to several partner molecules such as beta-catenin, p120, and presenilin-1...
  15. ncbi Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON M5G 2M9, Canada
    Endocr Pathol 15:141-8. 2004
    ..In addition, the endocrine lesions were composed of two main cell types (typical and oncocytic cells) with the oncocytic component invading lymphatic channels and spreading to regional lymph nodes...
  16. ncbi Gastric neuroendocrine carcinoma arising from heterotopic pancreatic tissue
    R Chetty
    Department of Pathology, University Health Network and University of Toronto, Princess Margaret Hospital, 610 University Avenue, Room 312, Toronto, Ontario M5G 2M9, Canada
    J Clin Pathol 57:314-7. 2004
    ..Pathologists should be aware of the occurrence of pancreatic heterotopia in the stomach and the association of carcinoma with it...
  17. ncbi Vasculopathic changes, a somatostatin-producing neuroendocrine carcinoma and a jejunal gastrointestinal stromal tumor in a patient with type 1 neurofibromatosis
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 20:177-81. 2009
    ..These abnormal vessels were within and close to the somatostatinoma only and were not found away from the tumor. It is thought that the vasculopathy is related to NF-1 with abnormal neurofibromin possibly playing a role...
  18. ncbi Nuclear expression of E-cadherin in solid pseudopapillary tumors of the pancreas
    Stefano Serra
    Department of Pathology, University Health Network Toronto Medical Laboratories, Toronto, ON, Canada
    JOP 8:296-303. 2007
    ..Moreover, there is a close relationship between beta-catenin and E-cadherin...
  19. ncbi Psammomatous melanotic schwannoma presenting as colonic polyps
    Runjan Chetty
    Department of Pathology, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Room 312, Toronto, Ontario, M5G 2C4, Canada
    Virchows Arch 451:717-20. 2007
    ..The lack of malignant features separates this lesion from melanoma while the immunophenotype of the other lesions is characteristic...
  20. ncbi Small and microscopically detected gastrointestinal stromal tumours: an overview
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Pathology 40:9-12. 2008
    ..They are biologically indolent, and the majority of lesions appear to remain small and/or show evidence of involution. However, it is possible that some are the precursors of clinically significant GISTs...
  21. ncbi Myxoid perineurioma presenting as a gastric polyp
    Runjan Chetty
    Department of Pathology, Laboratory Medicine Programme, University Health Network University of Toronto, Toronto, Canada M5G 2C4
    Ann Diagn Pathol 14:125-8. 2010
    ..The overall morphological and immunophenotypic features of this lesion are in keeping with a myxoid gastric perineurioma. This lesion needs to be separated from an inflammatory fibroid polyp and a gastrointestinal stromal tumor...
  22. ncbi Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid
    Runjan Chetty
    Department of Pathology, Laboratory Medicine Programme, University Health Network University of Toronto, Toronto, Canada
    Am J Surg Pathol 34:401-4. 2010
    ..The presence of multi-vacuolated, foamy and clear cells, some resembling signet ring or goblet cells, in otherwise classic carcinoid tumors is rare but should be considered in this context in the appendix...
  23. ncbi Pancreatic endocrine tumour with ductules: further observations of an unusual histological subtype
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Pathology 38:5-9. 2006
    ..A study of 21 cases of this variant was undertaken with particular attention paid to the distribution and morphology of the ductules, the presence of entrapped acinar tissue and the surrounding uninvolved pancreatic tissue...
  24. ncbi An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, Ontario, Canada
    Arch Pathol Lab Med 132:1285-9. 2008
    ..With advances in imaging techniques, more of these tumors are being removed and sent for pathologic evaluation. It is important for the diagnostic pathologist to be aware of recent developments in this field...
  25. ncbi Intraductal pancreatic neuroendocrine tumor
    Runjan Chetty
    Department of Pathology, Laboratory Medicine Programme, University Health Network, The Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    Endocr Pathol 20:262-6. 2009
    ..While an intraductal location of a pancreatic neuroendocrine tumor is rare, it should be borne in mind when confronted by an intraductal lesion in the pancreas...
  26. ncbi Solitary fibrous tumor of the pancreas
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, Ontario, Canada
    Ann Diagn Pathol 13:339-43. 2009
    ..This is an unusual primary spindle cell neoplasm of the pancreas and should be considered in the differential diagnosis of all spindle cell lesions that occur in the pancreas...
  27. ncbi Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, The Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, ON M5G 2C4, Canada
    Histopathology 55:270-6. 2009
    ..Three cases of ITA are presented, the literature reviewed and their association with intraductal papillary mucinous neoplasm (IPMN) is postulated...
  28. ncbi Membrane loss and aberrant nuclear localization of E-cadherin are consistent features of solid pseudopapillary tumour of the pancreas. An immunohistochemical study using two antibodies recognizing different domains of the E-cadherin molecule
    R Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON, Canada
    Histopathology 52:325-30. 2008
    ..To examine the expression of E-cadherin in solid pseudopapillary tumours (SPT) of the pancreas using two monoclonal antibodies recognizing two different domains of the E-cadherin molecule...
  29. ncbi Pancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term "rhabdoid" appropriate?
    R Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON M5G 2M9, Canada
    J Clin Pathol 57:1106-10. 2004
    ..It is suggested that the term "cytokeratin aggresomes" should be used to describe this distinctive phenotype...
  30. ncbi Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas
    Sima Salahshor
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 21:271-81. 2008
    ....
  31. ncbi The predictive value of CK19 and CD99 in pancreatic endocrine tumors
    Abdullah Ali
    Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Ont, Canada
    Am J Surg Pathol 30:1588-94. 2006
    ..CD99 does not appear to be as useful. There is no compelling evidence, from our study, to suggest that both these markers may be used in concert to predict the behavior of PETs...
  32. ncbi CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix
    Khaled O Alsaad
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Ontario, Canada, and Institute of Clinical Pathology, Department of Pathologie, University Hospital, Zurich, Switzerland
    Int J Surg Pathol 15:252-7. 2007
    ..There is no difference in the immunostaining for CK19 and CD99 between GCCs and classic carcinoids, and both types of neuroendocrine tumor show the same extent of expression of both markers...
  33. ncbi Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis
    Runjan Chetty
    Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Ontario, Canada
    Hum Pathol 37:212-7. 2006
    ..These findings suggest that a proportion of cases of IPMN may show abnormalities in the Wnt-signaling pathway with consequent altered expression of downstream related proteins...
  34. ncbi Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma
    Kriebashne S Nair
    Pfizer Molecular Biology Research Facility, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Hum Pathol 37:125-34. 2006
    ..Although alpha- and beta-catenin as well as E-cadherin showed no direct prognostic value, E-cadherin may warrant further investigation as an indirect prognostic indicator by allowing more accurate prediction of lymph node metastases...
  35. ncbi Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis
    Sima Salahshor
    Department of Medical Biophysics, Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
    BMC Cancer 5:66. 2005
    ....
  36. ncbi CEACAM1 expression in pancreatic endocrine tumors
    Stefano Serra
    Department of Pathology, University Health Network, University of Toronto, Toronto, Canada
    Appl Immunohistochem Mol Morphol 17:286-93. 2009
    ..05). PETs showing CEACAM1 positivity have a statistically significant correlation with several of the pathologic parameters of aggressive behavior and its overexpression is seen in those cases with increased invasiveness...
  37. ncbi The prognostic value of grade of regression and oncocytic change in rectal adenocarcinoma treated with neo-adjuvant chemoradiotherapy
    Paromita Roy
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    J Surg Oncol 105:130-4. 2012
    ..Oncocytic change (OC) has also been described in the residual tumor. This study assesses the correlation of degree of pathological response and OC with clinical outcome...
  38. ncbi Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining
    Mina Jamali
    Department of Pathology, University Health Network, The Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, ON M5G 2C4, Canada
    Endocr Pathol 19:282-8. 2008
    ..We conclude that most studies favor the utility of the Ki-67 proliferation index despite different critical percentages and in concert with other pathological parameters in the routine work-up of PETs...
  39. ncbi A descriptive analysis of gastric cancer specimen processing techniques
    Alyson L Mahar
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Surg Oncol 103:248-56. 2011
    ..A survey of pathologists in Ontario was performed to outline the processing techniques and practices for assessing gastric cancer specimens...
  40. ncbi Improving the quality of processing gastric cancer specimens: the pathologist's perspective
    Alyson L Mahar
    Centre for Health Services Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Surg Oncol 101:195-9. 2010
    ..To understand factors affecting optimal assessment we surveyed pathologists to identify external barriers...
  41. ncbi Gastric hyperplastic polyps: a review
    Richa Jain
    Department of Pathology, University Health Network University of Toronto, Toronto, ON, Canada
    Dig Dis Sci 54:1839-46. 2009
    ....
  42. ncbi Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases
    Ilan Weinreb
    Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Surg Pathol 33:409-16. 2009
    ..Three cases showed skin or bone invasion. None had lymph node/distant metastases. In summary, OMEC behaves as a low-grade tumor, and is diffusely positive for p63, which may aid in its differential diagnosis...
  43. ncbi Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications
    Amsha Ramburan
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Mod Pathol 17:89-95. 2004
    ..In conclusion, this study has found that multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas, and hence confer a poorer prognosis...
  44. ncbi Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix
    Khaled O Alsaad
    Department of Pathology, University Health Network Toronto Medical Laboratories, The Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario M5G 2C4, Canada
    Endocr Pathol 18:16-22. 2007
    ..Goblet cell carcinoid should be regarded as a crypt cell or an amphicrine carcinoma rather than a variant of carcinoid tumor, a lesion that has benign connotations...
  45. ncbi Abnormalities of chromosome 17 in oesophageal cancer
    Revendran Moodley
    Pfizer Molecular Biology Research Facility, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    J Clin Pathol 60:990-4. 2007
    ..The tylosis oesophageal cancer (TOC) gene, localised to a small region on chromosome 17q25, has been shown to be associated with oesophageal squamous cell carcinoma...
  46. ncbi The use of Cytokeratin 19 (CK19) immunohistochemistry in lesions of the pancreas, gastrointestinal tract, and liver
    Richa Jain
    Department of Pathology, The Toronto General Hospital, University Health Network University of Toronto, Toronto, Ontario, Canada
    Appl Immunohistochem Mol Morphol 18:9-15. 2010
    ..It can also be used to highlight native ductules in the liver and helps separate conditions such as focal nodular hyperplasia from hepatic adenoma. The vast majority of adenocarcinomas in the GIT and pancreas are CK19 positive...
  47. ncbi Ductal adenomas of salivary gland showing features of striated duct differentiation ('striated duct adenoma'): a report of six cases
    Ilan Weinreb
    Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada
    Histopathology 57:707-15. 2010
    ..To describe a salivary adenoma composed largely of unilayered ducts resembling striated ducts, and to differentiate it from similar adenomas, including canalicular and intercalated duct adenoma...
  48. ncbi Intercalated duct lesions of salivary gland: a morphologic spectrum from hyperplasia to adenoma
    Ilan Weinreb
    Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario M5G 2C4, Canada
    Am J Surg Pathol 33:1322-9. 2009
    ..There is an association with basal cell adenomas and EMC, which lends credence to their role as a putative precursor lesion...
  49. ncbi A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma"
    Vidhya Nair
    Department of Pathology, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Room 312, Toronto, M5G 2C4, Ontario, Canada
    Eur J Dermatol 18:332-6. 2008
    ..This case raises a nosological debate given the histological, immunophenotypic and cytogenetic findings...
  50. ncbi Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience
    Andrew J Evans
    Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
    Semin Diagn Pathol 26:165-76. 2009
    ..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP...
  51. ncbi Paucicellular infiltrating ductal carcinoma of pancreas: an unusual variant
    Mosa Fagih
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada M5G 2M9
    Ann Diagn Pathol 11:46-8. 2007
    ..Very focal ductal and signet-ring cell differentiation was noted. This unusual variant of pancreatic cancer was characterized by paucicellularity and a pattern of invasion resembling lobular carcinoma of breast...
  52. ncbi Intracytoplasmic inclusions (including the so-called "rhabdoid" phenotype) in pancreatic endocrine tumors
    Stefano Serra
    Department of Pathology, University Health Network/Toronto Medical Laboratories and University of Toronto, Toronto, Canada
    Endocr Pathol 17:75-81. 2006
    ..This phenotype, in particular the rhabdoid cells, is worthy of attention as a proportion may show lymphovascular invasion with evidence of metastasis at the time of presentation, irrespective of size, mitotic rates, or necrosis...
  53. ncbi Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix
    Runjan Chetty
    Department of Pathology, University Health Network, Toronto, Canada
    Am J Surg Pathol 34:1163-7. 2010
    ....
  54. ncbi Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix
    Khaled O Alsaad
    Department of Laboratory Medicine and Pathobiology, University of Toronto and University Health Network, Toronto, Ontario M5G 2C4, Canada
    World J Gastroenterol 15:3431-3. 2009
    ..In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination...
  55. ncbi Cutaneous melanocytoneuroma: the first case of a distinctive intraneural tumor with dual nerve sheath and melanocytic differentiation
    Ilan Weinreb
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    J Cutan Pathol 34:52-7. 2007
    ..In conclusion, this unusual lesion represents an intraneural proliferation with melanocytic and nerve sheath cell differentiation, to which we have accorded the appellation, MCN...
  56. ncbi Oncocytic papillary neoplasms of the biliary tract: a clinicopathological, mucin core and Wnt pathway protein analysis of four cases
    Marjan Rouzbahman
    Department of Pathology, University Health Network University of Toronto, Toronto, Canada
    Pathology 39:413-8. 2007
    ....
  57. ncbi Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma
    Chaturika Harshini Pavithra Herath
    Department of Pathology, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Arch Pathol Lab Med 132:706-9. 2008
    ....
  58. ncbi Clear cell (glycogen rich) gastric adenocarcinoma: a distinct tubulo-papillary variant with a predilection for the cardia/gastro-oesophageal region
    Zohreh Afshar Ghotli
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Ontario, Canada
    Pathology 39:466-9. 2007
    ..To explore the clinicopathological and immunohistochemical profile of clear cell gastric cancers with a tubulo-papillary pattern...
  59. ncbi Spiradenocarcinoma arising from a spiradenocylindroma: unusual case with lymphoepithelioma-like areas
    Runjan Chetty
    Department of Pathology, University Health Network University of Toronto, Toronto, ON, Canada
    J Cutan Med Surg 13:215-20. 2009
    ..Hybrid skin adnexal tumors are common, and spiradenocylindroma is well described...
  60. ncbi An unusual composite pilomatrix carcinoma with intralesional melanocytes: differential diagnosis, immunohistochemical evaluation, and review of the literature
    Prashant Jani
    Department of Pathology, Thunder Bay Regional Health Science Centre, Thunder Bay, Ontario, Canada
    Am J Dermatopathol 30:174-7. 2008
    ..It is possible that sun damage played a role in stimulating migration of melanocytes among matrical cells in this case...
  61. ncbi Perivascular epithelioid cell neoplasms (PEComas): four malignant cases expanding the histopathological spectrum and a description of a unique finding
    Ilan Weinreb
    Department of Pathology, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, ON, M5G 2C4, Canada
    Virchows Arch 450:463-70. 2007
    ..These tumours may manifest largely as sarcomas appearing to be undifferentiated and should be considered in their differential diagnosis...
  62. ncbi Primary gastrointestinal tract lymphoma: diagnosis and management of common neoplasms
    Brendan C Dickson
    University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto General Hospital, Department of Pathology, 200 Elizabeth Street, 11th Floor, Residents and Fellows Room, Toronto, Ontario, Canada
    Expert Rev Anticancer Ther 6:1609-28. 2006
    ..Thus, this review is intended to offer clinicians and pathologists an overview of primary gastrointestinal lymphomas...
  63. ncbi Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience
    Andrew J Evans
    Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
    Hum Pathol 40:1070-81. 2009
    ..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP...
  64. ncbi Combined large cell neuroendocrine, small cell and squamous carcinomas of the lung with rhabdoid cells
    R Chetty
    Department of Pathology, University of Natal School of Medicine and King Edward VIII Hospital, Durban, South Africa
    Pathology 32:209-12. 2000
    ..An additional feature was the presence of rhabdoid cells in both cases. It is felt that the rhabdoid component is a reflection of de-differentiation or poor differentiation, and may contribute to the aggressive nature of both tumors...
  65. ncbi Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells
    Blaise A Clarke
    Department of Pathology, Laboratory Medicine Programme, University Health Network University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada
    Int J Gynecol Pathol 29:432-7. 2010
    ..These two cells types have individually been implicated as harbingers of a poor prognosis in leiomyosarcomas. Their prominence in the recurrent tumor and the loss of muscle marker expression are in keeping with biologic progression...
  66. ncbi Rhabdomyomatous multilocular thymic cyst
    Runjan Chetty
    Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
    Am J Clin Pathol 119:816-21. 2003
    ..The muscle elements, most likely, were derived from thymic myoid cells, while the multilocular cyst arose from remnants of the thymomedullary system...
  67. ncbi Adenosquamous carcinoma of the pancreas with clear cell and rhabdoid components. A case report
    Mina Jamali
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON, Canada
    JOP 8:330-4. 2007
    ..In as much as no such variant of this pancreatic tumour has been previously reported in the literature, we report an unusual case of an adenosquamous carcinoma of the pancreas characterized by clear cells and rhabdoid cells...
  68. ncbi Expression profiling by microarrays in colorectal cancer (Review)
    Warren Shih
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Oncol Rep 13:517-24. 2005
    ..Validations of the results using other more precise techniques and at the biological level represent critical follow-up goals for microarray studies...
  69. ncbi Chromosome 2p, 3p, 5q and 18q status in sporadic gastric cancer
    Runjan Chetty
    Department of Pathology and Molecular Biology Research Facility, Nelson R Mandela School of Medicine, Faculty of Health Sciences, University of Natal, Durban, South Africa
    Pathology 34:275-81. 2002
    ..The genetic make-up of gastric cancers in low-risk population groups from South Africa is largely unknown. The purpose of this study was to ascertain the incidence of microsatellite instability and loss of heterozygosity in this population...
  70. ncbi TAL-1 protein expression in vascular lesions
    R Chetty
    Department of Anatomical Pathology, University of Natal, Durban, South Africa
    J Pathol 181:311-5. 1997
    ..Protein expression appears to be stronger in the spindle cell areas, perhaps reflecting greater expression in less-differentiated endothelial cells...
  71. ncbi CD31 (JC70) expression in plasma cells: an immunohistochemical analysis of reactive and neoplastic plasma cells
    D Govender
    Department of Anatomical Pathology, University of Natal Medical School, Durban, South Africa
    J Clin Pathol 50:490-3. 1997
    ..To investigate the immunohistochemical expression of CD31 (JC70) in normal and neoplastic plasma cells...
  72. ncbi Test and teach. A uterine tumour causing a diagnostic dilemma. Low-grade endometrial stromal sarcoma with extensive endometrioid glandular differentiation
    Komala Pillay
    Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
    Pathology 35:344-6. 2003
  73. ncbi Quality indicators for gastric cancer surgery: a survey of practicing pathologists in Ontario
    Alia P Qureshi
    Division of General Surgery, University of Toronto, Toronto, ON, Canada
    Ann Surg Oncol 16:1883-9. 2009
    ..Because disease management is highly collaborative, we surveyed pathologists to assess their knowledge of LN assessment and margins for processing gastric cancer specimens...
  74. ncbi Primary extramedullary plasmacytoma of the esophagus
    Runjan Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Ann Diagn Pathol 7:174-9. 2003
    ..PEMP is biologically and prognostically different to other plasma cell neoplasms. Although rare, esophageal PEMP should be considered in the differential diagnosis of so-called undifferentiated malignant tumors of the esophagus...
  75. ncbi Cyclin E immunoexpression in gastric cancer does not correlate with clinicopathological parameters
    R Chetty
    Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Histopathology 42:66-9. 2003
    ..To ascertain whether cyclin E immunoexpression relates to clinicopathological characteristics of gastric cancer and is of possible routine use...
  76. ncbi Cyclin D1 and human neoplasia
    R Donnellan
    Department of Pathology, University of Natal Medical School, Durban, South Africa
    Mol Pathol 51:1-7. 1998
    ..Knowledge of cyclin D1's role in malignancy at the various sites, provides a basis on which future treatment directed against this molecule can proceed...
  77. ncbi Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum
    A Makino
    Department of Pathology, University Health Network, Princess Margaret Hospital, 610 University Avenue, Fourth Floor, Suite 302, Room 312, Toronto, ON, M5G 2M9, Canada
    Virchows Arch 448:644-7. 2006
    ..This cytokeratin profile suggests a possible origin from the anal transitional zone...
  78. ncbi Bizarre stromal cells in ischemic bowel disease
    Stefano Serra
    Department of Pathology, University Health Network/Toronto Medical Laboratories, Toronto, ON, Canada M5G 2M9
    Ann Diagn Pathol 9:193-6. 2005
    ..However, immunohistochemistry, together with an awareness of those atypical stromal cells, can occur in the setting of ulceration and/or polypoid lesions, preventing an incorrect diagnosis...
  79. ncbi Pancreatic endocrine tumors: an update
    Runjan Chetty
    Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Adv Anat Pathol 11:202-10. 2004
    ..Loss of a sex chromosome has been shown to be associated with metastasis, local invasion, and poor survival...
  80. ncbi Rectal adenocarcinoma with oncocytic features: possible relationship with preoperative chemoradiotherapy
    M Rouzbahman
    Department of Pathology, University Health Network, Toronto, Canada
    J Clin Pathol 59:1039-43. 2006
    ..Oncocytic change may be an under-recognised histopathological change in rectal cancers receiving preoperative chemoradiation...
  81. ncbi Infiltrating ductal carcinoma of the breast with rhabdoid phenotype
    L Mogotlane
    Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
    Int J Surg Pathol 9:237-9. 2001
    ..In keeping with other epithelial malignancies that contain rhabdoid cells, aggressive biological behavior is noted. Int J Surg Pathol 9(3):237-239, 2001..
  82. ncbi Lymphoepithelioma-like carcinoma of the breast with associated sclerosing lymphocytic lobulitis
    P Naidoo
    Division of Anatomical Pathology, School of Pathology and Laboratory Medicine, University of Natal, Durban, South Africa
    Arch Pathol Lab Med 125:669-72. 2001
    ..This is the second report of a lymphoepithelioma-like carcinoma of the breast, but to the best of our knowledge, it is the first description of coexistent sclerosing lymphocytic lobulitis...
  83. ncbi ALK protein expression in rhabdomyosarcomas
    K Pillay
    Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
    Histopathology 41:461-7. 2002
    ..However, ALK expression is not restricted to this subtype. An extension of this study is to determine if this over-expression is as a result of the t(2;5) translocation...
  84. ncbi Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland
    R Chetty
    Division of Anatomical Pathology, University of Natal School of Pathology and Laboratory Medicine, Durban, South Africa
    Histopathology 37:260-3. 2000
    ....
  85. ncbi Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells
    S Alwaheeb
    Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Toronto, Ontario, Canada
    J Clin Pathol 58:987-90. 2005
    ..Although an acantholytic pattern has been noted in squamous carcinomas in other sites, this is the first report of such a pattern in an adenosquamous carcinoma of the pancreas...
  86. ncbi Follicular thyroid carcinoma with rhabdoid phenotype
    R Chetty
    Department of Pathology, University of Natal School of Medicine, Durban, South Africa
    Virchows Arch 435:133-6. 1999
    ..Two tumours pursued an aggressive biological course similar to other composite extrarenal rhabdoid tumours. A rhabdoid component accompanying thyroid follicular carcinomas is an adverse prognostic factor...
  87. ncbi Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinosarcoma
    K Pillay
    Department of Pathology, Nelson R. Mandela School of Medicine, Faculty of Health Sciences, University of Natal, Congella, Durban, South Africa
    Int J Surg Pathol 9:317-21. 2001
    ..The tumor behaved aggressively because of the angiosarcomatous component, and since the patient was assessed as having stage IV disease, no further treatment was offered...
  88. ncbi Primary aorto-esophageal fistula due to Takayasu's aortitis
    A Reddi
    Department of Cardiothoracic Surgery, Nelson R Mandela School of Medicine, University of Natal and Wentworth Hospital, Durban, South Africa
    Cardiovasc Pathol 12:112-4. 2003
    ..CONCLUSIONS: This case illustrates an unusual complication of Takayasu's arteritis, in the form of a fistula between the aorta and the esophagus, which resulted in massive hematemesis and the ultimate demise of the patient...
  89. ncbi Bcl-2 and p53 immunoprofile in Kaposi's sarcoma
    P Pillay
    University of Natal Medical School, Department of Pathology, Durban, South Africa
    Pathol Oncol Res 5:17-20. 1999
    ..These results show a progression of immunoexpression of both bcl-2 and p53 from the early histological stages to the late tumor stage, implying that these proteins are upregulated late in the evolution of KS...
  90. ncbi Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value
    K S Nair
    Pfizer Molecular Biology Research Facility, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of Natal, Congella 4013, Durban, South Africa
    J Clin Pathol 58:343-51. 2005
    ....
  91. ncbi Clear cell (glycogen-rich) rhabdomyosarcoma presenting as cervical lymphadenopathy
    D Govender
    Department of Pathology, University of Natal Medical School, Durban, South Africa
    ORL J Otorhinolaryngol Relat Spec 61:52-4. 1999
    ..The tumour recurred in a cervical lymph node after 2 years. This is yet another tumour that must be considered in the differential diagnosis of clear cell tumours of the head and neck region...
  92. ncbi p53 protein expression in nephroblastomas: a predictor of poor prognosis
    D Govender
    Department of Anatomical Pathology, University of Natal Medical School and King Edward VIII Hospital, Durban, South Africa
    Br J Cancer 77:314-8. 1998
    ..It may also be of practical value to the practising pathologist by identifying those tumours that require careful assessment for the presence of anaplasia...
  93. ncbi Myxoid invasive papillary urothelial carcinoma of the bladder and urethra
    R Chetty
    Department of Anatomical Pathology, Nelson R Mandela Medical School, University of Natal, Durban, South Africa
    Pathology 33:515-8. 2001
    ..This case highlights an uncommon variety of papillary urothelial carcinoma that invokes a wide differential diagnosis. Immunohistochemistry is essential in making the correct diagnosis...
  94. ncbi Intraductal papillary mucinous neoplasm of the pancreas and associated lesions
    Runjan Chetty
    Arch Surg 141:716-7; author reply 717. 2006
  95. ncbi Ductules in pancreatic neuroendocrine tumors
    Runjan Chetty
    Am J Surg Pathol 28:417. 2004
  96. ncbi Nuclear expression of E-cadherin
    Runjan Chetty
    Am J Surg Pathol 32:1269-70. 2008
  97. ncbi Pancreatic endocrine tumors with ductules
    Runjan Chetty
    Am J Surg Pathol 29:136-7; author reply 137-8. 2005
  98. ncbi Lipid-rich variant of pancreatic endocrine neoplasms
    Rajendra Singh
    Department of Pathology, Harper Hospital and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 30:194-200. 2006
    ..EM supports the name lipid-rich for this variant. The findings suggest that the pathogenesis of lipid-rich tumors may be different from the VHL-associated clear-cell variants of PENs...
  99. ncbi Epidermal growth factor receptor expression in anal canal carcinoma
    Lyly H Le
    Department of Medical Oncology, Fraser Valley Cancer Centre, Surrey, Canada
    Am J Clin Pathol 124:20-3. 2005
    ..The 21 samples studied universally and strongly expressed EGFR and were negative for HER-2. Clinical studies of EGFR inhibitors in advanced ACC are warranted...
  100. ncbi Nitric oxide: does it have an etiological role in pre-eclampsia?
    Mooken Rajagopal
    Obstetrics and Gynecology and MRC UN Pregnancy Hypertension Research Unit, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Acta Obstet Gynecol Scand 82:216-9. 2003
    ..To determine evidence of nitric oxide (NO) in decidual biopsies and fetal membranes of preeclamptic women...
  101. ncbi Lymphedematous HIV-associated Kaposi's sarcoma
    Pratistadevi K Ramdial
    Department of Anatomical Pathology, Nelson R Mandela School of Medicine, Durban, South Africa
    J Cutan Pathol 33:474-81. 2006
    ..In addition, the pathogenesis of fibroma-like nodules and cLO is revisited...