D Z I Cherney

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    David Zi Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto 8N 845, M5G 2N2, Ontario, Canada
    Cardiovasc Diabetol 13:28. 2014
  2. doi request reprint The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes
    David Z I Cherney
    Division of Nephrology, University Health Network Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Diabetologia 56:2308-17. 2013
  3. pmc Sex differences in renal responses to hyperglycemia, L-arginine, and L-NMMA in humans with uncomplicated type 1 diabetes
    David Z I Cherney
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 36:1290-6. 2013
  4. doi request reprint Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria
    D Z I Cherney
    Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, ON, Canada
    Diabet Med 29:1297-302. 2012
  5. pmc The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes
    David Z I Cherney
    Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Diabetes Care 35:2324-30. 2012
  6. pmc Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Toronto General Hospital, Toronto, Ontario
    Am J Physiol Regul Integr Comp Physiol 303:R710-8. 2012
  7. doi request reprint Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Can J Physiol Pharmacol 90:113-21. 2012
  8. pmc Evolution of renal hyperfiltration and arterial stiffness from adolescence into early adulthood in type 1 diabetes
    David Z I Cherney
    University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 34:1821-6. 2011
  9. doi request reprint Ability of cystatin C to detect acute changes in glomerular filtration rate provoked by hyperglycaemia in uncomplicated Type 1 diabetes
    D Z I Cherney
    Division of Nephrology, University Health Network, Hospital for Sick Children, University of Toronto, ON, Canada
    Diabet Med 27:1358-65. 2010
  10. doi request reprint The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto ON, Canada
    Nephrol Dial Transplant 25:4093-6. 2010

Detail Information

Publications24

  1. doi request reprint The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    David Zi Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto 8N 845, M5G 2N2, Ontario, Canada
    Cardiovasc Diabetol 13:28. 2014
    ....
  2. doi request reprint The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes
    David Z I Cherney
    Division of Nephrology, University Health Network Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Diabetologia 56:2308-17. 2013
    ....
  3. pmc Sex differences in renal responses to hyperglycemia, L-arginine, and L-NMMA in humans with uncomplicated type 1 diabetes
    David Z I Cherney
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 36:1290-6. 2013
    ..Our aim was to determine if increased nitric oxide generation by l-arginine infusion would reverse this deleterious response to clamped hyperglycemia in women with type 1 diabetes mellitus...
  4. doi request reprint Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria
    D Z I Cherney
    Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, ON, Canada
    Diabet Med 29:1297-302. 2012
    ..Our goal was to characterize the urinary excretion of cytokines/chemokines in normoalbuminuric adolescents with Type 1 diabetes to determine whether higher range normoalbuminuria is associated with evidence of renal inflammation...
  5. pmc The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes
    David Z I Cherney
    Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Diabetes Care 35:2324-30. 2012
    ..Accordingly, our aim was to determine if direct renin inhibition alone, and in combination with an ACE inhibitor, corrects early hemodynamic abnormalities associated with type 1 diabetes...
  6. pmc Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Toronto General Hospital, Toronto, Ontario
    Am J Physiol Regul Integr Comp Physiol 303:R710-8. 2012
    ....
  7. doi request reprint Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Can J Physiol Pharmacol 90:113-21. 2012
    ..The lack of effect on Ang II responses suggests that PKCβ inhibition may act through non-RAS pathways in humans with DM...
  8. pmc Evolution of renal hyperfiltration and arterial stiffness from adolescence into early adulthood in type 1 diabetes
    David Z I Cherney
    University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 34:1821-6. 2011
    ....
  9. doi request reprint Ability of cystatin C to detect acute changes in glomerular filtration rate provoked by hyperglycaemia in uncomplicated Type 1 diabetes
    D Z I Cherney
    Division of Nephrology, University Health Network, Hospital for Sick Children, University of Toronto, ON, Canada
    Diabet Med 27:1358-65. 2010
    ..To test whether it can reflect acute changes, we examined the impact of clamped hyperglycaemia on GFR(CYSTATIN C) and GFR(INULIN) in subjects with Type 1 diabetes...
  10. doi request reprint The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto ON, Canada
    Nephrol Dial Transplant 25:4093-6. 2010
    ..An AT2R G1675A gene polymorphism has been described, but the functional effects of this polymorphism are unknown...
  11. pmc The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 34:177-80. 2011
    ..Our objective was to determine whether acute hyperglycemia affects urinary secretion of inflammatory cytokines/chemokines in humans with uncomplicated type 1 diabetes...
  12. pmc Renal hyperfiltration and arterial stiffness in humans with uncomplicated type 1 diabetes
    David Z I Cherney
    Toronto General Hospital, Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:2068-70. 2010
    ..However, the relationship between renal hyperfiltration and arterial stiffness is unknown. Accordingly, we measured arterial stiffness in type 1 diabetic subjects with hyperfiltering (n = 20) or normofiltering (n = 18)...
  13. doi request reprint Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R206-14. 2010
    ....
  14. pmc Renal hyperfiltration is a determinant of endothelial function responses to cyclooxygenase 2 inhibition in type 1 diabetes
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1344-6. 2010
    ..Our aim was to examine the effect of cyclooxygenase 2 (COX2) inhibition on endothelial function in subjects with type 1 diabetes analyzed on the basis of renal filtration status...
  15. pmc Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:361-5. 2010
    ..The recent development of direct renin inhibitors (DRIs) provides a new approach to block the RAS, but the effects of DRIs on renal and systemic vascular function in uncomplicated type 1 diabetes have not been elucidated...
  16. doi request reprint The effect of renal hyperfiltration on urinary inflammatory cytokines/chemokines in patients with uncomplicated type 1 diabetes mellitus
    R Har
    Division of Nephrology, Toronto General Hospital, University Health Network, Banting and Best Diabetes Centre, University of Toronto, 585 University Ave, 8N 845, Toronto, ON, Canada M5G 2N2
    Diabetologia 56:1166-73. 2013
    ..Our objective was to determine whether renal hyperfiltration, a surrogate for intraglomerular hypertension, is associated with increased excretion of urinary cytokines/chemokines in patients with type 1 diabetes mellitus...
  17. ncbi request reprint The effect of oral contraceptives on the nitric oxide system and renal function
    D Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto
    Am J Physiol Renal Physiol 293:F1539-44. 2007
    ..04). In summary, these findings suggest that the NO system is upregulated by OC use in young, healthy women. Increased activity of the NO pathway may modulate the hemodynamic effects of RAS activation in OC users...
  18. ncbi request reprint The effect of cyclooxygenase-2 inhibition on renal hemodynamic function in humans with type 1 diabetes
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Canada
    Diabetes 57:688-95. 2008
    ..73 m(2)), and 12 subjects exhibited normofiltration (GFR <135 ml/min per 1.73 m(2))...
  19. doi request reprint Renal hemodynamic effect of cyclooxygenase 2 inhibition in young men and women with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, 585 Univ Ave, 8N 846, Toronto, Ontario, Canada M5G 2N2
    Am J Physiol Renal Physiol 294:F1336-41. 2008
    ..The ANG II response suggests that with uncomplicated type 1 DM, prostaglandins may contribute to RAS-mediated gender differences. Our results are consistent with experimental data suggesting augmented female prostanoid dependence...
  20. ncbi request reprint Insights into the regulation of renal hemodynamic function in diabetic mellitus
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Canada
    Curr Diabetes Rev 4:280-90. 2008
    ..In addition, gender may have important modulatory effects on some of these putative pathways that have been implicated in the development of alterations in renal hemodynamic function related to DM...
  21. ncbi request reprint Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetes
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, Toronto, Ontario, Canada
    Kidney Int 68:1722-8. 2005
    ....
  22. ncbi request reprint Impact of renin angiotensin system modulation on the hyperfiltration state in type 1 diabetes
    Etienne B Sochett
    Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 2N2, Canada
    J Am Soc Nephrol 17:1703-9. 2006
    ..The interaction between glomerular vasoconstrictors and vasodilators requires examination in future studies...
  23. doi request reprint Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 75:327-32. 2009
    ..Our study shows that the G894T allele of endothelial NOS is associated with a blunted response to L-arginine, suggesting this polymorphism may be a functional variant in humans...
  24. doi request reprint Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk
    Yoav Yinon
    Department of Medicine, Sunnybrook Health Sciences Center A139, Toronto, Ontario, Canada
    Circulation 122:1846-53. 2010
    ..The aim of this study was to assess vascular function in postpartum women and to determine whether differences emerged depending on the presentation of placental disease...