M George Cherian

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Biochem 95:1120-34. 2005
  2. ncbi request reprint Metallothionein and liver cell regeneration
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Exp Biol Med (Maywood) 231:138-44. 2006
  3. pmc Potential role of p53 on metallothionein induction in human epithelial breast cancer cells
    L Z Fan
    Department of Pathology, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Br J Cancer 87:1019-26. 2002
  4. ncbi request reprint Metallothioneins in human tumors and potential roles in carcinogenesis
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A 5C1
    Mutat Res 533:201-9. 2003
  5. ncbi request reprint P53 mediated regulation of metallothionein transcription in breast cancer cells
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Biochem 102:1571-83. 2007
  6. ncbi request reprint Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide
    Jordan R Oliver
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building 4044, London, ON, Canada N6A 5C1
    Toxicol Appl Pharmacol 210:190-9. 2006
  7. ncbi request reprint Zinc supplementation decreases hepatic copper accumulation in LEC rat: a model of Wilson's disease
    Blanca P Esparza Gonzalez
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, N6A 5C1
    Biol Trace Elem Res 105:117-34. 2005
  8. ncbi request reprint Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis
    Lu Cai
    Department of Pathology, University of Western Ontario London, Canada N6A 5C1
    Toxicol Lett 146:217-26. 2004
  9. ncbi request reprint Interaction of metallothionein with tumor suppressor p53 protein
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A 5C1
    FEBS Lett 580:1235-8. 2006
  10. ncbi request reprint Role of tumor necrosis factor-alpha in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats
    Rodolfo Niño Fong
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Canada N6A 5C1
    Toxicol Appl Pharmacol 200:121-30. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Biochem 95:1120-34. 2005
    ..Our data suggest that copper induces apoptosis through depolarization of mitochondrial membrane with release of AIF, and this process is MEK/ERK independent...
  2. ncbi request reprint Metallothionein and liver cell regeneration
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Exp Biol Med (Maywood) 231:138-44. 2006
    ..Several studies have suggested a defective liver regeneration after an injury in MT-knockout mice. There is cumulative evidence that indicates an essential role for MT in liver cell regeneration...
  3. pmc Potential role of p53 on metallothionein induction in human epithelial breast cancer cells
    L Z Fan
    Department of Pathology, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Br J Cancer 87:1019-26. 2002
    ..This effect may be associated with the occurrence of apoptosis and suggests a role for p53 and oestrogen-receptor on the expression and induction of metallothionein in epithelial cells...
  4. ncbi request reprint Metallothioneins in human tumors and potential roles in carcinogenesis
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A 5C1
    Mutat Res 533:201-9. 2003
    ..Therefore, additional experimental data on MT and its isoforms in human tumors, are needed to elucidate the biological functions of MT during tumor progression, along with other tumor markers...
  5. ncbi request reprint P53 mediated regulation of metallothionein transcription in breast cancer cells
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Cell Biochem 102:1571-83. 2007
    ..On the contrary, MRE activity remained unaltered in MDD2 cells with inactive p53. The above results demonstrate that activation of p53 is an important factor in metal regulation of MT...
  6. ncbi request reprint Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide
    Jordan R Oliver
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building 4044, London, ON, Canada N6A 5C1
    Toxicol Appl Pharmacol 210:190-9. 2006
    ..These results show that the liver cells of MT-null mice with no functional MT are unable to regenerate after TAA-induced hepatic injury, demonstrating an important role for MT in cellular regeneration...
  7. ncbi request reprint Zinc supplementation decreases hepatic copper accumulation in LEC rat: a model of Wilson's disease
    Blanca P Esparza Gonzalez
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, N6A 5C1
    Biol Trace Elem Res 105:117-34. 2005
    ..Although the actual mechanism of protection is unknown, it could be explained by sequestration of dietary Cu by intestinal MT, induced by high dietary Zn content...
  8. ncbi request reprint Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis
    Lu Cai
    Department of Pathology, University of Western Ontario London, Canada N6A 5C1
    Toxicol Lett 146:217-26. 2004
    ..These results suggest that MT protected human CNS cells from apoptosis following ionizing radiation, probably through its antioxidant property...
  9. ncbi request reprint Interaction of metallothionein with tumor suppressor p53 protein
    Elena A Ostrakhovitch
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A 5C1
    FEBS Lett 580:1235-8. 2006
    ..Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT. Our data suggest that co-expression of MT and p53 and their complex formation in tumor cells may be involved in regulation of apoptosis in these cells...
  10. ncbi request reprint Role of tumor necrosis factor-alpha in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats
    Rodolfo Niño Fong
    Department of Pathology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Canada N6A 5C1
    Toxicol Appl Pharmacol 200:121-30. 2004
    ..Thus, these results suggest a major role for TNF-alpha on the pathogenesis of Cu-induced acute hepatitis in LEC rats...
  11. ncbi request reprint Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy
    Jordan R Oliver
    Department of Pathology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Exp Biol Med (Maywood) 230:61-7. 2005
    ..Cell proliferation was significantly less in MT-null mice as compared to WT mice during liver regeneration after PH. These results suggest that MT may play a positive role in hepatic regeneration after PH...
  12. ncbi request reprint Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins
    Lu Cai
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A5C1
    Toxicol Lett 136:193-8. 2003
    ..These results suggest that MT, in particular bound to zinc, is a high-capacity antioxidant to protect radiation-induced DNA damage...
  13. pmc Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats
    Lu Cai
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada
    Int J Exp Diabetes Res 3:193-8. 2002
    ..No significant effects of bosentan treatment on nondiabetic rats were observed. The data suggest that the possible effects of ET antagonism in diabetes may be mediated via changes in MT and trace metals...
  14. ncbi request reprint Metallothionein expression as prognostic factor for transitional cell carcinoma of bladder
    Yasuto Yamasaki
    Division of Urology, Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Urology 67:530-5. 2006
    ..To determine whether metallothionein (MT) protein expression is associated with clinical outcomes in patients with transitional cell carcinoma (TCC) of the bladder...
  15. ncbi request reprint Mouse astrocyte cultures used to study antioxidant property of metallothionein isoforms
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Methods Enzymol 348:337-42. 2002
  16. ncbi request reprint Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells
    Zhi Min Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    FEBS Lett 581:2465-72. 2007
    ....
  17. ncbi request reprint Essentiality, toxicology and chelation therapy of zinc and copper
    Lu Cai
    Department of Medicine, The University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202, USA
    Curr Med Chem 12:2753-63. 2005
    ..In this review, we summarize the toxicity of zinc and copper and the potential treatment for zinc or copper toxicity by zinc- or copper-specific chelators as well as strategy to up-regulate metallothionein...
  18. ncbi request reprint Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone
    Jason D Czachor
    London Regional Cancer Centre, London Regional Cancer Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6
    J Inorg Biochem 88:213-22. 2002
    ..These data indicate that TTM, but not L1, may be useful in treating diseases of copper overload including WND...
  19. ncbi request reprint Metallothionein induction is not involved in cadmium accumulation in the duodenum of mice and rats fed diets containing high-cadmium rice or sunflower kernels and a marginal supply of zinc, iron, and calcium
    Philip G Reeves
    U S Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, USA
    J Nutr 135:99-108. 2005
    ..In addition, they support the hypothesis that marginal deficiencies of Fe, Zn, and Ca, commonly found in certain human populations subsisting on rice-based diets, play an important role in increasing the risk of dietary Cd exposure...
  20. ncbi request reprint Copper-binding proteins in human erythrocytes: searching for potential biomarkers of copper over-exposure
    Hernan Speisky
    Nutritional Toxicology, INTA, University of Chile, Santiago, Chile
    Biometals 16:113-23. 2003
    ..Preliminary data indicate that the two bands bind 64Cu within a range of concentrations, relevant to those expected to occur during copper over-exposure conditions...
  21. pmc The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 160:1047-56. 2002
    ..This study reveals important roles for MT in chronic lead toxicity, lead accumulation, and inclusion body formation...
  22. doi request reprint Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications
    Lina Yang
    School of Public Health, Jilin University, Changchun, China
    Am J Physiol Endocrinol Metab 294:E987-92. 2008
    ..Furthermore, MT1A gene in rs8052394 SNP is most likely the predisposition gene locus for diabetes or changes of serum superoxide dismutase activity...