Jean Pierre Chanoine

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Should I stay or should I go? Understanding families' decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study
    Geoff D C Ball
    Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, Edmonton, AB, Canada
    BMC Health Serv Res 12:486. 2012
  2. ncbi Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidism
    J P Chanoine
    Children s Hospital Reine Fabiola, B 1020 Brussels, Belgium
    J Clin Endocrinol Metab 86:1160-3. 2001
  3. doi GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Obesity (Silver Spring) 16:202-4. 2008
  4. doi Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver, Canada
    Int J Pediatr Obes 6:95-101. 2011
  5. ncbi Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Horm Res 66:81-8. 2006
  6. ncbi Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, Canada
    JAMA 293:2873-83. 2005
  7. ncbi Ghrelin in growth and development
    J P Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, B C, Canada
    Horm Res 63:129-38. 2005
  8. ncbi Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, BC, Canada
    Biofactors 20:109-18. 2004
  9. ncbi Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4
    Endocrinology 145:3813-20. 2004
  10. ncbi Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis
    J P Chanoine
    Department of Pediatrics, Endocrine and Diabetes Unit, University of British Columbia, Vancouver V5Z 4H4, BC, Canada
    Biofactors 14:229-38. 2001

Collaborators

Detail Information

Publications35

  1. pmc Should I stay or should I go? Understanding families' decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study
    Geoff D C Ball
    Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, Edmonton, AB, Canada
    BMC Health Serv Res 12:486. 2012
    ..This research aims to understand the interplay between individual, family, environmental, and systemic factors that influence families' decisions regarding the management of pediatric obesity...
  2. ncbi Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidism
    J P Chanoine
    Children s Hospital Reine Fabiola, B 1020 Brussels, Belgium
    J Clin Endocrinol Metab 86:1160-3. 2001
    ....
  3. doi GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Obesity (Silver Spring) 16:202-4. 2008
    ..Increased physical activity is an integral part of weight loss programs in adolescents. We prospectively investigated the effects of exercise on glucagon-like peptide-1 (GLP-1) concentrations and on appetite markers...
  4. doi Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver, Canada
    Int J Pediatr Obes 6:95-101. 2011
    ..Pharmacotherapy, associated with a comprehensive weight loss intervention, has emerged as a promising therapeutic approach in adolescents. Identification of subjects who best respond to a pharmacological intervention remains difficult...
  5. ncbi Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Horm Res 66:81-8. 2006
    ..Acylated ghrelin inhibits insulin secretion. We investigated the plasma and tissue ontogeny of ghrelin and obestatin in the rat...
  6. ncbi Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, Canada
    JAMA 293:2873-83. 2005
    ..In this population, behavioral therapy alone has had limited success in providing meaningful, sustained weight reduction, and pharmacological treatment has not been extensively studied...
  7. ncbi Ghrelin in growth and development
    J P Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, B C, Canada
    Horm Res 63:129-38. 2005
    ..These data raise a number of fascinating questions on the potential physiologic role of this hormone during growth and development...
  8. ncbi Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the rat
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, BC, Canada
    Biofactors 20:109-18. 2004
    ..Our results suggest that oxidative stress causes a decrease in circulating corticosterone in response to ACTH, and, as a consequence, a decrease in plasma leptin concentrations...
  9. ncbi Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4
    Endocrinology 145:3813-20. 2004
    ..Furthermore, the presence of a strong ghrelin gene expression and of ghrelin receptor mRNA in the fetal pancreas is intriguing and suggests that ghrelin may play an important role in beta-cell development...
  10. ncbi Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis
    J P Chanoine
    Department of Pediatrics, Endocrine and Diabetes Unit, University of British Columbia, Vancouver V5Z 4H4, BC, Canada
    Biofactors 14:229-38. 2001
    ..Glutathione peroxidase (GPx-1) is a selenoenzyme that metabolizes H(2)O(2), a source of potentially toxic free radicals. Steroidogenesis is markedly inhibited by H(2)O(2) in vitro...
  11. ncbi Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, Room K4212, British Columbia Children s Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada
    J Pediatr Gastroenterol Nutr 35:282-6. 2002
    ..Leptin and ghrelin central effects are mediated, at least partly, through the neuropeptide Y/Y1 receptor pathway in the hypothalamus...
  12. doi Ghrelin and the growth hormone secretagogue receptor in growth and development
    J P Chanoine
    Endocrinology and Diabetes Unit, Department of Pediatrics, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, British Columbia, Canada
    Int J Obes (Lond) 33:S48-52. 2009
    ..These data point toward a physiological role for ghrelin and GHSR in growth and/or in the maturation of hormonal systems involved in the regulation of energy balance...
  13. ncbi Umbilical cord ghrelin concentrations in Asian and Caucasian neonates
    Jean Pierre Chanoine
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, Vancouver, Canada
    Horm Res 60:116-20. 2003
    ..To compare the relationship between cord plasma ghrelin and growth hormone (GH) concentrations and birth weight in Asian and Caucasian neonates...
  14. ncbi Selenium and thyroid function in infants, children and adolescents
    Jean Pierre Chanoine
    Department of Pediatrics, Endocrinology and Diabetes Unit, University of British Columbia, Vancouver V6H 3V4, BC, Canada
    Biofactors 19:137-43. 2003
    ....
  15. ncbi Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelin
    Kerry J MacKelvie
    Endocrinology and Diabetes Unit, Room K4 212, British Columbia s Children s Hospital, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4
    J Clin Endocrinol Metab 92:648-54. 2007
    ..We hypothesized that exercise could affect appetite-regulating hormones and the subjective desire to eat, which could partly explain the poor success rate of the existing interventions...
  16. doi In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis
    Hehong Ni
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Res 67:609-13. 2010
    ..In summary, AG has insulinostatic effects in vitro as early as during the perinatal period. These effects could not be confirmed in vivo, possibly due to the short half-life of AG in rat neonates...
  17. ncbi Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents
    Sue Stock
    Endocrinology and Diabetes Unit, Room K4 212, British Columbia s Children s Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
    J Clin Endocrinol Metab 90:2161-8. 2005
    ..Ghrelin is unlikely to play a causal role in anorexia nervosa or obesity. The lower GIP observed in AN subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients...
  18. doi Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndrome
    Kathleen De Waele
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada
    Eur J Endocrinol 159:381-8. 2008
    ..We evaluated whether long-acting octreotide (Oct) decreases acylated and desacyl ghrelin concentrations, body mass, appetite and compulsive behaviour towards food in adolescents with PWS...
  19. ncbi Elevated umbilical cord ghrelin concentrations in small for gestational age neonates
    Juliet Farquhar
    Special Care Nursery, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    J Clin Endocrinol Metab 88:4324-7. 2003
    ..In conclusion, SGA neonates present with higher umbilical cord ghrelin plasma concentrations than AGA/LGA neonates. Ghrelin may play a physiological role in fetal adaptation to intrauterine malnutrition...
  20. pmc Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin, and adiponectin in pregnant women with diabetes
    William Gibson
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada V6H 3N1
    Metabolism 59:841-7. 2010
    ..Glucose and insulin regulate desacyl ghrelin concentrations in pregnant women with diabetes. Impaired desacyl ghrelin regulation may affect energy metabolism in pregnant women with poorly controlled diabetes...
  21. ncbi Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release
    Denton Hirsh
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Horm Res 63:111-8. 2005
    ..Because glucagon stimulates the promoter of the ghrelin gene in vitro as well as ghrelin secretion by the perfused rat stomach, we sought to determine whether ghrelin mediates glucagon-induced GH secretion...
  22. ncbi Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates
    Louisa P K Yeung
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, Vancouver BC V6H 3V4, Canada
    Pediatr Res 53:1019-24. 2003
    ..This may represent the first clinical evidence of a difference in leptin regulation between these two ethnic groups...
  23. ncbi Iodine overload and severe hypothyroidism in a premature neonate
    Minesh Khashu
    Division of Neonatology, Department of Pediatrics, British Columbia Children s Hospital and University of British Columbia, Vancouver BC V6H 3V4, Canada
    J Pediatr Surg 40:E1-4. 2005
    ....
  24. doi Ontogeny of acylated ghrelin degradation in the rat
    Hehong Ni
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver V6H 3V4, Canada
    Peptides 31:301-6. 2010
    ..We speculate that this process allows for fine tuning of the physiological effects of both AG and UAG...
  25. doi Thyroid function from birth to adolescence in Prader-Willi syndrome
    Mohamad Sharkia
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 163:800-5. 2013
    ....
  26. pmc The centre for healthy weights--shapedown BC: a family-centered, multidisciplinary program that reduces weight gain in obese children over the short-term
    Constadina Panagiotopoulos
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    Int J Environ Res Public Health 8:4662-78. 2011
    ..These data also emphasize the need for ongoing evaluation to assess the long-term implications of this unique program and ultimately optimize utilization of governmental resources...
  27. pmc Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase
    Elaine Tham
    British Columbia s Children s Hospital, Vancouver, BC, Canada V6H 3V4
    Am J Physiol Endocrinol Metab 296:E1093-100. 2009
    ..Desacyl ghrelin increases in gestational diabetes, possibly reflecting resistance to the inhibitory effect of insulin on ghrelin secretion...
  28. doi Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach
    Pallavi Walia
    Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, British Columbia, V6H 3V4, Canada
    Pediatr Res 65:39-44. 2009
    ..In pancreas, the colocalization of PC1/3 or PC2 in ghrelin positive cells points to a role for both PCs in preproghrelin processing...
  29. doi Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity
    Alexander L Rogovik
    Pediatric Research in Emergency Therapeutics Program, BC Children s Hospital, Vancouver, British Columbia, and The Hospital for Sick Children, Toronto, Ontario, Canada
    Drugs 70:335-46. 2010
    ..No single approach will successfully treat obesity, and lifestyle modification presently remains the main pillar of any intervention aiming at decreasing bodyweight...
  30. ncbi Healthy Buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary school
    Suzanne Stock
    Endocrinology and Diabetes Unit, Department of Psychology, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatrics 120:e1059-68. 2007
    ..We designed and tested a novel health promotion program for elementary schools that was based on peer teaching from older to younger schoolchildren ("Healthy Buddies")...
  31. doi Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay
    Arjun Trivedi
    Department of Pediatrics, British Columbia Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada, V6H 3V4
    Clin Biochem 45:178-80. 2012
    ..To investigate the effect of hemolysis and protease inhibitors on acylated ghrelin (AG) concentrations measured with a double antibody enzyme immunometric assay that uses an acetylcholinesterase (AChE)-Fab' conjugate...
  32. pmc Obesity and physical activity in children
    Mia Pradinuk
    BC Children s Hospital, Department of Pediatrics, Room K4 226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4
    Can Fam Physician 57:779-82. 2011
    ..What advice should I give parents of overweight children about physical activity? How can we encourage these children to become more physically active?..
  33. pmc Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands
    Rasha Abu-Khudir
    Department of Pediatrics, Endocrinology Service and Research Center, CHU Sainte Justine, University of Montreal, Montreal, Canada
    PLoS ONE 5:e13420. 2010
    ..Moreover, a survey of monozygotic twins yielded a discordance rate of 92%, suggesting that somatic events, genetic or epigenetic, probably play an important role in the etiology of CHTD...
  34. ncbi Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure
    Karla L Bretherick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 143:945-51. 2007
    ..X-chromosome abnormalities undetectable by array, or reduced follicular pool due to an early trisomic rescue event, may explain the skewed XCI observed in POF patients presenting with primary amenorrhea...
  35. ncbi Editorial: Individual differences in the hormonal control of appetite: a step toward a (more) successful treatment of childhood overweight?
    Jean Pierre Chanoine
    J Clin Endocrinol Metab 91:2864-6. 2006