Research Topics
Genomes and Genes | Hong ChangSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cellsMu Hao
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College Tianjin China
J Hematol Oncol 4:37. 2011..In conclusion, our data suggest that via suppressing miRNA-15a and -16 expressions, IL-6 secreted by BMSCs promotes drug-resistance in myeloma cells...- Applying mass spectrometry based proteomic technology to advance the understanding of multiple myelomaJohann Micallef
Department of Laboratory Hematology, University Health Network, Toronto, Canada
J Hematol Oncol 3:13. 2010..In addition, mass spectrometry was employed to study relevant signaling pathways activated in MM. This review will focus on how mass spectrometry has been applied to increase our understanding of MM... 
Genetic aberrations including chromosome 1 abnormalities and clinical features of plasma cell leukemiaHong Chang
Department of Laboratory Hematology, University Health Network, Toronto, Canada
Leuk Res 33:259-62. 2009..008)...
Analysis of PTEN deletions and mutations in multiple myelomaHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, Ont, Canada M5G 2M9
Leuk Res 30:262-5. 2006..Our results indicate that alterations of PTEN are uncommon in MM patients, and PTEN deletions tend to occur in advanced disease suggesting that they are secondary, rather than primary, events in the pathogenesis of MM...- The absence of CD56 on malignant plasma cells in the cerebrospinal fluid is the hallmark of multiple myeloma involving central nervous systemHong Chang
Department of Laboratory Haematology, Princess Margaret Hospital University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Br J Haematol 129:539-41. 2005..0001). The prevalence of CD56-negative myeloma cells in the BM and CSF of our patients suggests that CD56 downregulation may play a role in the pathogenesis of CNS MM... - Aberrant nuclear p53 protein expression detected by immunohistochemistry is associated with hemizygous P53 deletion and poor survival for multiple myelomaHong Chang
Laboratory Hematology, and Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada
Br J Haematol 138:324-9. 2007..Our data indicate that nuclear p53 protein expression, detected by a widely available immunohistochemical method, is strongly associated with TP53 deletion and an adverse clinical outcome for MM... - Identification of cell lineages involved by t(15;17) in acute promyelocytic leukemia by combined fluorescence activated cell sorting and FISHHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, 610 University Avenue, 4 320, Toronto, Ontario M5G 2M9, Canada
Cancer Genet Cytogenet 158:43-8. 2005..These results suggest that lymphocytes and erythroblasts are not clonally involved in APL, and that malignant transformation in some cases of APL may occur at the level of CD34+ cells... - Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myelomaHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, McLaughlin Center for Molecular Medicine, University of Toronto, ON, Canada
Blood 106:353-5. 2005..001), a shorter progression-free survival (median, 11.5 versus 25.8 months; P < .001), and a shorter overall survival (median, 19.2 versus 46.3 months; P < .001)... - CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myelomaHong Chang
Department of Laboratory Hematology, University Health Network, 200 Elizabeth Street, 11E 413 Toronto, ON, M5G 2C4
Haematologica 95:1542-7. 2010..The aim of this study was to correlate nuclear CKS1B protein immunoreactivity, 1q21 amplification status, p27(Kip1) expression and survival in patients with newly-diagnosed multiple myeloma... - Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16Hong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, 4 320 Toronto, ON, M5G 2M9, Canada
Cancer Genet Cytogenet 156:175-8. 2005..The current study provides a direct evidence for the clonal involvement of myeloid lineage cells and B-lymphocytes and suggests that T-cells are not part of the malignant clone in this disease... - Genomic aberrations in plasma cell leukemia shown by interphase fluorescence in situ hybridizationHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, Department of Laboratory Medicine and Pathobiology, 610 University Avenue, University of Toronto, Toronto ON M5G 2M9, Canada
Cancer Genet Cytogenet 156:150-3. 2005..The frequent TP53 deletions may represent a marker of genetic instability giving rise to an increased propensity for myeloma cells to emigrate from the bone marrow environment and enter leukemic phase... - Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantationH Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
Bone Marrow Transplant 36:793-6. 2005..High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies... - Prognostic relevance of CD56 expression in multiple myeloma: a study including 107 cases treated with high-dose melphalan-based chemotherapy and autologous stem cell transplantHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, ON, Canada
Leuk Lymphoma 47:43-7. 2006.... - Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myelomaHong Chang
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, ON, Canada
Br J Haematol 139:51-4. 2007..002) than those without 1p21 deletions. On multivariate analysis, which included deletions of 13q, TP53, t(4;14) and CKS1B amplification, 1p21 deletion remained as an independent risk factor for PFS (P = 0.01) and OS (P = 0.04)... - Analysis of 6q deletion in Waldenstrom macroglobulinemiaHong Chang
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, ON, Canada
Eur J Haematol 79:244-7. 2007..92). Our study confirms that 6q deletion is a frequent event, but it does not appear to be a prognostic marker for patients with WM... - Prognostic relevance of 6q deletion in Waldenström's macroglobulinemia: a multicenter studyHong Chang
University Health Network, Toronto, Canada
Clin Lymphoma Myeloma 9:36-8. 2009..46), or overall survivals in patients with and without del (6q) (163 months vs. not reached; P = .83). Our study confirms that the 6q deletion is a frequent event, but it does not appear to affect the clinical outcome of WM... - Bortezomib therapy response is independent of cytogenetic abnormalities in relapsed/refractory multiple myelomaHong Chang
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
Leuk Res 31:779-82. 2007..Our data suggest that, in this pilot study, bortezomib is an effective salvage therapy for refractory/relapsed myeloma, irrespective of genetic risk factors... - Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantationHong Chang
Department of Laboratory Hematology, Toronto General Hospital, University Health Network, Toronto, Canada
Br J Haematol 135:486-91. 2006..In this cohort of patients, CKS1B was frequently amplified in MM and may represent genetic instability associated with disease progression... - 1p21 deletions are strongly associated with 1q21 gains and are an independent adverse prognostic factor for the outcome of high-dose chemotherapy in patients with multiple myelomaH Chang
Department of Laboratory Hematology, University Health Network, Toronto, Ontario, Canada
Bone Marrow Transplant 45:117-21. 2010..003) and OS (P=0.013) after adjusting for del(13q), del(p53), t(4;14) and 1q21 amplifications. Our results indicate that del(1p21) is an independent poor prognostic factor associated with disease progression in MM... - Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisationHong Chang
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, ON, Canada
Br J Haematol 134:613-5. 2006..001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL... - CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotypeHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, 4 320, Toronto, Ont, Canada M5G 2M9
Leuk Res 31:157-62. 2007..003 and P=0.0157, respectively) and shorter OS (P</=0.001 and P=0.007, respectively). Multivariate analysis of age, WBC, CD34, HLA-DR and CD7 showed that CD7 expression was an independent risk factor for DFS (P=0.01) and PRS (P=0.02)... - Impact of cytogenetics in patients with relapsed or refractory multiple myeloma treated with bortezomib: Adverse effect of 1q21 gainsHong Chang
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
Leuk Res 35:95-8. 2011..Multivariate analysis confirmed that 1q21 gain is an independent risk factor for PFS (p=0.03) and OS (p=0.009) of bortezomib-treated relapsed/refractory myeloma... - Prognostic relevance of immunophenotyping in 379 patients with acute myeloid leukemiaHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ont, Canada M5G 2M9
Leuk Res 28:43-8. 2004..Defined by number of factors, this score system may help to stratify AML patients to alternative treatment for better outcome... - The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplantHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
Br J Haematol 125:64-8. 2004..Our results indicate that the t(4;14) detected by cIg-FISH is associated with a poor prognosis in MM patients receiving intensive chemotherapy and autotransplant... - Molecular cytogenetic abnormalities in patients with concurrent chronic lymphocytic leukemia and multiple myeloma shown by interphase fluorescence in situ hybridization: evidence of distinct clonal originHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital and University Health Network, University of Toronto, 610 University Avenue, 4 320, Toronto, Ontario M5G 2M9, Canada
Cancer Genet Cytogenet 148:44-8. 2004..Our results show that the cytogenetic profiles differ between CLL and MM within the same patients, and provide evidence for two distinct malignant clones in both patients... - Interphase cytogenetic analysis of clonality in peripheral blood cells from a patient with Down syndrome and acute megakaryoblastic leukemiaHong Chang
Princess Margaret Hospital, University Health Network, University of Toronto, 4 320 Toronto, Ontario M5G 2M9, Canada
Cancer Genet Cytogenet 148:141-4. 2004..The transformation occurs in progenitor cells with limited myeloid differentiation and without involvement of lymphoid lineage cells... - Impact of genomic aberrations including chromosome 1 abnormalities on the outcome of patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasoneHong Chang
Department of Laboratory Hematology, University Health Network, Toronto, Canada
Leuk Lymphoma 51:2084-91. 2010..Our data suggest that chromosome 17p and 1p21 deletions adversely impact the outcome of lenalidomide and dexamethasone treated patients with relapsed/refractory MM. Improved therapeutic strategies are required for these patients... - Chronic lymphocytic leukemia in the course of chronic myelocytic leukemia: evidence of independent clonal origin as shown by interphase fluorescence in situ hybridization and fluorescence-activated cell sortingHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, University of Toronto, 610 University Ave, Toronto, ON M5G 2M9, Canada
Cancer Genet Cytogenet 152:146-8. 2004..We provide evidence that the CLL cells arose in a Ph(-) clone... - Extramedullary infiltrates of AML are associated with CD56 expression, 11q23 abnormalities and inferior clinical outcomeHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
Leuk Res 28:1007-11. 2004..0016). Our study of adult AML patients demonstrates that EMI at diagnosis is associated with CD56 expression by leukemic blasts, 11q23 karyotypic abnormalities, low complete remission rate and poor overall survival... - Detection of chromosome 13q deletions and IgH translocations in patients with multiple myeloma by FISH: comparison with karyotype analysisHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, Toronto, Canada
Leuk Lymphoma 45:965-9. 2004..Since 13q deletions, IgH translocations and a hypodiploid karyotype are significant prognostic factors for MM, our study illustrates the importance of combining conventional cytogenetics with interphase FISH analysis in patients with MM... - p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantationHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital University Health Network, Toronto, ON, Canada
Blood 105:358-60. 2005..0009) or overall survival (P = .0002) in patients with MM after high-dose chemotherapy and autologous stem cell transplantation... - Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletionsHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
Br J Haematol 127:280-4. 2004..3 (FGFR3), the other involving 16q23 (c-maf). The high incidence of p53 deletions detected by cIg-FISH in CNS myeloma may be a marker for chromosomal instability, and may be associated with metastatic features of myeloma cells... - Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13Donna Reece
Division of Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
Blood 114:522-5. 2009..001) and median overall survival of 4.67 months (hazard ratio, 3.23; P < .001). Improved therapeutic strategies are required for this subgroup of patients. This study was registered at www.ClinicalTrials.gov as #NCT00179647... - Clinical outcomes in t(4;14) multiple myeloma: a chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistanceWilfrid Jaksic
Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Canada
J Clin Oncol 23:7069-73. 2005..The development of novel therapeutic agents is required, including the early clinical study of targeted fibroblast growth factor receptor 3 tyrosine kinase inhibitors, which have shown promise in preclinical studies... - MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activityManujendra N Saha
Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
Cancer Biol Ther 9:936-44. 2010..These preclinical studies provide the framework for clinical trial of nutlin, alone and in combination with conventional and novel therapies such as velcade to increase efficacy and improve patient outcome in MM... - Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotypeJennifer Luo
Departments of 1Laboratory Hematology, University Health Network, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Am J Clin Pathol 133:34-40. 2010..Our data confirm that cytoplasmic NPM1 immunoreactivity predicts NPM1 mutations and warrants inclusion in the routine diagnostic and prognostic workup of AML... - CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myelomaSuzanne Trudel
Department of Medical Oncology, University Health Network, Princess Margaret Hospital and McLaughlin Centre of Molecular Medicine, University of Toronto, 620 University Ave, Rm 8 204, Toronto, ON, Canada M5G 2C1
Blood 105:2941-8. 2005..Finally, therapeutic efficacy of CHIR-258 was demonstrated in a xenograft mouse model of FGFR3 MM. These studies support the clinical evaluation of CHIR-258 in MM... - Prognostic factors in normal karyotype acute myeloid leukemia in the absence of the FLT3-ITD mutationAllan Jiang
Department of Laboratory Hematology, University Health Network, Toronto, ON, Canada
Leuk Res 35:492-8. 2011..045 and P=0.028, respectively), and CD56 positivity predicted shorter EFS (P=0.012). Our results confirm the favorable impact of NPM1 mutations and identify the adverse prognostic relevance of CD56 expression in this subgroup of AML... - Analysis of chromosome 12p deletion in plasma cell dyscrasiasNan Jiang
Department of Laboratory Hematology, University Health Network, Toronto, Canada
Leuk Res 36:32-6. 2012..Our results do not support the use of 12p deletion as a prognostic marker in MM, rather, it tends to occur in advanced disease, may represent a secondary change associated with the disease progression... - Cyclin kinase subunit 1B nuclear expression predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with bortezomibMei Hsi Chen
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Hum Pathol 43:858-64. 2012..Our results indicated that cyclin kinase subunit 1B nuclear expression detected by immunohistochemistry is an adverse prognostic factor for patients with multiple myeloma treated with bortezomib therapy... - p53 nuclear expression correlates with hemizygous TP53 deletion and predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with lenalidomideMei Hsi Chen
Dept of Laboratory Hematology, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada
Am J Clin Pathol 137:208-12. 2012.... - Acute leukemia of donor origin arising after stem cell transplantation for acute promyelocytic leukemiaAndrew S Daly
Allogeneic Bone Marrow Transplant Service, Department of Medical Oncology and Hematology, Princess Margaret Hospital/University Health Network, Toronto, Ont, Canada
Leuk Res 28:1107-11. 2004..To our knowledge, this is the first report of donor cell leukemia following BMT for APL. We hypothesize that replicative stress may lead to the development of some cases of donor cell acute leukemia... - Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid-associated antigen expression is associated with a lower complete remission rate following induction chemotherapyMurtadha Al Khabori
Departments of Laboratory Hematology and Medical Oncology, University Health Network, Toronto, Ont, Canada
Acta Haematol 120:5-10. 2008..Our study indicates that expression of myeloid-associated antigens is associated with a lower CR rate in adult T-ALL and may be considered in risk stratification for induction chemotherapy... - Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimenJohn M Storring
Department of Medical Oncology and Haematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
Br J Haematol 146:76-85. 2009..Effective delivery of asparaginase dosing appears to be important in achieving an optimal antileukaemic effect... - RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responsesManujendra N Saha
Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Mol Cancer Ther 9:3041-51. 2010..56 to 0.82 in MM cells. Our data support further clinical evaluation of RITA as a potential novel therapeutic intervention in MM... - Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathwaysManujendra N Saha
Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Dept of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
Cancer Biol Ther 10:567-78. 2010..Our study provides the evidence that nutlin-induced apoptosis in MM cells is mediated by transcription-dependent and -independent pathways and supports further clinical evaluation of nutlin as a novel therapeutic agent in MM... - p53 nuclear accumulation is associated with extramedullary progression of multiple myelomaNeil Sheth
Department of Laboratory Hematology, University Health Network, Toronto, ON, Canada
Leuk Res 33:1357-60. 2009..0001). Our data indicates that p53 nuclear expression but not CD56 expression, along with increased proliferation index is associated with disease progression from intramedullary to extramedullary sites in MM... - T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disordersHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, ON, Canada
Am J Clin Pathol 123:196-9. 2005..These data show that T-LGL leukemia should be included as one of the types of posttransplantation lymphoproliferative disorders that can occur after allogeneic BMT for B-cell neoplasms... - Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myelomaManujendra N Saha
Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada
PLoS ONE 7:e30215. 2012..Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with JNK activators in the treatment of MM... - Genomic aberrations and survival of patients with light-chain-only multiple myeloma undergoing autologous stem cell transplantationNan Jiang
Department of Laboratory Haematology, Department of Medical Oncology and Haematology, University Health Network, University of Toronto, Toronto, Canada
Biol Blood Marrow Transplant 17:1790-5. 2011..9 vs 18.2 months, P = .001). There was no significant difference in PFS or OS in patients with or without t(4;14) or del(17p). On multivariate analysis, del(13q) was an independent prognostic factor for PFS and OS... - Genomic stratification of multiple myeloma treated with novel agentsAllan Jiang
Department of Laboratory Hematology and Medical Oncology, University Health Network, Toronto, Ontario, Canada
Leuk Lymphoma 53:202-7. 2012..Here we review recent studies that analyze the impact of specific genomic aberrations on the outcome of MM treated with bortezomib and/or lenalidomide... - The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cellsSuzanne Trudel
University Health Network, Princess Margaret Hospital, McLaughlin Centre of Molecular Medicine, 620 University Avenue, Rm 8204, Toronto, Ontario, Canada M5G 2C1
Blood 107:4039-46. 2006..The data demonstrate that PRO-001 is a potent and specific inhibitor of FGFR3 and deserves further study for the treatment of FGFR3-expressing myeloma... - Aberrant expression of T-cell-associated markers CD4 and CD7 on B-cell chronic lymphocytic leukemiaPrashant Jani
Department of Laboratory Hematology, Toronto General Hospital University Health Network, University of Toronto, Toronto, Canada
Am J Hematol 82:73-6. 2007.... - Prognostic value of immunophenotyping and gene mutations in elderly patients with acute myeloid leukemia with normal karyotypeHarry Dang
Department of Laboratory Hematology, University Health Network, Toronto, Ontario, Canada
Hum Pathol 44:55-61. 2013..By combining genetic and immunophenotypic markers, we can divide patients into distinct prognostic groups with important implications for prognostic stratification and risk-adapted therapy... - Acute myeloid leukemia with pseudo-Chèdiak-Higashi anomaly exhibits a specific immunophenotype with CD2 expressionHong Chang
Department of Laboratory Hematology, Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, 610 University Avenue 4-320, Toronto, Ontario, Canada
Am J Clin Pathol 125:791-4. 2006..9%) of 140 cases of newly diagnosed AML without PCH anomaly. CD2 expression correlated strongly with AML with PCH anomaly (P < .01), suggesting a link between a specific immunophenotypic marker, CD2, and AML with PCH anomaly... - The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomesPierre Villeneuve
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
Leuk Res 32:269-73. 2008..Our data indicate that the prognosis of AML M5 is similar to non-M5 AML and that M5a and M5b do not differ in immunophenotype, cytogenetics or clinical outcome... - Molecular characterization of chronic lymphocytic leukemia with two distinct cell populations: Evidence for separate clonal originsHong Chang
Department of Laboratory Hematology, University Health Network and University of Toronto, Toronto, Canada
Am J Clin Pathol 126:23-8. 2006..Our results demonstrated that the immunophenotypically different cell populations originated from 2 separate clones... - Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemiaDong Hwan Kim
Chronic Myelogenous Leukemia Group, Department of Hematology Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Haematologica 94:135-9. 2009.... - Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesisPurna A Joshi
Department of Laboratory Medicine and Pathobiology, Room 6318, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Dev Biol 297:284-94. 2006..Thus, the activity of the stromally restricted homeodomain factor, Alx4, is required for normal branching morphogenesis of the ductal epithelia during pubescent mammary gland development... - Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myelomaJoshua L Paterson
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Br J Haematol 124:595-603. 2004..Myeloma cells lacking the t(4;14) or with the t(4;14) and a secondary RAS mutation did not respond to therapy. These findings support the development of clinical trials of early intervention with FGFR3 inhibitors in t(4;14) myeloma... - No significance of derivative chromosome 9 deletion on the clearance kinetics of BCR/ABL fusion transcripts, cytogenetic or molecular response, loss of response, or treatment failure to imatinib mesylate therapy for chronic myeloid leukemiaDong Hwan Dennis Kim
Chronic Myelogenous Leukemia Group, Department of Hematology Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Cancer 113:772-81. 2008.... - Aberrant nuclear p53 expression predicts hemizygous 17p (TP53) deletion in chronic lymphocytic leukemiaHong Chang
Departments of 1Laboratory Hematology, Toronto General Hospital, University Health Network, Toronto, Canada
Am J Clin Pathol 133:70-4. 2010.... - Activation of Erk by sonic hedgehog independent of canonical hedgehog signallingHong Chang
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Int J Biochem Cell Biol 42:1462-71. 2010..These data reveal novel binding activities for the C-terminal region of Ptch1 and define a signalling pathway stimulated by the Hh-ligands operating independently of pathways requiring Smo... - Pharmacological activation of the p53 pathway in haematological malignanciesManujendra N Saha
Division of Cellular and Molecular Biology, Toronto General Hospital Research Institute, University of Toronto, Canada
J Clin Pathol 63:204-9. 2010..This review will highlight recent findings in the research into molecules capable of modulating p53 protein activities and mechanisms that activate the p53 pathway, restoring response to therapy in haematological malignancies... - A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignanciesAaron D Schimmer
Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
Clin Cancer Res 14:8295-301. 2008..Therefore, we conducted a phase I clinical trial of the small-molecule pan-Bcl-2 inhibitor, obatoclax mesylate, in patients with refractory leukemia and myelodysplasia to assess its safety and define its optimal dose... - Diagnosing PNH with FLAER and multiparameter flow cytometryD Robert Sutherland
Clinical Flow Cytometry Laboratory, University Health Network, Toronto, Canada
Cytometry B Clin Cytom 72:167-77. 2007..Our goals were to develop a FLAER-based assay to diagnose and monitor patients with PNH and to improve detection of minor populations of PNH clones in other hematologic disorders... - A novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell deathRose Hurren
Ontario Cancer Institute, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada M5G 2M9
Apoptosis 13:748-55. 2008..Thus, Q(2) is a novel quinolinium with preclinical activity in malignancies such as leukemia and myeloma and warrants further investigation... - Hairy cell leukemia variant with features of intrasinusoidal bone marrow involvementCharin Ya-In
Department of Laboratory Hematology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada
Arch Pathol Lab Med 129:395-8. 2005..This case illustrates an atypical marrow presentation of HCL-V and emphasizes the need to correlate all clinical and pathologic data, including tissue biopsy, in reaching a diagnosis... - Complete remission of tumour with interleukin 2 therapy in a patient with non-Hodgkin's lymphoma post allogeneic bone marrow transplant associated with polyclonal T-cell bone marrow lymphocytosisThomas L Kiss
Bone Marrow Transplant Service, Department of Medical Oncology and Haematology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Canada
Br J Haematol 120:523-5. 2003..The patient remains in complete remission 37 months following allogeneic BMT... - Bone marrow aspirates as part of routine donor assessment for allogeneic blood and marrow transplantation can reveal presence of occult hematological malignancies in otherwise asymptomatic individualsT L Kiss
Department of Medical Oncology and Hematology, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada
Bone Marrow Transplant 33:855-8. 2004..Clonogenic assays can contribute to detect hemopoietic abnormalities pre transplant... - Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitorsNadine C Becknell
Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
Bioorg Med Chem Lett 16:5368-72. 2006..The isopropyl carbamate 39 displayed good dual enzyme, cell potency, and rat pharmacokinetic properties for advancement to in vivo evaluation... - Karyotype stability of the DT40 chicken B cell line: macrochromosome variation and cytogenetic mosaicismHong Chang
Department of Animal Science, 2131D Meyer Hall, One Shields Avenue, University of California, Davis, CA 95616, USA
Chromosome Res 12:299-307. 2004..The results are discussed in regard to current knowledge of cytogenetic anomalies associated with chicken cancers... - Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteumHong Chang
College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
Mol Reprod Dev 68:135-41. 2004..However, no basigin expression was detected from days 6 to 15 post-hCG injection. In conclusion, our data suggest that basigin may play a role during the mouse follicle development and corpus luteum formation... - Antiangiogenic and antitumor efficacy of EphA2 receptor antagonistPawel Dobrzanski
Division of Oncology, Cephalon, Inc, West Chester, Pennsylvania, USA
Cancer Res 64:910-9. 2004..These data demonstrate a critical role of EphA signaling in tumor growth and metastasis and provide a strong rationale for targeting EphA2 receptors for anticancer therapies... - Acute promyelocytic leukemia in patients aged 70 years and over -- a single center experience of unselected patientsPatricia Disperati
Leuk Lymphoma 48:1654-8. 2007 - CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical modelsBruce Ruggeri
Department of Oncology, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
Cancer Res 63:5978-91. 2003..Orally administered CEP-7055 has entered Phase I clinical trials in cancer patients... - Basigin expression and hormonal regulation in mouse uterus during the peri-implantation periodLi Juan Xiao
College of Life Science, Northeast Agricultural University, Harbin, China
Mol Reprod Dev 63:47-54. 2002..A high level of basigin immunostaining and mRNA was also seen in proestrus and estrus uteri. These results suggest that basigin expression is closely related to mouse implantation and up-regulated by estrogen... - Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndromeMarco Tartaglia
Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
Am J Hum Genet 75:492-7. 2004.... - [Subcloning of human neurotrophin-3 gene and construction of its genetically engineered cell model]Hong Chang
Department of Otolaryngology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China
Di Yi Jun Yi Da Xue Xue Bao 24:805-8. 2004..To subclone human neurotrophin-3 gene (NT3) and transfer this gene into human bone marrow mesenchymal stem cells (BM-MSCs) to construct genetically engineered cells that produce NT3 in vitro... - Relationship between all-cause mortality and cumulative working life course psychosocial and physical exposures in the United States labor market from 1968 to 1992Benjamin C Amick
Center for Society and Population Health, University of Texas School of Public Health, Houston, Texas, USA
Psychosom Med 64:370-81. 2002..To examine the relationship between cumulative exposures to psychosocial and physical work conditions and mortality in a nationally representative sample... - [Studies of hereditary conditionality index on some morphological characters of Tupaia belangeri chinensis.]Yong-Mei Yu
Shanghai Cancer Institute, Shanghai 200032, China
Yi Chuan 26:478-80. 2004.... - The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicitySheila Miknyoczki
Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
Mol Cancer Ther 6:2290-302. 2007..These data indicate that CEP-8983 and its prodrug are effective chemosensitizing agents when administered in combination with select chemotherapeutic agents against chemoresistant tumors... - Human IgG1 Cgamma1 domain is crucial for the bioactivity of the engineered anti-CD20 antibodiesShusheng Geng
College of Life Science, Hebei University, Baoding, China
Cell Mol Immunol 4:121-5. 2007..Our study highlights some interests and advantages of a methodology based on the homology modeling and analysis of molecular structural properties... - Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesisRabindranath Tripathy
Cephalon, Inc, Discovery Research, 145 Brandywine Parkway, West Chester, PA 19380, USA
Bioorg Med Chem Lett 16:2158-62. 2006.... - Comparative analysis of tropism between canarypox (ALVAC) and vaccinia viruses reveals a more restricted and preferential tropism of ALVAC for human cells of the monocytic lineageQigui Yu
Hawaii AIDS Clinical Research Program, Department of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
Vaccine 24:6376-91. 2006..These findings have implications in terms of choosing optimal pox virus derived vectors as vaccines in terms of reducing clinical reactogenicity and inducing dendritic cell (DC) maturation... - c-Maf nuclear oncoprotein is frequently expressed in multiple myelomaHong Chang
Leukemia 21:1572-4. 2007 - The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude miceSheila J Miknyoczki
Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
Clin Cancer Res 8:1924-31. 2002..CONCLUSIONS: These data add further support for the therapeutic potential of disrupting trk-signaling events in select types of nonneuronal human cancers, specifically prostatic and pancreatic carcinomas...