C B Chan

Summary

Affiliation: University of Prince Edward Island
Country: Canada

Publications

  1. pmc Uncoupling proteins: role in insulin resistance and insulin insufficiency
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Curr Diabetes Rev 2:271-83. 2006
  2. ncbi request reprint Cross-sectional relationship of pedometer-determined ambulatory activity to indicators of health
    Catherine B Chan
    Departments of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada
    Obes Res 11:1563-70. 2003
  3. ncbi request reprint Glucose-inducible hypertrophy and suppression of anion efflux in rat beta cells
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, C1A 4P3 Canada
    J Endocrinol 173:45-52. 2002
  4. ncbi request reprint Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI C1A 4P3, Canada
    Diabetes 50:1302-10. 2001
  5. ncbi request reprint Uncoupling protein 2 and islet function
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward, Canada
    Diabetes 53:S136-42. 2004
  6. ncbi request reprint Glucose refractoriness of beta-cells from fed fa/fa rats is ameliorated by nonesterified fatty acids
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Can J Physiol Pharmacol 77:934-42. 1999
  7. ncbi request reprint Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Diabetes 48:1482-6. 1999
  8. ncbi request reprint Beta-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Diabetes 48:997-1005. 1999
  9. ncbi request reprint Ultrastructural and secretory heterogeneity of fa/fa (Zucker) rat islets
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Mol Cell Endocrinol 136:119-29. 1998
  10. ncbi request reprint KATP channel-dependent and -independent pathways of insulin secretion in isolated islets from fa/fa Zucker rats
    C B Chan
    Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada
    Biochem Cell Biol 74:403-10. 1996

Collaborators

Detail Information

Publications39

  1. pmc Uncoupling proteins: role in insulin resistance and insulin insufficiency
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Curr Diabetes Rev 2:271-83. 2006
    ..The mechanism(s) of action of UCP2 and UCP3 are poorly understood. However, findings support roles for UCP2 and UCP3 as modifiers of fatty acid metabolism and in mitigating damage from reactive oxygen species...
  2. ncbi request reprint Cross-sectional relationship of pedometer-determined ambulatory activity to indicators of health
    Catherine B Chan
    Departments of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada
    Obes Res 11:1563-70. 2003
    ....
  3. ncbi request reprint Glucose-inducible hypertrophy and suppression of anion efflux in rat beta cells
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, C1A 4P3 Canada
    J Endocrinol 173:45-52. 2002
    ..However, hypertrophy alone did not predict functional characteristics of overnight-cultured beta cells from fa/fa rats...
  4. ncbi request reprint Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI C1A 4P3, Canada
    Diabetes 50:1302-10. 2001
    ..These studies also raise the possibility that a pathological upregulation of UCP-2 expression in the prediabetic state could contribute to the loss of glucose responsiveness observed in obesity-related type 2 diabetes in humans...
  5. ncbi request reprint Uncoupling protein 2 and islet function
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward, Canada
    Diabetes 53:S136-42. 2004
    ..Interestingly, the latter appears to be the dominant outcome, because UCP2 knockout mice display an increased beta-cell mass and retained insulin secretion capacity in the face of glucolipotoxicity...
  6. ncbi request reprint Glucose refractoriness of beta-cells from fed fa/fa rats is ameliorated by nonesterified fatty acids
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Can J Physiol Pharmacol 77:934-42. 1999
    ..When acutely exposed to nonesterified fatty acids, islets from fa/fa rats have a potentiated insulin response despite chronic elevation of plasma lipids in vivo...
  7. ncbi request reprint Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Diabetes 48:1482-6. 1999
    ..These data suggest that increased expression of UCP-2 has the potential to cause the lack of a glucose effect on insulin secretion in type 2 diabetes...
  8. ncbi request reprint Beta-cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Diabetes 48:997-1005. 1999
    ..Glucose regulates beta-cell responsiveness in the short term, and these effects may involve altered expression of SNARE proteins...
  9. ncbi request reprint Ultrastructural and secretory heterogeneity of fa/fa (Zucker) rat islets
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Mol Cell Endocrinol 136:119-29. 1998
    ....
  10. ncbi request reprint KATP channel-dependent and -independent pathways of insulin secretion in isolated islets from fa/fa Zucker rats
    C B Chan
    Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada
    Biochem Cell Biol 74:403-10. 1996
    ..Further studies are required to understand the basis of insulin secretion in ATP-depleted islets from fa/fa rats...
  11. ncbi request reprint Health benefits of a pedometer-based physical activity intervention in sedentary workers
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3
    Prev Med 39:1215-22. 2004
    ..Here, we examined the effects of a pedometer-based physical activity intervention (Prince Edward Island-First Step Program, PEI-FSP) on activity and specific health indices in 106 sedentary workers...
  12. ncbi request reprint Regulation of insulin secretion by uncoupling protein
    C B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3
    Biochem Soc Trans 34:802-5. 2006
    ..These results support a role for UCP2 as a gene contributing to the pathogenesis of Type 2 diabetes...
  13. ncbi request reprint Endogenous regulation of insulin secretion by UCP2
    Catherine B Chan
    Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, PE Canada
    Clin Lab 48:599-604. 2002
    ..Thus, insufficient insulin secretion in models of type 2 diabetes is associated with elevated UCP2 expression in islets. The evidence for such a role for UCP2 in the regulation of insulin secretion in islets is reviewed...
  14. ncbi request reprint cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells
    T S McQuaid
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
    J Endocrinol 190:669-80. 2006
    ..Thus, elevating cellular cAMP can reverse the deficiency in GSIS invoked by ucp2-OE, at least partly through PKA-mediated effects on the K(ATP) channel...
  15. ncbi request reprint Increased glucose phosphorylating activity correlates with insulin secretory capacity of male JCR:LA-corpulent rat islets
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Can J Physiol Pharmacol 73:501-8. 1995
    ..However, other factors must also be considered because female cp/cp rats have moderately increased insulin secretory capacity without marked changes in total glucose phosphorylating capacity...
  16. ncbi request reprint Evidence for defective glucose sensing by islets of fa/fa obese Zucker rats
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, P E I, Canada
    Can J Physiol Pharmacol 71:34-9. 1993
    ..We conclude that fa/fa rat islets have an exaggerated insulin response to hypoglycemic stimuli, possibly as a result of a defect in B-cell glucokinase function...
  17. ncbi request reprint Effect of adrenalectomy on the development of a pancreatic islet lesion in fa/fa rats
    M T Kibenge
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Diabetologia 39:190-8. 1996
    ....
  18. pmc Glucokinase activity in isolated islets from obese fa/fa Zucker rats
    C B Chan
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Biochem J 295:673-7. 1993
    ..Pharmacol. 71, 34-39]. The data from glucose and mannoheptulose experiments support the hypothesis that glucokinase function is altered in fa/fa Zucker rats and may contribute to fasting hyperinsulinaemia in vivo in these animals...
  19. ncbi request reprint Identification of biochemical defects in pancreatic islets of fa/fa rats: a developmental study
    M T Kibenge
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    Obes Res 3:171-8. 1995
    ..The presence of defective regulation of the glycolytic pathway by mannoheptulose in suckling and weanling rats may contribute to development of hyperinsulinemia in fa/fa rats...
  20. ncbi request reprint Uncoupling protein-2: evidence for its function as a metabolic regulator
    M C Saleh
    Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, PE I, Canada
    Diabetologia 45:174-87. 2002
    ..The possibility of functions of uncoupling protein-2 in other tissues such as the brain are beginning to emerge...
  21. ncbi request reprint Interactions between effects of adrenalectomy and diet on insulin secretion in fa/fa Zucker rats
    M T Kibenge
    Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada
    Can J Physiol Pharmacol 79:1-7. 2001
    ....
  22. ncbi request reprint Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice
    Monique C Saleh
    Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward, C1A 4P3 Canada
    J Endocrinol 190:659-67. 2006
    ..Moreover, the glucolipotoxic conditions observed are predicted to increase UCP2 activity, contributing to lower islet ATP and GSIS...
  23. ncbi request reprint Estrogen reduces the severity of autonomic dysfunction in spinal cord-injured male mice
    Aubrey A Webb
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Canada
    Behav Brain Res 171:338-49. 2006
    ..We have shown that E reduces autonomic dysreflexic responses to visceral but not somatic stimulation in male mice independent of the size of the primary afferent arbour, the degree of chronic inflammation, and the presence of UCP-2...
  24. ncbi request reprint The effects of high-fat diet on exercise-induced changes in metabolic parameters in Zucker fa/fa rats
    Molly T Kibenge
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada
    Metabolism 51:708-15. 2002
    ..We conclude that beneficial effects of moderate exercise on metabolism are not mediated by effects on pancreatic beta cells. Diets elevated in fat decrease the beneficial effects of exercise on metabolic indices in vivo...
  25. ncbi request reprint Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats
    Monique C Saleh
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada
    Diabetes Metab Res Rev 24:392-403. 2008
    ..We investigated the cellular basis for reduced insulin secretion and compensatory mechanisms that mitigate the effects of the ATP synthase mutation...
  26. ncbi request reprint Impact of uncoupling protein-2 overexpression on proinsulin processing
    Narudee Kashemsant
    Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island, Canada C1A 4P3
    J Mol Endocrinol 37:517-26. 2006
    ....
  27. ncbi request reprint Use of pedometers to measure physical activity in dogs
    Catherine B Chan
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
    J Am Vet Med Assoc 226:2010-5. 2005
    ..To determine whether pedometers can be used to measure physical activity in dogs...
  28. ncbi request reprint The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion
    Feihan F Dai
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 281:21942-53. 2006
    ..Increased VILIP-1 enhanced insulin secretion in a cAMP-associated manner. Down-regulation of VILIP-1 was accompanied by decreased cAMP accumulation but increased insulin gene transcription...
  29. ncbi request reprint Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells
    Jingyu Diao
    Department of Physiology, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 280:33487-96. 2005
    ..This study provides direct evidence that appropriate expression of the IR in alpha-cells is required for glucose-dependent glucagon secretion...
  30. ncbi request reprint Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
    Jamie W Joseph
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes 51:3211-9. 2002
    ..These results further establish UCP2 as a component in glucose sensing and suggest a possible new aspect of UCP2 function during the progression of type 2 diabetes...
  31. ncbi request reprint Role of mitochondria in toxic oxidative stress
    Marc W Fariss
    Department of Pharmaceutical Sciences, University of Colorado Cancer Center, Denver, CO 80262, USA
    Mol Interv 5:94-111. 2005
    ....
  32. ncbi request reprint Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression
    Jamie W Joseph
    Departments of Medicine and Physiology, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 279:51049-56. 2004
    ..We propose that higher free fatty acid oxidation rates prevent accumulation of triglyceride in UCP2(-/-) islets, such accumulation being a phenomenon associated with lipotoxicity...
  33. ncbi request reprint The characterization of mitochondrial permeability transition in clonal pancreatic beta-cells. Multiple modes and regulation
    Vasilij Koshkin
    Departments of Physiology and Medicine, University of Toronto, Toronto M5S 1A8, Canada
    J Biol Chem 279:41368-76. 2004
    ....
  34. ncbi request reprint Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion
    Patrick E MacDonald
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:44938-45. 2002
    ..1 is an important component of beta-cell stimulus-secretion coupling, and a compound that enhances, but does not initiate, beta-cell electrical activity by acting on Kv2.1 would be a useful antidiabetic agent...
  35. ncbi request reprint Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids
    Vasilij Koshkin
    Departments of Physiology and Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:19709-15. 2003
    ..Together, these events may underlie FFA-induced depression of the ATP/ADP ratio in beta-cells, which accounts for the defective glucose-stimulated insulin secretion associated with lipotoxicity...
  36. ncbi request reprint Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells
    Vasilij Koshkin
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 283:7936-48. 2008
    ..These findings suggest that in the beta-cell, MPTs can act as both initiators of cell death and as versatile modulators of cell metabolism, depending on the mode of the MPT pore induced...
  37. ncbi request reprint Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6
    Xiaolin Wang
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 53:129-40. 2004
    ..Importantly, these findings indicate that chronic OA exposure can impair beta-cell function through ROS-dependent and -independent mechanisms...
  38. pmc UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival
    Jingyu Diao
    Departments of Physiology and Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 105:12057-62. 2008
    ..In summary, we demonstrate a direct role for UCP2 in maintaining alpha-cell function at the level of glucose metabolism, glucagon secretion, and cytoprotection...