An Wen Chan
Affiliation: University of Toronto
- Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articlesAn Wen Chan
Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford, England
JAMA 291:2457-65. 2004..Selective reporting of outcomes within published studies based on the nature or direction of their results has been widely suspected, but direct evidence of such bias is currently limited to case reports...
- Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health ResearchAn Wen Chan
Randomized Controlled Trials Unit, Canadian Institutes of Health Research, Ottawa, Ont
CMAJ 171:735-40. 2004..We sought to determine whether outcome reporting bias would be present in a cohort of government-funded trials subjected to rigorous peer review...
- Assessing clinical trial resultsAn Wen Chan
Science 312:365-6; author reply 365-6. 2006
- SPIRIT 2013 statement: defining standard protocol items for clinical trialsAn Wen Chan
Women s College Research Institute, Women s College Hospital, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
Ann Intern Med 158:200-7. 2013....
- Compliance of clinical trial registries with the World Health Organization minimum data set: a surveyLorenzo P Moja
Italian Cochrane Centre, Mario Negri Institute for Pharmacological Research, Milan, Italy
Trials 10:56. 2009..The objective is to evaluate registries' and individual trial records' compliance with the 2006 version of the WHO minimum data set...
- Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authorsAn Wen Chan
University Health Network, Department of Medicine, Suite RFE 3 805, 190 Elizabeth Street, Toronto, ON M5G 2C4, Canada
BMJ 330:753. 2005..To examine the extent and nature of outcome reporting bias in a broad cohort of published randomised trials...
- Epidemiology and reporting of randomised trials published in PubMed journalsAn Wen Chan
Department of Medicine, University Health Network Toronto, Canada
Lancet 365:1159-62. 2005..The small sample sizes are worrying, and poor reporting of methodological characteristics will prevent reliable quality assessment of many published trials...
- Research protocols: waiving confidentiality for the greater goodAn Wen Chan
Randomized Controlled Trials Unit, Canadian Institutes of Health Research, Toronto, Canada
BMJ 332:1086-9. 2006
- Investigator experiences with financial conflicts of interest in clinical trialsPaula A Rochon
Women s College Research Institute at Women s College Hospital, Toronto, Canada
Trials 12:9. 2011..We obtained information from investigators about adherence to practices that minimize the introduction of such bias in their clinical trials experience...
- SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trialsAn Wen Chan
Women s College Research Institute at Women s College Hospital, Department of Medicine, University of Toronto, Toronto, Canada M5G 1N8
BMJ 346:e7586. 2013..Complete documentation of key trial elements can facilitate transparency and protocol review for the benefit of all stakeholders...
- [Selective reporting of positive outcomes in randomised trials--secondary publication.. A comparison of protocols with published reports]Asbjørn Hróbjartsson
H S Rigshopitalet, Det Nordiske Cochrane Center, University Health Network Toronto, Department of Medicine
Ugeskr Laeger 167:3189-91. 2005..Selective reporting of positive outcomes is associated with bias...
- [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]Karmela Krleza-Jeric
Canadian Institutes of Health Research, Ottawa, Ontario, Canada
Rev Panam Salud Publica 19:413-6. 2006
- National evaluation of policies on individual financial conflicts of interest in Canadian academic health science centersJoel Lexchin
School of Health Policy and Management, York University, Toronto, ON, Canada
J Gen Intern Med 23:1896-903. 2008..Conflicts of interest (COI) in research are an important emerging topic of investigation and are frequently cited as a serious threat to the integrity of human participant research...
- Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1)Karmela Krleza-Jeric
Randomised Controlled Trials Unit, Canadian Institutes of Health Research, Ottawa, 160 Elgin Street, Ottawa ON, K1A 0W9, Canada
BMJ 330:956-8. 2005
- Guidelines for randomized clinical trial protocol content: a systematic reviewJennifer M Tetzlaff
Ottawa Methods Centre, Ottawa Hospital Research Institute, Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
Syst Rev 1:43. 2012..The objective of this study was to systematically identify and review RCT protocol guidelines, to assess their characteristics and methods of development, and to compare recommendations...
- Developing a guideline for clinical trial protocol content: Delphi consensus surveyJennifer Marie Tetzlaff
Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Trials 13:176. 2012....
- Poor reporting of scientific leadership information in clinical trial registersMelanie Sekeres
Kunin Lunenfeld Applied Research Unit, Baycrest, Toronto, Ontario, Canada
PLoS ONE 3:e1610. 2008..Identifying those scientifically responsible for trial conduct increases accountability. The objective is to examine the proportion of registered clinical trials providing valid scientific leadership information...
- Reporting on covariate adjustment in randomised controlled trials before and after revision of the 2001 CONSORT statement: a literature reviewLy Mee Yu
Centre for Statistics in Medicine, University of Oxford, Wolfson College Annexe, Oxford, UK
Trials 11:59. 2010..To evaluate the use and reporting of adjusted analysis in randomised controlled trials (RCTs) and compare the quality of reporting before and after the revision of the CONSORT Statement in 2001...
- [Constraints on publication rights in industry-initiated clinical trials--secondary publication]Peter C Gøtzsche
H S Rigshospitalet, Det Nordiske Cochrane Center, DK 2100 København Ø
Ugeskr Laeger 168:2467-9. 2006..These facts were not noted in any of the trial reports. We found similar constraints on publication rights in 44 protocols from 2004. This tight sponsor control over industry-initiated trials should be changed...
- Ghost authorship in industry-initiated randomised trialsPeter C Gøtzsche
Nordic Cochrane Centre, Copenhagen, Denmark
PLoS Med 4:e19. 2007..The prevalence and nature of ghost authorship in industry-initiated randomised trials is not known...
- Constraints on publication rights in industry-initiated clinical trialsPeter C Gøtzsche
JAMA 295:1645-6. 2006
- Clinical trial registration: transparency is the watchwordIda Sim
Department of Research Policy and Cooperation, World Health Organization, 1211 Geneva 27, Switzerland
Lancet 367:1631-3. 2006
- Comparison of descriptions of allocation concealment in trial protocols and the published reports: cohort studyJulie Pildal
Nordic Cochrane Centre, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
BMJ 330:1049. 2005....