Alastair Carruthers

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Botulinum toxin type A: history and current cosmetic use in the upper face
    A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Semin Cutan Med Surg 20:71-84. 2001
  2. doi request reprint A validated brow positioning grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S150-4. 2008
  3. doi request reprint Evaluation of injectable calcium hydroxylapatite for the treatment of facial lipoatrophy associated with human immunodeficiency virus
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 34:1486-99. 2008
  4. ncbi request reprint Dose-ranging study of botulinum toxin type A in the treatment of glabellar rhytids in females
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:414-22; discussion 422. 2005
  5. doi request reprint Radiographic and computed tomographic studies of calcium hydroxylapatite for treatment of HIV-associated facial lipoatrophy and correction of nasolabial folds
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S78-84. 2008
  6. ncbi request reprint Botulinum toxin type A
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Acad Dermatol 53:284-90. 2005
  7. ncbi request reprint Prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in men with glabellar rhytids
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, 943 West Broadway, Ste 820, Vancouver, British Columbia V5Z 4E1, Canada
    Dermatol Surg 31:1297-303. 2005
  8. ncbi request reprint Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine cream versus vehicle cream during botulinum toxin type A treatments
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, BC
    Dermatol Surg 31:1655-9. 2005
  9. ncbi request reprint Polymethylmethacrylate microspheres/collagen as a tissue augmenting agent: personal experience over 5 years
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1561-4; discussion 1565. 2005
  10. ncbi request reprint Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, restylane perlane and hylaform, in the treatment of nasolabial folds
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1591-8; discussion 1598. 2005

Detail Information

Publications72

  1. ncbi request reprint Botulinum toxin type A: history and current cosmetic use in the upper face
    A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Semin Cutan Med Surg 20:71-84. 2001
    ..The published literature and our current experience are outlined. Botulinum toxin type A in the upper face has become an extremely poplular cosmetic procedure and is outstandingly safe...
  2. doi request reprint A validated brow positioning grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S150-4. 2008
    ..Movement and positioning of the brows are also sex specific. Men may desire a low brow, whereas women may prefer high, arched brows...
  3. doi request reprint Evaluation of injectable calcium hydroxylapatite for the treatment of facial lipoatrophy associated with human immunodeficiency virus
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 34:1486-99. 2008
    ..To evaluate the safety and effectiveness of soft tissue augmentation with calcium hydroxylapatite (CaHA) microspheres in an aqueous gel in patients with facial lipoatrophy (FLA) secondary to human immunodeficiency virus (HIV) disease...
  4. ncbi request reprint Dose-ranging study of botulinum toxin type A in the treatment of glabellar rhytids in females
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:414-22; discussion 422. 2005
    ..To compare the efficacy, safety, and duration of effect of four doses of botulinum toxin type A in the treatment of glabellar rhytids in females...
  5. doi request reprint Radiographic and computed tomographic studies of calcium hydroxylapatite for treatment of HIV-associated facial lipoatrophy and correction of nasolabial folds
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S78-84. 2008
    ..following augmentation to correct the nasolabial folds or facial wasting associated with human immunodeficiency virus lipoatrophy...
  6. ncbi request reprint Botulinum toxin type A
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Acad Dermatol 53:284-90. 2005
  7. ncbi request reprint Prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in men with glabellar rhytids
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, 943 West Broadway, Ste 820, Vancouver, British Columbia V5Z 4E1, Canada
    Dermatol Surg 31:1297-303. 2005
    ..The effective dose for treating glabellar lines with botulinum toxin type A in men has not been studied adequately...
  8. ncbi request reprint Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine cream versus vehicle cream during botulinum toxin type A treatments
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, BC
    Dermatol Surg 31:1655-9. 2005
    ..Botulinum toxin type A (BTX-A) injections are overwhelmingly safe and effective treatment in cosmetic treatment, but some patients are apprehensive about pain associated with injection...
  9. ncbi request reprint Polymethylmethacrylate microspheres/collagen as a tissue augmenting agent: personal experience over 5 years
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1561-4; discussion 1565. 2005
    ..Polymethylmethacrylate microspheres/collagen has been used in Canada since 1998. A closely related product will probably be approved in the United States shortly. Concerns have been expressed about the use of permanent fillers such as this...
  10. ncbi request reprint Randomized, double-blind comparison of the efficacy of two hyaluronic acid derivatives, restylane perlane and hylaform, in the treatment of nasolabial folds
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1591-8; discussion 1598. 2005
    ..Cross-linked hyaluronic acid gels may offer longer-lasting cosmetic correction and a lower risk of immunogenicity than other soft tissue augmentation agents...
  11. ncbi request reprint Non-animal-based hyaluronic acid fillers: scientific and technical considerations
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, Canada
    Plast Reconstr Surg 120:33S-40S. 2007
    ..Recent advances in the technology and biocompatibility of the hyaluronans in all skin types mean that they are becoming the temporary facial filling agents of choice for many aesthetic physicians and surgeons...
  12. ncbi request reprint Patient-reported outcomes with botulinum neurotoxin type A
    Alastair Carruthers
    Department of Dermatology and Skin Science, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Cosmet Laser Ther 9:32-7. 2007
    ..These outcomes data help in understanding patient objectives and motivations, establishing a treatment plan, and ensuring patient satisfaction. Clinicians can use the SPA measure for all patients to help show the value of treatment...
  13. ncbi request reprint A randomized, evaluator-blinded, two-center study of the safety and effect of volume on the diffusion and efficacy of botulinum toxin type A in the treatment of lateral orbital rhytides
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:567-71. 2007
    ..There has been considerable discussion about the effect of the degree of dilution of botulinum toxin (BTX) but very few scientific studies...
  14. ncbi request reprint Eyebrow height after botulinum toxin type A to the glabella
    Alastair Carruthers
    Department of Dermatology, University of Bristish Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S26-31. 2007
    ..Numerous reports have cited an associated brow lift with BTX-A injections in the glabellar complex, presumably caused by deactivation of the brow depressor muscles. Few analyses examining this phenomenon more closely exist, however...
  15. ncbi request reprint Dilution volume of botulinum toxin type A for the treatment of glabellar rhytides: does it matter?
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S97-104. 2007
    ..Because well-controlled studies examining the efficacy and safety of various dilutions of botulinum toxin type A (BTX-A) have not been performed, dilutions used in clinical practice are chosen at the discretion of the clinician...
  16. doi request reprint A validated grading scale for forehead lines
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S155-60. 2008
    ..As with other facial wrinkles, the gradual loss and disorganization of collagen fibers and elastin, connective tissues that provide underlying support for skin, cause horizontal forehead rhytides in large part...
  17. ncbi request reprint Botulinum toxin type A for the treatment of glabellar rhytides
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, BC, Canada
    Dermatol Clin 22:137-44. 2004
    ....
  18. doi request reprint Multicenter, randomized, parallel-group study of the safety and effectiveness of onabotulinumtoxinA and hyaluronic acid dermal fillers (24-mg/ml smooth, cohesive gel) alone and in combination for lower facial rejuvenation
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:2121-34. 2010
    ..Combination treatment with toxins and fillers is the standard regimen in facial rejuvenation. Systematic studies of botulinum toxin alone and in combination with hyaluronic acid (HA) have not, however, been conducted in the lower face...
  19. doi request reprint A validated facial grading scale: the future of facial ageing measurement tools?
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    J Cosmet Laser Ther 12:235-41. 2010
    ..Validation studies show that these scales have good intra- and inter-rater reliability, with intra-class correlation coefficients generally in the range 0.85-0.95, and similar test-retest correlations...
  20. doi request reprint Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment
    J Alastair Carruthers
    Carruthers Dermatology Centre, Inc, Vancouver, BC, Canada
    Dermatol Surg 36:1130-7. 2010
    ..Literature cautions against applying lidocaine 15%/prilocaine 5% over an area larger than 300 cm(2). The area of the face, neck, and chest is 400 cm(2) or greater...
  21. ncbi request reprint A prospective, double-blind, randomized, parallel- group, dose-ranging study of botulinum toxin type a in female subjects with horizontal forehead rhytides
    Alastair Carruthers
    Division of Dermatology, Vancouver, British Columbia, Canada
    Dermatol Surg 29:461-7. 2003
    ..Botulinum toxin type A is used cosmetically to improve facial lines, but it has not been thoroughly investigated for the treatment of horizontal forehead rhytides...
  22. ncbi request reprint A single-center dose-comparison study of botulinum neurotoxin type A in females with upper facial rhytids: assessing patients' perception of treatment outcomes
    Alastair Carruthers
    University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada
    J Drugs Dermatol 8:924-9. 2009
    ..Few studies evaluate patient-reported outcomes (PROs)...
  23. doi request reprint A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: safety and efficacy
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, 943 W Broadway, Suite 820, Vancouver, British Columbia V5Z 4E1, Canada
    J Am Acad Dermatol 60:972-9. 2009
    ..Treating multiple upper facial rhytids at one time is common, but has not been researched extensively...
  24. ncbi request reprint Dose-finding, safety, and tolerability study of botulinum toxin type B for the treatment of hyperfunctional glabellar lines
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S60-8. 2007
    ..Previous open-label studies have demonstrated that botulinum toxin type B (BTX-B, Myobloc, Solstice Neurosciences) in doses of up to 3,000 U is safe and effective in the treatment of glabellar wrinkles...
  25. doi request reprint A validated lip fullness grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S161-6. 2008
    ..To develop the Lip Fullness Grading Scale for objective quantification of lip volume for a reliable assessment and to establish the reliability of this photonumeric scale for clinical research and practice...
  26. doi request reprint A validated grading scale for marionette lines
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S167-72. 2008
    ..Melomental folds, or marionette lines, are one of the consequences of facial aging. The curvilinear wrinkles formed because of facial movements and the aging process extend downward from the oral commissures...
  27. ncbi request reprint History of the clinical use of botulinum toxin A and B
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Dermatol 21:469-72. 2003
    ..Alan Scott put together the idea of Ed Maumenee to use BTX to affect extraocular muscles, Art Jampolsky's electromyographic control delivery system, and Ed Schantz' work on the purification of BTX...
  28. doi request reprint A validated grading scale for crow's feet
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S173-8. 2008
    ..To develop the Crow's Feet Grading Scale for objective quantification of the severity of lateral canthal lines and to establish the reliability of this photonumeric scale for clinical research and practice...
  29. doi request reprint A validated hand grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S179-83. 2008
    ..Irregular surface pigmentation, prominence of superficial veins and tendons, thinning of the dermis, and loss of subcutaneous fat typically characterize aging of the hand...
  30. doi request reprint Multicenter, randomized, parallel-group study of onabotulinumtoxinA and hyaluronic acid dermal fillers (24-mg/ml smooth, cohesive gel) alone and in combination for lower facial rejuvenation: satisfaction and patient-reported outcomes
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:2135-45. 2010
    ..Patient-reported outcomes (PROs) are important assessment benchmarks after aesthetic procedures. Systematic studies of PROs have not been conducted in the lower face...
  31. ncbi request reprint Adjunctive botulinum toxin type A: fillers and light-based therapies
    Jean Carruthers
    Carruthers Cosmetic Centre, 790 943 West Broadway, Vancouver, British Columbia, Canada V5Z 4E1
    Int Ophthalmol Clin 45:143-51. 2005
  32. doi request reprint Anatomic guidelines for augmentation of the cheek and infraorbital hollow
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 38:1223-33. 2012
    ..Mid-face reflation requires a sophisticated knowledge of bony and soft tissue anatomy...
  33. ncbi request reprint Safety and efficacy of nonanimal stabilized hyaluronic acid for improvement of mouth corners
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia
    Dermatol Surg 31:276-80. 2005
    ..A new technique to offer structural support using the recently approved filler nonanimal stabilized hyaluronic acid (NASHA; Restylane, Q-med Inc., Uppsala, Sweden) is described...
  34. ncbi request reprint Facial sculpting and tissue augmentation
    Jean D A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1604-12. 2005
    ....
  35. ncbi request reprint Botulinum toxin A in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, 943 West Broadway, Suite 720, Vancouver, BC V5M 4E1, Canada
    Dermatol Clin 22:151-8. 2004
    ..In addition to its use as primary procedure, botulinum toxin is also an effective adjunct to other cosmetic procedures, enhancing and prolonging the benefits of surgery, soft tissue augmentation, and laser resurfacing...
  36. ncbi request reprint The use of botulinum toxin type A in the upper face
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, 943 West Broadway, Suite 720, Vancouver, BC V5M 4E1, Canada
    Facial Plast Surg Clin North Am 14:253-60. 2006
  37. doi request reprint Validated assessment scales for the mid face
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 38:320-32. 2012
    ..The improvement of aesthetic treatment options for age-related mid face changes, such as volume loss, and the increase in patient expectations necessitates the development of more-complex and globally accepted assessment tools...
  38. ncbi request reprint Botulinum toxin below the eyes
    Jean Carruthers
    Carruthers Cosmetic Centre, 790 943 West Broadway, Vancouver, British Columbia, Canada V5Z 4E1
    Int Ophthalmol Clin 45:133-41. 2005
  39. ncbi request reprint Facial aesthetics: achieving the natural, relaxed look
    Alastair Carruthers
    Department of Dermatology and Skin Science, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Cosmet Laser Ther 9:6-10. 2007
    ..The article also offers suggestions intended to help clinicians provide each patient with appropriate outcomes and satisfaction...
  40. ncbi request reprint Hyaluronic acid gel in skin rejuvenation
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Canada
    J Drugs Dermatol 5:959-64. 2006
    ..The more viscous agents are very helpful in the treatment of facial lipoatrophy particularly in the region of the cheeks and chin...
  41. doi request reprint Botulinum toxin in facial rejuvenation: an update
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 943 West Broadway, Suite 740, Vancouver, BC, Canada
    Dermatol Clin 27:417-25, v. 2009
    ..Although recent reports have questioned the safety of BTX, 25 years of therapeutic and over 20 years of cosmetic use has demonstrated an impressive record of safety and efficacy when used appropriately by experienced injectors...
  42. ncbi request reprint The natural history of polymethylmethacrylate microspheres granulomas
    Allison Gelfer
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 33:614-20. 2007
  43. ncbi request reprint Botulinum toxin type A treatment of multiple upper facial sites: patient-reported outcomes
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S10-7. 2007
    ..Aesthetic treatment planning must address subjects' goals and include subject-reported outcomes...
  44. ncbi request reprint Aesthetic botulinum A toxin in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Dermatol Surg 29:468-76. 2003
    ..Botulinum toxin type A (BOTOX formulation) is used extensively for smoothing hyperkinetic lines in the upper face. The use of botulinum toxin for aesthetic indications in the mid and lower face and neck is now becoming increasingly popular...
  45. doi request reprint Multicenter, randomized, phase III study of a single dose of incobotulinumtoxinA, free from complexing proteins, in the treatment of glabellar frown lines
    Alastair Carruthers
    Carruthers Clinical Research, Vancouver, British Columbia, Canada
    Dermatol Surg 39:551-8. 2013
    ..IncobotulinumtoxinA (NT 201, Xeomin/Xeomeen/Bocouture, Merz Pharmaceuticals GmbH, Frankfurt, Germany) is a 150-kDa botulinum toxin type A free of complexing proteins...
  46. ncbi request reprint A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox) and nonanimal sourced hyaluronic acid (NASHA, Restylane) in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: trea
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 29:802-9. 2003
    ..Over the past 15 years, BTX-A has become the standard treatment for dynamic glabellar furrowing. Some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone...
  47. ncbi request reprint Deep resting glabellar rhytides respond to BTX-A and Hylan B
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 29:539-44. 2003
    ..BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone...
  48. doi request reprint Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:1886-92. 2010
    ..OBJECTIVE Evaluate clinical experience with 20 mg/mL HA dermal filler to date and comment on its current and potential uses within the facial rejuvenation treatment paradigm...
  49. ncbi request reprint The evolution of botulinum neurotoxin type A for cosmetic applications
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cosmet Laser Ther 9:186-92. 2007
    ..Although BOTOX is the most clinically substantiated and published of the BoNTA preparations, other BoNTA products, as well as a BoNT type B product, are available in some parts of the world, and others are in development...
  50. ncbi request reprint The effect of full-face broadband light treatments alone and in combination with bilateral crow's feet Botulinum toxin type A chemodenervation
    Jean Carruthers
    Opthalmology, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 30:355-66; discussion 366. 2004
    ..Irvine, CA) treatment of the lateral periocular region relaxes the vertical fibers of the orbicularis oculi and results in softening of the lateral orbital crow's feet rhytides and widening of the palpebral aperture...
  51. ncbi request reprint Shrinking upper and lower eyelid skin with a novel radiofrequency tip
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:802-9. 2007
    ..25-cm(2) monopolar radiofrequency tip in a prospective noncomparative study as a novel nonsurgical method to safely tighten upper and lower eyelid skin in subjects of differing ethnicity and sex...
  52. ncbi request reprint Botox: beyond wrinkles
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia School of Medicine, Vancouver, British Columbia, Canada
    Clin Dermatol 22:89-93. 2004
    ..Moreover, other conditions-notably some pain and gastrointestinal disorders-have responded to BTX injections...
  53. doi request reprint OnabotulinumtoxinA treatment of mild glabellar lines in repose
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 36:2168-71. 2010
    ..OnabotulinumtoxinA is an established treatment for glabellar frown lines, but its effects on lines at repose are less well documented...
  54. ncbi request reprint Two-center Canadian report on the safety and effectiveness of Evolence Breeze
    Jean Carruthers
    Department of Ophthalmology andVisual Sciences, University of British Columbia
    J Drugs Dermatol 8:830-4. 2009
    ..This represents our initial experience with both subject satisfaction and product safety during this one year period approximately 1.5 years after Health Canada product approval...
  55. doi request reprint The convergence of medicine and neurotoxins: a focus on botulinum toxin type A and its application in aesthetic medicine--a global, evidence-based botulinum toxin consensus education initiative: part I: botulinum toxin in clinical and cosmetic practice
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 39:493-509. 2013
    ..The latest approval of a BoNTA with no complexing proteins (incobotulinumtoxinA) necessitates a review and discussion of differences between available formulations and the effect that these differences may have on clinical practice...
  56. ncbi request reprint Complications of botulinum toxin type A
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, V5Z 4E1, Canada
    Facial Plast Surg Clin North Am 15:51-4, vi. 2007
    ..Complications can occur, particularly when used by the inexperienced injectors. Through knowledge of its mechanism of action and effect and careful attention to dosing and technique can minimize the risk of more serious adverse events...
  57. ncbi request reprint HIV-associated facial lipoatrophy
    Julia James
    Division of Dermatology and Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 28:979-86. 2002
    ..HIV-infected individuals are living long, healthy lives. They are now concerned with less life-threatening problems, especially lipodystrophy...
  58. doi request reprint Handling botulinum toxins: an updated literature review
    Ada R Trindade de Almeida
    Clinica Dermatológica do Hospital do Servidor Público Municipal de São Paulo, Sao Paulo, Brazil
    Dermatol Surg 37:1553-65. 2011
    ..During these years of clinical use, some of the initial ideas have changed, and others have remained stable along with increasing experience with and knowledge about BoNTs...
  59. ncbi request reprint Botulinum toxin in facial rejuvenation: an update
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 943 West Broadway, Suite 740, Vancouver, BC, Canada V5Z 4E1
    Obstet Gynecol Clin North Am 37:571-82, ix. 2010
    ..Although recent reports have questioned the safety of BTX, 25 years of therapeutic and over 20 years of cosmetic use has demonstrated an impressive record of safety and efficacy when used appropriately by experienced injectors...
  60. doi request reprint Commentary: Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 37:929-30. 2011
    ..Drs. Alastair and Jean Carruthers are consultants to Allergan, Inc., and have been paid to do research by Allergan, Inc...
  61. ncbi request reprint The skin in pregnancy
    Benjamin Barankin
    Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    J Cutan Med Surg 6:236-40. 2002
    ..Physicians may mistake normal skin changes in pregnancy as pathologic change within the skin, and so an appreciation of the common and less common skin manifestations will assist in appropriate patient care...
  62. ncbi request reprint Surgical pearl: the use of the Ultra-Fine II short needle 0.3-cc insulin syringe for botulinum toxin injections
    Timothy Corcoran Flynn
    Department of Dermatology, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    J Am Acad Dermatol 46:931-3. 2002
  63. ncbi request reprint Botulinum toxin type A: history and current cosmetic use in the upper face
    Alastair Carruthers
    Dis Mon 48:299-322. 2002
    ..The published literature and our current experience are outlined. Botulinum toxin type A in the upper face has become an extremely popular cosmetic procedure and is outstandingly safe...
  64. ncbi request reprint Botulinum treatment of forehead wrinkles
    Alastair Carruthers
    Plast Reconstr Surg 117:1354; author reply 1355. 2006
  65. ncbi request reprint Late-appearing abscesses after injections of nonabsorbable hydrogel polymer for HIV-associated facial lipoatrophy
    Derek H Jones
    Division of Dermatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Dermatol Surg 33:S193-8. 2007
  66. doi request reprint Comparisons among botulinum toxins: an evidence-based review
    Arnold W Klein
    David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif, USA
    Plast Reconstr Surg 121:413e-422e. 2008
    ..A number of serotypes and formulations are available worldwide. Similarities and differences among these toxins were evaluated by reviewing the existing literature...
  67. ncbi request reprint Highly purified 1000-cSt silicone oil for treatment of human immunodeficiency virus-associated facial lipoatrophy: an open pilot trial
    Derek H Jones
    Division of Dermatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Dermatol Surg 30:1279-86. 2004
    ..Affected patients require more persistent, affordable, safe, and effective treatment options...
  68. ncbi request reprint Botulinum toxin A: its expanding role in dermatology and esthetics
    Samireh Said
    University of California, Irvine, California, USA
    Am J Clin Dermatol 4:609-16. 2003
    ..Botulinum toxin A can provide an alternative treatment of palmar and axillary hyperhidrosis when options such as topical agents (aluminum chloride) and iontophoresis have failed...
  69. ncbi request reprint A randomized, double-blind, placebo-controlled study of botulinum toxin type A for the treatment of glabellar lines: determination of optimal dose
    Gary Monheit
    Department of Dermatology, University of Alabama Medical Center, Birmingham, Alabama 35205, USA
    Dermatol Surg 33:S51-9. 2007
    ..Botulinum toxin is used to treat glabellar lines, but the optimal dose of Reloxin (Dysport, Ipsen Biopharm Ltd.) for this indication remains to be established...
  70. ncbi request reprint Mad cows, prions, and wrinkles
    Jean Carruthers
    Arch Dermatol 138:667-70. 2002
  71. ncbi request reprint Surgical pearl: accurate documentation of facial lesions using only one landmark
    Alastair Carruthers
    J Am Acad Dermatol 49:359-60. 2003
  72. ncbi request reprint Infraorbital hollow treatment by dermal fillers
    Ranella J Hirsch
    Skincare Doctors, Cambridge, Massachusetts, USA
    Dermatol Surg 33:1116-9. 2007