Research Topics
Species | Richard M CamicioliSummaryAffiliation: University of Alberta Country: Canada Publications
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Publications
Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementiaRichard Camicioli
Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
Mov Disord 26:1443-50. 2011..Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss...- Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonismRichard Camicioli
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Parkinsonism Relat Disord 15:187-95. 2009..To determine overall patterns of brain atrophy associated with memory, executive function (EF) and dopamine non-responsive motor measures in older parkinsonian patients... 
Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's diseaseRichard M Camicioli
Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
Mov Disord 22:382-6. 2007..AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD...- Dual-tasks and walking fast: relationship to extra-pyramidal signs in advanced Alzheimer diseaseRichard Camicioli
Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
J Neurol Sci 248:205-9. 2006..Given their high falls risk, and retained ability to modulate walking, EPS+ AD patients may be ideal candidates for interventions aimed at preventing falls... - Early, untreated Parkinson's disease patients show reaction time variabilityRichard M Camicioli
Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
Neurosci Lett 441:77-80. 2008..In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD... - Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinationsRichard Camicioli
University of Alberta, Edmonton, Alberta, Canada
Mov Disord 20:989-94. 2005..Psychosis risk was not associated with ApoE4, COMT, or sex. The observation that males have increased dementia risk and the trend for ApoE4 requires confirmation in larger prospective autopsy studies... - Motor impairment predicts falls in specialized Alzheimer care unitsRichard Camicioli
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Alzheimer Dis Assoc Disord 18:214-8. 2004..In conclusion, falls in advanced AD can be predicted using simple clinical measures of motor impairment or cadence. These measures may be useful for targeting interventions... - Gait and posture impairment, parkinsonism and cognitive decline in older peopleR Camicioli
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Neural Transm 114:1355-61. 2007..In conclusion, motor impairment and frailty are common in older people and are associated with an increased risk of cognitive decline and dementia. GPI is common in CIND, while GPI and parkinsonism are both common in dementia... - Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson's disease patientsRichard M Camicioli
Department of Medicine Neurology, University of Alberta, Edmonton, Alberta Canada
Mov Disord 24:176-82. 2009..Hcy was influenced by PD, MTHFR 677 genotype, and vitamin use, but not by the MTHFR 1298 genotype. There was no clear association with motor or cognitive measures, but dyskinesias were less likely with higher B12... - Parkinson's disease is associated with hippocampal atrophyRichard Camicioli
Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
Mov Disord 18:784-90. 2003..In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD... - Relationship between mild cognitive impairment and falls in older people with and without Parkinson's disease: 1-Year Prospective Cohort StudyRichard Camicioli
Department of Medicine, University of Alberta, E223 Glenrose Rehabilitation Hospital, 10230 111th Avenue, Edmonton, AB, Canada T5G 0B7
Gait Posture 32:87-91. 2010..We conclude that mild cognitive impairment might contribute to falls risk beyond conventional risk factors in older people with and without PD... - Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's diseaseThomas P Bouchard
Department of Medicine Neurology, University of Alberta, 10230, 111th Avenue, Edmonton, Alberta, Canada
Neurobiol Aging 29:1027-39. 2008..35, p=0.02); AG volumes correlated with CVLT-II recall (r=0.35, p=0.02). No correlations were found in non-PD (p>0.4). In conclusion, functionally meaningful age-associated hippocampal and amygdala atrophy occurs in PD... - Axial signs and magnetic resonance imaging correlates in Parkinson's diseaseHernish J Acharya
Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Canada
Can J Neurol Sci 34:56-61. 2007..Age-related brain changes may contribute to axial features in Parkinson's disease (PD)... - Intact presupplementary motor area function in early, untreated Parkinson's diseaseW R Wayne Martin
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Mov Disord 23:1756-9. 2008..We suggest that pre-SMA dysfunction is in part responsible for the dopamine nonresponsive features associated with disease progression... 
The course of depressive symptoms in early Parkinson's diseaseBernard Ravina
Department of Neurology, University of Rochester School of Medicine and Dentistry, New York, USA
Mov Disord 24:1306-11. 2009..83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course...- Corpus callosum in neurodegenerative diseases: findings in Parkinson's diseaseKatie Wiltshire
University of Alberta, Edmonton, Canada
Dement Geriatr Cogn Disord 20:345-51. 2005..80, -2.18 to -1.43). We conclude that PD and PDD patients do not have callosal atrophy in contrast to other neurodegenerative diseases, including AD. Callosal atrophy was correlated with dementia severity in patients with AD but not PDD... - Aging hippocampus and amygdalaNikolai V Malykhin
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Neuroreport 19:543-7. 2008.... - Temporal lobe changes in early, untreated Parkinson's diseaseW R Wayne Martin
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Mov Disord 24:1949-54. 2009..These results suggest that right anterior temporal lobe changes occur in untreated patients with PD. The earliest changes may occur in subcortical white matter rather than temporal cortex... - Intraindividual variability in neurocognitive speed: a comparison of Parkinson's disease and normal older adultsCindy M de Frias
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Neuropsychologia 45:2499-507. 2007..Intraindividual variability was not correlated with tapping speed and gait speed in any group. Executive functioning and neurocognitive speed may be valid and distinct clinical markers of disease progression in PD... - Age at onset of Parkinson disease and apolipoprotein E genotypesSepideh Zareparsi
Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Am J Med Genet 107:156-61. 2002..There was a trend for earlier onset of PD in varepsilon2varepsilon3 patients than in varepsilon3varepsilon3 patients only in the Oregon sample. In conclusion, APOE is associated with age at onset of PD... - Botulinum toxin injections do not improve freezing of gait in Parkinson diseaseMarguerite Wieler
Department of Medicine, University of Alberta, Edmonton, Canada
Neurology 65:626-8. 2005..The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures... - Independent predictors of cognitive decline in healthy elderly personsScott Marquis
Department of Medicine Neurology, University of Alberta, 2E3 08, 8440 112th St, Edmonton, Alberta, Canada T6G 2B7
Arch Neurol 59:601-6. 2002..Several studies have shown that individually memory, hippocampal volume, and motor measures presage the onset of dementia. It is unclear if these independently contribute to the prediction of mild cognitive impairment... - Cancer incidence in a trial of an antiapoptotic agent for Parkinson's diseaseSteven R Schwid
Department of Neurology, University of Rochester, Rochester, New York, USA
Mov Disord 25:1801-8. 2010..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted... - Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tailNikolai V Malykhin
Department of Psychiatry, University of Alberta, Walter Mackenzie Centre, 8440 112 Street, Edmonton, Alberta, Canada
Psychiatry Res 155:155-65. 2007..662+/-0.120 cm(3); hippocampal head: 1.23+/-0.174 cm(3); total hippocampus: 2.218+/-0.217 cm(3), and amygdala: 0.808+/-0.185 cm(3). In conclusion, the study demonstrates that the amygdala and hippocampal parts can be quantified reliably... - Clinical trials in Parkinson's disease dementia and dementia with Lewy bodiesRichard Camicioli
Glenrose Rehabilitation Hospital, Edmonton, AB, Canada
Can J Neurol Sci 34:S109-17. 2007..At present PDD and DLB are distinct entities by definition. Future studies, including clinical trials and biomarker studies, will help to further define the clinical and therapeutic implications of this distinction... - Circulating endothelial progenitor cells and age-related white matter changesGlen Jickling
Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada
Stroke 40:3191-6. 2009..EPC incorporate into sites endothelial damage and are thought to be involved in the repair of vascular risk factor induced endothelial injury. ARWMC can be evaluated using CT or MRI... - Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer diseaseJohn C Adair
Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Stroke 35:e159-62. 2004.... - Identification of parkinsonism and Parkinson's diseaseRichard Camicioli
Department of Medicine, University of Alberta, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Drugs Today (Barc) 38:677-86. 2002..There are numerous approaches available to the identification of parkinsonism and Parkinson's disease. The gold standard remains a clinical diagnosis, confirmed by autopsy... - Progress in clinical neurosciences: Parkinson's disease with dementia and dementia with Lewy bodiesRichard Camicioli
Department of Medicine, Division of Neurology, University of Alberta, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Can J Neurol Sci 31:7-21. 2004..Associated psychiatric and imaging findings are also considered. Lastly, current and emerging approaches to assessment and treatment in patients with these Lewy body associated dementias are presented... - A longitudinal program for biomarker development in Parkinson's disease: a feasibility studyBernard Ravina
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mov Disord 24:2081-90. 2009..The PostCEPT cohort and associated studies strongly support the feasibility of the LABS-PD approach of retaining and repurposing clinical trial cohorts to collect longitudinal clinical and biomarker data... - Parkinsonian syndromes and differential diagnosisJodi Kashmere
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
Curr Opin Neurol 15:461-6. 2002..Investigations reported during the last year provide new insight into the distinguishing features of these syndromes and may help clinicians and researchers define these disorders more precisely... - Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography studyStijn Michielse
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Neuroimage 52:1190-201. 2010..This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings... - Corpus callosum and cingulum tractography in Parkinson's diseaseKatie Wiltshire
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Can J Neurol Sci 37:595-600. 2010..Diffusion tensor imaging is a quantitative imaging method sensitive to the micro-structure of white matter tracts...