W R Bruce

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, ON, Canada
    Nutr Cancer 37:19-26. 2000
  2. ncbi Possible mechanisms relating diet and risk of colon cancer
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 9:1271-9. 2000
  3. ncbi A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, 150 College Street, and Division of Gastroenterology, St Michael s Hospital, Toronto, Ontario, Canada M5S 2E3
    Br J Cancer 93:639-46. 2005
  4. ncbi Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats
    W Robert Bruce
    Department of Nutritional Sciences, University of Toronto, 150 College Street, Toronto, Ont M5S 3E2, Canada
    Cancer Lett 202:125-9. 2003
  5. ncbi Counterpoint: From animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies
    W Robert Bruce
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Cancer Epidemiol Biomarkers Prev 12:401-4. 2003
  6. ncbi Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde
    Kai Yang
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Chem Biol Interact 191:315-21. 2011
  7. ncbi Possible mechanisms relating diet to colorectal cancer risk
    W R Bruce
    Departments of Nutritional Sciences, Physiology and Pathology, University of Toronto, Canada
    IARC Sci Publ 156:277-81. 2002
  8. ncbi Fructose and carbonyl metabolites as endogenous toxins
    O Lee
    Department of Pharmacology, University of Toronto, Toronto, ON, Canada
    Chem Biol Interact 178:332-9. 2009
  9. ncbi Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse
    D Naigamwalla
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 60:6856-8. 2000
  10. ncbi Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways
    Flore Depeint
    Department of Pharmaceutical Sciences, University of Toronto, Canada Department of Nutritional Sciences, University of Toronto, Canada
    Chem Biol Interact 163:113-32. 2006

Collaborators

Detail Information

Publications20

  1. ncbi Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, ON, Canada
    Nutr Cancer 37:19-26. 2000
    ..Finally, we consider the implications of this scheme on possible future research directions, including studies of satiety and clinical tests of the importance of insulin resistance in the colon carcinogenesis process...
  2. ncbi Possible mechanisms relating diet and risk of colon cancer
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 9:1271-9. 2000
    ..The two mechanisms, i.e., insulin resistance acting throughout the body and focal epithelial barrier failure acting locally, can describe most of the known relationships between diet and colon cancer risk...
  3. ncbi A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation
    W R Bruce
    Department of Nutritional Sciences, University of Toronto, 150 College Street, and Division of Gastroenterology, St Michael s Hospital, Toronto, Ontario, Canada M5S 2E3
    Br J Cancer 93:639-46. 2005
    ..We suggest that long-term intervention studies with tumour-related end points should be undertaken when the intervention agents used are found effective in short-term biochemical risk marker trials...
  4. ncbi Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats
    W Robert Bruce
    Department of Nutritional Sciences, University of Toronto, 150 College Street, Toronto, Ont M5S 3E2, Canada
    Cancer Lett 202:125-9. 2003
    ..Since typical Western diets can provide marginal levels of thiamin with high levels of simple sugars, individuals could be exposed to an increased risk of colon and perhaps other cancers...
  5. ncbi Counterpoint: From animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies
    W Robert Bruce
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Cancer Epidemiol Biomarkers Prev 12:401-4. 2003
    ....
  6. ncbi Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde
    Kai Yang
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Chem Biol Interact 191:315-21. 2011
    ..Iron chelators EGTA or deferoxamine inhibited cytotoxicity as well as the extensive ROS formation. The Girard assay confirmed that glyoxal was a common autoxidation product from glyceraldehyde, glycolaldehyde and hydroxypyruvate...
  7. ncbi Possible mechanisms relating diet to colorectal cancer risk
    W R Bruce
    Departments of Nutritional Sciences, Physiology and Pathology, University of Toronto, Canada
    IARC Sci Publ 156:277-81. 2002
  8. ncbi Fructose and carbonyl metabolites as endogenous toxins
    O Lee
    Department of Pharmacology, University of Toronto, Toronto, ON, Canada
    Chem Biol Interact 178:332-9. 2009
    ..The carbon radicals and glyoxal formed compromise the cell's resistance to H(2)O(2)...
  9. ncbi Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse
    D Naigamwalla
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 60:6856-8. 2000
    ..001). Although the chemopreventive effect of PEG 8000 in rats is remarkable, we suggest a cautious approach in long-term testing of PEG as a chemopreventive agent for subjects at risk for colonic neoplasia...
  10. ncbi Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways
    Flore Depeint
    Department of Pharmaceutical Sciences, University of Toronto, Canada Department of Nutritional Sciences, University of Toronto, Canada
    Chem Biol Interact 163:113-32. 2006
    ..The current experimental and clinical evidence that supplementation alleviates deficiency symptoms as well as the effectiveness of vitamins as antioxidants will also be reviewed...
  11. ncbi Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity
    Kai Yang
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Chem Biol Interact 191:322-9. 2011
    ..GO-caused cytotoxicity and protein carbonylation were also increased with ALDH2-inhibited hepatocytes whereas such an increase was only observed with MGO in GSH-depleted hepatocytes...
  12. ncbi Hepatocyte inflammation model for cytotoxicity research: fructose or glycolaldehyde as a source of endogenous toxins
    C Y Feng
    Department of Pharmacology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Arch Physiol Biochem 115:105-11. 2009
    ..Glyoxal was also the Fenton product responsible for glycolaldehyde protein carbonylation as carbonylation was prevented by aminoguanidine or Fenton inhibitors...
  13. ncbi Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats
    Thien T Tran
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Cancer Epidemiol Biomarkers Prev 12:47-56. 2003
    ..These correlations do not prove causality, however, they suggest possible mechanisms linking diet, insulin resistance with its related parameters, and promotion of CRC...
  14. ncbi Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism
    Flore Depeint
    Department of Pharmaceutical Sciences, University of Toronto, Canada; Department of Nutritional Sciences, University of Toronto, Canada
    Chem Biol Interact 163:94-112. 2006
    ..The effectiveness of B vitamins as antioxidants preventing oxidative stress toxicity is also reviewed...
  15. ncbi A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat
    Nandita Shangari
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ont M5S 3M2, Canada
    Chem Biol Interact 169:100-9. 2007
    ..This increased endogenous alpha-oxoaldehydes and oxidative stress has the potential to injure tissues that have low levels of antioxidant defenses such as the colon...
  16. ncbi Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo
    Thien T Tran
    Departments of Nutritional Sciences, University of Toronto, Canada
    Endocrinology 147:1830-7. 2006
    ..These results provide evidence for an acute role of insulin, at levels observed in insulin resistance, in the proliferation of colorectal epithelial cells in vivo...
  17. ncbi Toxicity of glyoxals--role of oxidative stress, metabolic detoxification and thiamine deficiency
    N Shangari
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 19 Russell St, Toronto, Ontario, Canada M5S 2S2
    Biochem Soc Trans 31:1390-3. 2003
    ....
  18. ncbi The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats
    Nandita Shangari
    Department of Pharmaceutical Sciences, University of Toronto, ON, Canada
    FEBS Lett 579:5596-602. 2005
    ..These observations are consistent with our suggestion that the induction of aberrant crypt foci with marginally thiamin-deficient diets may be a consequence of the formation of methylglyoxal adducts...
  19. ncbi Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat
    Denis E Corpet
    Universite de Toulouse, INRA, ENVT, UMR1089 Xenobiotiques, F 31076 Toulouse, France
    Food Chem Toxicol 46:3037-42. 2008
    ..These results do not support the notion that lysinoalanine or dehydroalanine are a hazard with respect to colon carcinogenicity...
  20. ncbi Polyethylene glycol reduces inflammation and aberrant crypt foci in carcinogen-initiated rats
    Pernilla C Karlsson
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Cancer Lett 223:203-9. 2005
    ..PEG may reduce colon carcinogenesis through a mechanism involving colonic inflammation...