P L Brubaker

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    P L Brubaker
    Room 3366, Medical Science Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 145:2653-9. 2004
  2. pmc Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression
    Yuanfang Liu
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, 101 College Street CCRW3 845, Toronto, Canada M5G 2C4
    Biochem J 366:633-41. 2002
  3. ncbi request reprint Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine
    Sean C McDonagh
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G461-8. 2007
  4. doi request reprint Life in the crypt: a role for glucagon-like peptide-2?
    Katherine J Rowland
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Mol Cell Endocrinol 288:63-70. 2008
  5. pmc GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    Lina M Lauffer
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 58:1058-66. 2009
  6. doi request reprint Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer
    Shivangi Trivedi
    Department of 1Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G840-9. 2012
  7. ncbi request reprint The glucagon-like peptides: pleiotropic regulators of nutrient homeostasis
    Patricia L Brubaker
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8 Canada
    Ann N Y Acad Sci 1070:10-26. 2006
  8. doi request reprint Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue
    Ganesh V Sangle
    Department of Physiology, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8 Canada
    Endocrinology 153:564-73. 2012
  9. doi request reprint Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell
    Andrew J Mulherin
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Endocrinology 152:4610-9. 2011
  10. ncbi request reprint Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
    Patricia L Brubaker
    Department of Physiology, University of Toronto, ON, Canada
    Can J Physiol Pharmacol 81:1005-12. 2003

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    P L Brubaker
    Room 3366, Medical Science Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 145:2653-9. 2004
    ..These proliferative and antiapoptotic actions of GLP-1 and GLP-2 may contribute to protective and regenerative actions of these peptides in human subjects with diabetes and intestinal disorders, respectively...
  2. pmc Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression
    Yuanfang Liu
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, 101 College Street CCRW3 845, Toronto, Canada M5G 2C4
    Biochem J 366:633-41. 2002
    ..These findings identify Foxa3 as a member of the proglucagon gene G2 element binding-protein family that, unlike Foxa1, is not essential for control of islet or intestinal proglucagon gene expression in vivo...
  3. ncbi request reprint Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine
    Sean C McDonagh
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G461-8. 2007
    ..Together, these findings demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon-like peptides to inhibit GI motility, but not in intestinal growth...
  4. doi request reprint Life in the crypt: a role for glucagon-like peptide-2?
    Katherine J Rowland
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Mol Cell Endocrinol 288:63-70. 2008
    ..This extrinsic pathway represents a novel mechanism by which intestinal stem cell dynamics may be regulated...
  5. pmc GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    Lina M Lauffer
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 58:1058-66. 2009
    ..We therefore hypothesized that OEA stimulates GLP-1 release through a GPR119-dependent mechanism...
  6. doi request reprint Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer
    Shivangi Trivedi
    Department of 1Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G840-9. 2012
    ..7 ± 8.6% (P < 0.05). In conclusion, the results of this study indicate a role for hGly(2)GLP-2 and endogenous GLP-2 as potential cancer promoters in rodents...
  7. ncbi request reprint The glucagon-like peptides: pleiotropic regulators of nutrient homeostasis
    Patricia L Brubaker
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8 Canada
    Ann N Y Acad Sci 1070:10-26. 2006
    ..When taken together, these findings demonstrate the diverse actions of the intestinal glucagon-like peptides to regulate nutrient homeostasis...
  8. doi request reprint Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue
    Ganesh V Sangle
    Department of Physiology, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8 Canada
    Endocrinology 153:564-73. 2012
    ..05-0.01). These studies demonstrate, for the first time, that sitagliptin exerts direct, DPP-IV-independent effects on intestinal L cells, activating cAMP and ERK1/2 signaling and stimulating total GLP-1 secretion...
  9. doi request reprint Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell
    Andrew J Mulherin
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Endocrinology 152:4610-9. 2011
    ..01) at 30 min. These studies elucidate the mechanism underlying metformin-induced GLP-1 secretion and highlight the benefits of using metformin with dipeptidylpeptidase-IV inhibitors in patients with type 2 diabetes...
  10. ncbi request reprint Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
    Patricia L Brubaker
    Department of Physiology, University of Toronto, ON, Canada
    Can J Physiol Pharmacol 81:1005-12. 2003
    ..In this review, we will focus on the complex integrative mechanisms that regulate the secretion of these peptides from L cells, including both direct and indirect regulation by ingested nutrients...
  11. ncbi request reprint Incretin-based therapies: mimetics versus protease inhibitors
    Patricia L Brubaker
    Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada
    Trends Endocrinol Metab 18:240-5. 2007
    ....
  12. doi request reprint Minireview: update on incretin biology: focus on glucagon-like peptide-1
    Patricia L Brubaker
    Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 151:1984-9. 2010
    ..A better understanding of the fundamental biology of GLP-1 may lead to new therapeutic modalities for the clinical use of this intestinal hormone...
  13. ncbi request reprint Adventure travel and type 1 diabetes: the complicating effects of high altitude
    Patricia L Brubaker
    Department of Physiology, Room 3366 Medical Sciences Bldg, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Diabetes Care 28:2563-72. 2005
  14. ncbi request reprint Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor
    Patricia L Brubaker
    Departments of Physiology, University of Toronto, Room 3366 Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Clin Endocrinol Metab 87:3078-83. 2002
    ..Overexpression of glucagon-like peptide-1 and -2 is associated with markedly prolonged gastrointestinal transit in humans. These findings are consistent with a role for these peptides in the regulation of gastrointestinal motility...
  15. ncbi request reprint Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2
    P L Brubaker
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocrinology 138:4837-43. 1997
    ..Thus, while GLP-2-(1-33) is a major circulating and tissue form of GLP-2, GLP-2-(3-33) is a significant component ofimmunoreactive GLP-2 in both intestine and plasma...
  16. ncbi request reprint Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line
    P L Brubaker
    Department of Physiology, Toronto Hospital, and Banting and Best Diabetes Center, University of Toronto, Ontario, Canada
    Endocrinology 139:4108-14. 1998
    ..Therefore, by comparison with results obtained using primary L cell cultures or in vivo models, GLUTag cells appear to respond appropriately to the regulatory mechanisms controlling intestinal GLP-1 secretion...
  17. ncbi request reprint Nutrient and peptide regulation of somatostatin-28 secretion from intestinal cultures
    P L Brubaker
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocrinology 139:148-55. 1998
    ..Thus, luminal nutrients and neuro/endocrine peptides exert differential effects on S28 release from the rat intestine compared with those on S14. These findings implicate S28 as a distinct regulatory peptide in the physiological setting...
  18. ncbi request reprint Truncated and full-length glucagon-like peptide-1 (GLP-1) differentially stimulate intestinal somatostatin release
    P L Brubaker
    Departments of Physiology and Medicine, University of Toronto, Canada
    Endocrine 6:91-5. 1997
    ..These findings define a novel biological role for GLP-1(7-36NH2) in the regulation of intestinal somatostatin secretion, and demonstrate that GLP-1(1-36NH2) exerts unique biological activities in this system...
  19. ncbi request reprint Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo
    Q Xiao
    Department of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada
    Biochemistry 40:2860-9. 2001
    ..Replacement of certain residues in the midchain of GLP-1 also augment biological activity...
  20. ncbi request reprint Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    Q Wang
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 45:1263-73. 2002
    ..We have therefore investigated the effects of glucagon-like peptide-1 on the development of diabetes, using db/db mice as a model of Type II diabetes...
  21. ncbi request reprint Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B
    L Li
    Department of Physiology, University of Toronto, Room 3366, Medical Sciences Building, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Diabetologia 48:1339-49. 2005
    ..In the present study we used rat INS-1E beta cells and primary rat islet cells to examine the potential role of PKB as a mediator of the effect of GLP-1 on cytokine-induced apoptosis...
  22. ncbi request reprint A glucagon-like peptide-1 receptor agonist and an antagonist modify macronutrient selection by rats
    C T Peters
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    J Nutr 131:2164-70. 2001
    ..In contrast, exendin 4 decreased intake of only the PRO diet. Thus, we suggest that peripheral GLP-1 plays a role in the regulation of macronutrient selection as well as food intake in rats...
  23. ncbi request reprint Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo
    F A Adatia
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 143:3464-71. 2002
    ..These findings may be useful for engineering cells that express a lizard pro-Ex4 transgene for the treatment of type 2 diabetes...
  24. ncbi request reprint Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    Q Wang
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 47:478-87. 2004
    ..Using a clonal rat pancreatic beta cell line (INS-1), we examined the role of protein kinase B in mediating beta-cell growth and survival stimulated by glucagon-like peptide-1...
  25. ncbi request reprint Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors
    P L Brubaker
    Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada
    Receptors Channels 8:179-88. 2002
    ..This article provides an overview of the biology of these receptors with an emphasis on understanding the unique actions of glucagon-related peptides through studies of the biology of their cognate receptors...
  26. ncbi request reprint beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    Yazhou Li
    Department of Medicine, University of Toronto, Banting and Best Diabetes Centre, Toronto General Hospital, 200 Elizabeth St, MBRW 4R402 2, Toronto, Canada M5G 2C4
    Diabetes 54:482-91. 2005
    ..These findings demonstrate that Pdx1 expression is essential for integrating GLP-1R-dependent signals regulating alpha-cell glucagon secretion and for the growth, differentiated function, and survival of islet beta-cells...
  27. ncbi request reprint Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells
    J A Lovshin
    Department of Medicine, University of Toronto, Toronto General Hospital, Banting and Best Diabetes Center, Canada
    Endocrinology 145:3495-506. 2004
    ..These findings establish the presence of a functional GLP-2-GLP-2R axis in the developing rodent brain and demonstrate that GLP-2 exerts cytoprotective actions in cells derived from the central nervous system...
  28. pmc The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties
    D M Irwin
    Department of Clinical Biochemistry, University of Toronto, Toronto, ON, Canada M5G IL5
    Proc Natl Acad Sci U S A 94:7915-20. 1997
    ..These results demonstrate that despite an average of nine amino acid differences between the predicted Xenopus GLPs and hGLP-1, all act as hGLP-1R agonists...
  29. ncbi request reprint Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV
    D J Drucker
    Department of Medicine, Toronto Hospital, University of Toronto, Ontario
    Nat Biotechnol 15:673-7. 1997
    ..Treatment of wild-type rats with r[Gly2]GLP-2 produced a statistically significant increase in small bowel mass. DPP-IV-mediated inactivation of GLP-2 is a critical determinant of the growth factor-like properties of GLP-2...
  30. ncbi request reprint Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    L A Scrocchi
    Department of Medicine, University of Toronto, Ontario
    Nat Med 2:1254-8. 1996
    ....
  31. ncbi request reprint Role of leptin in the regulation of glucagon-like peptide-1 secretion
    Younes Anini
    Department of Physiology, University of Toronto, Ontario, Canada
    Diabetes 52:252-9. 2003
    ..05). These results show for the first time that leptin stimulates GLP-1 secretion from rodent and human intestinal L cells, and they suggest that leptin resistance may account for the decreased levels of GLP-1 found in obese humans...
  32. ncbi request reprint Role of prohormone convertases in the tissue-specific processing of proglucagon
    S Dhanvantari
    Department of Physiology, University of Toronto, Ontario, Canada
    Mol Endocrinol 10:342-55. 1996
    ....
  33. ncbi request reprint Nutrient, neural and endocrine control of glucagon-like peptide secretion
    P E Dubé
    Department of Physiology, University of Toronto, ON M5S 1A8, Canada
    Horm Metab Res 36:755-60. 2004
    ..The purpose of this review is to discuss the regulation of GLP-1 and GLP-2 secretion in both health and disease...
  34. doi request reprint R-spondin1 deficiency in mice improves glycaemic control in association with increased beta cell mass
    V S C Wong
    Department of Physiology, Room 3366 Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, ON, Canada, M5S 1A8
    Diabetologia 54:1726-34. 2011
    ..We thus investigated the role of RSPO1 in beta cells in vivo using Rspo1 ( -/- ) mice...
  35. ncbi request reprint Mucosal adaptation to enteral nutrients is dependent on the physiologic actions of glucagon-like peptide-2 in mice
    Eric D Shin
    Department of Physiology, University of Toronto, Ontario, Canada
    Gastroenterology 128:1340-53. 2005
    ..However, the physiologic role of GLP-2 in mucosal growth and adaptation to nutritional stimulation remains poorly understood...
  36. ncbi request reprint Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium
    Denny K Y Trinh
    Department of Medicine, Banting and Best Diabetes Center, Toronto General Hospital, University of Toronto, Ontario, Canada
    Diabetes 52:425-33. 2003
    ..These data demonstrate that Pax-6, but not Cdx-2/3, is capable of activating the endogenous proglucagon gene in both immortalized enteroendocrine cells and the nontransformed intestinal epithelium in vivo...
  37. doi request reprint GPR119: "double-dipping" for better glycemic control
    L Lauffer
    Department of Physiology, University of Toronto, Medical Science Building, Room 3366, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 149:2035-7. 2008
  38. pmc Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells
    M A Poreba
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 303:E899-907. 2012
    ..01) but a normal response to intraileal OA. Together, these findings demonstrate a key role for FATP4 in OA-induced GLP-1 secretion from the murine L cell in vitro and in vivo, whereas the precise role of CD36 remains unclear...
  39. ncbi request reprint Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa
    Natalie A Walsh
    Department of Physiology, University of Toronto, Toronto, Canada M5S 1A8
    Endocrinology 144:4385-92. 2003
    ..These results provide the first evidence that activation of the endogenous rat mucosal GLP-2 receptor is linked to activation of a cAMP/protein kinase A-dependent, growth-promoting pathway in vitro...
  40. ncbi request reprint Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells
    Younes Anini
    Department of Physiology, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 144:3244-50. 2003
    ..These results demonstrate the role of M1 and M2 muscarinic receptors expressed by human L cells in the control of GLP-1 secretion...
  41. ncbi request reprint Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine
    Younes Anini
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8 Canada
    Am J Physiol Endocrinol Metab 292:E1599-606. 2007
    ..However, PI3-Kgamma is important for the enhancement of mucous cell number by GLP-2 and in the ability of the GLP-2 receptor to couple to cAMP in the enteric nervous system...
  42. ncbi request reprint Therapeutic potential of the intestinotropic hormone, glucagon-like peptide-2
    P L Brubaker
    Department of Physiology, University of Toronto, Ontario, Canada
    Ann Med 33:229-35. 2001
    ..The results of these studies indicate that GLP-2 is a promising therapeutic agent for the treatment of various forms of intestinal insufficiency in humans...
  43. ncbi request reprint Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats
    Younes Anini
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 143:2420-6. 2002
    ..M2 muscarinic receptors also seem to play a role in controlling GLP-1 secretion by fetal, but not adult, L cells...
  44. ncbi request reprint The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice
    Philip E Dubé
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 131:589-605. 2006
    ..We investigated the role of the insulin-like growth factors (IGF-1 and IGF-2) as mediators of GLP-2-enhanced growth in the murine intestine...
  45. ncbi request reprint PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP
    Liang Chen
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario
    FEBS J 272:2746-59. 2005
    ..Taken together, our observations suggest that Cdx-2 expression is regulated by the second messenger cAMP, cell-type specifically, via the Epac pathway...
  46. ncbi request reprint TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    Fenghua Yi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2M1, Canada
    J Biol Chem 280:1457-64. 2005
    ..We have therefore identified a unique mechanism that regulates glu expression in gut endocrine cells only. Tissue-specific expression of TCF factors thus may play a role in the diversity of the Wnt pathway...
  47. ncbi request reprint From cradle to grave: pancreatic beta-cell mass and glucagon-like peptide-1
    V S C Wong
    Department of Physiology, University of Toronto, ON, Canada
    Minerva Endocrinol 31:107-24. 2006
    ..These findings are considered in this review in the context of newer studies on the intestinal hormone, glucagon-like peptide-1, which not only enhances beta-cell function, but also stimulates beta-cell growth, neogenesis and survival...
  48. ncbi request reprint Glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis
    Marie Claude L'Heureux
    Department of Physiology, University of Toronto, Medical Sciences Building, Room 3366, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    J Pharmacol Exp Ther 306:347-54. 2003
    ....
  49. pmc R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue
    Victor S C Wong
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21292-302. 2010
    ..These findings suggest that Rspo1 and the cWnt signaling pathway may serve as a novel target to enhance beta-cell growth and function in patients with type 2 diabetes...
  50. ncbi request reprint Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1
    Li Xin Li
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 147:3318-25. 2006
    ..These studies reveal a new role for PI3-Kgamma as a positive regulator of insulin secretion, and reinforce the importance of GLP-1 for the maintenance of normal beta-cell function...
  51. ncbi request reprint Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators
    Philip E Dubé
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 293:E460-5. 2007
    ..Determining how GLP-2 produces its full range of biological effects, which mediators are involved, and how these mediators interact is a continuing area of active research...
  52. pmc Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts
    Jason L S Leen
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 152:436-46. 2011
    ....
  53. doi request reprint The "cryptic" mechanism of action of glucagon-like peptide-2
    Katherine J Rowland
    Department of Physiology, University of Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 301:G1-8. 2011
    ..Further consideration of the molecular cross-talk and downstream signaling pathways mediating the intestinotropic effects of GLP-2 is clearly warranted...
  54. doi request reprint Essential role for protein kinase Cζ in oleic acid-induced glucagon-like peptide-1 secretion in vivo in the rat
    Roman Iakoubov
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Endocrinology 152:1244-52. 2011
    ..PKCζ may therefore serve as a novel therapeutic target to enhance GLP-1 levels in patients with type 2 diabetes...
  55. ncbi request reprint A mathematical model of the oral glucose tolerance test illustrating the effects of the incretins
    Patricia L Brubaker
    Department of Physiology, University of Toronto, Toronto, Canada
    Ann Biomed Eng 35:1286-300. 2007
    ....
  56. ncbi request reprint Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice
    Tanvi Talsania
    Department of Physiology, Room 3366, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 146:3748-56. 2005
    ..These findings suggest that administration of low doses of Ex4 together with PYY(3-36NH2) may increase the suppression of FI without inducing significant side effects...
  57. ncbi request reprint Glucagon-like peptide-2 activates beta-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I
    Philip E Dubé
    Department of Physiology, University of Toronto, Ontario, Canada M5S 1A8
    Endocrinology 149:291-301. 2008
    ..However, IGF-I is required only for the GLP-2-induced alterations in beta-catenin...
  58. doi request reprint The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell
    Gareth E Lim
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 150:5249-61. 2009
    ..Taken together, these data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1, and GLP-1 secretion in response to insulin...
  59. doi request reprint Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36
    Joanne Hsieh
    Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 137:997-1005, 1005.e1-4. 2009
    ..We investigated the effects of GLP-2 on intestinal lipid absorption and lipoprotein production...
  60. ncbi request reprint Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding
    Gregg W Van Citters
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089 9142, USA
    J Clin Endocrinol Metab 87:5191-8. 2002
    ..Glucose is not the primary cause of hyperinsulinemia in the fat-fed dog. Corequisite meal-related signals may be permissive for development of hyperinsulinemia...
  61. ncbi request reprint Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells
    Zuyao Ni
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Ontario M5G 2M1, Canada
    J Biol Chem 278:1380-7. 2003
    ..These observations indicate that the proglucagon gene is among the targets of the Wnt signaling pathway...
  62. pmc Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
    Robert S Jackson
    Chemical Pathology Department, East Surrey Hospital, Surrey, United Kingdom
    J Clin Invest 112:1550-60. 2003
    ....