Robert Brownlie

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. doi request reprint Avian toll-like receptors
    Robert Brownlie
    Vaccine and Infectious Diseases Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, S7N 5E3, Canada
    Cell Tissue Res 343:121-30. 2011
  2. doi request reprint Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides
    Robert Brownlie
    Vaccine and Infectious Diseases Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:3163-70. 2009
  3. doi request reprint Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8
    Jianzhong Zhu
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:884-92. 2009
  4. doi request reprint Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization
    Jianzhong Zhu
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:978-90. 2009
  5. pmc Characterization of the nuclear localization and nuclear export signals of bovine herpesvirus 1 VP22
    Chunfu Zheng
    Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, Saskatchewan S7N 5E3, Canada
    J Virol 79:11864-72. 2005
  6. pmc Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system
    Francois Meurens
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Immunology 120:544-55. 2007
  7. ncbi request reprint Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9
    Jason Kindrachuk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Biol Chem 282:13944-53. 2007
  8. ncbi request reprint Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens
    Arshud Dar
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
    Avian Dis 56:73-81. 2012
  9. pmc Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response
    Katharina L Lohmann
    Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan Lohmann, Manning, Marqués, Sangster, Townsend Vaccine and Infectious Disease Organization VIDO International Vaccine Centre Inter Vac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan Lopez, Brownlie, Mutwiri, Gerdts, Potter, Townsend Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan Allen
    Can J Vet Res 77:161-9. 2013
  10. doi request reprint Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway
    Candice Jackel-Cram
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Gen Virol 91:1388-95. 2010

Collaborators

Detail Information

Publications13

  1. doi request reprint Avian toll-like receptors
    Robert Brownlie
    Vaccine and Infectious Diseases Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, S7N 5E3, Canada
    Cell Tissue Res 343:121-30. 2011
    ....
  2. doi request reprint Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides
    Robert Brownlie
    Vaccine and Infectious Diseases Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:3163-70. 2009
    ..We hypothesize that avian TLR21 plays a similar role to that of mammalian TLR9 and enables recognition of microbial DNA as a danger signal resulting in downstream innate and adaptive immune responses...
  3. doi request reprint Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8
    Jianzhong Zhu
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:884-92. 2009
    ..Our results suggest that multiple regions, including ECD, TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment...
  4. doi request reprint Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization
    Jianzhong Zhu
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:978-90. 2009
    ..A model for activation of bTLR8 was described based on these data...
  5. pmc Characterization of the nuclear localization and nuclear export signals of bovine herpesvirus 1 VP22
    Chunfu Zheng
    Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, Saskatchewan S7N 5E3, Canada
    J Virol 79:11864-72. 2005
    ..This demonstrates that this leucine-rich motif is a functional NES. These data represent the first identification of a functional NLS and NES in a herpesvirus VP22 homologue...
  6. pmc Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system
    Francois Meurens
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Immunology 120:544-55. 2007
    ..Consequently, we hypothesize that CCL25 and CCL28 play an important role in the lymphocyte colonization of fetal tissues, enabling the development of a functional immune system...
  7. ncbi request reprint Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9
    Jason Kindrachuk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Biol Chem 282:13944-53. 2007
    ..In each model receptor sensitivity is determined within the second step with the crucial distinction that Toll undergoes negative cooperativity, whereas TLR9 is sensitized through a positive cooperative effect...
  8. ncbi request reprint Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens
    Arshud Dar
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
    Avian Dis 56:73-81. 2012
    ....
  9. pmc Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response
    Katharina L Lohmann
    Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan Lohmann, Manning, Marqués, Sangster, Townsend Vaccine and Infectious Disease Organization VIDO International Vaccine Centre Inter Vac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan Lopez, Brownlie, Mutwiri, Gerdts, Potter, Townsend Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan Allen
    Can J Vet Res 77:161-9. 2013
    ..Postmortem lung severity scores did not differ between groups. Two foals shed virulent R. equi in feces; however, real-time polymerase chain reaction (PCR) revealed the isolates to be different from the challenge strain...
  10. doi request reprint Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway
    Candice Jackel-Cram
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Gen Virol 91:1388-95. 2010
    ..These results indicate a role for PI3K and Akt-2 in increasing SREBP-1 activity by HCV-3a core protein and provide a mechanism of steatosis caused by HCV...
  11. ncbi request reprint Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression
    Philip J Griebel
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
    Vet Immunol Immunopathol 108:11-6. 2005
    ..Collectively, these analyses revealed substantial conservation of TLR9 structure and TLR9 function in blood leukocytes of humans, cattle and other domestic species...
  12. ncbi request reprint Expression of TECK/CCL25 and MEC/CCL28 chemokines and their respective receptors CCR9 and CCR10 in porcine mucosal tissues
    Francois Meurens
    Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Vet Immunol Immunopathol 113:313-27. 2006
    ....
  13. ncbi request reprint Characterization of nuclear localization and export signals of the major tegument protein VP8 of bovine herpesvirus-1
    Chunfu Zheng
    Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 324:327-39. 2004
    ..This leucine-rich NES caused transport of YFP to the cytoplasm. These results demonstrate that VP8 shuttles between the nucleus and cytoplasm...