Gordon Broderick

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 28:159-69. 2013
  2. ncbi Systems biology of complex symptom profiles: capturing interactivity across behavior, brain and immune regulation
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 29:1-8. 2013
  3. ncbi Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
    Gordon Broderick
    Division of Pulmonary Medicine, Department of Medicine, University of Alberta, WMC 2E4 41 WC Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, AB T6G 2R7, Canada
    J Transl Med 10:191. 2012
  4. ncbi Exploring the diagnostic potential of immune biomarker coexpression in Gulf War Illness
    Gordon Broderick
    Department of Medicine, Division of Pulmonary Medicine, University of Alberta, Edmonton, AB, Canada
    Methods Mol Biol 934:145-64. 2012
  5. ncbi Using an agent-based model to analyze the dynamic communication network of the immune response
    Virginia A Folcik
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Davis Heart and Lung Research Institute, Columbus, OH, USA
    Theor Biol Med Model 8:1. 2011
  6. ncbi Extraction of elementary rate constants from global network analysis of E. coli central metabolism
    Jiao Zhao
    Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    BMC Syst Biol 2:41. 2008
  7. ncbi Identifying illness parameters in fatiguing syndromes using classical projection methods
    Gordon Broderick
    University of Alberta, Institute for Biomolecular Design, Edmonton, Alberta, T6G 2H7, Canada
    Pharmacogenomics 7:407-19. 2006
  8. ncbi Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood
    Anne L Aspler
    Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Behav Brain Funct 4:44. 2008
  9. ncbi A formal analysis of cytokine networks in chronic fatigue syndrome
    Gordon Broderick
    Division of Pulmonary Medicine, Department of Medicine, University of Alberta, College Plaza, 8215 112 Street NW, Edmonton, Alberta, Canada
    Brain Behav Immun 24:1209-17. 2010
  10. ncbi A pilot study of immune network remodeling under challenge in Gulf War Illness
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 25:302-13. 2011

Collaborators

  • Jiao Zhao
  • Suzanne D Vernon
  • Renee Taylor
  • MARY A FLETCHER
  • Ben Z Katz
  • Toni Whistler
  • J H Weiner
  • Douglas Ridgway
  • Michael J Ellison
  • Ana Lopez-Campistrous
  • Virginia A Folcik
  • Amos Ben-Zvi
  • Anne L Aspler
  • Jim Fuite
  • Chirantan Ekbote
  • Clay B Marsh
  • Brian Block
  • Marc Khoury
  • John Doolittle
  • Shunmugam Mohan
  • Luke Davis
  • Carly Bolshin
  • Matthew Hamilton
  • Melania Ru'aini
  • Pierre Boulanger
  • Philip Winter
  • Andriy Kovalenko
  • Stephen J Brokx
  • Taunja Palmer-Stone
  • Lorne Burke
  • Drell Bottorff
  • Sandra Bolch
  • Paul Semchuk

Detail Information

Publications16

  1. ncbi Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 28:159-69. 2013
    ..These exploratory results suggest an over-expression of known exercise response mechanisms as well as illness-specific changes that may involve an overlapping stress-potentiated neuro-inflammatory response...
  2. ncbi Systems biology of complex symptom profiles: capturing interactivity across behavior, brain and immune regulation
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 29:1-8. 2013
    ..While this work by no means constitutes an exhaustive list of all these methods, this work highlights the principal sub-disciplines presently driving the field as well as future directions of progress...
  3. ncbi Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
    Gordon Broderick
    Division of Pulmonary Medicine, Department of Medicine, University of Alberta, WMC 2E4 41 WC Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, AB T6G 2R7, Canada
    J Transl Med 10:191. 2012
    ..We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM). We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively...
  4. ncbi Exploring the diagnostic potential of immune biomarker coexpression in Gulf War Illness
    Gordon Broderick
    Department of Medicine, Division of Pulmonary Medicine, University of Alberta, Edmonton, AB, Canada
    Methods Mol Biol 934:145-64. 2012
    ..In a separate test set these same features allowed for discrimination of new GWI subjects (n = 16) from unhealthy (n = 9) and healthy control subjects with a sensitivity of 70% and a specificity of 90%...
  5. ncbi Using an agent-based model to analyze the dynamic communication network of the immune response
    Virginia A Folcik
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Davis Heart and Lung Research Institute, Columbus, OH, USA
    Theor Biol Med Model 8:1. 2011
    ..This model served to integrate existing knowledge and allowed us to examine the immune response from a novel perspective directed at exploiting complex dynamics, ultimately for the design of therapeutic interventions...
  6. ncbi Extraction of elementary rate constants from global network analysis of E. coli central metabolism
    Jiao Zhao
    Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    BMC Syst Biol 2:41. 2008
    ..There is therefore a need to develop a method which is capable of automatically transforming ARL kinetic information into more detailed MRL rate constants...
  7. ncbi Identifying illness parameters in fatiguing syndromes using classical projection methods
    Gordon Broderick
    University of Alberta, Institute for Biomolecular Design, Edmonton, Alberta, T6G 2H7, Canada
    Pharmacogenomics 7:407-19. 2006
    ....
  8. ncbi Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood
    Anne L Aspler
    Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Behav Brain Funct 4:44. 2008
    ..abstract:..
  9. ncbi A formal analysis of cytokine networks in chronic fatigue syndrome
    Gordon Broderick
    Division of Pulmonary Medicine, Department of Medicine, University of Alberta, College Plaza, 8215 112 Street NW, Edmonton, Alberta, Canada
    Brain Behav Immun 24:1209-17. 2010
    ..Furthermore this analysis identifies key sub-networks such as IL-2:IFN-γ:TNF-α that might be targeted in restoring normal immune function...
  10. ncbi A pilot study of immune network remodeling under challenge in Gulf War Illness
    Gordon Broderick
    Department of Medicine, University of Alberta, Edmonton, Canada
    Brain Behav Immun 25:302-13. 2011
    ..This potentially heightened lymphocyte and HPA axis responsiveness to IL-1 stimulation in the context of a mixed Th1:Th2 immune signature supports an autoimmune component in GWI etiology...
  11. ncbi Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis
    Jim Fuite
    Department of Medicine, Division of Pulmonary Faculty of Medicine and Dentistry, University of Alberta, 2E4 41 Walter Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, AB, Canada
    Genomics 92:393-9. 2008
    ..Findings align with known mechanisms of chronic inflammation and support possible immune-mediated loss of thyroid function in CFS exacerbated by blunted HPA axis responsiveness...
  12. ncbi Accommodating space, time and randomness in network simulation
    Douglas Ridgway
    Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Curr Opin Biotechnol 17:493-8. 2006
    ....
  13. ncbi A life-like virtual cell membrane using discrete automata
    Gordon Broderick
    Project CyberCell, Institute for Biomolecular Design, 3-67, Medical Sciences Bldg, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
    In Silico Biol 5:163-78. 2005
    ..The computational scalability of this methodology has been tested and results from benchmarking experiments indicate that real-time simulation of a complete bacterial cell will be possible within 10 years...
  14. ncbi Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction
    Amos Ben-Zvi
    Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
    PLoS Comput Biol 5:e1000273. 2009
    ....
  15. ncbi Coarse-grained molecular simulation of diffusion and reaction kinetics in a crowded virtual cytoplasm
    Douglas Ridgway
    Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta, Canada
    Biophys J 94:3748-59. 2008
    ..These observations illustrate that quantitative realism in biosimulation will depend to some extent on mesoscale phenomena that are not currently well understood...
  16. ncbi Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth
    Ana Lopez-Campistrous
    Institute for Biomolecular Design, 3-55 Medical Sciences Building, Alberta T6G 2H7, Canada
    Mol Cell Proteomics 4:1205-9. 2005
    ....