Dion R Brocks

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding
    Dion R Brocks
    Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada
    Biopharm Drug Dispos 23:9-15. 2002
  2. ncbi Rate and extent of drug accumulation after multiple dosing revisited
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    Clin Pharmacokinet 49:421-38. 2010
  3. ncbi Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Biopharm Drug Dispos 27:387-406. 2006
  4. ncbi The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biopharm Drug Dispos 27:7-16. 2006
  5. ncbi A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a commercially available internal standard and low sample volume
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 8:124-31. 2005
  6. ncbi Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Clin Pharmacokinet 42:1359-82. 2003
  7. ncbi Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Pharm Pharmacol 54:1049-53. 2002
  8. ncbi The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB Canada
    J Pharm Sci 91:1817-26. 2002
  9. ncbi Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Eur J Pharm Biopharm 75:90-5. 2010
  10. ncbi Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection
    Hesham M Korashy
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada
    Cancer Lett 258:135-43. 2007

Collaborators

Detail Information

Publications57

  1. ncbi Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding
    Dion R Brocks
    Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada
    Biopharm Drug Dispos 23:9-15. 2002
    ..In contrast, binding of HF enantiomers was non-stereoselective. The lower degree of stereoselectivity for DHF in heart tissues was attributable to its greater stereoselectivity in plasma protein binding...
  2. ncbi Rate and extent of drug accumulation after multiple dosing revisited
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    Clin Pharmacokinet 49:421-38. 2010
    ..In this article, drug accumulation is reviewed in a comprehensive manner, and the influences of the route of administration, nonlinear elimination and tissue concentrations are discussed...
  3. ncbi Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Biopharm Drug Dispos 27:387-406. 2006
    ..In this review data from a number of representative studies involving pharmacokinetics of chiral drugs are presented and discussed...
  4. ncbi The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biopharm Drug Dispos 27:7-16. 2006
    ..In humans and rats the pharmacokinetics of CyA in the face of increased lipoprotein levels do not correspond well to what is typically seen for other drugs that are known to bind to lipoproteins...
  5. ncbi A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a commercially available internal standard and low sample volume
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 8:124-31. 2005
    ..To develop an alternate high performance liquid chromatographic method (HPLC) for the analysis of the positive inotropic agent, milrinone, in rat and human plasma...
  6. ncbi Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Clin Pharmacokinet 42:1359-82. 2003
    ..It is concluded that knowledge of the stereoselective aspects of these agents may be helpful in better understanding their mechanisms of action and possibly optimising their clinical safety and/or effectiveness...
  7. ncbi Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    J Pharm Pharmacol 54:1049-53. 2002
    ..The ability of an encapsulated proliposomal product to significantly increase the oral absorption of HF was clearly demonstrated...
  8. ncbi The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB Canada
    J Pharm Sci 91:1817-26. 2002
    ....
  9. ncbi Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Eur J Pharm Biopharm 75:90-5. 2010
    ..27% versus 14.85%). Our results show that PEO-b-PCL micelles can efficiently solubilize valspodar and favorably modify its pharmacokinetic profile in rat after i.v. administration by decreasing the CL and Vd...
  10. ncbi Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection
    Hesham M Korashy
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada
    Cancer Lett 258:135-43. 2007
    ..This study provides the first evidence for the ability of KTZ and ITZ to induce the Nqo1 gene expression through an AhR-dependent mechanism...
  11. ncbi An analytical method for cyclosporine using liquid chromatography-mass spectrometry
    Srividya V Kanduru
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biomed Chromatogr 24:148-53. 2010
    ..The reported assay method displayed high measures of linearity, sensitivity, reliability and precision, allowing its applicability in pharmacokinetic studies in rat...
  12. ncbi The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes
    Marwa E Elsherbiny
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Toxicol Lett 195:147-54. 2010
    ..Amiodarone treatment did not affect basal or induced CYP1A activity...
  13. ncbi Effects of intestinal constituents and lipids on intestinal formation and pharmacokinetics of desethylamiodarone formed from amiodarone
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Alberta, Canada
    J Pharm Pharmacol 60:1625-32. 2008
    ....
  14. ncbi The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism
    Negar Gharavi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chirality 19:22-33. 2007
    ..In vivo, oral (+/-)-KTZ caused significant increases in plasma halofantrine and decreases in DHF enantiomer plasma concentrations...
  15. ncbi Nonlinear stereoselective pharmacokinetics of ketoconazole in rat after administration of racemate
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chirality 21:704-12. 2009
    ..Stereoselectivity in KTZ pharmacokinetics is attributable to plasma protein binding, although other processes such as transport or intestinal metabolism may also contribute...
  16. ncbi Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs
    Jigar P Patel
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chirality 22:275-83. 2010
    ..The results were consistent with previous in vivo evaluations showing that the desbutylhalofantrine to halofantrine ratio was decreased by the ingestion of a high fat meal...
  17. ncbi Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biopharm Drug Dispos 29:159-66. 2008
    ..Amiodarone and DEA differed in their pharmacokinetic characteristics mostly due to a higher CL of DEA. With oral dosing, AM appeared to undergo significant presystemic first-pass metabolism within the intestinal tract...
  18. ncbi Effect of gastric bypass surgery on azithromycin oral bioavailability
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Antimicrob Chemother 67:2203-6. 2012
    ..Gastric bypass, a procedure that circumvents the upper gut, may compromise azithromycin plasma levels. We hypothesized that azithromycin concentrations would be reduced following gastric bypass...
  19. ncbi Encapsulation of P-glycoprotein inhibitors by polymeric micelles can reduce their pharmacokinetic interactions with doxorubicin
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Eur J Pharm Biopharm 81:142-8. 2012
    ..In conclusion, encapsulation of cyclosporines, particularly valspodar, in polymeric micelles was shown to reduce their effects on the pharmacokinetics of DOX in rat...
  20. ncbi Characterization of the self assembly of methoxy poly(ethylene oxide)-block-poly(α-benzyl carboxylate-ε-caprolactone) for the solubilization and in vivo delivery of valspodar
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    Curr Drug Deliv 9:164-71. 2012
    ..In conclusion, the results show a potential for PEO-b-PBCL nanocarriers as efficient solubilizing agents for delivery of valspodar...
  21. ncbi The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Int J Pharm 361:78-86. 2008
    ..This experimental hyperlipidemia caused a complex pattern of changes in tissue distribution of AM. In addition, there are decreases in the expression of some important rat CYP isoenzymes...
  22. ncbi The effect of oral lipids and circulating lipoproteins on the metabolism of drugs
    Jigar P Patel
    University of Alberta, Dentistry Pharmacy Centre, Edmonton, Canada
    Expert Opin Drug Metab Toxicol 5:1385-98. 2009
    ..The components of lipoproteins may also modulate the expression or activity of hepatic and extrahepatic drug metabolizing enzymes...
  23. ncbi Disposition of drugs in block copolymer micelle delivery systems: from discovery to recovery
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Clin Pharmacokinet 47:619-34. 2008
    ....
  24. ncbi The effect of CYP1A induction on amiodarone disposition in the rat
    Marwa E Elsherbiny
    Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Sci 99:539-48. 2010
    ..9-, 2.5-, 3.8-, 3.4-, and 2.7-fold, respectively. In both groups of rats, the highest concentrations of AM and DEA were in the lung. Exposure to BNF was shown to increase DEA concentrations in the rat...
  25. ncbi The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine
    Jigar P Patel
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Sci 98:2516-28. 2009
    ..It would appear that both reduced plasma unbound fraction and lipoprotein associated directed uptake of lipoprotein-bound drug by tissues play roles in enantiomer biodistribution...
  26. ncbi The influence of hyperlipoproteinemia on in vitro distribution of amiodarone and desethylamiodarone in human and rat plasma
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, 3118 Dentistry Pharmacy Centre, University of Alberta, Edmonton, AB, Canada
    Pharm Res 24:672-8. 2007
    ..To study the effect of hyperlipoproteinemia on in vitro distribution of amiodarone (AM) and its prevalent metabolite desethylamiodarone (DEA) in human and rat plasma...
  27. ncbi Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada T6G 2N8
    Drug Metab Dispos 34:43-50. 2006
    ..v. treated rats. Although low to undetectable concentrations of DEA were a limitation for determination of AUC of DEA in vivo, it was confirmed that ketoconazole could cause a significant increase in AM concentrations in rat...
  28. ncbi The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Xenobiotica 41:137-43. 2011
    ..In conclusion, HL caused an increase in V(ss), and possibly decreased liver uptake of the more potent CYP-inhibiting (-) enantiomer...
  29. ncbi Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    J Pharm Sci 100:4986-92. 2011
    ..HL caused a more pronounced KTZ-associated inhibition of MDZ CL. This may be related to the decrease of MDZ's unbound fraction and perhaps to attenuation of CYP3A by HL in the rat...
  30. ncbi Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Biomaterials 26:7251-9. 2005
    ..Our results show that PEO-b-PCL micelles can effectively solubilize CsA, at the same time confining CsA to the blood circulation and restricting its access to tissues such as kidney, perhaps limiting the onset of toxicity...
  31. ncbi A liquid chromatography-mass spectrometry assay method for simultaneous determination of amiodarone and desethylamiodarone in rat specimens
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Biomed Chromatogr 21:284-90. 2007
    ..The method was successfully used to measure tissue and plasma concentrations of drug. The validated lower limit of quantitation was 2.5 ng/mL for drug and metabolite, based on 0.1 mL of plasma...
  32. ncbi Insights into the effects of hyperlipoproteinemia on cyclosporine A biodistribution and relationship to renal function
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    AAPS J 8:E672-81. 2006
    ....
  33. ncbi High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin
    Zengshuan Ma
    University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Biomed Chromatogr 21:546-52. 2007
    ..It was found that polymeric micelles increased the half-life of curcumin 162-fold that of solubilized curcumin and increased the volume of distribution (Vd(ss)) by 70-fold...
  34. ncbi A novel use of an in vitro method to predict the in vivo stability of block copolymer based nano-containers
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Control Release 122:63-70. 2007
    ..PEO-b-PCL micelles containing higher CyA-loaded levels are shown to be more stable changing the pharmacokinetics of the encapsulated CyA to a higher extent...
  35. ncbi Polymeric micellar delivery reduces kidney distribution and nephrotoxic effects of Cyclosporine A after multiple dosing
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    J Pharm Sci 97:1916-26. 2008
    ..Compared to Sandimmune, polymeric micelles reduced kidney uptake of CyA by 2.6-fold, and increased CyA levels in blood by 2.1-fold. The results show a potential for PEO-b-PCL micelles in restricting the nephrotoxicity of CyA...
  36. ncbi A stereospecific high-performance liquid chromatographic assay for the determination of ketoconazole enantiomers in rat plasma
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biomed Chromatogr 22:542-7. 2008
    ..In rats, plasma concentrations of (+)-KTZ were higher than those of antipode after single oral doses. The assay was shown to be sensitive and appropriate for use in pharmacokinetics study of KTZ in rat...
  37. ncbi The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole
    Marwa E Elsherbiny
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta
    J Pharm Pharm Sci 11:147-59. 2008
    ..To evaluate the metabolism of amiodarone (AM) to desethylamiodarone (DEA) by selected human and rat cytochrome P450, and the inhibitory effect of ketoconazole (KTZ)...
  38. ncbi The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition
    Marwa E Elsherbiny
    Department of Oncology, University of Alberta, Cross Cancer Institute, Canada
    Drug Metab Rev 43:457-75. 2011
    ..In this article, the pharmacokinetic properties of PAH, the possible mechanisms by which they can alter drug disposition, and specific examples are discussed...
  39. ncbi A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone
    Raniah Q Gabr
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Biomed Chromatogr 25:1124-31. 2011
    ..The method was highly specific, sensitive and applicable as a tool in detecting and monitoring the passive exposure to tobacco smoke using small specimen volumes (0.1 mL)...
  40. ncbi Effect of gastric bypass surgery on the absorption and bioavailability of metformin
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 34:1295-300. 2011
    ..Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin...
  41. ncbi Development of a liquid chromatography-mass spectrometry (LC/MS) assay method for the quantification of PSC 833 (Valspodar) in rat plasma
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 869:31-7. 2008
    ..PSC 833 and IS eluted within 4 min, free of interfering peaks. The method was found to be fast, sensitive, and specific for the quantification of PSC 833 in rat plasma...
  42. ncbi High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Biomed Anal 53:617-22. 2010
    ..5h, respectively. In conclusion, the assay was shown to be rapid, sensitive and appropriate for use in drug-drug interaction studies involving MDZ and KTZ in rat, and potentially in humans...
  43. ncbi Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines
    Hesham M Korashy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Toxicol Sci 97:32-43. 2007
    ..This study provides the first evidence for the ability of KTZ and ITZ to induce the CYP1A1 gene expression through an AhR-dependent mechanism, and suggests a novel mechanism of the KTZ- and ITZ-mediated toxicities...
  44. ncbi Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models
    Anooshirvan Shayeganpour
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biopharm Drug Dispos 26:249-57. 2005
    ....
  45. ncbi Assessment of the inactivation potential of desethylamiodarone on human CYP1A1
    Marwa E Elsherbiny
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Drug Metab Lett 4:9-14. 2010
    ..1 microM and 9.6 microM, respectively) of CYP1A1 by desethylamiodarone. NADPH addition and/or replenishment were found to be important factors in determining the control activity in inactivation studies...
  46. ncbi Pharmacokinetic characterization of intravenous cyclosporine treatment for cardioprotection during resuscitation of asphyxiated newborn piglets
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Crit Care Med 14:e156-62. 2013
    ..We aimed to assess the pharmacokinetics of a single intravenous cyclosporine treatment during resuscitation of asphyxiated newborn piglets and compare these parameters with healthy newborn piglets...
  47. ncbi Metformin and exercise in type 2 diabetes: examining treatment modality interactions
    Normand G Boule
    Faculty of Physical Education and Recreation, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    Diabetes Care 34:1469-74. 2011
    ....
  48. ncbi Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats
    Jigar P Patel
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Br J Pharmacol 161:1427-40. 2010
    ..Hyperlipidaemia elevates plasma concentration of halofantrine and may influence its tissue uptake. The present study examined the effect of experimental hyperlipidaemia on QT interval prolongation induced by halofantrine in rats...
  49. ncbi Experimental hyperlipidemia causes an increase in the electrocardiographic changes associated with amiodarone
    Dalia A Hamdy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Cardiovasc Pharmacol 53:1-8. 2009
    ..The cholesterol to triglyceride plasma ratio was linearly related to QT interval and plasma and heart AM concentrations. HL increased the ECG effects of AM by increasing heart concentrations...
  50. ncbi Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
    Dion R Brocks
    University of Alberta, Edmonton, Alberta, Canada
    J Pharm Sci 102:262-70. 2013
    ..When coincubated with serum, an additional effect of increased binding to lipoproteins seemed to further contribute to a reduced CL of AM...
  51. ncbi The effects of gastric bypass surgery on drug absorption and pharmacokinetics
    Dion R Brocks
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Expert Opin Drug Metab Toxicol 8:1505-19. 2012
    ..Drugs will differ in their pharmacokinetic response to surgery, limiting any general conclusions regarding the impact of the surgery on drug disposition...
  52. ncbi Cyclosporine treatment reduces oxygen free radical generation and oxidative stress in the brain of hypoxia-reoxygenated newborn piglets
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e40471. 2012
    ..Conclusively, post-resuscitation administration of cyclosporine significantly attenuates H(2)O(2) production and minimizes oxidative stress in newborn piglets following hypoxia-reoxygenation...
  53. ncbi Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma
    Ommoleila Molavi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 9:158-64. 2006
    ..CONCLUSION: The developed assay is sensitive, specific, reproducible and reliable for quantitative analysis of cucurbitacin I. Application in a pharmacokinetic assessment was proven in the rats given the drug...
  54. ncbi Determination of metformin in human plasma and urine by high-performance liquid chromatography using small sample volume and conventional octadecyl silane column
    Raniah Q Gabr
    University of Alberta, Edmonton, AB Canada
    J Pharm Pharm Sci 13:486-94. 2010
    ..To develop a selective and sensitive high-performance liquid chromatographic method for the determination of metformin in human plasma and urine, using a conventional reverse phase column and low specimen volume...
  55. ncbi Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs
    Reza Mehvar
    School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, USA
    Clin Pharmacokinet 41:533-58. 2002
    ..Because the effects of these drugs are related to their plasma concentrations, this information is of special clinical relevance...
  56. ncbi Metabolic acidosis: separation methods and biological relevance of organic acids and lactic acid enantiomers
    Julia B Ewaschuk
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 781:39-56. 2002
    ..Sample preparation techniques developed for these analytes are also discussed...
  57. ncbi Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
    Kishor M Wasan
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada V6T 1Z3
    Nat Rev Drug Discov 7:84-99. 2008
    ....