James D Brierley

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis
    Elliot Sampson
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Cancer 110:1451-6. 2007
  2. ncbi request reprint The value of collecting population-based cancer stage data to support decision-making at organizational, regional and population levels
    James D Brierley
    James D Brierley, MBBS, FRCPC, is a staff radiation oncologist in the Department of Radiation Oncology, University of Toronto, in Toronto, Ontario a member of the Radiation Medicine Program at Princess Margaret Hospital stage lead for Cancer Care Ontario CCO and surveillance lead for the Canadian Partnership Against Cancer CPAC Dr Brierley can be contacted at 416 946 2124 or by email at
    Healthc Q 16:27-33. 2013
  3. doi request reprint The role of external beam radiation and targeted therapy in thyroid cancer
    James Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada
    Semin Radiat Oncol 22:254-62. 2012
  4. ncbi request reprint Squamous cell carcinoma of the oesophagus treated with radiation and 5-fluorouracil, with and without mitomycin C
    J Brierley
    Princess Margaret Hospital Ontario Cancer Institute, Toronto, Canada
    Clin Oncol (R Coll Radiol) 13:157-63. 2001
  5. doi request reprint External beam radiation therapy for thyroid cancer
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada
    Endocrinol Metab Clin North Am 37:497-509, xi. 2008
  6. doi request reprint Rectal motion in patients receiving preoperative radiotherapy for carcinoma of the rectum
    James D Brierley
    Department of Radiation Medicine, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 80:97-102. 2011
  7. doi request reprint Update on external beam radiation therapy in thyroid cancer
    James D Brierley
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:2289-95. 2011
  8. ncbi request reprint The "y" symbol: an important classification tool for neoadjuvant cancer treatment
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 106:2526-7. 2006
  9. ncbi request reprint Prognostic factors and the effect of treatment with radioactive iodine and external beam radiation on patients with differentiated thyroid cancer seen at a single institution over 40 years
    J Brierley
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 63:418-27. 2005
  10. ncbi request reprint Outcome and toxicity of postoperative short course adjuvant radiation and chemotherapy following resection of adenocarcinoma of the rectum
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto Ontario, Canada
    Acta Oncol 43:567-70. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis
    Elliot Sampson
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Cancer 110:1451-6. 2007
    ..Differentiated thyroid cancer has a good prognosis and only rarely presents with distant metastasis at diagnosis. The clinical outcome of this presentation was assessed with respect to survival and factors that may determine prognosis...
  2. ncbi request reprint The value of collecting population-based cancer stage data to support decision-making at organizational, regional and population levels
    James D Brierley
    James D Brierley, MBBS, FRCPC, is a staff radiation oncologist in the Department of Radiation Oncology, University of Toronto, in Toronto, Ontario a member of the Radiation Medicine Program at Princess Margaret Hospital stage lead for Cancer Care Ontario CCO and surveillance lead for the Canadian Partnership Against Cancer CPAC Dr Brierley can be contacted at 416 946 2124 or by email at
    Healthc Q 16:27-33. 2013
    ..International comparisons can also be made. ..
  3. doi request reprint The role of external beam radiation and targeted therapy in thyroid cancer
    James Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada
    Semin Radiat Oncol 22:254-62. 2012
    ....
  4. ncbi request reprint Squamous cell carcinoma of the oesophagus treated with radiation and 5-fluorouracil, with and without mitomycin C
    J Brierley
    Princess Margaret Hospital Ontario Cancer Institute, Toronto, Canada
    Clin Oncol (R Coll Radiol) 13:157-63. 2001
    ..The treatment was well tolerated. Further studies are required to determine the most effective combination of radiation and chemotherapy or other radiation sensitizers for squamous cell carcinoma of the oesophagus...
  5. doi request reprint External beam radiation therapy for thyroid cancer
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada
    Endocrinol Metab Clin North Am 37:497-509, xi. 2008
    ..The use of XRT for the palliation of symptomatic disease and recent advances in the technology of radiation delivery also will be discussed...
  6. doi request reprint Rectal motion in patients receiving preoperative radiotherapy for carcinoma of the rectum
    James D Brierley
    Department of Radiation Medicine, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 80:97-102. 2011
    ..To assess the movement of rectum, mesorectum, and rectal primary during a course of preoperative chemoradiotherapy...
  7. doi request reprint Update on external beam radiation therapy in thyroid cancer
    James D Brierley
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:2289-95. 2011
    ..The important advances in the delivery of EBRT using intensity-modulated radiation and image-guided radiation that result in more accurate and potentially more effective radiation therapy with less toxicity are also discussed...
  8. ncbi request reprint The "y" symbol: an important classification tool for neoadjuvant cancer treatment
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 106:2526-7. 2006
  9. ncbi request reprint Prognostic factors and the effect of treatment with radioactive iodine and external beam radiation on patients with differentiated thyroid cancer seen at a single institution over 40 years
    J Brierley
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 63:418-27. 2005
    ..To assess the prognostic factors and the role of radioactive iodine (RAI) and external beam radiotherapy (RT) in patients with differentiated thyroid cancer...
  10. ncbi request reprint Outcome and toxicity of postoperative short course adjuvant radiation and chemotherapy following resection of adenocarcinoma of the rectum
    James D Brierley
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto Ontario, Canada
    Acta Oncol 43:567-70. 2004
    ..In view of the changes in surgical and pathological techniques in the last decade, further studies are required to determine the merits or otherwise of postoperative Short Course Adjuvant Radiation...
  11. ncbi request reprint Accuracy of recorded tumor, node, and metastasis stage in a comprehensive cancer center
    James D Brierley
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    J Clin Oncol 20:413-9. 2002
    ..An audit was performed to determine the accuracy of recorded stage and to act as a baseline before the implementation of an education program...
  12. pmc Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer--a randomized controlled trial
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Trials 11:81. 2010
    ..This decision is often difficult because of conflicting reports of RAI treatment benefit and medical evidence uncertainty due to the lack of long-term randomized controlled trials...
  13. ncbi request reprint Basis for physician recommendations for adjuvant radioiodine therapy in early-stage thyroid carcinoma: principal findings of the Canadian-American thyroid cancer survey
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network, Toronto, Ontario, Canada
    Endocr Pract 14:175-84. 2008
    ....
  14. doi request reprint An updated systematic review and commentary examining the effectiveness of radioactive iodine remnant ablation in well-differentiated thyroid cancer
    Anna M Sawka
    Department of Medicine, Division of Endocrinology, University Health Network, Toronto, ON, Canada
    Endocrinol Metab Clin North Am 37:457-80, x. 2008
    ..The incremental benefit of RRA in low risk patients with well-differentiated thyroid cancer after total or near-total thyroidectomy who are receiving thyroid hormone suppressive therapy remains unclear...
  15. doi request reprint A usability study of a computerized decision aid to help patients with, early stage papillary thyroid carcinoma in, decision-making on adjuvant radioactive iodine treatment
    Anna M Sawka
    Department of Medicine, University Health Network Toronto General Hospital, Toronto, Canada
    Patient Educ Couns 84:e24-7. 2011
    ..This decision is complicated by uncertainty of the medical evidence relating to potential treatment benefits...
  16. doi request reprint A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 69:479-90. 2008
    ..For women with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gonadal and reproductive function is an important consideration...
  17. pmc The impact of thyroid cancer and post-surgical radioactive iodine treatment on the lives of thyroid cancer survivors: a qualitative study
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 4:e4191. 2009
    ..Participants provided recommendations for healthcare providers on counseling future patients on adjuvant RAI treatment...
  18. doi request reprint Patients' experiences following local-regional recurrence of thyroid cancer: a qualitative study
    Shikha Misra
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Surg Oncol 108:47-51. 2013
    ..The psychosocial impact of local-regional thyroid cancer recurrence is not known. The aim of this study was to explore thyroid cancer patients' experiences relating to diagnosis and treatment of local-regional disease recurrence...
  19. doi request reprint Randomized controlled trial of a computerized decision aid on adjuvant radioactive iodine treatment for patients with early-stage papillary thyroid cancer
    Anna M Sawka
    University Health Network and University of Toronto, Toronto General Hospital, 200 Elizabeth St, 12 EN 212, Toronto, Ontario, Canada M5G 2C4
    J Clin Oncol 30:2906-11. 2012
    ..The DA describes the rationale, possible risks and benefits, and the medical evidence uncertainty relating to the choice...
  20. ncbi request reprint Regional differences in opinions on adjuvant radioactive iodine treatment of thyroid carcinoma within Canada and the United States
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network Toronto, Ontario, Canada
    Thyroid 17:1235-42. 2007
    ..To identify regional differences in recommendations for radioactive iodine remnant ablation (RRA) in early stage well-differentiated thyroid carcinoma (WDTC) within Canada and the United States...
  21. doi request reprint Second primary malignancy risk after radioactive iodine treatment for thyroid cancer: a systematic review and meta-analysis
    Anna M Sawka
    Division of Endocrinology and Department of Medicine, University Health Network, Toronto, Ontario, Canada
    Thyroid 19:451-7. 2009
    ..Our objective was to determine if the risk of SPMs is increased in individuals with thyroid cancer treated with radioactive iodine (RAI), compared to those not treated with RAI...
  22. ncbi request reprint A systematic review of the gonadal effects of therapeutic radioactive iodine in male thyroid cancer survivors
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 68:610-7. 2008
    ..For patients with well-differentiated thyroid carcinoma (WDTC), the gonadal effects of radioactive iodine (RAI) therapy is an important consideration...
  23. pmc Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review
    Anna M Sawka
    Division of Endocrinology, Department of Medicine, University Health Network, 200 Elizabeth St, Toronto, Ontario, Canada
    Thyroid 20:1129-38. 2010
    ....
  24. doi request reprint A randomized controlled trial of lorazepam to reduce liver motion in patients receiving upper abdominal radiation therapy
    Derek S Tsang
    Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Toronto, Canada
    Int J Radiat Oncol Biol Phys 87:881-7. 2013
    ..We hypothesized that pretreatment lorazepam would lead to a measurable reduction of liver motion...
  25. ncbi request reprint Changing physician practice: an evaluation of knowledge transfer strategies to enhance physician documentation of cancer stage
    Sara Lankshear
    Stage Capture Project, Cancer Care Ontario, Toronto, Ontario
    Healthc Q 13:84-92. 2010
    ..Evaluation results reveal an increase in the provincial cancer stage data from 30 to 68%. The information presented here will be of interest to organizations implementing practice changes requiring physician engagement...
  26. ncbi request reprint The consistency of panelists' appropriateness ratings: do experts produce clinically logical scores for rectal cancer treatment?
    David C Hodgson
    Department of Radiation Oncology, Princess Margaret Hospital, 610 University Ave, Toronto, Ont, Canada M5G 2M9
    Health Policy 71:57-65. 2005
    ..To quantify the clinical consistency of expert panelists' ratings of appropriateness of pre-operative and post-operative chemotherapy plus radiation for rectal cancer...
  27. ncbi request reprint Malignant teratoma of the thyroid: aggressive chemoradiation therapy is required after surgery
    Richard W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Thyroid 13:401-4. 2003
    ..This case and the modern experience of combined modality therapy in extragonadal germ cell tumors of the thyroid and other sites illustrate that these tumors should be managed aggressively in order to achieve best results...
  28. ncbi request reprint Outcomes of patients with differentiated thyroid carcinoma following initial therapy
    Jacqueline Jonklaas
    Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 16:1229-42. 2006
    ..We were unable to show any impact, positive or negative, of specific therapies in stage I patients...
  29. ncbi request reprint Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis
    Shoba Subramanian
    Endocrinology, Stanford University, Palo Alto, California, USA
    Thyroid 17:1277-88. 2007
    ..To determine the risk of second primary malignancies (SPMs) in thyroid cancer survivors...