Rod Bremner

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Subretinal gene delivery using helper-dependent adenoviral vectors
    Linda Wu
    Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
    Cell Biosci 1:15. 2011
  2. doi request reprint Retinoblastoma, an inside job
    Rod Bremner
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Cell 137:992-4. 2009
  3. ncbi request reprint The RB protein family in retinal development and retinoblastoma: new insights from new mouse models
    Rod Bremner
    Toronto Western Research Institute, University Health Network, Rm Mc6 424, 399 Bathurst Street, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    Dev Neurosci 26:417-34. 2004
  4. doi request reprint Cyclins, Cdks, E2f, Skp2, and more at the first international RB Tumor Suppressor Meeting
    Rod Bremner
    Toronto Western Research Institute, Toronto, Ontario, Canada
    Cancer Res 70:6114-8. 2010
  5. pmc Division and apoptosis of E2f-deficient retinal progenitors
    Danian Chen
    Toronto Western Research Institute, University Health Network, Department of Ophthalmology, and Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5T 2S8, Canada
    Nature 462:925-9. 2009
  6. doi request reprint The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers
    Zuyao Ni
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada
    Nat Immunol 9:785-93. 2008
  7. pmc Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina
    Izzy Livne-Bar
    Toronto Western Research Institute, University Health Network
    Proc Natl Acad Sci U S A 103:4988-93. 2006
  8. ncbi request reprint CHX10 targets a subset of photoreceptor genes
    Kimberley M Dorval
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    J Biol Chem 281:744-51. 2006
  9. pmc Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a
    Danian Chen
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
    PLoS Biol 5:e179. 2007
  10. pmc Maximizing functional photoreceptor differentiation from adult human retinal stem cells
    Tomoyuki Inoue
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 28:489-500. 2010

Collaborators

Detail Information

Publications26

  1. pmc Subretinal gene delivery using helper-dependent adenoviral vectors
    Linda Wu
    Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
    Cell Biosci 1:15. 2011
    ..Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector...
  2. doi request reprint Retinoblastoma, an inside job
    Rod Bremner
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Cell 137:992-4. 2009
    ..Why are some cell types more prone to transformation than others? In this issue, Xu et al. (2009) show that retinoblastoma cells co-opt several intrinsic features of cone photoreceptors for their survival and growth...
  3. ncbi request reprint The RB protein family in retinal development and retinoblastoma: new insights from new mouse models
    Rod Bremner
    Toronto Western Research Institute, University Health Network, Rm Mc6 424, 399 Bathurst Street, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    Dev Neurosci 26:417-34. 2004
    ..The new mouse models of retinoblastoma will be invaluable for testing these possibilities...
  4. doi request reprint Cyclins, Cdks, E2f, Skp2, and more at the first international RB Tumor Suppressor Meeting
    Rod Bremner
    Toronto Western Research Institute, Toronto, Ontario, Canada
    Cancer Res 70:6114-8. 2010
    ..We summarize major new breakthroughs and emerging trends presented at the meeting...
  5. pmc Division and apoptosis of E2f-deficient retinal progenitors
    Danian Chen
    Toronto Western Research Institute, University Health Network, Department of Ophthalmology, and Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5T 2S8, Canada
    Nature 462:925-9. 2009
    ..Thus, activating E2fs are not universally required for normal mammalian cell division, but have an unexpected pro-survival role in development...
  6. doi request reprint The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers
    Zuyao Ni
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada
    Nat Immunol 9:785-93. 2008
    ..Like BRG1, each remote element was critical for the induction of CIITA expression. Thus, BRG1 regulates CIITA through many interdependent remote enhancers, not through the promoter alone...
  7. pmc Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina
    Izzy Livne-Bar
    Toronto Western Research Institute, University Health Network
    Proc Natl Acad Sci U S A 103:4988-93. 2006
    ..Thus, Chx10 directly controls bipolar cell genesis by inhibiting rod differentiation independent of its temporally limited early effect on RPC proliferation...
  8. ncbi request reprint CHX10 targets a subset of photoreceptor genes
    Kimberley M Dorval
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    J Biol Chem 281:744-51. 2006
    ..Our data suggest that CHX10 may target these motifs to inhibit rod photoreceptor gene expression in bipolar cells...
  9. pmc Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a
    Danian Chen
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
    PLoS Biol 5:e179. 2007
    ..These data reveal a mechanism through which Rb regulates neural differentiation directly, and, unexpectedly, it involves inhibition of E2f3a, not potentiation of tissue-specific factors...
  10. pmc Maximizing functional photoreceptor differentiation from adult human retinal stem cells
    Tomoyuki Inoue
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 28:489-500. 2010
    ..This study suggests that gene modulation in human RSCs may provide a source of photoreceptor cells for the treatment of photoreceptor disease...
  11. ncbi request reprint Brahma-related gene 1-dependent STAT3 recruitment at IL-6-inducible genes
    Zuyao Ni
    Toronto Western Research Institute, University Health Network, Department of Ophthalmology and Vision Science, Vision Science Research Program, University of Toronto, Ontario, Canada
    J Immunol 178:345-51. 2007
    ....
  12. ncbi request reprint Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1
    Kimberley M Dorval
    Toronto Western Research Institute, University Health Network Program, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 280:10100-8. 2005
    ..Therefore, CHX10 and VSX1 may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types...
  13. ncbi request reprint Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    Danian Chen
    Toronto Western Research Institute, University Health Network, Vision Science Research Program, Department of Ophthalmology and Visual Sciences, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8
    Cancer Cell 5:539-51. 2004
    ..We suggest that additional lesions common in retinoblastoma overcome growth arrest, not apoptosis...
  14. doi request reprint Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons
    Marek Pacal
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Dev Dyn 241:1525-44. 2012
    ..Here, we timed cell cycle and neuronal protein silencing/induction during cell birth in the developing murine retina...
  15. ncbi request reprint Retinoblastoma protein purification and transduction of retina and retinoblastoma cells using improved alphavirus vectors
    David P Diciommo
    Ontario Cancer Institute Cancer Informatics, University Health Network, Toronto, Canada
    Invest Ophthalmol Vis Sci 45:3320-9. 2004
    ..To develop and use improved Semliki Forest vectors (SFVs) for functional and structural analyses of the retinoblastoma protein (RB) in developing retina and retinoblastoma cells...
  16. pmc A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence
    Srikanth Talluri
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 30:948-60. 2010
    ..Remarkably, this reveals that pRB recruits chromatin regulators primarily to engage a stress-responsive G(1) arrest program...
  17. doi request reprint The double-stranded RNA-binding protein Staufen 2 regulates eye size
    Diane M Cockburn
    Toronto Western Research Institute, Genetics and Development Division, MCL 6 415, Toronto M5T 2S8, Ontario, Canada
    Mol Cell Neurosci 51:101-11. 2012
    ..These data highlight a new biological function for Stau2 and suggest that translation control of specific Stau2-associated transcripts may be a key regulator of tissue size...
  18. ncbi request reprint Insights from animal models on the origins and progression of retinoblastoma
    Marek Pacal
    Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Room Mc6 424, Toronto, Ontario, M5T 2S8 Canada
    Curr Mol Med 6:759-81. 2006
    ..Two years have dramatically improved our understanding of Rb function in the tissue that gave us this important tumor suppressor...
  19. ncbi request reprint Direct and indirect effects of hedgehog pathway activation in the mammalian retina
    Chuan Yu
    Molecular Medicine Program, Ottawa Health Research Institute and University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Mol Cell Neurosci 32:274-82. 2006
    ..SMO-M2 expression also inhibited rhodopsin expression in uninfected cells, thus highlighting an unexpected non-cell autonomous effect of Hh pathway activation on photoreceptor development...
  20. pmc Apical role for BRG1 in cytokine-induced promoter assembly
    Zuyao Ni
    Toronto Western Research Institute, University Health Network, Department of Ophthalmology and Vision Science, Vision Science Research Program, University of Toronto, Toronto, ON, Canada M5T 2S8
    Proc Natl Acad Sci U S A 102:14611-6. 2005
    ..Furthermore, BRG1 is required for IFN-induced restriction enzyme and DNase I accessibility at promoters. Thus, BRG1 has an apical role in cytokine-induced promoter assembly, acting upstream of STAT complexes at multiple IFN target loci...
  21. ncbi request reprint VSX1: a gene for posterior polymorphous dystrophy and keratoconus
    Elise Heon
    Cellular and Molecular Division, Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Hum Mol Genet 11:1029-36. 2002
    ..These data define the molecular basis of two important corneal dystrophies and reveal the importance of the CVC domain in the human retina...
  22. doi request reprint Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319
    Jillian M Couto
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 153:447-62. 2010
    ..Our data indicates that this putative regulatory region is a likely site of genetic variation contributing to RD in our sample, further narrowing the candidate region...
  23. ncbi request reprint The search for the retinoblastoma cell of origin
    Michael A Dyer
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Cancer 5:91-101. 2005
    ..Identifying the cell of origin for this tumour would advance our understanding of how cellular context affects the requirement of specific mutations for cancer initiation and progression...
  24. pmc Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly
    Daniel L Popkin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14309-14. 2003
    ....
  25. ncbi request reprint Re: Update on retinoblastoma
    Rod Bremner
    Retina 25:950-1; author reply 951-2. 2005
  26. pmc Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions
    Kelly A McClellan
    Department of Cellular and Molecular Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
    Mol Cell Biol 27:4825-43. 2007
    ..This study not only outlines overlapping and distinct functions for E2Fs in neurogenesis but also is the first to establish a physiologically relevant role for the Rb/E2F pathway beyond cell cycle regulation in vivo...