Donald R Branch

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury
    Newton Cho
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Center, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    J Neuroinflammation 9:134. 2012
  2. doi request reprint Solving the dilemma of prevention of red cell alloimmunization
    Donald R Branch
    Department of Medicine, Division of Hematology, University of Toronto, Toronto, Ontario, Canada
    Immunotherapy 4:903-5. 2012
  3. ncbi request reprint Antenatal administration of Rh-immune globulin causes significant increases in the immunomodulatory cytokines transforming growth factor-beta and prostaglandin E2
    Donald R Branch
    Transfusion Immunology Hub, Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 46:1316-22. 2006
  4. doi request reprint Unexpected suppression of anti-Fya and prevention of hemolytic disease of the fetus and newborn after administration of Rh immune globulin
    Donald R Branch
    Canadian Blood Services, 67 College Street, Toronto, Ontario, M5G 2M1, Canada
    Transfusion 51:816-9. 2011
  5. doi request reprint Blood groups and susceptibility to virus infection: new developments
    Donald R Branch
    Research and Development, Canadian Blood Services, Department of Medicine, Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Hematol 17:558-64. 2010
  6. ncbi request reprint Gender-selective toxicity of thimerosal
    Donald R Branch
    Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Exp Toxicol Pathol 61:133-6. 2009
  7. pmc Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro
    Pei Lin Shi
    Department of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada
    Toxins (Basel) 4:1517-34. 2012
  8. doi request reprint The human P(k) histo-blood group antigen provides protection against HIV-1 infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Blood 113:4980-91. 2009
  9. ncbi request reprint Chemical treatment of anti-D results in improved efficacy for the inhibition of Fcgamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 47:2250-9. 2007
  10. ncbi request reprint HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor
    Payman Baradar Bokaei
    The Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5G 2M1
    Virology 362:38-49. 2007

Collaborators

Detail Information

Publications39

  1. pmc Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury
    Newton Cho
    Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, Krembil Neuroscience Center, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    J Neuroinflammation 9:134. 2012
    ..Since members of the gp130 family all share a common signal transduction pathway via the JAK/STAT system, we performed the first study of a relatively new member of the gp130 family, IL-11, in SCI...
  2. doi request reprint Solving the dilemma of prevention of red cell alloimmunization
    Donald R Branch
    Department of Medicine, Division of Hematology, University of Toronto, Toronto, Ontario, Canada
    Immunotherapy 4:903-5. 2012
    ..These results open the door for therapies aimed at the prevention and/or treatment of alloimmunization in both a transfusion setting and, importantly, in hemolytic disease of the fetus and newborn...
  3. ncbi request reprint Antenatal administration of Rh-immune globulin causes significant increases in the immunomodulatory cytokines transforming growth factor-beta and prostaglandin E2
    Donald R Branch
    Transfusion Immunology Hub, Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 46:1316-22. 2006
    ..Production of specific cytokines in response to administration of Rh-immune globulin (RhIG) was examined to assess the mechanism of inhibition of the anti-D production and prevention of hemolytic disease of the newborn (HDN)...
  4. doi request reprint Unexpected suppression of anti-Fya and prevention of hemolytic disease of the fetus and newborn after administration of Rh immune globulin
    Donald R Branch
    Canadian Blood Services, 67 College Street, Toronto, Ontario, M5G 2M1, Canada
    Transfusion 51:816-9. 2011
    ..It was suggested that induction of TGFβ-1 and immunosuppression may be independent of cognate antigen recognition by RhIG. Herein, we present a description of a mother and baby that supports this hypothesis...
  5. doi request reprint Blood groups and susceptibility to virus infection: new developments
    Donald R Branch
    Research and Development, Canadian Blood Services, Department of Medicine, Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Hematol 17:558-64. 2010
    ..These recent findings have raised additional questions regarding the possible role of the P/Gb3 histo-blood group antigen in HIV-1 infection...
  6. ncbi request reprint Gender-selective toxicity of thimerosal
    Donald R Branch
    Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Exp Toxicol Pathol 61:133-6. 2009
    ....
  7. pmc Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro
    Pei Lin Shi
    Department of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada
    Toxins (Basel) 4:1517-34. 2012
    ..VT blocked HDAC inhibitor enhancement of HIV infection, consistent with a histone-mediated mechanism. We speculate that VT1A may provide a benign approach to reduction of (X4 or R5) HIV cell susceptibility...
  8. doi request reprint The human P(k) histo-blood group antigen provides protection against HIV-1 infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Blood 113:4980-91. 2009
    ..We conclude that P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P(k) as a new endogenous cell-surface factor that may provide protection against HIV-1 infection...
  9. ncbi request reprint Chemical treatment of anti-D results in improved efficacy for the inhibition of Fcgamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 47:2250-9. 2007
    ..If successful, this approach may provide the possibility of targeting these chemicals to monocyte-macrophages for increased efficacy of immunoglobulin-based therapies in vivo...
  10. ncbi request reprint HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor
    Payman Baradar Bokaei
    The Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5G 2M1
    Virology 362:38-49. 2007
    ..These data reveal that VPAC2 agonists are appropriate candidates for further study as possible treatments aimed at the amelioration of HIV/AIDS...
  11. doi request reprint Induction of HIV-1 resistance: cell susceptibility to infection is an inverse function of globotriaosyl ceramide levels
    Stephanie Ramkumar
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Glycobiology 19:76-82. 2009
    ..Variable Gb(3) expression may provide a natural HIV resistance factor in the general population, and pharmacological manipulation of Gb(3) levels may provide an approach to induction of HIV resistance...
  12. doi request reprint A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms
    Amanda L Harrison
    Canadian Blood Services Research and Development Toronto General Research Institute, 67 College St, Toronto, Ontario, M5G 2M1, Canada
    Glycoconj J 27:515-24. 2010
    ....
  13. ncbi request reprint Structure-function studies for in vitro chemical inhibition of Fc gamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Division of Cell and Molecular Biology, Toronto General Research Institute, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 47:290-8. 2007
    ....
  14. doi request reprint CD4(+) T-cells are unable to express the HIV natural resistance factor globotriosylceramide
    Minji Kim
    aDepartment of Medicine, University of Toronto bMolecular Structure and Function, Hospital for Sick Children Research Institute cCanadian Blood Services, Research and Development dDepartments of Laboratory Medicine and Pathobiology, and Biochemistry, University of Toronto, Toronto, Ontario M5G 2M1, Canada
    AIDS 27:1029-32. 2013
    ..Thus, HIV treatment or prevention strategies must focus on development of soluble Gb(3) analogues for inhibition of HIV infection...
  15. ncbi request reprint Comparison of detection methods for cell surface globotriaosylceramide
    Minji Kim
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    J Immunol Methods 371:48-60. 2011
    ....
  16. doi request reprint Reduction of disulfide bonds within anti-D results in enhanced Fcgamma receptor blockade
    Andrew S Kruspe
    Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Transfusion 49:928-36. 2009
    ..If successful, this would provide a rationale to explore this mechanism of enhancing FcgammaR blockade for future use in immunoglobulin therapies for immune cytopenias...
  17. doi request reprint Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells
    Meena K Purohit
    Center for Molecular Design and Preformulations, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7
    Bioorg Med Chem Lett 23:2324-7. 2013
    ..Confirmation of the disulfide bridge additionally provides clues for the non-thiol or non-disulfide bridge carrying ligands targeting ITP and other similar disorders...
  18. ncbi request reprint A novel soluble mimic of the glycolipid, globotriaosyl ceramide inhibits HIV infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    AIDS 20:333-43. 2006
    ..To determine the effect of a gp120 binding, non-cytotoxic soluble analogue of the glycosphingolipid (GSL), globotriaosyl ceramide (Gb3) on HIV infection in vitro...
  19. ncbi request reprint Constitutively polarized granules prime KHYG-1 NK cells
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Suite 5 211, Toronto, ON M5G2M9, Canada
    Int Immunol 18:1347-54. 2006
    ..Thus, a functional role for NKG2D in KHYG-1 cytotoxicity is demonstrated. Moreover, the novel primed state may contribute to the high cytotoxicity exhibited by KHYG-1...
  20. ncbi request reprint c-Src and Pyk2 protein tyrosine kinases play protective roles in early HIV-1 infection of CD4+ T-cell lines
    Stephen D S McCarthy
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Department of Microbiology and Biochemistry, Laval University, Quebec, Canada Centre for Innovation, Canadian Blood Services, Toronto, Canada and Division of Advanced Diagnostics, Infection and Immunity Group, Toronto General Research Institute, Toronto, Canada
    J Acquir Immune Defic Syndr 66:118-26. 2014
    ..Whether their activation facilitates or impedes infection remains to be determined...
  21. pmc ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes
    Kayla T Wolofsky
    Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 8:e1002942. 2012
    ..These data provide the first evidence that ABO blood group antigens influence macrophage clearance of P. falciparum-infected erythrocytes and suggest an additional mechanism by which blood group O may confer resistance to severe malaria...
  22. ncbi request reprint Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors
    Payman Baradar Bokaei
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 1A8
    Genomics 88:791-800. 2006
    ..The identification of these splice variants in various cells and their expression and differential signal transduction compared to the 7TM form suggest that these novel receptors have biological relevance...
  23. doi request reprint Acute hemolysis after intravenous immunoglobulin amid host factors of ABO-mismatched bone marrow transplantation, inflammation, and activated mononuclear phagocytes
    Fotios V Michelis
    Blood and Marrow Transplant Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada Research and Development, Canadian Blood Services, Toronto, Ontario, Canada Transfusion Medicine Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transfusion 54:681-90. 2014
    ..Hemolysis may follow intravenous immunoglobulin (IVIG), with product, dosing, and host factors contributing. The importance of recipient features remains unclear...
  24. doi request reprint Characterization of SHP-1 protein tyrosine phosphatase transcripts, protein isoforms and phosphatase activity in epithelial cancer cells
    Sevan Evren
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 2M1, Canada Department of Medicine, University of Toronto, Toronto, ON M5G 2M1, Canada
    Genomics 102:491-9. 2013
    ..This study is the first to document utilization of promoter 2 by SHP-1 transcripts and a noncoding transcript in human epithelial cells. ..
  25. doi request reprint Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin
    Danila Leontyev
    Research and Development, Canadian Blood Services, Immunology Hub, Toronto Centre, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Transfusion 52:1799-805. 2012
    ....
  26. doi request reprint Red blood cell storage lesions and related transfusion issues: a Canadian Blood Services research and development symposium
    Katerina Pavenski
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, ON, Canada
    Transfus Med Rev 26:68-84. 2012
    ....
  27. ncbi request reprint Detection of antibodies reacting with the antithetical duffy blood group antigens Fy(a) and Fy(b) using recombinant fusion proteins containing the duffy extracellular domain
    William P Sheffield
    Canadian Blood Services, Research and Development, Hamilton and Toronto, Canada
    Transfus Apher Sci 35:207-16. 2006
    ..Recombinant ECD-Fy proteins are suitable and sensitive reagents for the detection of anti-Fy that use technology amenable to automation and/or miniaturization and avoid the need for intact red cells...
  28. doi request reprint Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fcγ receptor for the amelioration of experimental ITP
    Danila Leontyev
    Research and Development, Canadian Blood Services, Toronto, ON, Canada
    Blood 119:5261-4. 2012
    ..Our findings led us to the conclusion that different strains of mice respond differently to IVIG and that FcγRIIB plays no role in the mechanism of effect of IVIG in experimental ITP...
  29. doi request reprint Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction
    Yulia Katsman
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 50:1285-94. 2010
    ..Thus, it was important to develop an improved mouse model of human ITP so as to maintain PLT nadir over time...
  30. doi request reprint Transfusion-related acute lung injury (TRALI): A Canadian blood services research and development symposium
    Elianna Saidenberg
    University of Ottawa and Ottawa General Hospital, Ottawa, Ontario, Canada
    Transfus Med Rev 24:305-24. 2010
    ..Finally, animal models of TRALI have provided insight into the possible mechanisms of this disorder and can be used to explore potential treatment modalities...
  31. ncbi request reprint Chemical compounds that target thiol-disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red blood cells
    Gregory C Rampersad
    Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 45:384-93. 2005
    ..Thus, whether chemical compounds that interact with SH or disulfide (SS) groups on mononuclear phagocytes can inhibit phagocytosis of antibody-coated cells was examined...
  32. ncbi request reprint Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    AIDS 19:1543-6. 2005
    ..Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism...
  33. ncbi request reprint Cellular therapies: a Canadian blood services research and development symposium
    Nadine Shehata
    Division of Hematology, St Michael s Hospital, Toronto, Canada
    Transfus Med Rev 21:317-36. 2007
  34. doi request reprint SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL
    Sevan Evren
    Cell and Molecular Biology, Toronto General Research Institute, Toronto, Ontario, Canada
    Exp Hematol 40:1055-9. 2012
    ..This study is the first to identify and define an interaction between SHP-1 and an SH3 domain-containing protein. Our findings provide an alternative way that SHP-1 can be linked to potential substrates...
  35. ncbi request reprint KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Ontario, Canada
    Exp Hematol 33:1160-71. 2005
    ..To compare the cytotoxicity of KHYG-1 with other natural killer (NK)/NK T-cell lines and identify molecules that may be associated with enhanced cytotoxicity, thereby eventually leading to improved NK cell-mediated cancer immunotherapy...
  36. ncbi request reprint The role of glycosphingolipids in HIV/AIDS
    Clifford A Lingwood
    Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Discov Med 11:303-13. 2011
    ....
  37. ncbi request reprint Relaxin receptor antagonist AT-001 synergizes with docetaxel in androgen-independent prostate xenografts
    Anton Neschadim
    Armour Therapeutics Inc, 124 Orchard View Boulevard, Toronto, Ontario, Canada Rna Diagnostics Inc, 595 Bay Street, Suite 1204, Toronto, Ontario, Canada Departments of Laboratory Medicine and Pathobiology Surgery, University of Toronto, Toronto, Ontario, Canada Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada Departments of Medicine Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Centre for Innovation, Canadian Blood Services, Toronto, Ontario, Canada Division of Advanced Diagnostics Infection and Immunity, Toronto General Research Institute TGRI, University Health Network, Toronto, Ontario, Canada Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada Departments of Surgery and Medical Imaging, University of Toronto, Toronto, Ontario, Canada Division of Urology, Department of Surgical Oncology Prostate Centre, Princess Margaret Hospital Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
    Endocr Relat Cancer 21:459-71. 2014
    ..Our data support developing AT-001 for clinical use as an anti-relaxin hormonal therapy for advanced prostate cancer. ..
  38. ncbi request reprint Blood group biochemistry: a canadian blood services research and development symposium
    William P Sheffield
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 19:295-307. 2005
  39. ncbi request reprint MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity
    Manujendra N Saha
    Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Cancer Biol Ther 9:936-44. 2010
    ..These preclinical studies provide the framework for clinical trial of nutlin, alone and in combination with conventional and novel therapies such as velcade to increase efficacy and improve patient outcome in MM...