Donald R Branch

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Solving the dilemma of prevention of red cell alloimmunization
    Donald R Branch
    Department of Medicine, Division of Hematology, University of Toronto, Toronto, Ontario, Canada
    Immunotherapy 4:903-5. 2012
  2. ncbi Unexpected suppression of anti-Fya and prevention of hemolytic disease of the fetus and newborn after administration of Rh immune globulin
    Donald R Branch
    Canadian Blood Services, 67 College Street, Toronto, Ontario, M5G 2M1, Canada
    Transfusion 51:816-9. 2011
  3. ncbi Blood groups and susceptibility to virus infection: new developments
    Donald R Branch
    Research and Development, Canadian Blood Services, Department of Medicine, Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Hematol 17:558-64. 2010
  4. ncbi Gender-selective toxicity of thimerosal
    Donald R Branch
    Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Exp Toxicol Pathol 61:133-6. 2009
  5. ncbi Antenatal administration of Rh-immune globulin causes significant increases in the immunomodulatory cytokines transforming growth factor-beta and prostaglandin E2
    Donald R Branch
    Transfusion Immunology Hub, Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 46:1316-22. 2006
  6. ncbi The human P(k) histo-blood group antigen provides protection against HIV-1 infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Blood 113:4980-91. 2009
  7. ncbi Chemical treatment of anti-D results in improved efficacy for the inhibition of Fcgamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 47:2250-9. 2007
  8. ncbi HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor
    Payman Baradar Bokaei
    The Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5G 2M1
    Virology 362:38-49. 2007
  9. ncbi A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms
    Amanda L Harrison
    Canadian Blood Services Research and Development Toronto General Research Institute, 67 College St, Toronto, Ontario, M5G 2M1, Canada
    Glycoconj J 27:515-24. 2010
  10. ncbi Structure-function studies for in vitro chemical inhibition of Fc gamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Division of Cell and Molecular Biology, Toronto General Research Institute, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 47:290-8. 2007

Collaborators

Detail Information

Publications33

  1. ncbi Solving the dilemma of prevention of red cell alloimmunization
    Donald R Branch
    Department of Medicine, Division of Hematology, University of Toronto, Toronto, Ontario, Canada
    Immunotherapy 4:903-5. 2012
    ..These results open the door for therapies aimed at the prevention and/or treatment of alloimmunization in both a transfusion setting and, importantly, in hemolytic disease of the fetus and newborn...
  2. ncbi Unexpected suppression of anti-Fya and prevention of hemolytic disease of the fetus and newborn after administration of Rh immune globulin
    Donald R Branch
    Canadian Blood Services, 67 College Street, Toronto, Ontario, M5G 2M1, Canada
    Transfusion 51:816-9. 2011
    ..It was suggested that induction of TGFβ-1 and immunosuppression may be independent of cognate antigen recognition by RhIG. Herein, we present a description of a mother and baby that supports this hypothesis...
  3. ncbi Blood groups and susceptibility to virus infection: new developments
    Donald R Branch
    Research and Development, Canadian Blood Services, Department of Medicine, Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Hematol 17:558-64. 2010
    ..These recent findings have raised additional questions regarding the possible role of the P/Gb3 histo-blood group antigen in HIV-1 infection...
  4. ncbi Gender-selective toxicity of thimerosal
    Donald R Branch
    Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Exp Toxicol Pathol 61:133-6. 2009
    ....
  5. ncbi Antenatal administration of Rh-immune globulin causes significant increases in the immunomodulatory cytokines transforming growth factor-beta and prostaglandin E2
    Donald R Branch
    Transfusion Immunology Hub, Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 46:1316-22. 2006
    ..Production of specific cytokines in response to administration of Rh-immune globulin (RhIG) was examined to assess the mechanism of inhibition of the anti-D production and prevention of hemolytic disease of the newborn (HDN)...
  6. ncbi The human P(k) histo-blood group antigen provides protection against HIV-1 infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Blood 113:4980-91. 2009
    ..We conclude that P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P(k) as a new endogenous cell-surface factor that may provide protection against HIV-1 infection...
  7. ncbi Chemical treatment of anti-D results in improved efficacy for the inhibition of Fcgamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 47:2250-9. 2007
    ..If successful, this approach may provide the possibility of targeting these chemicals to monocyte-macrophages for increased efficacy of immunoglobulin-based therapies in vivo...
  8. ncbi HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor
    Payman Baradar Bokaei
    The Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5G 2M1
    Virology 362:38-49. 2007
    ..These data reveal that VPAC2 agonists are appropriate candidates for further study as possible treatments aimed at the amelioration of HIV/AIDS...
  9. ncbi A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms
    Amanda L Harrison
    Canadian Blood Services Research and Development Toronto General Research Institute, 67 College St, Toronto, Ontario, M5G 2M1, Canada
    Glycoconj J 27:515-24. 2010
    ....
  10. ncbi Structure-function studies for in vitro chemical inhibition of Fc gamma receptor-mediated phagocytosis
    Alison H Foo
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Division of Cell and Molecular Biology, Toronto General Research Institute, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 47:290-8. 2007
    ....
  11. ncbi Induction of HIV-1 resistance: cell susceptibility to infection is an inverse function of globotriaosyl ceramide levels
    Stephanie Ramkumar
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Glycobiology 19:76-82. 2009
    ..Variable Gb(3) expression may provide a natural HIV resistance factor in the general population, and pharmacological manipulation of Gb(3) levels may provide an approach to induction of HIV resistance...
  12. ncbi Reduction of disulfide bonds within anti-D results in enhanced Fcgamma receptor blockade
    Andrew S Kruspe
    Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Transfusion 49:928-36. 2009
    ..If successful, this would provide a rationale to explore this mechanism of enhancing FcgammaR blockade for future use in immunoglobulin therapies for immune cytopenias...
  13. ncbi Comparison of detection methods for cell surface globotriaosylceramide
    Minji Kim
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    J Immunol Methods 371:48-60. 2011
    ....
  14. ncbi A novel soluble mimic of the glycolipid, globotriaosyl ceramide inhibits HIV infection
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    AIDS 20:333-43. 2006
    ..CONCLUSIONS: These results suggest that adamantylGb3 may provide a new basis for blocking HIV infections, irrespective of HIV envelope/chemokine co-receptor preference or resistance to other therapeutics...
  15. ncbi Constitutively polarized granules prime KHYG-1 NK cells
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Suite 5 211, Toronto, ON M5G2M9, Canada
    Int Immunol 18:1347-54. 2006
    ..Thus, a functional role for NKG2D in KHYG-1 cytotoxicity is demonstrated. Moreover, the novel primed state may contribute to the high cytotoxicity exhibited by KHYG-1...
  16. ncbi ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes
    Kayla T Wolofsky
    Sandra Rotman Centre for Global Health, SA Rotman Laboratories, Toronto General Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 8:e1002942. 2012
    ..These data provide the first evidence that ABO blood group antigens influence macrophage clearance of P. falciparum-infected erythrocytes and suggest an additional mechanism by which blood group O may confer resistance to severe malaria...
  17. ncbi Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro
    Pei Lin Shi
    Department of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada
    Toxins (Basel) 4:1517-34. 2012
    ..VT blocked HDAC inhibitor enhancement of HIV infection, consistent with a histone-mediated mechanism. We speculate that VT1A may provide a benign approach to reduction of (X4 or R5) HIV cell susceptibility...
  18. ncbi Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors
    Payman Baradar Bokaei
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 1A8
    Genomics 88:791-800. 2006
    ..The identification of these splice variants in various cells and their expression and differential signal transduction compared to the 7TM form suggest that these novel receptors have biological relevance...
  19. ncbi Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin
    Danila Leontyev
    Research and Development, Canadian Blood Services, Immunology Hub, Toronto Centre, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Transfusion 52:1799-805. 2012
    ....
  20. ncbi Red blood cell storage lesions and related transfusion issues: a Canadian Blood Services research and development symposium
    Katerina Pavenski
    Department of Laboratory Medicine, St Michael s Hospital, Toronto, ON, Canada
    Transfus Med Rev 26:68-84. 2012
    ....
  21. ncbi Detection of antibodies reacting with the antithetical duffy blood group antigens Fy(a) and Fy(b) using recombinant fusion proteins containing the duffy extracellular domain
    William P Sheffield
    Canadian Blood Services, Research and Development, Hamilton and Toronto, Canada
    Transfus Apher Sci 35:207-16. 2006
    ..Recombinant ECD-Fy proteins are suitable and sensitive reagents for the detection of anti-Fy that use technology amenable to automation and/or miniaturization and avoid the need for intact red cells...
  22. ncbi Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fcγ receptor for the amelioration of experimental ITP
    Danila Leontyev
    Research and Development, Canadian Blood Services, Toronto, ON, Canada
    Blood 119:5261-4. 2012
    ..Our findings led us to the conclusion that different strains of mice respond differently to IVIG and that FcγRIIB plays no role in the mechanism of effect of IVIG in experimental ITP...
  23. ncbi Transfusion-related acute lung injury (TRALI): A Canadian blood services research and development symposium
    Elianna Saidenberg
    University of Ottawa and Ottawa General Hospital, Ottawa, Ontario, Canada
    Transfus Med Rev 24:305-24. 2010
    ..Finally, animal models of TRALI have provided insight into the possible mechanisms of this disorder and can be used to explore potential treatment modalities...
  24. ncbi Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus
    Nicole Lund
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    AIDS 19:1543-6. 2005
    ..Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism...
  25. ncbi Cellular therapies: a Canadian blood services research and development symposium
    Nadine Shehata
    Division of Hematology, St Michael's Hospital, Toronto, Canada
    Transfus Med Rev 21:317-36. 2007
  26. ncbi Chemical compounds that target thiol-disulfide groups on mononuclear phagocytes inhibit immune mediated phagocytosis of red blood cells
    Gregory C Rampersad
    Research and Development, Canadian Blood Services, Toronto, Ontario, Canada
    Transfusion 45:384-93. 2005
    ..CONCLUSION: These studies indicate that pharmacologic strategies that target SH groups on mononuclear phagocytes may have future efficacy for the treatment of immune cytopenias...
  27. ncbi Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction
    Yulia Katsman
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Transfusion 50:1285-94. 2010
    ..Thus, it was important to develop an improved mouse model of human ITP so as to maintain PLT nadir over time...
  28. ncbi SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL
    Sevan Evren
    Cell and Molecular Biology, Toronto General Research Institute, Toronto, Ontario, Canada
    Exp Hematol 40:1055-9. 2012
    ..This study is the first to identify and define an interaction between SHP-1 and an SH3 domain-containing protein. Our findings provide an alternative way that SHP-1 can be linked to potential substrates...
  29. ncbi KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity
    Garnet Suck
    Department of Medical Oncology and Hematology, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Ontario, Canada
    Exp Hematol 33:1160-71. 2005
    ..To compare the cytotoxicity of KHYG-1 with other natural killer (NK)/NK T-cell lines and identify molecules that may be associated with enhanced cytotoxicity, thereby eventually leading to improved NK cell-mediated cancer immunotherapy...
  30. ncbi The role of glycosphingolipids in HIV/AIDS
    Clifford A Lingwood
    Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Discov Med 11:303-13. 2011
    ....
  31. ncbi Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells
    Meena K Purohit
    Center for Molecular Design and Preformulations, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7
    Bioorg Med Chem Lett 23:2324-7. 2013
    ..Confirmation of the disulfide bridge additionally provides clues for the non-thiol or non-disulfide bridge carrying ligands targeting ITP and other similar disorders...
  32. ncbi MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity
    Manujendra N Saha
    Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Cancer Biol Ther 9:936-44. 2010
    ..These preclinical studies provide the framework for clinical trial of nutlin, alone and in combination with conventional and novel therapies such as velcade to increase efficacy and improve patient outcome in MM...
  33. ncbi Blood group biochemistry: a canadian blood services research and development symposium
    William P Sheffield
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfus Med Rev 19:295-307. 2005