J Bradwejn

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Cholecystokinin and panic disorder: past and future clinical research strategies
    J Bradwejn
    Department of Psychiatry, University of Ottawa and the Royal Ottawa Hospital, Ontario, Canada
    Scand J Clin Lab Invest Suppl 234:19-27. 2001
  2. ncbi request reprint A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
    J Bradwejn
    Royal Ottawa Hospital and the Department of Psychiatry, University of Ottawa, Ontario, Canada
    J Clin Psychopharmacol 20:680-4. 2000
  3. ncbi request reprint Venlafaxine extended-release capsules in panic disorder: flexible-dose, double-blind, placebo-controlled study
    Jacques Bradwejn
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
    Br J Psychiatry 187:352-9. 2005
  4. ncbi request reprint Effects of CCK-4 infusion on the acoustic eye-blink startle and psychophysiological measures in healthy volunteers
    J Shlik
    Royal Ottawa Hospital, University of Ottawa, Ontario, Canada
    J Psychopharmacol 13:385-90. 1999
  5. ncbi request reprint Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers
    D Koszycki
    Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, Ontario, Canada
    Depress Anxiety 8:1-7. 1998
  6. ncbi request reprint Effect of aging on cholecystokinin-induced panic
    A J Flint
    Department of Psychiatry, University of Toronto, Quebec, Canada
    Am J Psychiatry 155:283-5. 1998
  7. ncbi request reprint Investigation of cholecystokinin system genes in panic disorder
    J L Kennedy
    Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Mol Psychiatry 4:284-5. 1999
  8. ncbi request reprint CCK4-induced panic in healthy subjects II: neurochemical correlates
    I Jerabek
    Department of Psychiatry, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Eur Neuropsychopharmacol 9:157-64. 1999
  9. ncbi request reprint CCK4-induced panic in healthy subjects I: psychological and cardiovascular effects
    I Jerabek
    Department of Psychiatry, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Eur Neuropsychopharmacol 9:149-55. 1999
  10. ncbi request reprint Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide
    J M Le Melledo
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Peptides 22:1349-57. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Cholecystokinin and panic disorder: past and future clinical research strategies
    J Bradwejn
    Department of Psychiatry, University of Ottawa and the Royal Ottawa Hospital, Ontario, Canada
    Scand J Clin Lab Invest Suppl 234:19-27. 2001
    ....
  2. ncbi request reprint A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
    J Bradwejn
    Royal Ottawa Hospital and the Department of Psychiatry, University of Ottawa, Ontario, Canada
    J Clin Psychopharmacol 20:680-4. 2000
    ..These preliminary findings suggest that Gotu Kola has anxiolytic activity in humans as revealed by the ASR. It remains to be seen whether this herb has therapeutic efficacy in the treatment of anxiety syndromes...
  3. ncbi request reprint Venlafaxine extended-release capsules in panic disorder: flexible-dose, double-blind, placebo-controlled study
    Jacques Bradwejn
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
    Br J Psychiatry 187:352-9. 2005
    ..Venlafaxine extended-release (ER) has proven efficacy in the treatment of anxiety symptoms in major depression, generalised anxiety disorder and social anxiety disorder...
  4. ncbi request reprint Effects of CCK-4 infusion on the acoustic eye-blink startle and psychophysiological measures in healthy volunteers
    J Shlik
    Royal Ottawa Hospital, University of Ottawa, Ontario, Canada
    J Psychopharmacol 13:385-90. 1999
    ..The results of this study show that a prolonged intravenous administration of CCK-4 may be a useful challenge method for further studies on the role of CCK system in the modulation of human anxiety and stress response...
  5. ncbi request reprint Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers
    D Koszycki
    Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, Ontario, Canada
    Depress Anxiety 8:1-7. 1998
    ....
  6. ncbi request reprint Effect of aging on cholecystokinin-induced panic
    A J Flint
    Department of Psychiatry, University of Toronto, Quebec, Canada
    Am J Psychiatry 155:283-5. 1998
    ..The goal of this study was to determine whether aging has an effect on healthy subjects' responses to the panicogenic agent cholecystokinin tetrapeptide (CCK-4)...
  7. ncbi request reprint Investigation of cholecystokinin system genes in panic disorder
    J L Kennedy
    Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Mol Psychiatry 4:284-5. 1999
    ..Our genetic dissection of the CCK system thus far suggests that the CCK-B receptor gene variation may contribute to the neurobiology of panic disorder...
  8. ncbi request reprint CCK4-induced panic in healthy subjects II: neurochemical correlates
    I Jerabek
    Department of Psychiatry, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Eur Neuropsychopharmacol 9:157-64. 1999
    ..In summary, we have demonstrated that, in healthy subjects, CCK4 increases peripheral concentrations of catecholamines in both plasma and platelets, with the most consistent changes occurring in platelet NE and plasma EPI concentrations...
  9. ncbi request reprint CCK4-induced panic in healthy subjects I: psychological and cardiovascular effects
    I Jerabek
    Department of Psychiatry, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    Eur Neuropsychopharmacol 9:149-55. 1999
    ..We conclude that, in healthy subjects, CCK4 induces panic-like reaction characterized by a number of somatic, cognitive and emotional symptoms, which are accompanied by increases in heart rate and blood pressure...
  10. ncbi request reprint Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide
    J M Le Melledo
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Peptides 22:1349-57. 2001
    ..AVP and OT may play a role in the hypothalamo-pituitary adrenal (HPA) axis activity associated with the panic response induced by CCK-4...
  11. ncbi request reprint Neurohormonal responses to cholecystokinin tetrapeptide: a comparison of younger and older healthy subjects
    A J Flint
    The Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychoneuroendocrinology 25:633-47. 2000
    ..For the most part, maximum changes in hormonal levels were not correlated with symptom severity, suggesting that other factors may have contributed to the differential effect of panic on the HPA axis...
  12. ncbi request reprint Anxiety sensitivity does not predict fearful responding to 35% carbon dioxide in patients with panic disorder
    D Koszycki
    Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, 1145 Carling Avenue, K1Z 7K4, Ottawa, Canada
    Psychiatry Res 101:137-43. 2001
    ..Overall, these data do not support the view that anxiety sensitivity plays a key role in mediating behavioural sensitivity to CO(2) inhalation in panic disorder...
  13. ncbi request reprint Behavioral, neurochemical, anatomical and electrophysiological correlates of panic disorder: multiple transmitter interaction and neuropeptide colocalization
    R M Zacharko
    Psychology Department, Carleton University, Ottawa, Ontario, Canada
    Prog Neurobiol 47:371-423. 1995
    ..Such variables presumably underlie the diverse behavioral symptoms associated with panic disorder and variations in the therapeutic efficacy of pharmacological treatment...
  14. ncbi request reprint Decrease in short-term memory function induced by CCK-4 in healthy volunteers
    J Shlik
    Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, University of Ottawa, Ontario, Canada
    Peptides 19:969-75. 1998
    ..The results of this study indicate that CCK-4 may exert a negative influence on memory consolidation and retrieval...
  15. ncbi request reprint Effects of cholecystokinin tetrapeptide on respiratory function in healthy volunteers
    J Bradwejn
    Department of Psychiatry and Meakins Christie Laboratories, McGill University, Montreal, Canada
    Am J Psychiatry 155:280-2. 1998
    ..The authors evaluated respiratory response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers...
  16. ncbi request reprint Randomized trial of a meditation-based stress reduction program and cognitive behavior therapy in generalized social anxiety disorder
    Diana Koszycki
    Stress and Anxiety Clinical Research Unit, University of Ottawa Institute of Mental Health Research, Royal Ottawa Mental Health Centre, 1145 Carling Ave, Ottawa, Ont, Canada K1Z 7K4
    Behav Res Ther 45:2518-26. 2007
    ..The results confirm that CBGT is the treatment of choice of generalized SAD and suggest that MBSR may have some benefit in the treatment of generalized SAD...
  17. ncbi request reprint Acute cholecystokinin effects on event-related potentials in healthy volunteers
    Verner J Knott
    Department of Psychiatry, University of Ottawa and Royal Ottawa Hospital Institute of Mental Health Research, Ottawa, Ontario, Canada
    Hum Psychopharmacol 17:285-91. 2002
    ..These preliminary findings suggest that CCK-4 may interfere with information processing relating to the selection of significant stimuli and as such, may be of relevance to mechanisms underlying panic disorder...
  18. ncbi request reprint Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
    Verner Knott
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:179-84. 2003
    ..These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD)...
  19. ncbi request reprint Central cholecystokinin activity in irritable bowel syndrome, panic disorder, and healthy controls
    Diana Koszycki
    Department of Psychiatry, University of Ottawa, and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Psychosom Med 67:590-5. 2005
    ..To test this hypothesis, we assessed whether the enhanced panicogenic response to CCK-tetrapeptide (CCK-4) observed in PD is also present in IBS...
  20. ncbi request reprint Sensitivity to cholecystokinin-tetrapeptide in major depression
    Diana Koszycki
    Department of Psychiatry, University of Ottawa, and the Stress and Anxiety Clinical Research Unit, Institute of Mental Health Research, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    J Affect Disord 80:285-90. 2004
    ..In the present study, we determined whether sensitivity to CCK-4 is enhanced in patients with major depressive disorder (MDD) with no history of panic attacks. We also determined whether CCK-4 would exacerbate depressive symptoms...
  21. ncbi request reprint The ventilatory response to cholecystokinin tetrapeptide in healthy volunteers
    M A Katzman
    Centre for Addiction and Mental Health Clarke Division, Univerisyt of Toronto, Ontario, Canada
    Neuropsychopharmacology 26:824-31. 2002
    ..We conclude that CCK-4 does not act to induce panic by altering the central (CO(2) sensitive) chemoreceptor...
  22. doi request reprint A randomized trial of sertraline, self-administered cognitive behavior therapy, and their combination for panic disorder
    D Koszycki
    Faculty of Education, University of Ottawa, ON, Canada
    Psychol Med 41:373-83. 2011
    ..However, it is unknown whether combining SCBT and antidepressants can improve treatment. This trial evaluated the efficacy of SCBT and sertraline, alone or in combination, in PD...
  23. ncbi request reprint Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorder
    Martin A Katzman
    Centre for Addiction and Mental Health Clarke Division and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Depress Anxiety 20:51-8. 2004
    ..The lack of effect of CCK-4 on SP and OCD symptoms suggests that this peptide does not play a salient role in the pathophysiology of these disorders...
  24. ncbi request reprint Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and Germany
    C Rothe
    Department of Psychiatry, University of Ottawa and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Neurosci Lett 363:276-9. 2004
    ..Our data suggest thus that this polymorphism is unlikely to play a major role in the pathogenesis of panic disorder...
  25. ncbi request reprint Aging and panicogenic response to cholecystokinin tetrapeptide: an examination of the cholecystokinin system
    Alastair Flint
    Toronto General Hospital, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 27:663-71. 2002
    ..These findings are consistent with our hypothesis and suggest that age-related changes in the CCK system could contribute to the diminished panicogenic response to exogenous CCK-4 in older persons...
  26. doi request reprint A multifaith spiritually based intervention for generalized anxiety disorder: a pilot randomized trial
    Diana Koszycki
    Faculty of Education, University of Ottawa, Ontario, Canada
    J Clin Psychol 66:430-41. 2010
    ..These preliminary findings are encouraging and suggest that a multifaith SBI may be an effective treatment option for GAD. Further randomized controlled trials are needed to establish the efficacy of this intervention...
  27. ncbi request reprint Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder
    Claudia Rothe
    Clarke Division, Centre for Addiction and Mental Health, University of Toronto, Toronto, and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, ON, Canada
    Neuropsychopharmacology 31:2237-42. 2006
    ..No significant results were found for the other two markers. These results support the hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder...
  28. ncbi request reprint A randomized controlled trial of venlafaxine extended release in generalized social anxiety disorder
    Michael R Liebowitz
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 66:238-47. 2005
    ..This double-blind study evaluated the anxiolytic efficacy, safety, and tolerability of venlafaxine extended release (ER) in adult out-patients with generalized social anxiety disorder...
  29. ncbi request reprint Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder
    Subi Tharmalingam
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada
    Psychiatr Genet 16:93-7. 2006
    ..Further studies investigating additional polymorphisms in this gene and other components of the CRH signalling system may prove useful...
  30. ncbi request reprint Assessing patient beliefs in a clinical trial of Hypericum perforatum in major depression
    Carla M Bann
    RTI International, Research Triangle Park, North Carolina 27709 2194, USA
    Depress Anxiety 20:114-22. 2004
    ..Future studies should explore whether patient beliefs have an even greater impact when patients are aware of the treatment they are receiving and can determine whether that treatment is consistent with their beliefs...
  31. doi request reprint Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial
    Hany Bissada
    The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON, Canada K1H8L6
    Am J Psychiatry 165:1281-8. 2008
    ..The objective of this trial was to assess the efficacy of olanzapine in promoting weight gain and in reducing obsessive symptoms among adult women with anorexia nervosa...