T D Bradley

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Relationship of pharyngeal water content and jugular volume with severity of obstructive sleep apnea in renal failure
    Rosilene M Elias
    Correspondence and offprint requests to T D Bradley E mail
    Nephrol Dial Transplant 28:937-44. 2013
  2. pmc Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea
    Laura H White
    Department of Medicine, University Health Network Toronto General Hospital, Rehabilitation Institute, University of Toronto, Ontario, Canada
    J Physiol 591:1179-93. 2013
  3. doi request reprint Differing effects of obstructive and central sleep apneas on stroke volume in patients with heart failure
    Dai Yumino
    Sleep Research Laboratory, Centre for Sleep Health and Research, and Department of Medicine, University Health Network Toronto Rehabilitation Institute and Toronto General Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:433-8. 2013
  4. ncbi request reprint Sleep apnea and heart failure: Part II: central sleep apnea
    T Douglas Bradley
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Toronto, Ontario, Canada
    Circulation 107:1822-6. 2003
  5. ncbi request reprint Continuous positive airway pressure for central sleep apnea and heart failure
    T Douglas Bradley
    Department of Medicine, University of Toronto, Toronto
    N Engl J Med 353:2025-33. 2005
  6. ncbi request reprint Left ventricular structural adaptations to obstructive sleep apnea in dilated cardiomyopathy
    Kengo Usui
    Toronto General Hospital UHN, 9N 943, 200 Elizabeth Street, Toronto, ON, M5G 2C4 Canada
    Am J Respir Crit Care Med 173:1170-5. 2006
  7. ncbi request reprint Rationale and design of the Canadian Continuous Positive Airway Pressure Trial for Congestive Heart Failure patients with Central Sleep Apnea--CANPAP
    T D Bradley
    Department of Medicine, Toronto General Hospital of the University Health Network, Toronto, Canada
    Can J Cardiol 17:677-84. 2001
  8. ncbi request reprint Hemodynamic effects of simulated obstructive apneas in humans with and without heart failure
    T D Bradley
    Department of Medicine of the Toronto General Hospital and the Centre for Cardiovascular Research, University of Toronto, Toronto, Ontario, Canada
    Chest 119:1827-35. 2001
  9. ncbi request reprint CPAP should be used for central sleep apnea in congestive heart failure patients
    T Douglas Bradley
    Sleep Research Laboratories of the Toronto Rehabilitation Institute, and Toronto General Hospital of the University Health Network, ON, Canada
    J Clin Sleep Med 2:394-8. 2006
  10. ncbi request reprint Sleep apnea and heart failure: Part I: obstructive sleep apnea
    T Douglas Bradley
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Toronto, Ontario, Canada
    Circulation 107:1671-8. 2003

Collaborators

Detail Information

Publications66

  1. doi request reprint Relationship of pharyngeal water content and jugular volume with severity of obstructive sleep apnea in renal failure
    Rosilene M Elias
    Correspondence and offprint requests to T D Bradley E mail
    Nephrol Dial Transplant 28:937-44. 2013
    ..They also suggest the need for randomized trials to determine whether more aggressive fluid removal in ESRD patients will alleviate OSA...
  2. pmc Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea
    Laura H White
    Department of Medicine, University Health Network Toronto General Hospital, Rehabilitation Institute, University of Toronto, Ontario, Canada
    J Physiol 591:1179-93. 2013
    ..This review article will explore mechanisms by which overnight rostral fluid shift, and its prevention, can contribute to the pathogenesis and therapy of sleep apnoea...
  3. doi request reprint Differing effects of obstructive and central sleep apneas on stroke volume in patients with heart failure
    Dai Yumino
    Sleep Research Laboratory, Centre for Sleep Health and Research, and Department of Medicine, University Health Network Toronto Rehabilitation Institute and Toronto General Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 187:433-8. 2013
    ....
  4. ncbi request reprint Sleep apnea and heart failure: Part II: central sleep apnea
    T Douglas Bradley
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Toronto, Ontario, Canada
    Circulation 107:1822-6. 2003
  5. ncbi request reprint Continuous positive airway pressure for central sleep apnea and heart failure
    T Douglas Bradley
    Department of Medicine, University of Toronto, Toronto
    N Engl J Med 353:2025-33. 2005
    ....
  6. ncbi request reprint Left ventricular structural adaptations to obstructive sleep apnea in dilated cardiomyopathy
    Kengo Usui
    Toronto General Hospital UHN, 9N 943, 200 Elizabeth Street, Toronto, ON, M5G 2C4 Canada
    Am J Respir Crit Care Med 173:1170-5. 2006
    ....
  7. ncbi request reprint Rationale and design of the Canadian Continuous Positive Airway Pressure Trial for Congestive Heart Failure patients with Central Sleep Apnea--CANPAP
    T D Bradley
    Department of Medicine, Toronto General Hospital of the University Health Network, Toronto, Canada
    Can J Cardiol 17:677-84. 2001
    ..Treating CSR-CSA may, therefore, improve outcomes in patients with CHF...
  8. ncbi request reprint Hemodynamic effects of simulated obstructive apneas in humans with and without heart failure
    T D Bradley
    Department of Medicine of the Toronto General Hospital and the Centre for Cardiovascular Research, University of Toronto, Toronto, Ontario, Canada
    Chest 119:1827-35. 2001
    ..To determine whether generation of negative intrathoracic pressure during apnea would cause more pronounced and sustained reductions in cardiac output in patients with congestive heart failure (CHF) than in healthy subjects...
  9. ncbi request reprint CPAP should be used for central sleep apnea in congestive heart failure patients
    T Douglas Bradley
    Sleep Research Laboratories of the Toronto Rehabilitation Institute, and Toronto General Hospital of the University Health Network, ON, Canada
    J Clin Sleep Med 2:394-8. 2006
  10. ncbi request reprint Sleep apnea and heart failure: Part I: obstructive sleep apnea
    T Douglas Bradley
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Toronto, Ontario, Canada
    Circulation 107:1671-8. 2003
  11. ncbi request reprint Influence of obstructive sleep apnea on mortality in patients with heart failure
    Hanqiao Wang
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:1625-31. 2007
    ..This study sought to determine, in patients with heart failure (HF), whether untreated moderate to severe obstructive sleep apnea (OSA) is associated with a higher mortality rate than in patients with mild to no sleep apnea (M-NSA)...
  12. ncbi request reprint High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
    A G Logan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    J Hypertens 19:2271-7. 2001
    ..To determine the prevalence of obstructive sleep apnoea (OSA) in adult patients with drug-resistant hypertension, a common problem in a tertiary care facility...
  13. ncbi request reprint Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial
    Michael Arzt
    University of Toronto, Toronto, Ontario, Canada
    Circulation 115:3173-80. 2007
    ..This stratified analysis of CANPAP tested the hypothesis that suppression of CSA below this threshold by CPAP would improve left ventricular ejection fraction and heart transplant-free survival...
  14. doi request reprint Shift in sleep apnoea type in heart failure patients in the CANPAP trial
    C M Ryan
    Department of Medicine, University of Toronto, ON, Canada
    Eur Respir J 35:592-7. 2010
    ..6 s versus 0.6 s). In patients with HF, spontaneous conversion from predominantly CSA to OSA is associated with an improvement in left ventricular systolic function. Future studies will be necessary to further examine this relationship...
  15. doi request reprint Relationship between sleep apnoea and mortality in patients with ischaemic heart failure
    D Yumino
    Sleep Research Laboratory of Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada
    Heart 95:819-24. 2009
    ..To determine whether the influence of sleep apnoea (SA) on the risk of death differs in patients with ischaemic and in those with non-ischaemic heart failure (HF)...
  16. ncbi request reprint Overnight shift from obstructive to central apneas in patients with heart failure: role of PCO2 and circulatory delay
    R Tkacova
    Sleep Research Laboratory of the Toronto Rehabilitation Institute and the Department of Medicine of the Toronto General Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada
    Circulation 103:238-43. 2001
    ..This appears to be related to an overnight deterioration in cardiac function as suggested by the concurrent lengthening of circulation time. Therefore, in CHF patients, alterations in cardiac function may influence apnea type...
  17. ncbi request reprint Night-to-night alterations in sleep apnea type in patients with heart failure
    R Tkacova
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada
    J Sleep Res 15:321-8. 2006
    ..We conclude that in some patients with heart failure, OSA and CSA are part of a spectrum of periodic breathing that can shift over time in association with alterations in PCO(2), cycle length and probably cardiac function...
  18. pmc Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea
    C M Ryan
    Toronto General Hospital University Health Network, EC 6 248, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Thorax 60:781-5. 2005
    ....
  19. ncbi request reprint Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea
    Michael Arzt
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Center for Sleep Medicine and Circadian Biology, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 166:1716-22. 2006
    ..Therefore, we tested the hypothesis that patients with heart failure have less sleepiness and sleep less compared with subjects without heart failure for a given severity of OSA...
  20. ncbi request reprint Provocation of ventricular ectopy by cheyne-stokes respiration in patients with heart failure
    Richard S T Leung
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Ontario, Canada
    Sleep 27:1337-43. 2004
    ..The objective of this study was to determine whether CSR-CSA directly provokes ventricular ectopy and, if so, whether it is associated with any particular phase of the CSR-CSA breathing cycle...
  21. ncbi request reprint Augmented sympathetic neural response to simulated obstructive apnoea in human heart failure
    T Douglas Bradley
    Department of Medicine of The Toronto General Hospital University Health Network, University of Toronto, Toronto, ON, Canada
    Clin Sci (Lond) 104:231-8. 2003
    ..These present findings offer novel insight into the potential role of sleep apnoea in augmenting sympathetic activity and accelerating disease progression in heart failure...
  22. doi request reprint Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure
    Dai Yumino
    Toronto General Hospital University Health Network, 9N 943, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada
    Circulation 121:1598-605. 2010
    ....
  23. ncbi request reprint Influence of Cheyne-Stokes respiration on cardiovascular oscillations in heart failure
    Richard S T Leung
    Toronto General Hospital UHN, NU 9 112, 200 Elizabeth Street, Toronto ON, M5G 2C4, Canada
    Am J Respir Crit Care Med 167:1534-9. 2003
    ..Cheyne-Stokes respiration is therefore one of the mechanisms that contributes to the very low-frequency oscillations in heart rate and blood pressure observed in patients with heart failure...
  24. ncbi request reprint Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex
    A G Logan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Eur Respir J 21:241-7. 2003
    ..These data also suggest that continuous positive airway pressure may reduce nocturnal and daytime systolic blood pressure chronically. Randomised trials are needed to confirm the latter results...
  25. ncbi request reprint Treatment of sleep apnea in heart failure
    Michael Arzt
    Sleep Research Laboratories of the Toronto Rehabiliation Institute, Toronto General Hospital University Health Network, 9N 943, 200 Elizabeth Street, Toronto, ON, M5G 2C4 Canada
    Am J Respir Crit Care Med 173:1300-8. 2006
    ....
  26. ncbi request reprint Update in sleep and control of ventilation 2005
    Richard L Horner
    Department of Medicine and Physiology, University of Toronto, Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto General Hospital of the University Health Network, Toronto, ON, Canada M5S 1A8
    Am J Respir Crit Care Med 173:827-32. 2006
  27. ncbi request reprint Respiratory modulation of the autonomic nervous system during Cheyne-Stokes respiration
    Richard S T Leung
    University of Toronto Centre for Sleep and Chronobiology, ON, Canada
    Can J Physiol Pharmacol 84:61-6. 2006
    ..It is speculated that the rhythmic oscillations in autonomic tone brought about by CSR may ultimately contribute to the sympatho-excitation and increased mortality long observed in patients with heart failure and CSR...
  28. pmc Prevalence of sleep disordered breathing in lung transplant recipients
    Virjanand S Naraine
    Division of Respirology, Department of Medicine, University of Toronto, Canada
    J Clin Sleep Med 5:441-7. 2009
    ..The study objective was to determine the prevalence and clinical correlates of SDB in a cohort of lung transplant recipients...
  29. ncbi request reprint Update in sleep and control of ventilation 2006
    Richard L Horner
    Department of Medicine, University of Toronto, Toronto, Canada
    Am J Respir Crit Care Med 175:426-31. 2007
  30. doi request reprint Timing of nocturnal ventricular ectopy in heart failure patients with sleep apnea
    Clodagh M Ryan
    Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, ON, Canada
    Chest 133:934-40. 2008
    ....
  31. doi request reprint Obstructive sleep apnoea and its cardiovascular consequences
    T Douglas Bradley
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Canada
    Lancet 373:82-93. 2009
    ..However, large-scale randomised trials are needed to determine, definitively, whether treating OSA improves cardiovascular outcomes...
  32. ncbi request reprint Association between atrial fibrillation and central sleep apnea
    Richard S T Leung
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Ontario, Canada
    Sleep 28:1543-6. 2005
    ..We hypothesized that the prevalence of atrial fibrillation might also be increased in patients with central sleep apnea in the absence of other cardiac disease...
  33. ncbi request reprint Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure
    Kengo Usui
    University Health Network, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1XS, Canada
    J Am Coll Cardiol 45:2008-11. 2005
    ....
  34. ncbi request reprint Relationship of sleep apnea to functional capacity and length of hospitalization following stroke
    Yasuyuki Kaneko
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, the Centre for Sleep Medicine and Circadian Biology of the University of Toronto, Ontario, Canada
    Sleep 26:293-7. 2003
    ..We hypothesized that the presence of sleep apnea among stroke patients would be associated with a greater degree of functional disability and longer hospitalization following stroke...
  35. doi request reprint Update in sleep and control of ventilation 2007
    Richard L Horner
    Department of Medicine, University of Toronto, Toronto, Canada
    Am J Respir Crit Care Med 177:947-51. 2008
  36. ncbi request reprint Influence of Cheyne-Stokes respiration on ventricular response to atrial fibrillation in heart failure
    Richard S T Leung
    Toronto Rehabilitation Institute Sleep Research Laboratory, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Appl Physiol 99:1689-96. 2005
    ....
  37. ncbi request reprint Respiratory modulation of heart rate and blood pressure during Cheyne-Stokes respiration
    Richard S T Leung
    Toronto General Hospital University Health Network, Centre for Sleep Medicine and Circadian Biology, University of Toronto, Ontario, Canada
    J Electrocardiol 36:213-7. 2003
    ..We conclude that ventilatory oscillations during Cheyne-Stokes respiration can modulate HR and BP independent of the effects of hypoxia and arousals from sleep...
  38. ncbi request reprint Hemodynamic and sympathoinhibitory effects of nasal CPAP in congestive heart failure
    T D Bradley
    Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada
    Sleep 19:S232-5. 1996
    ..Longer-term trials of CPAP are needed to determine whether this intervention can provide long-lasting clinical benefit to patients with CHF and CSR-CSA...
  39. doi request reprint Independent association of drug-resistant hypertension to reduced sleep duration and efficiency
    Oded Friedman
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Hypertens 23:174-9. 2010
    ..The objective of this study was to test the hypothesis that short sleep duration is associated with resistant hypertension (RH) independently of OSA, which can itself disrupt and shorten sleep...
  40. ncbi request reprint Relationship of systolic BP to obstructive sleep apnea in patients with heart failure
    Don D Sin
    Sleep Research Laboratory, Toronto Rehabilitation Institute, ON, Canada
    Chest 123:1536-43. 2003
    ..Our objective was to determine whether OSA would be associated with elevated daytime BP in medically treated patients with CHF...
  41. doi request reprint Lower body positive pressure increases upper airway collapsibility in healthy subjects
    Mao chang Su
    The Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    Respir Physiol Neurobiol 161:306-12. 2008
    ....
  42. doi request reprint Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea
    Pimon Ruttanaumpawan
    Sleep and Cardiovascular Physiology Research Laboratories of the Mount Sinai Hospital, Toronto, Ontario, Canada
    J Hypertens 26:1163-8. 2008
    ....
  43. ncbi request reprint Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea
    Matthew P Gilman
    Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Sci (Lond) 114:243-9. 2008
    ..01). In conclusion, treatment of coexisting OSA by nocturnal CPAP in patients with heart failure increases HF-HRV during morning wakefulness, indicating improved vagal modulation of heart rate. This may contribute to improved prognosis...
  44. ncbi request reprint Cheyne-Stokes respiration in stroke: relationship to hypocapnia and occult cardiac dysfunction
    Cherdchai Nopmaneejumruslers
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Centre for Sleep Medicine and Circadian Biology of the University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 171:1048-52. 2005
    ..Central sleep apnea (CSA) and Cheyne-Stokes respiration have been reported in association with stroke, but their pathophysiologic correlates have not been well described...
  45. ncbi request reprint Periodicity of obstructive sleep apnea in patients with and without heart failure
    Clodagh M Ryan
    Toronto General Hospital University Health Network, EC 6 248, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada
    Chest 127:536-42. 2005
    ....
  46. ncbi request reprint Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea
    Jonas Spaak
    University Health Network, Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada
    Hypertension 46:1327-32. 2005
    ..This additional stimulus to central sympathetic outflow may accelerate the progression of HF; its attenuation by treatment of sleep apnea represents a novel nonpharmacological opportunity...
  47. pmc Association of sleep-disordered breathing and the occurrence of stroke
    Michael Arzt
    Toronto General Hospital University Health Network, 9N 943, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Am J Respir Crit Care Med 172:1447-51. 2005
    ..However, these studies either used surrogate markers of sleep-disordered breathing or could not, due to cross-sectional design, address the temporal relationship between sleep-disordered breathing and stroke...
  48. ncbi request reprint Interstitial lung disease, lung cancer, lung transplantation, pulmonary vascular disorders, and sleep-disordered breathing in AJRCCM in 2004
    T Douglas Bradley
    Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 171:675-85. 2005
  49. ncbi request reprint The role of continuous positive airway pressure in the treatment of congestive heart failure
    A T Yan
    Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada
    Chest 120:1675-85. 2001
    ..Although medium-term studies using CPAP to treat sleep-related breathing disorders associated with CHF have been encouraging, more definitive data from ongoing large clinical trials are necessary to clarify its therapeutic role...
  50. pmc Effect of continuous positive airway pressure on sleep structure in heart failure patients with central sleep apnea
    Pimon Ruttanaumpawan
    University of Toronto, Toronto, ON, Canada
    Sleep 32:91-8. 2009
    ..If so, they should diminish in frequency when CSA is attenuated. We therefore sought to determine whether attenuation of CSA by CPAP reduces arousal frequency...
  51. doi request reprint Central sleep apnea and Cheyne-Stokes respiration
    Dai Yumino
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, University of Toronto, Ontario, Canada
    Proc Am Thorac Soc 5:226-36. 2008
    ..Further research is therefore needed to elucidate mechanisms which contribute to the pathogenesis of CSR-CSA, and to determine whether its treatment can reduce morbidity and mortality in patients with HF...
  52. doi request reprint Difference in upper airway collapsibility during wakefulness between men and women in response to lower-body positive pressure
    Mao chang Su
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON M5G 2A2, Canada
    Clin Sci (Lond) 116:713-20. 2009
    ..5 cm H2O, P=0.035). We conclude that rostral fluid displacement by LBPP increases UA collapsibility more in healthy, non-obese men than in women. This may be one mechanism contributing to the higher prevalence of OSA in men than in women...
  53. doi request reprint Relationship between overnight rostral fluid shift and Obstructive Sleep Apnea in nonobese men
    Stefania Redolfi
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 179:241-6. 2009
    ..Prolonged sitting leads to dependent fluid accumulation in the legs...
  54. ncbi request reprint Avoidance of the left lateral decubitus position during sleep in patients with heart failure: relationship to cardiac size and function
    Richard S T Leung
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Ontario, Canada
    J Am Coll Cardiol 41:227-30. 2003
    ....
  55. doi request reprint Prevalence and physiological predictors of sleep apnea in patients with heart failure and systolic dysfunction
    Dai Yumino
    Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    J Card Fail 15:279-85. 2009
    ..We therefore determined, in patients with HF, prevalences and predictors of OSA and CSA and the influence of changes in HF therapy on prevalences...
  56. doi request reprint Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension
    Oded Friedman
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Hypertension 56:1077-82. 2010
    ..Our findings support the concept that fluid redistribution centrally during sleep accounts for the high prevalence of obstructive sleep apnea in drug-resistant hypertension...
  57. ncbi request reprint Pathogenesis of obstructive sleep apnea
    Clodagh M Ryan
    Sleep Research Laboratory of Toronto Rehabilitation Institute, Toronto General Hospital University Health Network, ON, Canada
    J Appl Physiol 99:2440-50. 2005
    ..Further elucidation of specific pathogenic mechanisms in individuals with OSA may facilitate the development of new therapies that can be tailored to individual patient needs according to the underlying mechanism(s) of their disease...
  58. pmc Alterations in upper airway cross-sectional area in response to lower body positive pressure in healthy subjects
    Satomi Shiota
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    Thorax 62:868-72. 2007
    ..It is hypothesised that acute fluid shifts from the legs to the upper body in healthy subjects would increase neck circumference and reduce the cross-sectional area of the UA (UA-XSA)...
  59. ncbi request reprint Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea
    Yasuyuki Kaneko
    Sleep Research Laboratories, Toronto Rehabilitation Institute, Toronto General Hospital, ON M5G 2C4, Canada
    N Engl J Med 348:1233-41. 2003
    ..We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function...
  60. ncbi request reprint Treating obstructive sleep apnea: is there more to the story than 2 millimeters of mercury?
    John S Floras
    Hypertension 50:289-91. 2007
  61. doi request reprint Respiratory sleep medicine: a coming of age
    T Douglas Bradley
    Am J Respir Crit Care Med 177:363-4. 2008
  62. ncbi request reprint Prospective evaluation of nocturnal oximetry for detection of sleep-related breathing disturbances in patients with chronic heart failure
    Frederic Series
    Centre de Pneumologie Hôpital Laval, 2725, Chemin Sainte Foy, Sainte Foy, PQ, Canada G1V 4G5
    Chest 127:1507-14. 2005
    ....
  63. ncbi request reprint Atrial overdrive pacing for sleep apnea: a door now closed?
    John S Floras
    Am J Respir Crit Care Med 172:1-3. 2005
  64. ncbi request reprint Pathogenesis of atherosclerosis: is obstructive sleep apnea the new kid on the block?
    Dai Yumino
    Am J Respir Crit Care Med 176:634-5. 2007
  65. ncbi request reprint Crossing the threshold: implications for central sleep apnea
    T Douglas Bradley
    Am J Respir Crit Care Med 165:1203-4. 2002
  66. ncbi request reprint The ups and downs of periodic breathing: implications for mortality in heart failure
    T Douglas Bradley
    J Am Coll Cardiol 41:2182-4. 2003