Norman F Boyd

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Pituitary growth hormone and growth hormone-releasing hormone receptor genes and associations with mammographic measures and serum growth hormone
    Cara Mulhall
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Room 10 415, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Cancer Epidemiol Biomarkers Prev 14:2648-54. 2005
  2. pmc Mammographic density and breast cancer risk: current understanding and future prospects
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Room 10 415, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Breast Cancer Res 13:223. 2011
  3. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
  4. ncbi request reprint Mammographic breast density as an intermediate phenotype for breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Lancet Oncol 6:798-808. 2005
  5. ncbi request reprint Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
  6. ncbi request reprint Mammographic density as a surrogate marker for the effects of hormone therapy on risk of breast cancer
    Norman F Boyd
    Ontario Cancer Institute, Room 10 415, 610 University Avenue, Toronto, Ontario, Canada M5G 2K9
    Cancer Epidemiol Biomarkers Prev 15:961-6. 2006
  7. ncbi request reprint Mammographic density: a hormonally responsive risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Br Menopause Soc 12:186-93. 2006
  8. doi request reprint Mammographic density and breast cancer risk: evaluation of a novel method of measuring breast tissue volumes
    Norman Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Cancer Epidemiol Biomarkers Prev 18:1754-62. 2009
  9. pmc Breast tissue composition and susceptibility to breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Room 10 415 610 University Ave, Toronto, ON, Canada M5G2M9
    J Natl Cancer Inst 102:1224-37. 2010
  10. doi request reprint Breast-tissue composition and other risk factors for breast cancer in young women: a cross-sectional study
    Norman Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada
    Lancet Oncol 10:569-80. 2009

Research Grants

Detail Information

Publications44

  1. ncbi request reprint Pituitary growth hormone and growth hormone-releasing hormone receptor genes and associations with mammographic measures and serum growth hormone
    Cara Mulhall
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Room 10 415, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Cancer Epidemiol Biomarkers Prev 14:2648-54. 2005
    ....
  2. pmc Mammographic density and breast cancer risk: current understanding and future prospects
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Room 10 415, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Breast Cancer Res 13:223. 2011
    ..Future prospects for the application of PMD include mammographic screening, risk prediction in individuals, breast cancer prevention research, and clinical decision making...
  3. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  4. ncbi request reprint Mammographic breast density as an intermediate phenotype for breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Lancet Oncol 6:798-808. 2005
    ....
  5. ncbi request reprint Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
    ..Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown...
  6. ncbi request reprint Mammographic density as a surrogate marker for the effects of hormone therapy on risk of breast cancer
    Norman F Boyd
    Ontario Cancer Institute, Room 10 415, 610 University Avenue, Toronto, Ontario, Canada M5G 2K9
    Cancer Epidemiol Biomarkers Prev 15:961-6. 2006
    ..This research was undertaken to determine whether the effect of hormone therapy on breast cancer risk is mediated by its effect on mammographic density...
  7. ncbi request reprint Mammographic density: a hormonally responsive risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Br Menopause Soc 12:186-93. 2006
    ..A better understanding of the factors that influence the response of breast tissue to these hormonal exposures may lead to an improved understanding of the aetiology of mammographic density and of breast cancer...
  8. doi request reprint Mammographic density and breast cancer risk: evaluation of a novel method of measuring breast tissue volumes
    Norman Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Cancer Epidemiol Biomarkers Prev 18:1754-62. 2009
    ..We have assessed a novel method of assessing breast tissue that is fully automated, does not require an observer, and measures the volume, rather than the projected area, of the relevant tissues in digitized screen-film mammogram...
  9. pmc Breast tissue composition and susceptibility to breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Room 10 415 610 University Ave, Toronto, ON, Canada M5G2M9
    J Natl Cancer Inst 102:1224-37. 2010
    ....
  10. doi request reprint Breast-tissue composition and other risk factors for breast cancer in young women: a cross-sectional study
    Norman Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada
    Lancet Oncol 10:569-80. 2009
    ..We used MRI to measure the water content of the breast, which provides a measurement of the fibro-glandular content of breast tissue with similar accuracy to mammography, but without the attendant exposure to radiation...
  11. ncbi request reprint Body size, mammographic density, and breast cancer risk
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2K9
    Cancer Epidemiol Biomarkers Prev 15:2086-92. 2006
    ..We have examined the associations of body size and mammographic density on breast cancer risk...
  12. ncbi request reprint Heritability of mammographic density, a risk factor for breast cancer
    Norman F Boyd
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Canada
    N Engl J Med 347:886-94. 2002
    ..8 to 6.0 times that of women of the same age with little or no density. Menopausal status, weight, and parity account for 20 to 30 percent of the age-adjusted variation in the percentage of dense tissue...
  13. doi request reprint Mammographic density, response to hormones, and breast cancer risk
    Norman F Boyd
    DSC, Ontario Cancer Institute, 610 University Ave, Room 10 415, Toronto, Ontario, Canada
    J Clin Oncol 29:2985-92. 2011
    ..We have examined the magnitude of the association of hormone exposure with PMD according to subsequent breast cancer risk...
  14. doi request reprint Family-based association study of IGF1 microsatellites and height, weight, and body mass index
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    J Hum Genet 55:255-8. 2010
    ..This study does not support an association between IGF1 and these anthropometric measures. Study limitations, including sample size and capturing genetic variation at IGF1 with these markers, could mean associations were missed...
  15. ncbi request reprint Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Breast Cancer Res Treat 88:217-30. 2004
    ..Our findings suggest that the CYP17 A2 allele is associated with hormone levels, and interacts with insulin levels and diet to affect breast density levels and potentially breast cancer risk...
  16. doi request reprint Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 118:415-24. 2009
    ..14; 5'CA 18-20, P = 0.25; 5'CA >20, P = 0.20). The associations we found could be due to chance as many comparisons were made. Our results do not strongly support an association between these IGF1 variants and breast cancer risk...
  17. doi request reprint Effect of a low-fat, high-carbohydrate dietary intervention on change in mammographic density over menopause
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Room 10 411, 610 University Ave, Toronto, ON, Canada M5G 2M9
    Breast Cancer Res Treat 113:163-72. 2009
    ..Menopause reduced density to a similar extent in the low-fat diet and control groups. If a low-fat diet reduces breast cancer risk, the effect is unlikely to be through changes in mammographic density at menopause...
  18. ncbi request reprint Risk factors for breast cancer associated with mammographic features in Singaporean chinese women
    Derrick Heng
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 13:1751-8. 2004
    ....
  19. pmc Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Ontario, Canada
    Breast Cancer Res 6:R352-65. 2004
    ..Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine...
  20. doi request reprint Food, beverage, and macronutrient intakes in postmenopausal Caucasian and Chinese-Canadian women
    Carolyn Y Tam
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Nutr Cancer 63:687-98. 2011
    ..Future work will examine whether these dietary differences are associated with biological markers of breast cancer risk...
  21. ncbi request reprint Influence of patterns of hormone replacement therapy use and mammographic density on breast cancer detection
    Anna M Chiarelli
    Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada M5G 2L7
    Cancer Epidemiol Biomarkers Prev 15:1856-62. 2006
    ..This study explores this relationship further by examining the influence of patterns of HRT use and the percentage of mammographic density on the detection of breast cancer by classification of interval cancer...
  22. doi request reprint Family history, mammographic density, and risk of breast cancer
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 19:456-63. 2010
    ..The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease...
  23. ncbi request reprint Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Ontario, M5G 2M9 Canada
    Cancer Epidemiol Biomarkers Prev 12:838-47. 2003
    ..These findings indicate that COMT genotype is associated with several risk factors for breast cancer and suggest that the low-activity COMT*2 allele is associated with a reduced risk of breast cancer among premenopausal women...
  24. pmc Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Ontario, Canada
    Breast Cancer Res 6:R338-51. 2004
    ..One enzyme that is able to affect both the mitogenic and mutagenic characteristics of estrogens is cytochrome P450 1A2 (CYP1A2), which is principally responsible for the metabolism of 17beta-estradiol...
  25. doi request reprint Tumor characteristics associated with mammographic detection of breast cancer in the Ontario breast screening program
    Victoria A Kirsh
    Prevention and Cancer Control, Cancer Care Ontario, 620 University Ave, Toronto, ON M5G 2L7, Canada
    J Natl Cancer Inst 103:942-50. 2011
    ..Few studies have compared the prognostic value of tumor characteristics by type of breast cancer diagnosed in the interval between mammographic screenings with screen-detected breast cancers...
  26. pmc Risk factors for breast cancer in postmenopausal Caucasian and Chinese-Canadian women
    Carolyn Y Tam
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2K9, Canada
    Breast Cancer Res 12:R2. 2010
    ..The goal of this cross-sectional study was to examine breast cancer risk factors in populations with different risks for breast cancer...
  27. doi request reprint Association between IGF1 CA microsatellites and mammographic density, anthropometric measures, and circulating IGF-I levels in premenopausal Caucasian women
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 116:413-23. 2009
    ..Therefore, we examined the association of IGF1 polymorphisms with circulating IGF-I levels and mammographic density...
  28. doi request reprint A randomized trial of dietary intervention for breast cancer prevention
    Lisa J Martin
    Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 71:123-33. 2011
    ..Weight and carbohydrate intakes were associated with risk of ER-positive breast cancer...
  29. doi request reprint Mammographic density: a heritable risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Methods Mol Biol 472:343-60. 2009
    ....
  30. doi request reprint Differences in measured mammographic density in the menstrual cycle
    Gayane Hovhannisyan
    Ontario Cancer Institute University Health Network, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 18:1993-9. 2009
    ..To examine this possible effect, we compared mammographic density in premenopausal women who had mammograms at different phases of the menstrual cycle...
  31. pmc A genome-wide linkage study of mammographic density, a risk factor for breast cancer
    Celia M T Greenwood
    Program in Genetics and Genome Biology, The Hospital for Sick Children, 101 College Street, East Tower, Toronto, ON M5G 1L7, Canada
    Breast Cancer Res 13:R132. 2011
    ..Mammographic breast density is a highly heritable (h2 > 0.6) and strong risk factor for breast cancer. We conducted a genome-wide linkage study to identify loci influencing mammographic breast density (MD)...
  32. doi request reprint Hormone therapy, mammographic density, and breast cancer risk
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Maturitas 64:20-6. 2009
    ..Further research to examine the potential role of PMD as a mediator of the effects of other risk factors is required...
  33. doi request reprint Lifetime physical activity in postmenopausal Caucasian and Chinese-Canadian women
    Carolyn Tam
    aCampbell Family Institute for Breast Cancer Research, Ontario Cancer Institute bDepartment of Nutritional Sciences, University of Toronto, Toronto, Ontario cDepartment of Population Health Research, Alberta Health Services, Calgary, Alberta dSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Cancer Prev 23:90-5. 2014
    ....
  34. pmc Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Avenue, Toronto, Canada M5G 2M9
    Breast Cancer Res 10:201. 2008
    ....
  35. ncbi request reprint Intervention with a low-fat, high-carbohydrate diet does not influence the timing of menopause
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada
    Am J Clin Nutr 84:920-8. 2006
    ..Later age at menopause is associated with a greater risk of breast cancer. Dietary factors may at least partially influence breast cancer risk through an effect on the age at menopause...
  36. ncbi request reprint A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer
    Barbara S Connolly
    Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9
    Nutr Cancer 44:127-38. 2002
    ..62 (95% CI = 1.28-2.04). This meta-analysis indicates that a greater WHR is associated with increased risk of breast cancer and suggests that the avoidance of abdominal obesity may reduce risk of the disease...
  37. ncbi request reprint A volumetric method for estimation of breast density on digitized screen-film mammograms
    Olga Pawluczyk
    Imaging Bioengineering Research, Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 30:352-64. 2003
    ..Clinical studies are ongoing to evaluate whether VBD can be a better indicator for breast cancer risk...
  38. pmc Experimental manipulation of radiographic density in mouse mammary gland
    Mehrdad Hariri
    Department of Medical Biophysics, Ontario Cancer Institute University Health Network, Toronto, Ontario, Canada
    Breast Cancer Res 6:R540-5. 2004
    ..Mouse models provide a powerful approach to the study of human diseases, but there is currently no model that is suited to the study of mammographic density...
  39. ncbi request reprint Characteristics associated with participation at various stages at the Ontario site of the cooperative family registry for breast cancer studies
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Epidemiol 12:27-33. 2002
    ..Sampling is based on age and defined genetic risk criteria. The purpose of this analysis was to evaluate the representativeness of the respondents...
  40. ncbi request reprint Critical assessment of new risk factors for breast cancer: considerations for development of an improved risk prediction model
    Richard J Santen
    Department of Internal Medicine Endocrinology, University of Virginia Health System, Box 801416, Charlottesville, Virginia 22908, USA
    Endocr Relat Cancer 14:169-87. 2007
    ..The BCPCG analyzed potentially available clinical material from previous prospective studies and determined that a large case/control study to evaluate these new factors might be feasible at this time...
  41. ncbi request reprint A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 8:3105-17. 2002
    ..Subjects were randomized to 6 months of oral DFMO (0.5 g/m(2)/day) or placebo, followed by repeat fine-needle aspiration and biomarker assessment. The main study end point was an improvement in cytologic pattern...
  42. ncbi request reprint The heritability of mammographically dense and nondense breast tissue
    Jennifer Stone
    Centre for Molecular Environmental Genetic and Analytic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 15:612-7. 2006
    ..Our previous twin study showed that the heritability of PMD was 63%. This study determined the heritabilities of the components of PMD, the areas of dense and nondense tissue in the mammogram...
  43. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  44. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006

Research Grants2

  1. MAMMOGRAPHIC DENSITITES IN CHINESE AND CAUCASIAN WOMEN
    Norman Boyd; Fiscal Year: 2002
    ..Information about selected risk factors and anthropometric variables will be collected by telephone interview. Mammograms will be obtained and digitized, and the volume of the breast and of dense tissue determined. ..
  2. Determinants of breast tissue composition in young women
    Johanna M Rommens; Fiscal Year: 2010
    ..For these reasons it may be easier at early ages to detect genetic effects, as well as the effects of environmental exposures unique to early life. ..