Research Topics
| Guido BocciSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
The effect of osteogenic growth peptide (OGP) on proliferation and adhesion of HEMC-1 human endothelial cellsGuido Bocci
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
Pharmacol Res 45:21-5. 2002..These in vitro findings may suggest a possible administration of OGP, as a haematopoietic factor, to patients affected by pathological conditions involving angiogenesis...
Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivoBastianina Canu
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Pisa, Italy
Neoplasia 13:217-29. 2011..To demonstrate the synergistic antiproliferative and proapoptotic activity of irinotecan and axitinib in vitro and the improvement of the in vivo effects on angiogenesis and pancreatic cancer...
CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivoAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100, Pisa, Italy
J Clin Endocrinol Metab 97:E528-36. 2012..We have studied the antitumor activity of a novel cyclic amide, CLM94, with anti-vascular endothelial growth factor (VEGF) receptor-2 and antiangiogenic activity in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo...- Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancerAnna Fioravanti
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
Eur J Pharmacol 619:8-14. 2009..The metronomic concept might not universally apply to every cytotoxic drug in colorectal cancer and metronomic combination regimens should be used with caution... - Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1Guido Bocci
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Neoplasia 14:833-45. 2012..To evaluate the antitumor and antiangiogenic activity of metronomic ceramide analogs and their relevant molecular mechanisms... - Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancersGiacomo Allegrini
Division of Medical Oncology, Pontedera, Pisa, Italy
Angiogenesis 15:275-86. 2012..To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies... - Discordant somatic and germline VEGF-A genotype in a cancer patient resistant to paclitaxel/bevacizumab with chemosensitive hepatic metastasisLuigi Coltelli
University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
Pharmacogenomics 10:1225-9. 2009.... - Targeting vascular endothelial growth factor pathway in first-line treatment of metastatic colorectal cancer: state-of-the-art and future perspectives in clinical and molecular selection of patientsFotios Loupakis
Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Italy
Curr Cancer Drug Targets 10:37-45. 2010..This review aims at resuming the state-of-the-art about the role of VEGF pathway inhibitors in the treatment of mCRC and at focusing on the present knowledge about candidate biomarkers as predictors of activity and toxicity... - Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cellsGuido Bocci
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma, Pisa, Italy
Biochem Pharmacol 81:1309-16. 2011.... - Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patientsFederica Amatori
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Pharmacogenet Genomics 16:809-16. 2006.... - A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicityGuido Bocci
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Clin Pharmacol Ther 80:384-95. 2006.... - In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatomaCecilia Barbara
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55 I-56126 Pisa, Italy
Eur J Pharmacol 549:27-34. 2006..In conclusion (NH3)2Pt(triacid) is a tolerable and active platinum derivative endowed by a preclinical antitumour activity by oral route... - Irinotecan in combination with thalidomide in patients with advanced solid tumors: a clinical study with pharmacodynamic and pharmacokinetic evaluationGiacomo Allegrini
U O Oncologia Medica, Presidio Ospedaliero, Viale Alfieri 36, 57124, Livorno, and Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Italy
Cancer Chemother Pharmacol 58:585-93. 2006..The main purpose of this study was to investigate possible interactions between CPT-11 pharmacokinetics and thalidomide to explain the previously described gastrointestinal toxicity reduction... - Angiogenesis and VEGF expression in pre-invasive lesions of the human breastPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy
J Pathol 204:140-6. 2004..No correlation was found between VEGF expression and the degree and/or type of vascularization... - Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patientsAntonello Di Paolo
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Curr Clin Pharmacol 1:311-23. 2006.... - Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancerAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, I 56100, Pisa, Italy
J Clin Endocrinol Metab 96:E288-96. 2011..We have studied the antitumoral activity of two new pyrazolo[3,4-d]pyrimidine compounds (CLM3 and CLM29) in primary papillary dedifferentiated thyroid cancer (DePTC) cells... - Pharmacokinetic and pharmacogenetic predictive markers of irinotecan activity and toxicityAntonello Di Paolo
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy
Curr Drug Metab 12:932-43. 2011..In the present review, pharmacokinetic and pharmacogenetic markers will be discussed... - Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodulesPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
Thyroid 17:191-7. 2007.... - Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimensRomano Danesi
Division of Pharmacology and Chemotherapy, Department of Oncology, University of Pisa, Italy
Clin Colorectal Cancer 4:344. 2005 - Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabineGuido Bocci
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma, 55, I-56126 Pisa, Italy
Eur J Pharmacol 498:9-18. 2004.... - 5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancerAntonello Di Paolo
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Clin Cancer Res 14:2749-55. 2008.... - Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degenerationElisa Agosta
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma, 55 56125, Pisa, Italy
Pharmacogenomics 13:1037-53. 2012.... - Metronomic chemotherapy for metastatic prostate cancer: a 'young' concept for old patients?Andrea Fontana
Unit of Medical Oncology 2, Azienda Ospedaliero Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy
Drugs Aging 27:689-96. 2010..Therefore, evaluation of metronomic chemotherapy strategies in prospective, randomized, phase II/III clinical studies of elderly patients with metastatic prostate cancer appears to be warranted... - Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profilingAntonello Di Paolo
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, 56126 Pisa, Italy
Ther Drug Monit 27:362-8. 2005.... - Microvessel density in human normal and neoplastic parathyroidsPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
Endocr Pathol 17:175-81. 2006..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size... - Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-angiogenic therapyGiuseppe Pasqualetti
University of Pisa, Division of Pharmacology and Chemotherapy, Department of Internal Medicine, Via Roma, 55, I 56126 Pisa, Italy
Pharmacogenomics 8:49-66. 2007.... - A rapid high-performance liquid chromatography method to measure linezolid and daptomycin concentrations in human plasmaMarialuisa Polillo
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
Ther Drug Monit 32:200-5. 2010.... - 5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in miceFederico Innocenti
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, I-56126 Pisa, Italy
Toxicol Appl Pharmacol 203:106-13. 2005..This effect seems to be ascribed to a reduction of viable hepatocytes, rather than to an inactivation of DPD activity... - Dihydropyrimidine dehydrogenase polymorphisms and fluoropyrimidine toxicity: ready for routine clinical application within personalized medicine?Marzia Del Re
Division of Pharmacology, Department of Internal Medicine, University of Pisa, 55, Via Roma, 56126 Pisa, Italy
EPMA J 1:495-502. 2010..However, the identification of deficient DPD genotypes may help identify poor-metabolizer patients at risk of developing potentially life-threatening toxicities after standard doses of fluoropyrimidines... - The possible role of chemotherapy in antiangiogenic drug resistanceGuido Bocci
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
Med Hypotheses 78:646-8. 2012..In conclusion, the consequences of our hypothesis could be promptly translated into the preclinical studies and verified in clinical trials, involving cancer patients resistant to chemotherapy plus antiangiogenic drug schedules... - Biologic basis of ovarian metastasis of colorectal cancerRomano Danesi
Division of Pharmacology and Chemotherapy, Department of Oncology, University of Pisa, Italy
Clin Colorectal Cancer 3:223-4. 2004 - EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesisFrancesco Crea
Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
Cancer Metastasis Rev 31:753-61. 2012..Based on this evidence, we propose the development of EZH2 inhibitors as anti-angiogenic and anti-metastatic therapy... - Pharmacokinetics and pharmacodynamics of combination chemotherapy with paclitaxel and epirubicin in breast cancer patientsRomano Danesi
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma 55, Italy
Br J Clin Pharmacol 53:508-18. 2002..To investigate the pharmacokinetics and pharmacodynamics of epirubicin and paclitaxel in combination, as well as the effects of paclitaxel and its vehicle Cremophor EL on epirubicin metabolism... - Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modificationAntonello Di Paolo
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126 Pisa, Italy
Curr Oncol Rep 9:109-14. 2007..The evaluation of liposomal and nanoparticle formulations and the characterization of newer bioreductive agents and drugs that should normalize tumor vasculature are in progress... - Drug therapeutic failures in emergency department patients. A university hospital experienceAlessandro Franceschi
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
Pharmacol Res 49:85-91. 2004..In conclusion, our results suggest that DTFs represent an important cause of emergency department admission, particularly in elderly subjects treated with pharmacological associations... - Definition of the microvascular pattern of the normal human adult mammary glandAntonio G Naccarato
Department of Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Italy
J Anat 203:599-603. 2003..4 +/- 1.5) in lobules and ducts, respectively. PR expression levels were in the range 10-13% (11.1 +/- 1.6) and 14-17% (15.2 +/- 1.4), respectively. No correlation was found between ER/PR expression and vascularization parameters... - Selective anti-endothelial effects of protracted low-dose BAL-9504, a novel geranylgeranyl-transferase inhibitorGuido Bocci
Molecular and Cell Biology Research, Sunnybrook and Women s College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, S 217, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Eur J Pharmacol 477:17-21. 2003..These results may have implications in terms of both increasing anti-tumor efficacy, mediated by antiangiogenic mechanisms, and reducing toxic side effects... - Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugsGuido Bocci
Molecular and Cell Biology Research, Sunnybrook and Women's College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M4N 3M5 Canada
Cancer Res 62:6938-43. 2002.... - Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking waterShan Man
Departments of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
Cancer Res 62:2731-5. 2002..o. metronomic chemotherapy regimen, which proved safe, reasonably efficacious, and potentially applicable to chronic treatment. Such a regimen may be particularly well suited for integration with antiangiogenic drugs... - Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapyGuido Bocci
Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, S 217, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Proc Natl Acad Sci U S A 100:12917-22. 2003..Taken together, the results implicate TSP-1 as a secondary mediator of the antiangiogenic effects of at least some low-dose metronomic chemotherapy regimens... - Three-dimensional in vitro culture of endometrial explants mimics the early stages of endometriosisAlessandro Fasciani
Department of Obstetrics and Gynecology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Fertil Steril 80:1137-43. 2003..The three-dimensional fibrin matrix used in the present study provides an opportunity to observe the earliest biological events of endometriosis in a quantifiable way... - A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasmaJohn M L Ebos
Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, S 217, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Mol Cancer Res 2:315-26. 2004.... - Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodiesGuido Bocci
Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Cancer Res 64:6616-25. 2004..Plasma VEGF should be considered as a possible surrogate pharmacodynamic marker for determining the optimal biological dose of antibody drugs that block VEGFR-2 (KDR) activity in a clinical setting... - Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activityFotios Loupakis
J Clin Oncol 25:1816-8. 2007 - Cellular and molecular surrogate markers to monitor targeted and non-targeted antiangiogenic drug activity and determine optimal biologic doseYuval Shaked
Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Curr Cancer Drug Targets 5:551-9. 2005..Finally, another promising marker we discuss is soluble VEGFR-2...