Pierre Blier

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder
    Mostafa El Mansari
    University of Ottawa Institute of Mental Health Research, Lady Grey Building, 1145 Carling Avenue, Ottawa, ON, Canada K1Z 7K4
    Prog Neuropsychopharmacol Biol Psychiatry 30:362-73. 2006
  2. ncbi request reprint Pharmacotherapies in the management of obsessive-compulsive disorder
    Pierre Blier
    Mood Disorders Research, University of Ottawa Institute of Mental Health Research, Ontario
    Can J Psychiatry 51:417-30. 2006
  3. ncbi request reprint Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers
    Pierre Blier
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 10:41-50. 2007
  4. ncbi request reprint Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety
    Pierre Blier
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Psychiatry 66:30-40. 2005
  5. pmc Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Ottawa, ON
    J Psychiatry Neurosci 29:208-18. 2004
  6. ncbi request reprint Differential physiological effects of a low dose and high doses of venlafaxine in major depression
    Guy Debonnel
    Department of Psychiatry, McGill University, Montreal, QC, and Royal Ottawa Hospital, ON, Canada
    Int J Neuropsychopharmacol 10:51-61. 2007
  7. doi request reprint Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain
    Ramez Ghanbari
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Eur Neuropsychopharmacol 22:518-26. 2012
  8. ncbi request reprint Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons
    Noam S Katz
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Psychopharmacol 24:1223-35. 2010
  9. doi request reprint Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain
    Ramez Ghanbari
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Pharmacol Exp Ther 335:197-206. 2010
  10. doi request reprint Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons
    Bruno P Guiard
    University of Ottawa, Institute of Mental Health Research, Ottawa, ON, Canada
    Int J Neuropsychopharmacol 14:211-23. 2011

Detail Information

Publications86

  1. ncbi request reprint Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder
    Mostafa El Mansari
    University of Ottawa Institute of Mental Health Research, Lady Grey Building, 1145 Carling Avenue, Ottawa, ON, Canada K1Z 7K4
    Prog Neuropsychopharmacol Biol Psychiatry 30:362-73. 2006
    ....
  2. ncbi request reprint Pharmacotherapies in the management of obsessive-compulsive disorder
    Pierre Blier
    Mood Disorders Research, University of Ottawa Institute of Mental Health Research, Ontario
    Can J Psychiatry 51:417-30. 2006
    ..We present this information to promote better understanding of the research endeavours needed to develop new pharmacotherapeutic approaches...
  3. ncbi request reprint Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers
    Pierre Blier
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 10:41-50. 2007
    ..While the reasons for this unexpected lack of action remain unclear, venlafaxine appeared to be an effective NE reuptake agent in depressed patients using the same approach...
  4. ncbi request reprint Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety
    Pierre Blier
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Psychiatry 66:30-40. 2005
    ..This effect may result in part from its antagonistic actions on dopaminergic receptors and alpha2-adrenoceptors on serotonin terminals...
  5. pmc Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Ottawa, ON
    J Psychiatry Neurosci 29:208-18. 2004
    ..Taken together, these observations strongly suggest that NK1 antagonists could become a new class of antidepressant and anxiolytic agents...
  6. ncbi request reprint Differential physiological effects of a low dose and high doses of venlafaxine in major depression
    Guy Debonnel
    Department of Psychiatry, McGill University, Montreal, QC, and Royal Ottawa Hospital, ON, Canada
    Int J Neuropsychopharmacol 10:51-61. 2007
    ....
  7. doi request reprint Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain
    Ramez Ghanbari
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Eur Neuropsychopharmacol 22:518-26. 2012
    ..The enhancement in α₂-adrenergic transmission by trazodone, and its 5-HT(2A) and 5-HT(2C) receptor antagonism may contribute to its therapeutic action in major depression...
  8. ncbi request reprint Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons
    Noam S Katz
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Psychopharmacol 24:1223-35. 2010
    ..Nomifensine likely treated depression by acting on dopamine, norepinephrine and 5-HT neurons, highlighting the importance of the functional connectivity between these three monoaminergic systems...
  9. doi request reprint Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain
    Ramez Ghanbari
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Pharmacol Exp Ther 335:197-206. 2010
    ..The enhanced 5-HT neurotransmission by trazodone is caused in part by reuptake blockade and activation of postsynaptic 5-HT(1A) receptors, which may account for its effectiveness in major depression...
  10. doi request reprint Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons
    Bruno P Guiard
    University of Ottawa, Institute of Mental Health Research, Ottawa, ON, Canada
    Int J Neuropsychopharmacol 14:211-23. 2011
    ..The results also suggest that the therapeutic action of triple reuptake inhibitors may be potentiated by antagonizing the cell body 5-HT(₁A) autoreceptors...
  11. pmc Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation
    Stella Manta
    Institute of Mental Health Research, University of Ottawa, Ont, Canada
    J Psychiatry Neurosci 34:272-80. 2009
    ..This study was conducted to further characterize these effects...
  12. ncbi request reprint Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons
    Eliyahu Dremencov
    University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue Suite 6419, Ottawa, ON K1Z 7K4, Canada
    Psychopharmacology (Berl) 194:63-72. 2007
    ..While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites...
  13. pmc Auditory P3 in antidepressant pharmacotherapy treatment responders, non-responders and controls
    Natalia Jaworska
    University of Ottawa, Institute of Mental Health Research, Ottawa, Ont, Canada Department of Psychology, University of Ottawa, Ottawa, Ont, Canada Department of Psychiatry, Hotchkiss Brain Institute HBI, Alberta Children s Hospital Research Institute ACRI, University of Calgary, Calgary, Alta, Canada Electronic address
    Eur Neuropsychopharmacol 23:1561-9. 2013
    ..These results suggest that greater (or control-like) baseline P3a/b amplitudes are associated with a positive antidepressant response, and that gender differences characterize the P3 and, by extension, basic attentive processes. ..
  14. pmc Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain
    Olga Chernoloz
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ont
    J Psychiatry Neurosci 37:113-21. 2012
    ..We hypothesized that PPX would increase overall DA and 5-HT neurotransmission in the forebrain as a result of these changes at the presynaptic level...
  15. doi request reprint Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder
    Olga Chernoloz
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada
    Psychopharmacology (Berl) 206:335-44. 2009
    ..However, the precise mechanisms responsible for the effectiveness of ARI augmentation are not fully understood...
  16. doi request reprint Mirtazapine and paroxetine in major depression: a comparison of monotherapy versus their combination from treatment initiation
    Pierre Blier
    Department of Psychiatry, McGill University, 1033 Avenue des Pins Ouest, Montreal, Quebec, Canada H3A 1A1
    Eur Neuropsychopharmacol 19:457-65. 2009
    ..Of these 30 patients, approximately 50% went on to achieve remission in the subsequent 2 weeks. These results indicate that the combined use of two antidepressants was well tolerated and produced a greater improvement than monotherapy...
  17. pmc Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area
    Eliyahu Dremencov
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Psychiatry Neurosci 34:223-9. 2009
    ..Since the mesolimbic DA system plays an important role in motivation and reward, a potential decrease in the firing of DA neurons may lead, in some patients, to a lack of adequate response to SSRIs...
  18. doi request reprint Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada K1Z 7K4
    Am J Psychiatry 167:281-8. 2010
    ..In this double-blind study, the authors sought to produce evidence for the superiority of different combinations of antidepressant drugs from treatment initiation...
  19. doi request reprint Sustained administration of bupropion alters the neuronal activity of serotonin, norepinephrine but not dopamine neurons in the rat brain
    Mostafa El Mansari
    University of Ottawa Institute of Mental Health Research, Room 7407, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
    Neuropharmacology 55:1191-8. 2008
    ....
  20. ncbi request reprint Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function
    Gabriella Gobbi
    Department of Psychiatry, McGill University, 1033 Pine Avenue, West Montreal, QC, Canada H3A 1A1
    Eur Neuropsychopharmacol 17:328-38. 2007
    ..In conclusion, NE neurons are essential for the action of NK1 antagonists on 5-HT neurons. In addition, the desensitization of 5-HT(1A) autoreceptors produced by NK1 receptor antagonism is not critical for enhancing 5-HT neuronal firing...
  21. pmc Response prediction to antidepressants using scalp and source-localized loudness dependence of auditory evoked potential (LDAEP) slopes
    Natalia Jaworska
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 44:100-7. 2013
    ..This work confirms that certain LDAEP measures are associated with treatment outcome and appear to be differentially modulated with varying antidepressant drug regimens, though this should be confirmed using larger samples...
  22. doi request reprint Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area
    Franck Chenu
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 12:475-85. 2009
    ..Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors...
  23. doi request reprint Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions
    Bruno P Guiard
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 11:625-39. 2008
    ..Indeed, based on the understanding of such interactions, it may be possible to develop strategies to improve the effectiveness of antidepressant drugs by preventing counter-productive negative feedback actions...
  24. ncbi request reprint Enhancement of serotonergic and noradrenergic neurotransmission in the rat hippocampus by sustained administration of bupropion
    Ramez Ghanbari
    Institute of Mental Health Research, University of Ottawa, Room 6411, 1145 Carling Avenue, Ottawa, K1Z7K4 ON, Canada
    Psychopharmacology (Berl) 217:61-73. 2011
    ..Previous studies reported that bupropion, an effective antidepressant, exerts modulatory actions on serotonin (5-HT) and norepinephrine (NE) neurons...
  25. pmc Effects of sustained administration of quetiapine alone and in combination with a serotonin reuptake inhibitor on norepinephrine and serotonin transmission
    Olga Chernoloz
    Institute of Mental Health Research IMHR, University of Ottawa, Ottawa, ON, Canada
    Neuropsychopharmacology 37:1717-28. 2012
    ..The enhancement of NE and 5-HT transmission by hQuet may contribute to its antidepressant action in mood disorders...
  26. ncbi request reprint Physiologic mechanisms underlying the antidepressant discontinuation syndrome
    Pierre Blier
    Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Psychiatry 67:8-13. 2006
    ..It also attempts to explain their implications in the therapeutic actions of antidepressants in patients with affective and anxiety disorders...
  27. doi request reprint Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampus
    Bruno P Guiard
    University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, K1Z 7K4, Ontario, Canada
    Mol Pharmacol 74:1463-75. 2008
    ..These findings might help in designing new antidepressant strategies aimed at enhancing DA and NE neurotransmission...
  28. pmc Relevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder
    Mostafa El Mansari
    University of Ottawa Institute of Mental Health Research, Ontario, Canada
    CNS Neurosci Ther 16:e1-17. 2010
    ..The elucidation of such relationships can help design new treatment strategies for MDD, especially treatment-resistant depression...
  29. pmc Serotonin and beyond: therapeutics for major depression
    Pierre Blier
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Philos Trans R Soc Lond B Biol Sci 368:20120536. 2013
    ..Novel approaches are also being used to treat MDD, which also appear to involve the monoaminergic system(s) to a varying extent...
  30. pmc α Power, α asymmetry and anterior cingulate cortex activity in depressed males and females
    Natalia Jaworska
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    J Psychiatr Res 46:1483-91. 2012
    ..Altered theta in the sgACC may reflect emotion regulation abnormalities in MDD...
  31. ncbi request reprint Optimization of vagus nerve stimulation parameters using the firing activity of serotonin neurons in the rat dorsal raphe
    Stella Manta
    Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, Ontario K1Z7K4, Canada
    Eur Neuropsychopharmacol 19:250-5. 2009
    ..Excessive enhancement of the charge delivered to the nerve can lead to a loss of VNS effect on 5-HT neuronal firing...
  32. ncbi request reprint Prospect of a dopamine contribution in the next generation of antidepressant drugs: the triple reuptake inhibitors
    Bruno P Guiard
    University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa K1Z7K4 ON, Canada
    Curr Drug Targets 10:1069-84. 2009
    ..This review synthetizes the pertinent litterature, focusing on the contribution of DA, to illustrate the rationale for designing improved antidepressants...
  33. doi request reprint Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain
    Stacey Shim
    University of Ottawa Institute of Mental Health Research S S, M E M, P B and Department of Cellular and Molecular Medicine, University of Ottawa S S, P B, Ottawa, Ontario, Canada
    J Pharmacol Exp Ther 347:487-96. 2013
    ..This serotonergic effect may be associated with an antiglutamatergic action and may contribute to the antidepressant-like effect of carisbamate in the forced swim test and the antidepressant properties of lamotrigine. ..
  34. ncbi request reprint Modification of serotonin neuron properties in mice lacking 5-HT1A receptors
    Maxime Richer
    Neurobiological Psychiatry Unit, McGill University, 1033 Avenue des Pins Ouest, H3A 1A1, Montreal, Quebec, Canada
    Eur J Pharmacol 435:195-203. 2002
    ..In addition, it was not associated with changes in the function of 5-HT1D and 5-HT1B autoreceptors and of alpha2-adrenergic heteroreceptors on 5-HT neurons, nor of that of alpha2-adrenoceptors on norepinephrine terminals...
  35. doi request reprint Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems
    Stella Manta
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 16:459-70. 2013
    ....
  36. ncbi request reprint Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression
    Pedro Rosa-Neto
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Arch Gen Psychiatry 61:556-63. 2004
    ..Reduced synthesis of serotonin in the brain pathways mediating the expression of mood (ie, the limbic cortex) is a plausible candidate mechanism...
  37. ncbi request reprint Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation
    Pierre Blier
    Department of Psychiatry, McGill University, Montreal, Canada
    Neuropsychopharmacology 27:301-8. 2002
    ....
  38. ncbi request reprint Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs
    Gabriella Gobbi
    Department of Psychiatry, Univ de Montreal and McGill University, 1033, Av des Pins Ouest, Montreal, Canada H3A 1A1
    Peptides 26:1383-93. 2005
    ..Further research is needed in order to develop more selective ligands for the human NK1 receptor and to gain better knowledge of required brain penetration and optimal pharmacodynamic conditions for their use in patients...
  39. pmc Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain
    Franck Chenu
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada
    Neuropsychopharmacology 38:275-84. 2013
    ....
  40. doi request reprint Scalp- and sLORETA-derived loudness dependence of auditory evoked potentials (LDAEPs) in unmedicated depressed males and females and healthy controls
    Natalia Jaworska
    University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada
    Clin Neurophysiol 123:1769-78. 2012
    ....
  41. doi request reprint Novel attempts to optimize vagus nerve stimulation parameters on serotonin neuronal firing activity in the rat brain
    Stella Manta
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Brain Stimul 5:422-9. 2012
    ..Thus far, it appears that the standard stimulation parameters currently used in depressed patients produce an optimal activation of 5-HT neurons...
  42. pmc Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder
    Alexandre Berney
    DERBH, Department of Psychiatry, McGill University, 1033 Pine Ave West, Montreal, QC H3A 1A1, Canada
    Arch Gen Psychiatry 68:732-41. 2011
    ..Serotonergic abnormalities in the unmedicated symptomatic state, however, remain to be fully characterized...
  43. ncbi request reprint Comparison of pharmacokinetic profiles of brand-name and generic formulations of citalopram and venlafaxine: a crossover study
    Franck Chenu
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    J Clin Psychiatry 70:958-66. 2009
    ..80 to 1.25 range. The aim of the present pilot study was to compare the pharmacokinetic profiles of brand-name and generic formulations of citalopram and extended-release venlafaxine...
  44. ncbi request reprint Noradrenergic augmentation of escitalopram response by risperidone: electrophysiologic studies in the rat brain
    Eliyahu Dremencov
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    Biol Psychiatry 61:671-8. 2007
    ....
  45. ncbi request reprint Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study
    Yoshihiro Tohyama
    Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 80:788-98. 2002
    ..The observed effects in the 7-day treatment could also be related to actions through the postsynaptic 5-HT(1B) sites and/or other 5-HT receptors since this compounds have limited selectivity...
  46. ncbi request reprint Neurochemical and psychotropic effects of bupropion in healthy male subjects
    Gabriella Gobbi
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Clin Psychopharmacol 23:233-9. 2003
    ..Presumably it enhances synaptic availability of NE by increasing release. Yet, because its behavioral profile is different from that of methylphenidate, it may not share all the biochemical properties of psychostimulants...
  47. doi request reprint Effects of repeated electroconvulsive shocks on catecholamine systems: electrophysiological studies in the rat brain
    Peter Tsen
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, K1Z 7K4, Canada
    Synapse 67:716-27. 2013
    ..These results showed that repeated ECS enhance DA activity in the SNc and NE transmission in the FMN, which could be a part of the mechanism behind the alleviation of depressive symptoms, including motor retardation, by ECT...
  48. doi request reprint Children of treatment-seeking depressed mothers: a comparison with the sequenced treatment alternatives to relieve depression (STAR*D) child study
    Lisa A Batten
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    J Am Acad Child Adolesc Psychiatry 51:1185-96. 2012
    ....
  49. doi request reprint Neurobiological bases and clinical aspects of the use of aripiprazole in treatment-resistant major depressive disorder
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Canada
    J Affect Disord 128:S3-10. 2011
    ..More gradual titration may lead in routine clinical practice to better outcomes, minimizing side effects and improving remission rates...
  50. pmc Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition
    Mostafa El Mansari
    University of Ottawa Institute of Mental Health Research, Ottawa, ON
    J Psychiatry Neurosci 30:268-74. 2005
    ..This study was undertaken to investigate if these OFC receptors adapt under such conditions...
  51. doi request reprint Altered function of the serotonin 1A autoreceptor and the antidepressant response
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, Canada
    Neuron 65:1-2. 2010
    ....
  52. doi request reprint A framework to avoid irrational polypharmacy in psychiatry
    Daniel Zigman
    University of Ottawa Institute for Mental Health Research, Ottawa, ON, Canada
    J Psychopharmacol 26:1507-11. 2012
    ..Clinicians should also (e) regularly reassess the need for and benefit of continued combination therapy...
  53. doi request reprint Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons
    Franck Chenu
    Institute of Mental Health Research, University of Ottawa, Ottawa, Canada
    J Psychopharmacol 28:162-7. 2014
    ..When 5-HT(2B) receptors were also blocked, the firing and the bursting activity of DA neurons were both enhanced, thus reproducing the effect of agomelatine...
  54. doi request reprint Brain-volume increase with sustained remission in patients with treatment-resistant unipolar depression
    Jennifer L Phillips
    Mood Disorders Research Unit, University of Ottawa Institute of Mental Health Research, Ontario, Canada
    J Clin Psychiatry 73:625-31. 2012
    ..The objective of this study was to prospectively examine brain-volume changes in patients with treatment-resistant depression, comparing those who achieved sustained remission with those who did not remit...
  55. ncbi request reprint Catecholaminergic strategies for the treatment of major depression
    Philippe Tremblay
    Institute of Mental Health Research, Lady Grey Building, Suite 2043, Royal Ottawa Hospital, University of Ottawa, Ottawa, Canada
    Curr Drug Targets 7:149-58. 2006
    ..Their use in treatment-resistant depressed patients is also addressed...
  56. pmc On the selection and use of atypical antipsychotics in the management of nonpsychotic mood and anxiety disorders
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ont
    J Psychiatry Neurosci 30:304. 2005
  57. doi request reprint Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain
    Ramez Ghanbari
    University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, Ontario K1Z7K4, Canada
    Eur Neuropsychopharmacol 19:177-87. 2009
    ..These results confirm that asenapine displays potent antagonistic activity at 5-HT(2A), D(2), alpha(2)-adrenergic receptors and provide evidence to support its 5-HT(1A) partial agonistic activity...
  58. doi request reprint Interpersonal psychotherapy versus brief supportive therapy for depressed infertile women: first pilot randomized controlled trial
    Diana Koszycki
    Faculty of Education, University of Ottawa, 145 Jean Jacques Lussier, Ottawa, Ontario, Canada
    Arch Womens Ment Health 15:193-201. 2012
    ..Should subsequent randomized controlled trials support these findings, this will inform clinical practice and take an important step in assuring optimal care for depressed women struggling with infertility...
  59. pmc Psychopharmacology for the clinician. Treating depression with selective norepinephrine reuptake inhibitors
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Ontario
    J Psychiatry Neurosci 31:288. 2006
  60. doi request reprint Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets
    Sidney H Kennedy
    University Health Network, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Affect Disord 132:S21-8. 2011
    ..This is of particular importance when considering the long term use of antidepressant therapies for relapse prevention...
  61. ncbi request reprint Preventing recurrent depression: long-term treatment for major depressive disorder
    Pierre Blier
    Department of Psychiatry, Institute of Mental Health Research, University of Ottawa, Canada
    J Clin Psychiatry 68:e06. 2007
    ..Maintenance therapy considerations for clinicians include assessing treatment guidelines, addressing nonadherent patients, and measuring medication treatment response...
  62. doi request reprint Neurotransmitter targeting in the treatment of depression
    Pierre Blier
    Institute of Mental Health Research, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada
    J Clin Psychiatry 74:19-24. 2013
    ..For patients to truly regain their quality of life, clinicians must target residual symptoms. ..
  63. pmc The temporal electrocortical profile of emotive facial processing in depressed males and females and healthy controls
    Natalia Jaworska
    University of Ottawa Institute of Mental Health Research, Department of Psychology, University of Ottawa, Ottawa, ON, Canada
    J Affect Disord 136:1072-81. 2012
    ....
  64. ncbi request reprint Specificities of treatment in pediatric obsessive-compulsive disorder
    Martine F Flament
    University of Ottawa Institute of Mental Health Research, Ontario, Canada
    CNS Spectr 12:43-58. 2007
    ..Current concerns with the use of SSRIs in children and adolescents were explored as regards OCD and anxiety disorders, and there is no evidence for an increase in suicide or related behaviors...
  65. ncbi request reprint Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons
    Steven T Szabo
    Department of Neuroscience and Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0383, USA
    J Pharmacol Exp Ther 302:983-91. 2002
    ..This NE activity, resulting from 5-HT reuptake inhibition plus 5-HT(2A) receptor antagonism, might confer additional benefits in affective and anxiety disorders...
  66. ncbi request reprint Effect of long-term administration of the antidepressant drug milnacipran on serotonergic and noradrenergic neurotransmission in the rat hippocampus
    Michel Weiss
    Neurobiological Psychiatry Unit, Mc Gill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Life Sci 81:166-76. 2007
    ....
  67. ncbi request reprint Neurokinin-1 receptors are decreased in major depressive disorder
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson 39216, USA
    Neuroreport 13:1223-7. 2002
    ..024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex...
  68. ncbi request reprint Which antidepressants have demonstrated superior efficacy? A review of the evidence
    Stuart A Montgomery
    Imperial College School of Medicine, University of London, UK
    Int Clin Psychopharmacol 22:323-9. 2007
    ..This review of published data found evidence that only a very few antidepressants are shown to be more effective than others...
  69. ncbi request reprint Is there a role for 5-HT1A agonists in the treatment of depression?
    Pierre Blier
    Departments of Psychiatry and Neuroscience, University of Florida Brain Institute, Gainesville, Florida 32610, USA
    Biol Psychiatry 53:193-203. 2003
    ..In sum, 5-HT1A receptor agonism represents a valuable and efficacious therapeutic approach to major depression...
  70. ncbi request reprint A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorder
    Nathan A Shapira
    Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida 32610 0256, USA
    Biol Psychiatry 55:553-5. 2004
    ..One of the few combination approaches to the treatment of obsessive-compulsive disorder (OCD) with encouraging support is the addition of an antipsychotic to a serotonin reuptake inhibitor...
  71. ncbi request reprint Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons
    Steven T Szabo
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 55:934-9. 2004
    ..Of interest, the activity of locus coeruleus neurons is a reflective index of these above mentioned behavioral states...
  72. ncbi request reprint Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus
    Nasser Haddjeri
    Laboratory of Neuropharmacology and Neurochemistry INSERM U512, University Claude Bernard, Avenue Rockfeller, Lyon, France
    Neuropsychopharmacology 29:1800-6. 2004
    ..When the fluctuations of the function of NE neurons normally produced by WAY 100,635 were prevented, a tonic activation of 5-HT(1A) autoreceptors by endogenous 5-HT was unmasked...
  73. ncbi request reprint Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research
    Alan F Schatzberg
    Stanford University School of Medicine, Stanford, Calif 94305 5717, USA
    J Clin Psychiatry 67:27-30. 2006
    ..This article summarizes recommendations with respect to future research as well as clinical management recommendations for SRI discontinuation syndrome...
  74. ncbi request reprint In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system
    Nasser Haddjeri
    Laboratory of Neuropharmacology and Neurochemistry, Faculty of Pharmacy, University Claude Bernard Lyon I, INSERM U 512, 8 Avenue Rockefeller 69373 Lyon Cedex 08, France
    Int J Neuropsychopharmacol 7:391-9. 2004
    ..c.) and reduced 8-OH-DPAT (0.1 mg/kg s.c.)-induced hypothermia. In conclusion, the present study reports a functional role of muscarinic receptors in the modulation of pre- and post-synaptic 5-HT1A receptors mediated responses...
  75. ncbi request reprint Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depression
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    J Clin Psychiatry 69:246-58. 2008
    ..This article reviews research on the current understanding and management of residual symptoms, i.e., subthreshold depressive symptoms present after recovery from a major depressive episode...
  76. ncbi request reprint Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1)
    Luca Santarelli
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    J Clin Psychiatry 63:11-7. 2002
    ..Future studies will attempt to delineate the interaction between the SP-NK1R system and various neurotransmitter pathways in greater detail and to address the specific role(s) of this system in different brain regions...
  77. doi request reprint World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia
    Rajiv Tandon
    University of Florida, Tallahassee, USA
    Schizophr Res 100:20-38. 2008
    ....
  78. pmc The usefulness of large studies in psychopharmacology: understanding their strong points and their drawbacks
    Pierre Blier
    J Psychiatry Neurosci 32:232-3. 2007
  79. ncbi request reprint Selecting methodologies for the evaluation of differences in time to response between antidepressants
    Stuart A Montgomery
    Imperial College School of Medicine, London, United Kingdom
    J Clin Psychiatry 63:694-9. 2002
    ..The delay in the therapeutic effect of antidepressants is a considerable impediment to their successful clinical use, and attention has recently been focused on antidepressant drugs that may have a faster onset of action...
  80. pmc Atypical antipsychotics for mood and anxiety disorders: safe and effective adjuncts?
    Pierre Blier
    J Psychiatry Neurosci 30:232-3. 2005
  81. pmc Do antidepressants really work?
    Pierre Blier
    J Psychiatry Neurosci 33:89-90. 2008
  82. ncbi request reprint The pharmacology of putative early-onset antidepressant strategies
    Pierre Blier
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Room L4 100, PO Box 100256, Gainesville, FL 32610 0383, USA
    Eur Neuropsychopharmacol 13:57-66. 2003
    ..Further studies are required to characterise in detail the interactions between NA and 5-HT systems and to definitively establish the early onset of candidate antidepressants such as mirtazapine, venlafaxine and pindolol augmentation...
  83. pmc Pregnancy, depression, antidepressants and breast-feeding
    Pierre Blier
    J Psychiatry Neurosci 31:226-8. 2006
  84. ncbi request reprint Media pressure and patient care
    Pierre Blier
    J Psychopharmacol 20:469-70. 2006
  85. pmc How many good antidepressant medications have we missed?
    Pierre Blier
    J Psychiatry Neurosci 29:248-9. 2004
  86. pmc Why treat depression differently from other medical problems?
    Pierre Blier
    J Psychiatry Neurosci 27:231-2. 2002