B J Blencowe

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs
    Brendan J Frey
    Electrical and Computer Engineering, University of Toronto, 10 King s College Rd, Toronto, Ontario M5S 3G4, Canada
    Nat Genet 37:991-6. 2005
  2. ncbi request reprint An RNA map predicting Nova-dependent splicing regulation
    Jernej Ule
    Howard Hughes Medical Institute, New York, New York 10021, USA
    Nature 444:580-6. 2006
  3. pmc Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay
    David R McIlwain
    Campbell Family Cancer Research Institute and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 107:12186-91. 2010
  4. pmc The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
    T McGarvey
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    J Cell Biol 150:309-20. 2000
  5. pmc Distinct types of disorder in the human proteome: functional implications for alternative splicing
    Recep Colak
    The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
    PLoS Comput Biol 9:e1003030. 2013
  6. doi request reprint An exon-centric perspective
    Benjamin J Blencowe
    Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College Street, Room 1016, Toronto, ON M5S 3E1, Canada
    Biochem Cell Biol 90:603-12. 2012
  7. pmc Functional coordination of alternative splicing in the mammalian central nervous system
    Matthew Fagnani
    Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1
    Genome Biol 8:R108. 2007
  8. pmc A systematic search for new mammalian noncoding RNAs indicates little conserved intergenic transcription
    Tomas Babak
    Banting and Best Department of Medical Research, 112 College St, Toronto, ON M5G 1L6, Canada
    BMC Genomics 6:104. 2005
  9. pmc Considerations in the identification of functional RNA structural elements in genomic alignments
    Tomas Babak
    Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, 160 College St, Toronto, ON M5S 3E1 Canada
    BMC Bioinformatics 8:33. 2007
  10. ncbi request reprint Transcription: surprising role for an elusive small nuclear RNA
    Benjamin J Blencowe
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, 112 College Street, Room 410, Ontario, M5G 1L6, Toronto, Canada
    Curr Biol 12:R147-9. 2002

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs
    Brendan J Frey
    Electrical and Computer Engineering, University of Toronto, 10 King s College Rd, Toronto, Ontario M5S 3G4, Canada
    Nat Genet 37:991-6. 2005
    ..GenRate also detected tens of thousands of potential new exons and reconciled discrepancies in current cDNA databases by 'stitching' new transcribed regions into previously annotated genes...
  2. ncbi request reprint An RNA map predicting Nova-dependent splicing regulation
    Jernej Ule
    Howard Hughes Medical Institute, New York, New York 10021, USA
    Nature 444:580-6. 2006
    ....
  3. pmc Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay
    David R McIlwain
    Campbell Family Cancer Research Institute and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 107:12186-91. 2010
    ..Our results demonstrate a critical role for Smg1 in early mouse development and link the loss of this NMD factor to major and widespread changes in the mammalian transcriptome...
  4. pmc The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
    T McGarvey
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    J Cell Biol 150:309-20. 2000
    ..Thus, DEK is a candidate factor for controlling postsplicing steps in gene expression that are influenced by the prior removal of an intron from pre-mRNA...
  5. pmc Distinct types of disorder in the human proteome: functional implications for alternative splicing
    Recep Colak
    The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
    PLoS Comput Biol 9:e1003030. 2013
    ....
  6. doi request reprint An exon-centric perspective
    Benjamin J Blencowe
    Banting and Best Department of Medical Research and Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College Street, Room 1016, Toronto, ON M5S 3E1, Canada
    Biochem Cell Biol 90:603-12. 2012
    ..This perspective provides an account of progress in these areas and also discusses future avenues of exon-centric exploration...
  7. pmc Functional coordination of alternative splicing in the mammalian central nervous system
    Matthew Fagnani
    Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1
    Genome Biol 8:R108. 2007
    ..However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood...
  8. pmc A systematic search for new mammalian noncoding RNAs indicates little conserved intergenic transcription
    Tomas Babak
    Banting and Best Department of Medical Research, 112 College St, Toronto, ON M5G 1L6, Canada
    BMC Genomics 6:104. 2005
    ..However, these non-genic transcripts often appear to be low in abundance, and their functional significance is not known...
  9. pmc Considerations in the identification of functional RNA structural elements in genomic alignments
    Tomas Babak
    Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, 160 College St, Toronto, ON M5S 3E1 Canada
    BMC Bioinformatics 8:33. 2007
    ....
  10. ncbi request reprint Transcription: surprising role for an elusive small nuclear RNA
    Benjamin J Blencowe
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, 112 College Street, Room 410, Ontario, M5G 1L6, Toronto, Canada
    Curr Biol 12:R147-9. 2002
    ..Two recent studies have shown that 7SK acts as a negative regulator of the RNA polymerase II elongation factor P-TEFb, and that this activity is influenced by stress response pathways...
  11. ncbi request reprint Alternative splicing: new insights from global analyses
    Benjamin J Blencowe
    Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, Centre for Cellular and Biomolecular Research, Donnelly CCBR Building, University of Toronto, Toronto, ON M5S 3E1, Canada
    Cell 126:37-47. 2006
    ..Recent progress in these areas is summarized in this review...
  12. doi request reprint Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes
    Benjamin J Blencowe
    Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Genes Dev 23:1379-86. 2009
    ..We also consider how future advances in HTS technology are likely to transform our understanding of integrated cellular networks operating at the RNA level...
  13. ncbi request reprint Splicing regulation: the cell cycle connection
    Benjamin J Blencowe
    C H Best Institute, University of Toronto, 112 College Street, Room 410, Toronto, Ontario, Canada M5G 1L6
    Curr Biol 13:R149-51. 2003
    ..A recent study suggests that splicing is also targeted for mitotic repression, in this case by dephosphorylation of the newly identified splicing factor SRp38...
  14. ncbi request reprint Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases
    B J Blencowe
    Dept of Medical Research, C H Best Institute, University of Toronto, 112 College St, Toronto, Ontario, Canada M5G 1L6
    Trends Biochem Sci 25:106-10. 2000
    ..Ominously, these latter studies predict that many human genetic diseases linked to mutations within exons might be caused by the inactivation of ESEs...
  15. ncbi request reprint SR-related proteins and the processing of messenger RNA precursors
    B J Blencowe
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, ON, Canada
    Biochem Cell Biol 77:277-91. 1999
    ..We review these findings and evidence that proteins containing RS domains may play a fundamental role in coordinating different steps in the synthesis and processing of pre-mRNA...
  16. pmc A genome-wide survey of RS domain proteins
    L Boucher
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Ontario, Canada
    RNA 7:1693-701. 2001
    ....
  17. ncbi request reprint Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract
    Y Li
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 274:35074-9. 1999
    ..The results indicate that an ESE promotes spliceosome formation through interactions that are distinct from those required for the binding of U2AF-65 kDa to the polypyrimidine tract...
  18. pmc The SRm160/300 splicing coactivator is required for exon-enhancer function
    A G Eldridge
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada
    Proc Natl Acad Sci U S A 96:6125-30. 1999
    ..The results suggest a model for ESE function in which the SRm160/300 splicing coactivator promotes critical interactions between ESE-bound "activators" and the snRNP machinery of the spliceosome...
  19. pmc Most "dark matter" transcripts are associated with known genes
    Harm van Bakel
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 8:e1000371. 2010
    ..We conclude that, while there are bona fide new intergenic transcripts, their number and abundance is generally low in comparison to known exons, and the genome is not as pervasively transcribed as previously reported...
  20. pmc Global analysis of alternative splicing differences between humans and chimpanzees
    John A Calarco
    Banting and Best Department of Medical Research, University of Toronto, Terrence Donnelly Center for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada
    Genes Dev 21:2963-75. 2007
    ..The results of this study thus support an important role for alternative splicing in establishing differences between humans and chimpanzees...
  21. pmc Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression
    Qun Pan
    Banting and Best Department of Medical Research, University of Toronto, Ontario, M5G 1L6, Canada
    Genes Dev 20:153-8. 2006
    ..Our results suggest that most PTC-introducing AS events are not under positive selection pressure and therefore may not contribute important functional roles...
  22. pmc Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay
    Arneet L Saltzman
    Department of Molecular Genetics, Centre for Cellular and Biomolecular Research, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 28:4320-30. 2008
    ..The results further implicate general spliceosomal components in AS regulation...
  23. pmc Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo
    Emanuel Rosonina
    Banting and Best Department of Medical Research, C H Best Institute, 112 College Street, Toronto, Ontario M5G 1L6, Canada
    Mol Cell Biol 25:6734-46. 2005
    ..Collectively, these results suggest that the recruitment of PSF to activated promoters and the pol II CTD provides a mechanism by which transcription and pre-mRNA processing are coordinated within the cell...
  24. pmc Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD
    Andrew Emili
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Ontario, Canada
    RNA 8:1102-11. 2002
    ..PSF and p54nrb/NonO may therefore provide a direct physical link between the pol II CTD and pre-mRNA processing components, at both the initiation and elongation phases of transcription...
  25. ncbi request reprint An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation
    Susan McCracken
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 278:44153-60. 2003
    ..Our combined results provide evidence for an evolutionarily conserved interaction between SRm160 and the 3'-end cleavage machinery that functions independently of EJC formation...
  26. ncbi request reprint Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform
    Qun Pan
    Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada
    Mol Cell 16:929-41. 2004
    ..These results demonstrate the utility of our quantitative microarray platform and data for revealing important global regulatory features of AS...
  27. pmc A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation
    Isabel Aznarez
    Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
    Genome Res 18:1247-58. 2008
    ..Based on our results, we estimate that approximately 15% of alternative cassette exons are regulated by TIA1/TIAL1 via U-rich intronic elements...
  28. ncbi request reprint Transcriptional activators control splicing and 3'-end cleavage levels
    Emanuel Rosonina
    Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 278:43034-40. 2003
    ..The results suggest that the efficiency of constitutive splicing and 3'-end cleavage is closely coordinated with transcription levels by promoter-bound activators...
  29. pmc Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing
    Blair R Szymczyna
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Genes Dev 17:461-75. 2003
    ..Thus, the PWI motif is a novel type of nucleic acid-binding domain that likely has multiple important functions in pre-mRNA processing, including SRm160-dependent stimulation of 3'-end formation...
  30. ncbi request reprint Inferring global levels of alternative splicing isoforms using a generative model of microarray data
    Ofer Shai
    Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada M5S 3G8
    Bioinformatics 22:606-13. 2006
    ..GenASAP has been successfully applied to the global discovery and analysis of AS in mammalian cells and tissues...
  31. pmc Model-based detection of alternative splicing signals
    Yoseph Barash
    Banting and Best Department of Medical Research, University of Toronto, ON, Canada
    Bioinformatics 26:i325-33. 2010
    ..It is necessary to accurately identify such splicing changes to elucidate the underlying regulatory programs or link the splicing changes to specific diseases...
  32. pmc The functional landscape of mouse gene expression
    Wen Zhang
    Banting and Best Department of Medical Research, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    J Biol 3:21. 2004
    ....
  33. pmc A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300
    May Khanna
    Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    RNA 15:2174-85. 2009
    ..Together, the results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1...
  34. doi request reprint Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
    Debashish Ray
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 27:667-70. 2009
    ..We anticipate that RNAcompete will be a valuable tool for the study of RNA-protein interactions...
  35. ncbi request reprint Gene expression: the close coupling of transcription and splicing
    Emanuel Rosonina
    Banting and Best Department of Medical Research, Department of Molecular and Medical Genetics, Charles H Best Institute, University of Toronto, 112 College St, Toronto, Ontario M5G 1L6, Canada
    Curr Biol 12:R319-21. 2002
    ..Surprisingly, it has now been demonstrated that splicing components influence the efficiency of transcription. This mutual stimulation has important implications for the regulation of gene expression...
  36. ncbi request reprint Alternative splicing of conserved exons is frequently species-specific in human and mouse
    Qun Pan
    CH Best Institute, University of Toronto, 112 College Street, Toronto, Ontario, Canada M5G 1L6
    Trends Genet 21:73-7. 2005
    ..The results thus provide evidence that species-specific AS of conserved exons constitutes an additional potential source of complexity and species-specific differences between mammals...
  37. pmc Probing microRNAs with microarrays: tissue specificity and functional inference
    Tomas Babak
    Banting and Best Department of Medical Research, 112 College St, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    RNA 10:1813-9. 2004
    ....
  38. ncbi request reprint Microarray analysis of RNA processing and modification
    Timothy R Hughes
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    Methods Enzymol 410:300-16. 2006
    ..This chapter also describes practical aspects of microarray design, sample preparation, hybridization, and data analysis...
  39. ncbi request reprint Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin
    Susan McCracken
    Banting and Best Department of Medical Research, C H Best Institute, Toronto, Ontario, Canada
    J Biol Chem 280:42227-36. 2005
    ..Co-immunoprecipitation and co-localization experiments, as well as combinatorial RNA interference in Caenorhabditis elegans, support the existence of conserved and functional interactions between SRm160 and cohesin...
  40. ncbi request reprint Characterization of disease-associated mutations affecting an exonic splicing enhancer and two cryptic splice sites in exon 13 of the cystic fibrosis transmembrane conductance regulator gene
    Isabel Aznarez
    Genetics and Genomics Biology Program, The Hospital for Sick Children, Toronto, Canada, M5G 1X8
    Hum Mol Genet 12:2031-40. 2003
    ..Taken together, our results suggest that the severity of CF disease could be modulated by changes in the fidelity of CFTR pre-mRNA splicing...
  41. pmc Global analysis of alternative splicing during T-cell activation
    Joanna Y Ip
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ont, Canada
    RNA 13:563-72. 2007
    ..In summary, by using AS microarray profiling, we have discovered many new AS changes associated with T-cell activation. Our results suggest an extensive role for AS in the regulation of the mammalian immune response...
  42. doi request reprint Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    Qun Pan
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
    Nat Genet 40:1413-5. 2008
    ..From a comparison with quantitative alternative splicing microarray profiling data, we also show that mRNA-Seq data provide reliable measurements for exon inclusion levels...
  43. ncbi request reprint Using expression profiling data to identify human microRNA targets
    Jim C Huang
    Department of Electrical and Computer Engineering, University of Toronto, 10 King s College Road, Toronto, Ontario M5S 3G4, Canada
    Nat Methods 4:1045-9. 2007
    ..Compared to sequence-based predictions, our high-scoring GenMiR++ predictions had much more consistent Gene Ontology annotations and were more accurate predictors of which mRNA levels respond to changes in let-7b levels...
  44. pmc Analysis of the requirement for RNA polymerase II CTD heptapeptide repeats in pre-mRNA splicing and 3'-end cleavage
    Emanuel Rosonina
    Banting and Best Department of Medical Research, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    RNA 10:581-9. 2004
    ..However, the extent of this length requirement depends on specific sequence features within the pre-mRNA substrate...
  45. ncbi request reprint CDKN1C mutation in Wiedemann-Beckwith syndrome patients reduces RNA splicing efficiency and identifies a splicing enhancer
    Jocelyne M Lew
    Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 127:268-76. 2004
    ..However, the total amount of spliced message was not reduced by the mutation in spite of the reduced efficiency of splicing. We discuss the possible role of the splicing defect in the pathogenesis of WBS in this pedigree...
  46. doi request reprint Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein
    John A Calarco
    Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Cell 138:898-910. 2009
    ..Our results thus reveal a critical neural-specific alternative splicing regulator, the evolution of which has contributed to increased complexity in the vertebrate nervous system...
  47. doi request reprint Deciphering the splicing code
    Yoseph Barash
    Biomedical Engineering, Department of Electrical and Computer Engineering, University of Toronto, 10 King s College Road, Toronto M5S 3G4, Canada
    Nature 465:53-9. 2010
    ..The code facilitates the discovery and detailed characterization of regulated alternative splicing events on a genome-wide scale...
  48. doi request reprint SnapShot: The splicing regulatory machinery
    Mathieu Gabut
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Cell 133:192.e1. 2008
  49. ncbi request reprint Technologies for the global discovery and analysis of alternative splicing
    John A Calarco
    Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada
    Adv Exp Med Biol 623:64-84. 2007
    ..Moreover, several non-microarray-based technologies are emerging that will likely further fuel progress in this area. This review focuses on recent advances made in the development and application of high-throughput methods to study AS...
  50. pmc SRm160 splicing coactivator promotes transcript 3'-end cleavage
    Susan McCracken
    Banting and Best Department of Medical Research, C H Best Institute, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 22:148-60. 2002
    ..The results provide evidence for a role for SRm160 in mRNA 3'-end formation and suggest that the level of this splicing coactivator is important for the proper coordination of pre-mRNA processing events...
  51. pmc Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer
    Christine M Misquitta-Ali
    Banting and Best Department of Medical Research, University of Toronto, Donnelly Centre, 160 College Street, Toronto, Ontario, Canada M5S 3E1
    Mol Cell Biol 31:138-50. 2011
    ..The results thus reveal widespread AS changes in NSCLC that impact cell signaling in a manner that likely contributes to tumorigenesis...
  52. ncbi request reprint Splicing on the brain
    Benjamin J Blencowe
    Nat Genet 37:796-7. 2005
  53. ncbi request reprint Highly consistent patterns for inherited human diseases at the molecular level
    Nuria Lopez-Bigas
    Genome Bioinformatics Laboratory, Center for Genomic Regulation, Universitat Pompeu Fabra, Pg Maritim de la Barceloneta 37 49, E 08003, Barcelona, Spain
    Bioinformatics 22:269-77. 2006
    ..The results further indicate that a comparative genomics approach for the analysis of genes linked to human genetic diseases will facilitate the elucidation of the underlying molecular and cellular mechanisms...
  54. ncbi request reprint Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation
    Puri Fortes
    Division of Gene Therapy and Hepatology, CIMA, University of Navarra, Pamplona, Spain
    FEBS Lett 581:3087-97. 2007
    ..These results suggest that RED120 may function to couple splicing with mRNA 3'-end formation...
  55. pmc In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei
    Noélia Custódio
    Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon 1649 028, Portugal
    RNA 10:622-33. 2004
    ..This shows that the accumulation of EJC proteins at transcription sites requires efficient processing of the nascent pre-mRNAs, arguing that transcription per se is not sufficient for the stable assembly of the EJC...
  56. pmc Exon skipping through the creation of a putative exonic splicing silencer as a consequence of the cystic fibrosis mutation R553X
    Isabel Aznarez
    J Med Genet 44:341-6. 2007
    ....
  57. ncbi request reprint Molecular biology: RNA in control
    Benjamin J Blencowe
    Nature 447:391-3. 2007