A Bezjak

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Lessons learned in the assessment of health-related quality of life: selected examples from the National Cancer Institute of Canada Clinical Trials Group
    Michael Brundage
    Department of Oncology, and National Cancer Institute of Canada Clinical Trials Group Queen s Cancer Research Institute, Queens University, Kingston, Kingston, Ontario, Canada
    J Clin Oncol 25:5078-81. 2007
  2. ncbi request reprint The management of thymoma: a systematic review and practice guideline
    Conrad B Falkson
    Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario, Canada
    J Thorac Oncol 4:911-9. 2009
  3. pmc Has the practice of radiation oncology for locally advanced and metastatic non-small-cell lung cancer changed in Canada?
    K Han
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON
    Curr Oncol 17:33-40. 2010
  4. pmc Predictors of radiotherapy induced bone injury (RIBI) after stereotactic lung radiotherapy
    Mojgan Taremi
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Radiat Oncol 7:159. 2012
  5. pmc Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases - an evidence-based practice guideline
    Jackson Sai Yiu Wu
    Department of Radiation Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada
    BMC Cancer 4:71. 2004
  6. ncbi request reprint Palliative therapy for lung cancer
    Andrea Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Semin Surg Oncol 21:138-47. 2003
  7. pmc Quality-of-life outcomes for adjuvant chemotherapy in early-stage non-small-cell lung cancer: results from a randomized trial, JBR.10
    Andrea Bezjak
    National Cancer Institute of Canada Clinical Trials Group, Cancer Centre of Southeastern Ontario, Kingston, ON, Canada
    J Clin Oncol 26:5052-9. 2008
  8. ncbi request reprint Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (NCIC CTG SC.15)
    Andrea Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 54:719-28. 2002
  9. ncbi request reprint Radiotherapy for brain metastases: defining palliative response
    A Bezjak
    Palliative Radiation Oncology Program, Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, M5G 2M9, Toronto, Canada
    Radiother Oncol 61:71-6. 2001
  10. ncbi request reprint Oncologists' use of quality of life information: results of a survey of Eastern Cooperative Oncology Group physicians
    A Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Ontario, Canada
    Qual Life Res 10:1-13. 2001

Detail Information

Publications100

  1. ncbi request reprint Lessons learned in the assessment of health-related quality of life: selected examples from the National Cancer Institute of Canada Clinical Trials Group
    Michael Brundage
    Department of Oncology, and National Cancer Institute of Canada Clinical Trials Group Queen s Cancer Research Institute, Queens University, Kingston, Kingston, Ontario, Canada
    J Clin Oncol 25:5078-81. 2007
    ....
  2. ncbi request reprint The management of thymoma: a systematic review and practice guideline
    Conrad B Falkson
    Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, Ontario, Canada
    J Thorac Oncol 4:911-9. 2009
    ..Thymoma is a rare tumor for which there is little randomized evidence to guide treatment. Because of the lack of high-quality evidence, a formal consensus-based approach was used to develop recommendations on treatment...
  3. pmc Has the practice of radiation oncology for locally advanced and metastatic non-small-cell lung cancer changed in Canada?
    K Han
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON
    Curr Oncol 17:33-40. 2010
    ..The aim of the present study was to determine the current patterns of practice for locally advanced and metastatic NSCLC among Canadian radiation oncologists...
  4. pmc Predictors of radiotherapy induced bone injury (RIBI) after stereotactic lung radiotherapy
    Mojgan Taremi
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Radiat Oncol 7:159. 2012
    ..The purpose of this study was to identify clinical and dosimetric factors associated with radiotherapy induced bone injury (RIBI) following stereotactic lung radiotherapy...
  5. pmc Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases - an evidence-based practice guideline
    Jackson Sai Yiu Wu
    Department of Radiation Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada
    BMC Cancer 4:71. 2004
    ..This practice guideline was developed to provide recommendations to clinicians in Ontario on the preferred standard radiotherapy fractionation schedule for the treatment of painful bone metastases...
  6. ncbi request reprint Palliative therapy for lung cancer
    Andrea Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Semin Surg Oncol 21:138-47. 2003
    ..Palliation of metastatic disease, particularly bone and brain metastases, is also reviewed...
  7. pmc Quality-of-life outcomes for adjuvant chemotherapy in early-stage non-small-cell lung cancer: results from a randomized trial, JBR.10
    Andrea Bezjak
    National Cancer Institute of Canada Clinical Trials Group, Cancer Centre of Southeastern Ontario, Kingston, ON, Canada
    J Clin Oncol 26:5052-9. 2008
    ..We report the QOL results of JBR.10, a North American, intergroup, randomized trial of adjuvant cisplatin and vinorelbine compared with observation in patients who have completely resected, stages IB to II NSCLC...
  8. ncbi request reprint Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer (NCIC CTG SC.15)
    Andrea Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 54:719-28. 2002
    ..This multi-institutional Phase III randomized study compared 10 Gy single-fraction radiotherapy (RT) with 20 Gy in five fractions in the palliation of thoracic symptoms from lung cancer...
  9. ncbi request reprint Radiotherapy for brain metastases: defining palliative response
    A Bezjak
    Palliative Radiation Oncology Program, Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, M5G 2M9, Toronto, Canada
    Radiother Oncol 61:71-6. 2001
    ..There is no established definition of palliative response. The aim of this study was to develop and test clinically useful criteria for response following palliative WBRT...
  10. ncbi request reprint Oncologists' use of quality of life information: results of a survey of Eastern Cooperative Oncology Group physicians
    A Bezjak
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Ontario, Canada
    Qual Life Res 10:1-13. 2001
    ....
  11. ncbi request reprint Quality of life in ovarian cancer patients: comparison of paclitaxel plus cisplatin, with cyclophosphamide plus cisplatin in a randomized study
    Andrea Bezjak
    University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
    J Clin Oncol 22:4595-603. 2004
    ..Formal quality-of-life (QOL) assessments may contribute important information on patient symptoms. Despite many trials of systemic chemotherapy in ovarian cancer, reports of its effect on QOL are few...
  12. ncbi request reprint Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21
    Andrea Bezjak
    Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:3831-7. 2006
    ..This report describes the quality of life (QOL) findings of a randomized placebo controlled study of erlotinib, an epidermal growth factor receptor inhibitor, in patients with non-small-cell lung cancer (NSCLC)...
  13. ncbi request reprint Communicating quality of life information to cancer patients: a study of six presentation formats
    M Brundage
    Division of Cancer Control and Epidemiology, Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    J Clin Oncol 23:6949-56. 2005
    ..Patients often want a great deal of information about cancer treatments, including information relevant to HRQL. Clinical trials provide methodologically sound HRQL data that may be useful to patients...
  14. ncbi request reprint Symptom response after palliative radiotherapy for patients with brain metastases
    A Bezjak
    Palliative Radiation Oncology Program, Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, M5G 2M9, Toronto, Canada
    Eur J Cancer 38:487-96. 2002
    ..Many patients with brain metastases have a short life expectancy and may not benefit from even short duration radiation schedules. Further effort is needed to optimise patient selection and tailor treatment appropriately...
  15. ncbi request reprint The prognostic effects of performance status and quality of life scores on progression-free survival and overall survival in advanced ovarian cancer
    M S Carey
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada
    Gynecol Oncol 108:100-5. 2008
    ..The purpose of this study was to evaluate the prognostic significance of PS and quality of life (QoL) assessment on progression-free survival (PFS) and overall survival (OS) in patients with advanced ovarian cancer...
  16. ncbi request reprint Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancer
    Karl L Uy
    Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 134:188-93. 2007
    ..The surgical arm of the North American Intergroup 0139 trial was adopted as the standard treatment for patients with resectable N2 disease at the University Health Network. Results after 7 years of experience are reported...
  17. ncbi request reprint Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome
    R W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Int J Radiat Oncol Biol Phys 50:113-20. 2001
    ..In this study, we attempt to identify factors that predict for local failure, progression to multiple myeloma, and disease-free survival (DFS) in patients mainly managed with local RT...
  18. pmc Quality-adjusted time without symptoms or toxicity analysis of adjuvant chemotherapy in non-small-cell lung cancer: an analysis of the National Cancer Institute of Canada Clinical Trials Group JBR.10 trial
    Raymond W Jang
    Department of Medical Oncology, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada
    J Clin Oncol 27:4268-73. 2009
    ..To aid in treatment decision making, quality-adjusted survival estimates of the JBR.10 trial were derived using a quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis...
  19. ncbi request reprint Erlotinib in previously treated non-small-cell lung cancer
    Frances A Shepherd
    Department of Medical Oncology, University Health Network, Princess Margaret Hospital Site, University of Toronto, Canada
    N Engl J Med 353:123-32. 2005
    ....
  20. ncbi request reprint Quality-of-life information and clinical practice: the oncologist's perspective
    A Bezjak
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto
    Cancer Prev Control 2:230-5. 1998
    ..To collect information from a group of Canadian oncologists about their perspectives on quality of life (QOL) and QOL information...
  21. doi request reprint Induction chemoradiotherapy facilitates radical resection of T4 non-small cell lung cancer invading the spine
    Masaki Anraku
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 137:441-447.e1. 2009
    ..We evaluated the outcome, long-term results, and factors affecting outcome of induction chemoradiotherapy followed by surgical resection for T4 non-small cell lung cancer invading the spine...
  22. ncbi request reprint Defining the impact and contribution of steroids in patients receiving whole-brain irradiation for cerebral metastases
    B M Millar
    Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 16:339-44. 2004
    ..To assess the impact of steroid therapy in the management of brain metastases by review of the published literature on whole-brain radiotherapy (WBRT) for multiple cerebral metastases...
  23. ncbi request reprint Dexamethasone for the prophylaxis of radiation-induced emesis: a National Cancer Institute of Canada Clinical Trials Group phase III study
    P Kirkbride
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada
    J Clin Oncol 18:1960-6. 2000
    ..To investigate the efficacy of dexamethasone as a prophylactic antiemetic for patients receiving fractionated radiotherapy to the upper abdomen in a randomized controlled trial...
  24. ncbi request reprint Stage I and II MALT lymphoma: results of treatment with radiotherapy
    R W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Int J Radiat Oncol Biol Phys 50:1258-64. 2001
    ..We analyzed our recent experience with Stage I/II MALT lymphoma presenting in the stomach and other organs to assess the outcome following involved field radiation therapy (RT)...
  25. doi request reprint The influence of sex on efficacy, adverse events, quality of life, and delivery of treatment in National Cancer Institute of Canada Clinical Trials Group non-small cell lung cancer chemotherapy trials
    Paul Wheatley-Price
    Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Canada
    J Thorac Oncol 5:640-8. 2010
    ..In small-cell lung cancer, women have been shown to experience greater toxicity from chemotherapy, but there are few studies of sex-related toxicity in non-small cell lung cancer (NSCLC)...
  26. ncbi request reprint Computed tomographic simulation in palliative radiotherapy: the Princess Margaret Hospital experience
    P Haddad
    Palliative Radiation Oncology Program, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Clin Oncol (R Coll Radiol) 16:425-8. 2004
    ..To examine the pattern of palliative radiation planning and the use of computed tomographic simulation (CTSIM) for this purpose...
  27. ncbi request reprint Construction of the Patient-Oriented Prostate Utility Scale (PORPUS): a multiattribute health state classification system for prostate cancer
    M Krahn
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 53:920-30. 2000
    ..In conjunction with a set of utility weights, it may be used to develop a health status index, to improve utility measurement in patients, and to serve as a short psychometric (nonutility) instrument...
  28. ncbi request reprint A novel four-dimensional radiotherapy method for lung cancer: imaging, treatment planning and delivery
    H Alasti
    Department of Radiation Physics, Princess Margaret Hospital, Toronto, ON, Canada
    Phys Med Biol 51:3251-67. 2006
    ..The motions of the chest cavity, tumour and thoracic structures of 24 lung cancer patients are also analysed...
  29. ncbi request reprint Interfraction and intrafraction changes in amplitude of breathing motion in stereotactic liver radiotherapy
    Robert B Case
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 77:918-25. 2010
    ..Interfraction and intrafraction changes in amplitude of liver motion were assessed in patients with liver cancer treated with kV cone beam computed tomography (CBCT)-guided stereotactic body radiation therapy (SBRT)...
  30. doi request reprint Incorporating heterogeneity correction and 4DCT in lung stereotactic body radiation therapy (SBRT): The effect on target coverage, organ-at-risk doses, and dose conformity
    Kevin N Franks
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Med Dosim 35:101-7. 2010
    ..Lower prescription doses may be required when prospectively planning with HC to achieve a similar level of toxicity and dose spillage as expected when planning based on homogeneous dose calculations...
  31. doi request reprint Validation of a predictive model for survival in metastatic cancer patients attending an outpatient palliative radiotherapy clinic
    Edward Chow
    Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:280-7. 2009
    ..To validate a predictive model for survival of patients attending a palliative radiotherapy clinic...
  32. ncbi request reprint A structured review of quality of life instruments for head and neck cancer patients
    J Ringash
    Department of Radiation Oncology, Princess Margaret Hospital/University Health Network, University of Toronto, Ontario, Canada
    Head Neck 23:201-13. 2001
    ..Efforts should be focused on the evaluation of existing instruments, rather than the development of new questionnaires...
  33. pmc Enhancing treatment decision-making: pilot study of a treatment decision aid in stage IV non-small cell lung cancer
    N B Leighl
    Division of Medical Oncology, Princess Margaret Hospital University Health Network, University of Toronto, Toronto, Ontario, Canada
    Br J Cancer 98:1769-73. 2008
    ..The DA for advanced NSCLC is feasible, acceptable to patients and improves understanding of advanced NSCLC without increasing patient anxiety...
  34. ncbi request reprint The ability of existing questionnaires to measure symptom change after paracentesis for symptomatic ascites
    Alexandra M Easson
    Department of Surgical Oncology, Princess Margaret Hospital and Mount Sinai Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9
    Ann Surg Oncol 14:2348-57. 2007
    ..The aim of this study was to assess the ability of existing symptom and quality-of-life questionnaires to detect change in symptoms after paracentesis...
  35. ncbi request reprint Cone-beam computed tomography for on-line image guidance of lung stereotactic radiotherapy: localization, verification, and intrafraction tumor position
    Thomas G Purdie
    Department of Radiation Physics, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 68:243-52. 2007
    ..Cone-beam computed tomography (CBCT) in-room imaging allows accurate inter- and intrafraction target localization in stereotactic body radiotherapy of lung tumors...
  36. ncbi request reprint Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in Stereotactic Lung Radiation Therapy
    Thomas G Purdie
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Acta Oncol 45:915-22. 2006
    ..Therefore, application of breathing motion data acquired at simulation for tracking or gating radiation therapy may not be suitable for all patients - even those receiving short course treatment techniques such as SBRT...
  37. doi request reprint Image guidance in non-small cell lung cancer
    B C John Cho
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Semin Radiat Oncol 20:164-70. 2010
    ..Furthermore, functional imaging, although in its infancy, has the potential to significantly improve RT, from RT planning and delivery to outcome assessment...
  38. ncbi request reprint A predictive model for survival in metastatic cancer patients attending an outpatient palliative radiotherapy clinic
    Edward Chow
    Toronto Sunnybrook Regional Cancer Centre, University of Toronto, Toronto, Canada
    Int J Radiat Oncol Biol Phys 53:1291-302. 2002
    ..To develop a predictive model for survival from the time of presentation in an outpatient palliative radiotherapy clinic...
  39. doi request reprint Effects of genistein following fractionated lung irradiation in mice
    Andrea E Para
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
    Radiother Oncol 92:500-10. 2009
    ..This study investigated protection of lung injury by genistein following fractionated doses of radiation and its effect on tumor response...
  40. ncbi request reprint Interpreting clinically significant changes in patient-reported outcomes
    Jolie Ringash
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada
    Cancer 110:196-202. 2007
    ....
  41. doi request reprint Quantifying interfraction and intrafraction tumor motion in lung stereotactic body radiotherapy using respiration-correlated cone beam computed tomography
    Jean Pierre Bissonnette
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 75:688-95. 2009
    ..However, the precise extent of these changes in breathing pattern is not well known. We evaluated the inter- and intrafractional changes in tumor motion amplitude (DeltaM) over an SBRT course...
  42. doi request reprint Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma
    Marc de Perrot
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 27:1413-8. 2009
    ..We examined the results of trimodality therapy with cisplatin-based chemotherapy followed by extrapleural pneumonectomy (EPP) and adjuvant high-dose (50 to 60 Gy) hemithoracic radiation therapy for MPM...
  43. doi request reprint Patients' and health care professionals' evaluation of health-related quality of life issues in bone metastases
    Kristin Harris
    Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Eur J Cancer 45:2510-8. 2009
    ..This information has been an important component in the development of a health-related quality of life questionnaire for patients with bone metastases (EORTC QLQ-BM 22)...
  44. doi request reprint Malignant ascites symptom cluster in patients referred for paracentesis
    Amna Husain
    Temmy Latner Centre for Palliative Care, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Ann Surg Oncol 17:461-9. 2010
    ..Malignant ascites (MA) is a distressing problem usually managed by repeated paracenteses. Paracentesis represents a meaningful time point in identifying patients with a specific presentation...
  45. doi request reprint Cone-beam computed tomographic image guidance for lung cancer radiation therapy
    Jean Pierre Bissonnette
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:927-34. 2009
    ..To determine the geometric accuracy of lung cancer radiotherapy using daily volumetric, cone-beam CT (CBCT) image guidance and online couch position adjustment...
  46. doi request reprint Practical considerations arising from the implementation of lung stereotactic body radiation therapy (SBRT) at a comprehensive cancer center
    Max Dahele
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Canada
    J Thorac Oncol 3:1332-41. 2008
    ..We discuss practical challenges that have been encountered in the implementation of lung SBRT at a single, large institution and emphasize the importance of a systematic approach to the design of lung SBRT services...
  47. doi request reprint Setup reproducibility for thoracic and upper gastrointestinal radiation therapy: Influence of immobilization method and on-line cone-beam CT guidance
    Winnie Li
    Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Med Dosim 35:287-96. 2010
    ..CBCT allows reduction to a single immobilization system that can be chosen for efficiency, logistics, and cost. Image guidance allows for increased geometric precision and accuracy and supports a corresponding reduction in PTV margin...
  48. doi request reprint Comparison of spine, carina, and tumor as registration landmarks for volumetric image-guided lung radiotherapy
    Jane Higgins
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:1404-13. 2009
    ..To assess the feasibility, reproducibility, and accuracy of volumetric lung image guidance using different thoracic landmarks for image registration...
  49. ncbi request reprint Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Canada
    J Thorac Cardiovasc Surg 133:111-6. 2007
    ..The impact of lymph node metastasis on the site of recurrence and the role of mediastinoscopy in the selection of patients for extrapleural pneumonectomy, however, remain unclear...
  50. ncbi request reprint Interpreting differences in quality of life: the FACT-H&N in laryngeal cancer patients
    Jolie Ringash
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Qual Life Res 13:725-33. 2004
    ..Quality of life (QOL) scores can be difficult to interpret, because small statistically significant differences can be clinically unimportant. Our goal was to estimate the magnitude of difference in QOL that is noticeable to patients...
  51. ncbi request reprint Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin's lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group
    Ralph M Meyer
    Juravinski Cancer Centre and McMaster University, Hamilton, Ontario, Canada
    J Clin Oncol 23:4634-42. 2005
    ..We report results of a randomized trial comparing ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy alone with treatment that includes radiation therapy in patients with limited-stage Hodgkin's lymphoma...
  52. ncbi request reprint Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Orga
    Frances A Shepherd
    National Cancer Institute of Canada Clinical Trials Group
    J Clin Oncol 20:4434-9. 2002
    ..This trial was undertaken to determine whether adjuvant treatment with the metalloproteinase inhibitor marimastat could prolong survival in responding patients with SCLC after chemotherapy...
  53. ncbi request reprint Does tumor status influence cancer patients' satisfaction with the doctor-patient interaction?
    Richard Bitar
    Department of Medical Imaging, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Support Care Cancer 12:34-40. 2004
    ..Patients with metastatic disease may feel less physician support than those with less advanced cancers. Increasing attention to satisfaction of different patient groups can pave the way to improved quality of care...
  54. ncbi request reprint Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18
    Natasha B Leighl
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Canada
    J Clin Oncol 23:2831-9. 2005
    ..In early phase studies, BMS- 275291 was not associated with dose-limiting joint toxicity seen with other MMPIs...
  55. ncbi request reprint Patient and community preferences for outcomes in prostate cancer: implications for clinical policy
    Murray Krahn
    Department of Medicine And Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Ontario, Candada
    Med Care 41:153-64. 2003
    ..Utilities can be elicited directly from patients using standard techniques, or indirectly, using questionnaires that incorporate preference weights from community members...
  56. doi request reprint The Canadian Association of Radiation Oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy
    A Sahgal
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 24:629-39. 2012
    ..The aim was to define the scope of practice guidelines for the profession to ensure safe practice specific for the most common sites of lung, liver and spine SBRT...
  57. pmc Outcomes of accelerated hypofractionated radiotherapy in stage i non-small-cell lung cancer
    T Yung
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON
    Curr Oncol 19:e264-9. 2012
    ..Outcomes after treatment with accelerated hypofractionated radiotherapy in stage i medically inoperable non-small-cell lung cancer (nsclc) patients were determined...
  58. ncbi request reprint Prognostic factors in brain metastases: can we determine patients who do not benefit from whole-brain radiotherapy?
    M Lock
    Department of Radiation Oncology, London Regional Cancer Centre, University of Western Ontario, London, Ontario, Canada
    Clin Oncol (R Coll Radiol) 16:332-8. 2004
    ..Patients with a short life expectancy may not derive benefit from the addition of radiation. The ability to identify this group would aid the decision of whether to recommend WBRT...
  59. ncbi request reprint Chest wall pain and rib fracture after stereotactic radiotherapy for peripheral non-small cell lung cancer
    Jon Paul J Voroney
    Department of Radiation Oncology, Tom Baker Cancer Centre Alberta, Canada
    J Thorac Oncol 4:1035-7. 2009
    ..The median dose to rib fracture sites was 46 to 50 Gy, depending on the method of dose calculation. We describe a typical case of poststereotactic radiotherapy rib fracture and present dosimetric analysis of patients with rib fracture...
  60. ncbi request reprint Recursive partitioning analysis of prognostic factors for survival in patients with advanced cancer
    Edward Chow
    Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:1169-76. 2009
    ..To construct a predictive model for survival of patients referred to the Rapid Response Radiotherapy Program using recursive partitioning (RP)...
  61. ncbi request reprint The difficulties of a randomized study in superior vena caval obstruction
    Paula Wilson
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    J Thorac Oncol 2:514-9. 2007
    ..Although small case series have supported the use of stents in SVCO, there are no randomized data...
  62. ncbi request reprint Does the incidence and outcome of brain metastases in locally advanced non-small cell lung cancer justify prophylactic cranial irradiation or early detection?
    Hannah Carolan
    Department of Radiation Oncology, Princess Margaret Hospital, 610 University Avenue, University of Toronto, Toronto, Canada M5G 2M9
    Lung Cancer 49:109-15. 2005
    ..We reviewed the outcomes of Stage IIIA and IIIB LA-NSCLC patients treated with CMT at our institution. We assessed the incidence of brain metastases and the management and outcome of these patients...
  63. ncbi request reprint Reliability and validity of the PORPUS, a combined psychometric and utility-based quality-of-life instrument for prostate cancer
    Paul Ritvo
    York University, and Cancer Care Ontario, Division of Preventive Oncology, 620 University Ave, 1236, Toronto, Ontario M5G, Canada
    J Clin Epidemiol 58:466-74. 2005
    ..In this study we developed and tested these two forms of quality-of-life instruments, both based on a single, validated, health classification system...
  64. ncbi request reprint Decision making in palliative radiation therapy: reframing hope in caregivers and patients with brain metastases
    Jacqueline Sze
    Princess Margaret Hospital, University of Toronto, 5th Floor, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada
    Support Care Cancer 14:1055-63. 2006
    ..To explore the major factors important in decision making for whole-brain radiotherapy (WBRT) for patients with brain metastases and their caregivers...
  65. ncbi request reprint Computerized tomographic simulation compared with clinical mark-up in palliative radiotherapy: a prospective study
    Peiman Haddad
    Palliative Radiation Oncology Program, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 65:824-9. 2006
    ..To evaluate the impact of computed tomographic (CT) planning in comparison to clinical mark-up (CM) for palliative radiation of chest wall metastases...
  66. doi request reprint Intensity-modulated radiotherapy in the treatment of lung cancer
    A Bezjak
    University of Toronto, Toronto, ON, Canada
    Clin Oncol (R Coll Radiol) 24:508-20. 2012
    ..Until randomised data are available, future research in IMRT for lung cancer should include a comprehensive prospective assessment of the relevant outcomes, including tumour control and normal tissue toxicity...
  67. ncbi request reprint Poster - Thur Eve - 20: Serial FDG 4DPET imaging during radiotherapy in advanced lung cancer patients
    N Becker
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Med Phys 39:4628. 2012
    ..Preliminary analysis suggests that variations in these trends could be useful in identifying non-responding patients that may require an alternative radiotherapeutic approach...
  68. ncbi request reprint Use of quality-of-life assessment for nasopharyngeal cancer
    J Ringash
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 18:725-7. 2006
    ..To determine the interest in and use of quality-of-life (QOL) questionnaires among international experts in nasopharyngeal cancer (NPC)...
  69. ncbi request reprint Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma
    A M Davis
    Toronto Rehabilitation Institute, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    J Clin Oncol 20:4472-7. 2002
    ..Functional outcome and health status of extremity STS patients randomized in a phase III trial comparing preoperative versus postoperative RT is described...
  70. ncbi request reprint Quality of life in a randomized trial of group psychosocial support in metastatic breast cancer: overall effects of the intervention and an exploration of missing data
    Louise Bordeleau
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    J Clin Oncol 21:1944-51. 2003
    ..To evaluate the effect of a standardized group psychosocial intervention on health-related quality of life (HrQOL) in women with metastatic breast cancer and to explore the effect of missing data in HrQOL analyses...
  71. ncbi request reprint A multicenter assessment of the adequacy of cancer pain treatment using the pain management index
    Gunita Mitera
    Department of Radiation Therapy, Odette Cancer Center, University of Toronto, Toronto, Ontario, Canada
    J Palliat Med 13:589-93. 2010
    ....
  72. ncbi request reprint Prospective comparison of breast pain in patients participating in a randomized trial of breast-conserving surgery and tamoxifen with or without radiotherapy
    Gamal Rayan
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 55:154-61. 2003
    ..To determine whether breast pain affects quality of life (QOL) after breast-conserving surgery and tamoxifen (TAM) with or without adjuvant breast radiotherapy (RT)...
  73. ncbi request reprint Prognostic significance of thymomas in patients with myasthenia gravis
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada
    Ann Thorac Surg 74:1658-62. 2002
    ..The presence of thymoma may be a negative prognostic factor with respect to the outcome of myasthenia gravis (MG)...
  74. doi request reprint The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for patients with bone metastases: the EORTC QLQ-BM22
    Edward Chow
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N3M5, Canada
    Eur J Cancer 45:1146-52. 2009
    ..The aim of this study was to develop a bone metastases module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) or the EORTC QLQ-C15-PAL for patients with bone metastases...
  75. ncbi request reprint Psychometric refinement of an outpatient, visit-specific satisfaction with doctor questionnaire
    D Andrew Loblaw
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Canada
    Psychooncology 13:223-34. 2004
    ..PMH/PSQ-MD correlated moderately with FACT-G (average r=0.37, p<0.005). The PMH/PSQ-MD questionnaire is a brief, valid and reliable questionnaire that taps two complementary facets of patient satisfaction...
  76. doi request reprint Superior vena cava syndrome
    Jonathan F Wan
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Emerg Med Clin North Am 27:243-55. 2009
    ..Management options including chemotherapy and radiation therapy (RT) and the role of endovascular stents are discussed along with the evidence for each of the therapeutic options...
  77. pmc Waiting lists for radiation therapy: a case study
    D P D'Souza
    Department of Radiation Oncology, Hamilton Regional Cancer Centre, McMaster University, Canada
    BMC Health Serv Res 1:3. 2001
    ....
  78. ncbi request reprint Quality of life and utility in irradiated laryngeal cancer patients
    J Ringash
    Princess Margaret Hospital University Health Network University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 47:875-81. 2000
    ..To determine quality of life (QOL) and health utility in irradiated laryngeal cancer survivors...
  79. ncbi request reprint Cancer patients' preferences for communicating clinical trial quality of life information: a qualitative study
    M Brundage
    Cancer Care and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Qual Life Res 12:395-404. 2003
    ..We conclude that cancer patients desire HRQL information, but vary in their preferences for its communication. Simple formats are generally preferred...
  80. doi request reprint Early metabolic response evaluation after stereotactic radiotherapy for lung cancer: pilot experience with 18F-fluorodeoxyglucose positron emission tomography-computed tomography
    M Dahele
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 23:359-63. 2011
    ..This imaging strategy therefore remains under ongoing evaluation with the aim of identifying predictive and prognostic factors...
  81. ncbi request reprint A phase II trial of palliative radiotherapy for metastatic renal cell carcinoma
    Justin Lee
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 104:1894-900. 2005
    ..The authors conducted a prospective study to assess the effect of RT on symptoms and quality of life (QOL) in patients with metastatic RCC...
  82. ncbi request reprint Dose-volume analysis of lung complications in the radiation treatment of malignant thymoma: a retrospective review
    Vitali Moiseenko
    London Regional Cancer Centre, Ontario, London, Canada
    Radiother Oncol 67:265-74. 2003
    ..The objectives of this study were to quantify the influence of irradiated lung volume and dose on lung response, and to evaluate the influence of other prognostic factors...
  83. ncbi request reprint Primary treatment endpoint following palliative radiotherapy for painful bone metastases: need for a consensus definition?
    Jackson S Y Wu
    Department of Radiation Oncology, Hamilton Regional Cancer Centre, McMaster University, Ontario, Canada
    Clin Oncol (R Coll Radiol) 14:70-7. 2002
    ....
  84. ncbi request reprint Outcome of hyperfractionated radiotherapy in chemotherapy-resistant non-Hodgkin's lymphoma
    Chandra Martens
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 64:1183-7. 2006
    ..Local symptoms are treated with radiotherapy (RT) for local control. We have reviewed local control and toxicity in patients treated with hyperfractionated accelerated RT...
  85. ncbi request reprint Context moderates illness-induced lifestyle disruptions across life domains: a test of the illness intrusiveness theoretical framework in six common cancers
    Gerald M Devins
    Department of Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, Canada
    Psychooncology 15:221-33. 2006
    ..The psychosocial impact of chronic life-threatening disease differs across life domains and depends on the context in which it is experienced...
  86. doi request reprint Sex or survival: short-term versus long-term androgen deprivation in patients with locally advanced prostate cancer treated with radiotherapy
    Derek R Wilke
    Department of Radiation Oncology, Nova Scotia Cancer Center, Queen Elizabeth II Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
    Cancer 116:1909-17. 2010
    ..The seminal question is whether or not the gains are worth the adverse effects of LTAD with respect to patient preferences...
  87. doi request reprint Predictive model for survival in patients with advanced cancer
    Edward Chow
    Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5
    J Clin Oncol 26:5863-9. 2008
    ..To derive and validate a simple predictive model for survival of patients with metastatic cancer attending a palliative radiotherapy clinic...
  88. ncbi request reprint The success of data collection in the palliative setting--telephone or clinic follow-up?
    Peiman Haddad
    Palliative Radiation Oncology Program, Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Support Care Cancer 11:555-9. 2003
    ....
  89. ncbi request reprint Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases
    Jackson Sai Yiu Wu
    Division of Radiation Oncology, Hamilton Regional Cancer Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 55:594-605. 2003
    ..To compare pain relief among various dose-fractionation schedules of localized radiotherapy (RT) in the treatment of painful bone metastases...
  90. ncbi request reprint Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer: a phase III trial of the Italian GEMVIN Investigators and the National Cancer Institute of Canada Clinical Trials
    Cesare Gridelli
    Clinical Trials Unit, National Cancer Institute, Via M Semmola, 80131 Naples, Italy
    J Clin Oncol 21:3025-34. 2003
    ..This trial aimed to assess whether a combination of gemcitabine and vinorelbine had benefits in terms of QoL, without influencing negatively on survival, compared with cisplatin-containing regimens...
  91. ncbi request reprint Travelling for radiation cancer treatment: patient satisfaction
    Margaret I Fitch
    Psychosocial and Behavioural Research Unit, Toronto Sunnybrook Regional Cancer Centre, Coordinator, Supportive Care, Cancer Care Ontario
    Can Oncol Nurs J 15:107-19. 2005
    ..Provision of information and support are important to cancer patients having to travel for cancer treatment...
  92. ncbi request reprint Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis
    Graeme G Duncan
    Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, 600 West 10th Ave, Vancouver, BC, Canada V6Z 4E6
    Head Neck 27:421-8. 2005
    ..We present the quality of life (QOL) analysis for this trial...
  93. ncbi request reprint Analysis and interpretation of health-related quality-of-life data from clinical trials: basic approach of The National Cancer Institute of Canada Clinical Trials Group
    David Osoba
    QOL Consulting, 4939 Edendale Court, West Vancouver, Canada BC V7W 3H7
    Eur J Cancer 41:280-7. 2005
    ..A rationale supporting each step is given. This approach is presented as a simple and practical aid to the analysis, interpretation and reporting of HRQOL results...
  94. ncbi request reprint Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    Minesh P Mehta
    University of Wisconsin Madison, Department Human Oncology Radiation Oncology, 53792, USA
    J Clin Oncol 21:2529-36. 2003
    ....
  95. ncbi request reprint Determining the relationship between toxicity and quality of life in an ovarian cancer chemotherapy clinical trial
    Lorna Butler
    Dalhousie University, Halifax, Nova Scotia, Canada
    J Clin Oncol 22:2461-8. 2004
    ....
  96. ncbi request reprint Palliative thoracic radiotherapy for lung cancer: a systematic review
    Alysa Fairchild
    Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2 Canada
    J Clin Oncol 26:4001-11. 2008
    ..The optimal dose of radiotherapy (RT) to palliate symptomatic advanced lung cancer is unclear. We systematically reviewed randomized controlled trials (RCTs) of palliative thoracic RT...
  97. ncbi request reprint Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial
    Christina A Meyers
    Department of Neuro Oncology, Unit 431, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Clin Oncol 22:157-65. 2004
    ....
  98. ncbi request reprint Evaluating health-related quality of life in cancer clinical trials: the National Cancer Institute of Canada Clinical Trials Group experience
    David Osoba
    QOL Consulting, West Vancouver, BC, Canada
    Value Health 10:S138-45. 2007
    ..The National Cancer Institute of Canada (NCIC) Clinical Trials Group (CTG) Quality of Life (QOL) Committee was initiated in 1986...
  99. ncbi request reprint Travelling for radiation cancer treatment: patient perspectives
    Margaret I Fitch
    Psychosocial and Behavioral Research Unit, Toronto Sunnybrook Regional Cancer Centre, Toronto, Canada
    Psychooncology 12:664-74. 2003
    ..Given the inevitability of travelling for radiation treatment, and the issues that arises for patients, supportive strategies need to be designed and implemented...
  100. ncbi request reprint An open letter to all members of the IASLC
    Fergus Macbeth
    Lung Cancer 45:119-20. 2004