C N Bernstein

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Hospitalization, surgery, and readmission rates of IBD in Canada: a population-based study
    Charles N Bernstein
    Department of Internal Medicine and University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 101:110-8. 2006
  2. ncbi Neoplasia in inflammatory bowel disease: surveillance and management strategies
    Charles N Bernstein
    University of Manitoba IBD Clinical and Research Centre, 804F 715 McDermot Avenue, Winnipeg, MB, Canada R3E 3P4
    Curr Gastroenterol Rep 8:513-8. 2006
  3. doi A review of mortality and surgery in ulcerative colitis: milestones of the seriousness of the disease
    Charles N Bernstein
    Section of Gastroenterology, IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 19:2001-10. 2013
  4. doi Direct medical cost of managing IBD patients: a Canadian population-based study
    Charles N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Inflamm Bowel Dis 18:1498-508. 2012
  5. doi Hospitalisations and surgery in Crohn's disease
    Charles N Bernstein
    Department of Internal Medicine, IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 61:622-9. 2012
  6. doi The Manitoba Inflammatory Bowel Disease Cohort Study: a prospective longitudinal evaluation of the use of complementary and alternative medicine services and products
    Patricia Rawsthorne
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gut 61:521-7. 2012
  7. pmc Health service utilization in IBD: comparison of self-report and administrative data
    Teresa Longobardi
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Canada
    BMC Health Serv Res 11:137. 2011
  8. ncbi Ulcerative colitis with low-grade dysplasia
    Charles N Bernstein
    University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Gastroenterology 127:950-6. 2004
  9. doi A prospective population-based study of triggers of symptomatic flares in IBD
    Charles N Bernstein
    IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 105:1994-2002. 2010
  10. ncbi Review article: Osteoporosis and inflammatory bowel disease
    C N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, and Manitoba Osteoporosis Programme, Winnipeg, Man, Canada
    Aliment Pharmacol Ther 19:941-52. 2004

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi Hospitalization, surgery, and readmission rates of IBD in Canada: a population-based study
    Charles N Bernstein
    Department of Internal Medicine and University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 101:110-8. 2006
    ..We aimed to define the rates of hospitalization and readmission for inflammatory bowel disease in Canada...
  2. ncbi Neoplasia in inflammatory bowel disease: surveillance and management strategies
    Charles N Bernstein
    University of Manitoba IBD Clinical and Research Centre, 804F 715 McDermot Avenue, Winnipeg, MB, Canada R3E 3P4
    Curr Gastroenterol Rep 8:513-8. 2006
    ..Although great interest has been expressed in the possible effectiveness of 5-aminosalicylic acid, it has not been proved to be an effective chemopreventive agent...
  3. doi A review of mortality and surgery in ulcerative colitis: milestones of the seriousness of the disease
    Charles N Bernstein
    Section of Gastroenterology, IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 19:2001-10. 2013
    ..e., at least 20% at 10 years), and perhaps, this reflects a higher rate of extensive disease. Acute severe colitis in patients with UC still represents a condition with a high early colectomy rate and a measurable mortality rate...
  4. doi Direct medical cost of managing IBD patients: a Canadian population-based study
    Charles N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Inflamm Bowel Dis 18:1498-508. 2012
    ..This study aimed to quantify the direct medical cost of treating inflammatory bowel disease (IBD) in Manitoba in 2005/2006...
  5. doi Hospitalisations and surgery in Crohn's disease
    Charles N Bernstein
    Department of Internal Medicine, IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 61:622-9. 2012
    ..Whether more aggressive medical therapy will decrease the requirement for surgery over long periods of time remains to be proven...
  6. doi The Manitoba Inflammatory Bowel Disease Cohort Study: a prospective longitudinal evaluation of the use of complementary and alternative medicine services and products
    Patricia Rawsthorne
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gut 61:521-7. 2012
    ..To determine the prevalence of complementary and alternative medicine (CAM) use over time in a population-based cohort of patients with inflammatory bowel disease (IBD)...
  7. pmc Health service utilization in IBD: comparison of self-report and administrative data
    Teresa Longobardi
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Canada
    BMC Health Serv Res 11:137. 2011
    ..The reliability of self-report regarding health care utilization in inflammatory bowel disease (IBD) is unknown. If proven reliable, it could help justify self-report as a means of determining health care utilization and associated costs...
  8. ncbi Ulcerative colitis with low-grade dysplasia
    Charles N Bernstein
    University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Gastroenterology 127:950-6. 2004
  9. doi A prospective population-based study of triggers of symptomatic flares in IBD
    Charles N Bernstein
    IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 105:1994-2002. 2010
    ..We aimed to determine whether any of the nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, infections, and stress trigger symptomatic flares of inflammatory bowel diseases (IBDs)...
  10. ncbi Review article: Osteoporosis and inflammatory bowel disease
    C N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, and Manitoba Osteoporosis Programme, Winnipeg, Man, Canada
    Aliment Pharmacol Ther 19:941-52. 2004
    ..To date, there remains no therapy proven to be efficacious in inflammatory bowel disease-related osteoporosis; however, calcium and vitamin D supplementation and bisphosphonates have their roles...
  11. doi Epidemiologic clues to inflammatory bowel disease
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Curr Gastroenterol Rep 12:495-501. 2010
    ..Other factors affect the gut microbiome, and several studies have explored the increase in incidence of IBD in relation to such factors as exogenous infections, use of antibiotics, and diet...
  12. pmc Population-based case control study of seroprevalence of Mycobacterium paratuberculosis in patients with Crohn's disease and ulcerative colitis
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Microbiol 42:1129-35. 2004
    ..paratuberculosis. Hence, the possibility of an association between M. paratuberculosis and CD remains inconclusive...
  13. doi New insights into IBD epidemiology: Are there any lessons for treatment?
    Charles N Bernstein
    Section of Gastroenterology, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Man, Canada
    Dig Dis 28:406-10. 2010
    ..In the future there may be approaches to modulate gut flora either with antibiotics targeted against identified noxious microbes or with selective probiotics that can rebalance the gut dysbiosis...
  14. ncbi Complementary and alternative medicine use by patients with inflammatory bowel disease: are Canadian physicians failing with conventional therapy, or not?
    Charles N Bernstein
    Section of Gastroenterology, University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada
    Can J Gastroenterol 18:47-8; discussion 48. 2004
  15. pmc Study of animal-borne infections in the mucosas of patients with inflammatory bowel disease and population-based controls
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Microbiol 41:4986-90. 2003
    ..In conclusion, by performing PCR with mucosal samples from patients with Crohn's disease and controls, no association between Crohn's disease and infection with M. avium or any of the other six zoonotic agents studied could be found...
  16. doi 5-aminosalicylate is not chemoprophylactic for colorectal cancer in IBD: a population based study
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 106:731-6. 2011
    ..We aimed to determine if use of 5-aminosalicylates (5-ASA) was associated with a reduced risk of colorectal cancer (CRC) in people with inflammatory bowel disease (IBD)...
  17. doi Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study
    Charles N Bernstein
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:2774-8. 2009
    ..There is anecdotal evidence that isotretinoin use is associated with development of colitis. We aimed at determining whether there is an association between isotretinoin use and development of inflammatory bowel disease (IBD)...
  18. ncbi Serum osteoprotegerin is increased in Crohn's disease: a population-based case control study
    Charles N Bernstein
    Department of Medicine, University of Manitoba, Manitoba, Canada
    Inflamm Bowel Dis 11:325-30. 2005
    ....
  19. pmc Testing the interaction between NOD-2 status and serological response to Mycobacterium paratuberculosis in cases of inflammatory bowel disease
    Charles N Bernstein
    Department of Internal Medicine, University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    J Clin Microbiol 45:968-71. 2007
    ..55-3.11). No interaction could be proven for UC or by combining CD and UC compared to controls. In conclusion, we could not find an interaction between the NOD-2 genotype and M. paratuberculosis serology in relationship to CD or UC...
  20. ncbi Population-based case-control study of measles, mumps, and rubella and inflammatory bowel disease
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 13:759-62. 2007
    ..We aimed to determine if Crohn's disease (CD) or ulcerative colitis (UC) subjects are more likely to be seropositive for measles, mumps, or rubella than controls...
  21. ncbi The placebo effect for gastroenterology: tool or torment
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Gastroenterol Hepatol 4:1302-8. 2006
    ..Clinical trial planners can harness aspects of the placebo response to design disease-specific trials that can minimize the placebo response...
  22. ncbi Natural history and management of flat and polypoid dysplasia in inflammatory bowel disease
    Charles N Bernstein
    Department of Internal Medicine and Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba, R3E 3P4, Canada
    Gastroenterol Clin North Am 35:573-9. 2006
    ..This topic is covered in greater detail elsewhere in this issue (see article by Rubin and Kavitt elsewhere in this issue); however, there is no definitive evidence that 5-ASA can reduce cancer incidence...
  23. ncbi Inflammatory bowel diseases as secondary causes of osteoporosis
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, 804F 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4, Canada
    Curr Osteoporos Rep 4:116-23. 2006
    ..Finally, in animal models of IBD, exogenous OPG has reversed both the osteopenia and the enterocolitis, suggesting that it may have a therapeutic role in human IBD...
  24. doi Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gut 57:1185-91. 2008
  25. doi Assessing environmental risk factors affecting the inflammatory bowel diseases: a joint workshop of the Crohn's & Colitis Foundations of Canada and the USA
    Charles N Bernstein
    University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 14:1139-46. 2008
  26. ncbi Surveillance programmes for colorectal cancer in inflammatory bowel disease: have we got it right?
    Charles N Bernstein
    University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada R3E 3P4
    Gut 57:1194-6. 2008
  27. ncbi Osteoporosis in patients with inflammatory bowel disease
    Charles N Bernstein
    IBD Clinical and Research Centre, University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 3P4
    Clin Gastroenterol Hepatol 4:152-6. 2006
  28. ncbi Therapy insight: Osteoporosis in inflammatory bowel disease--advances and retreats
    Charles N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Nat Clin Pract Gastroenterol Hepatol 2:232-9. 2005
    ....
  29. ncbi The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastroenterology 129:827-36. 2005
    ..We aimed to discern the relative risk for several chronic inflammatory conditions in patients with ulcerative colitis (UC) and Crohn's disease...
  30. ncbi The incidence of arterial thromboembolic diseases in inflammatory bowel disease: a population-based study
    Charles N Bernstein
    University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Gastroenterol Hepatol 6:41-5. 2008
    ..We aimed to determine if there was an increased risk for arterial thromboembolic diseases (ATED) in inflammatory bowel disease (IBD)...
  31. ncbi The pathophysiology of bone disease in gastrointestinal disease
    Charles N Bernstein
    Department of Internal Medicine, Clinical and Research Centre, University of Manitoba, Winnipeg, Canada
    Eur J Gastroenterol Hepatol 15:857-64. 2003
    ..This report will summarize current concepts regarding gastrointestinal diseases (primarily IBD, coeliac disease and postgastrectomy states) and low bone mass and fracture...
  32. pmc Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts
    Charles Noah Bernstein
    IBD Clinical and Research Center, University of Manitoba, Wimnipeg, Manitoba
    Can J Gastroenterol 25:269-73. 2011
    ....
  33. ncbi The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a population-based cohort study
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:430-4. 2001
    ....
  34. pmc Hospitalization-based major comorbidity of inflammatory bowel disease in Canada
    Charles N Bernstein
    Department of Internal Medicine, University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada
    Can J Gastroenterol 21:507-11. 2007
    ..To define the patterns of hospitalization for known major comorbidities associated with inflammatory bowel disease (IBD) in Canada...
  35. ncbi Development of an assay for antibodies to Saccharomyces cerevisiae: Easy, cheap and specific for Crohn's disease
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Can J Gastroenterol 15:499-504. 2001
    ..To develop a serological test to measure antibodies to Saccharomyces cerevisiae in patients with inflammatory bowel disease...
  36. ncbi The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study
    C N Bernstein
    Section of Gastroenterology, University of Manitoba, 804F 715 McDermot Avenue, John Buhler Research Centre, Winnipeg, Manitoba R3E 3P4, Canada
    Ann Intern Med 133:795-9. 2000
    ..The clinical significance of the high prevalence of osteopenia in inflammatory bowel disease is unclear...
  37. ncbi Neoplastic and other complications of inflammatory bowel disease
    C N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, GB 443 Health Sciences Centre, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada
    Curr Gastroenterol Rep 2:451-9. 2000
    ..These and data on other extraintestinal manifestations of IBD have all emerged in the past year...
  38. ncbi Colonoscopy plus biopsy in the inflammatory bowel diseases
    C N Bernstein
    University of Manitoba Inflammatory Bowel Diseases Clinical and Research Centre, Winnipeg, Canada
    Gastrointest Endosc Clin N Am 10:755-74. 2000
    ....
  39. ncbi Extraintestinal manifestations of inflammatory bowel disease
    C N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, MD804F 715 McDermot Avenue, John Buhler Research Centre, Winnipeg, Manitoba, Canada R3E 3P4
    Curr Gastroenterol Rep 3:477-83. 2001
    ..Studies in these and other areas are addressed in this review...
  40. ncbi Multifocal gastric neoplasia after recurrent laser therapy for the watermelon stomach
    C N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg
    Can J Gastroenterol 11:403-6. 1997
    ..This case suggests a possible association between use of laser therapy and development of gastric neoplasia...
  41. ncbi Alteration in expression of beta 2 integrins on lamina propria lymphocytes in ulcerative colitis and Crohn's disease
    Charles N Bernstein
    Department of Medicine and Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Immunol 104:67-72. 2002
    ..These results suggest that although currently there is great interest in harnessing alpha 4 beta 7 in treatment of inflammatory bowel disease, further consideration should be given to the role of CD11a in these disease states...
  42. ncbi Treatment of the extraintestinal manifestations of inflammatory bowel disease
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, John Buhler Research Centre, 804F 715 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 3P4
    Curr Gastroenterol Rep 4:513-6. 2002
    ..One study reported worsening IBD after orthotopic liver transplantation for primary sclerosing cholangitis, and another reported the benefit of renal transplantation in amyloidosis-induced renal failure...
  43. ncbi Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid
    Charles N Bernstein
    Section of Gastroenterology, University of Manitoba Inflammatory Bowel Disease Clinical and Research Center, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 8:356-61. 2002
    ..The scientific rationale for using these agents is sound but clinical data are lacking to fully support these approaches as chemoprevention in chronic colitis at present...
  44. ncbi Cancer risk in patients with inflammatory bowel disease: a population-based study
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P4
    Cancer 91:854-62. 2001
    ....
  45. doi Summing up: quality of life in chronic immune-mediated inflammatory diseases
    Charles N Bernstein
    John Buhler Research Centre, University of Manitoba, 804F 175 McDermot Avenue, Winnipeg, MB, Canada
    J Rheumatol Suppl 88:62-5. 2011
    ..There is increasing evidence that several available therapies benefit QOL. Among the factors that contribute to QOL, fatigue, depression, and stress are common and deserve attention from clinicians managing these patients...
  46. ncbi Beta2 integrin/ICAM expression in Crohn's disease
    C N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, R3A 1R9, Canada
    Clin Immunol Immunopathol 86:147-60. 1998
    ..The increased expression of these molecules may have implications for therapeutic interventions in Crohn's disease...
  47. doi Longitudinal study of quality of life and psychological functioning for active, fluctuating, and inactive disease patterns in inflammatory bowel disease
    Lisa M Lix
    Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada
    Inflamm Bowel Dis 14:1575-84. 2008
    ..The aim was to assess quality of life (QOL) and psychological functioning in inflammatory bowel disease (IBD) as related to patterns of disease activity over time...
  48. doi Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort
    J D Ryan
    Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Aliment Pharmacol Ther 38:274-83. 2013
    ..Predictors of complicated Crohn's disease (CD), defined as stricturing or penetrating behaviour, and surgery have largely been derived from referral centre populations...
  49. doi Time trends in colon cancer incidence and distribution and lower gastrointestinal endoscopy utilization in Manitoba
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 103:1249-56. 2008
    ..The aim of our study was to determine the concomitant trends in right-sided colon cancer incidence and utilization of colonoscopy and flexible sigmoidoscopy (FS) in Manitoba...
  50. ncbi Small-area variations and sociodemographic correlates for the incidence of Crohn's disease and ulcerative colitis
    J F Blanchard
    Epidemiology Unit, Public Health Branch, Manitoba Health, Winnipeg, Manitoba, Canada
    Am J Epidemiol 154:328-35. 2001
    ..57, 95% CI: 0.42, 0.79). A higher incidence of IBD was ecologically associated with a higher average family income, a lower proportion of immigrant and Aboriginal Canadian populations, and a smaller average family size...
  51. doi The Manitoba IBD Index: evidence for a new and simple indicator of IBD activity
    Ian Clara
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:1754-63. 2009
    ....
  52. doi Gastrointestinal symptoms before and during menses in women with IBD
    M T Bernstein
    The University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada
    Aliment Pharmacol Ther 36:135-44. 2012
    ..It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses...
  53. ncbi The use of 1H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease
    T Bezabeh
    Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba
    Am J Gastroenterol 96:442-8. 2001
    ..4% could not be classified unambiguously. CONCLUSIONS: There is a strong potential for MRS to be used in the accurate diagnosis of indeterminate colitis; it may also be sensitive in detecting preclinical inflammatory changes in the colon...
  54. ncbi The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Am J Gastroenterol 96:1116-22. 2001
    ..9%). CONCLUSIONS: The associations of immune mediated diseases in extraintestinal sites may help us to further our understanding of IBD pathogenesis, and it may help us in developing a paradigm of disease subsets...
  55. ncbi A BALANCING VIEW: Dysplasia surveillance in ulcerative colitis--sorting the pro from the con
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4, Canada
    Am J Gastroenterol 99:1636-7. 2004
  56. doi Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 103:1451-9. 2008
    ..Bone mineral density (BMD) is usually normal at the time of inflammatory bowel disease (IBD) diagnosis. The purpose of this study was to evaluate the role of vitamin D metabolism in recently diagnosed IBD...
  57. ncbi Predictors of medication adherence in inflammatory bowel disease
    Jason P Ediger
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 102:1417-26. 2007
    ....
  58. doi Do NSAIDs, antibiotics, infections, or stress trigger flares in IBD?
    Sunny Singh
    The Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:1298-313; quiz 1314. 2009
    ..Clinical implications given the current state of knowledge are discussed...
  59. ncbi Lack of relationship of calcium and vitamin D intake to bone mineral density in premenopausal women with inflammatory bowel disease
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 98:2468-73. 2003
    ..The objective of this study was to assess calcium and vitamin D intake and its relationship to bone mineral density (BMD) in premenopausal women with IBD...
  60. ncbi Work losses related to inflammatory bowel disease in Canada: results from a National Population Health Survey
    Teresa Longobardi
    Department of Statistics, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 98:844-9. 2003
    ..Our analysis reports the employment effects related to IBD as based on the 1998 sample of the Canadian National Population Health Survey (NPHS)...
  61. pmc New diagnostic imaging tools for inflammatory bowel disease
    B A MacKalski
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gut 55:733-41. 2006
  62. ncbi Osteonecrosis in a patient with Crohn's disease unrelated to corticosteroid use
    A Khan
    Department of Surgery, University of Manitoba, Winnipeg, Canada
    Can J Gastroenterol 15:765-8. 2001
    ..The association of systemic inflammatory disorders with osteonecrosis and the possible association with vascular thrombosis are discussed...
  63. doi How many duodenal biopsy specimens are required to make a diagnosis of celiac disease?
    Wilson P Pais
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastrointest Endosc 67:1082-7. 2008
    ..It is unknown how many endoscopic biopsy specimens are needed to diagnose celiac disease (CD)...
  64. ncbi Predictors of alternative and complementary medicine use in inflammatory bowel disease: do measures of conventional health care utilization relate to use?
    Twila Burgmann
    Department of Internal Medicine, and University of Manitoba Inflammatory Bowel Disease Clinical and Research Center, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 99:889-93. 2004
    ..It was our purpose to determine whether increased ACM use is associated with increased use of conventional health care resources. Additionally, demographics of use, subjective benefit, and cost were analyzed...
  65. ncbi A population-based ecologic study of inflammatory bowel disease: searching for etiologic clues
    Chris Green
    Public Health Branch, Manitoba Health, Winnipeg, Manitoba, Canada
    Am J Epidemiol 164:615-23; discussion 624-8. 2006
    ..This study underscores the importance of environment in IBD causation...
  66. ncbi The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease
    Benjamin A Goldenberg
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, 804F 715 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 3P4
    Am J Gastroenterol 99:1744-8. 2004
    ....
  67. pmc A comparison of self-perceived health status in inflammatory bowel disease and irritable bowel syndrome patients from a Canadian national population survey
    Linda Y L Tang
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Can J Gastroenterol 22:475-83. 2008
    ..To determine whether differences exist in perceptions of physical health, mental health and stress levels between patients with inflammatory bowel disease (IBD) and patients with irritable bowel syndrome (IBS)...
  68. ncbi Placebos in medicine
    C N Bernstein
    Section of Gastroenterology, University of Manitoba, Winnipeg, Canada
    Semin Gastrointest Dis 10:3-7. 1999
    ..Physicians should attempt to better understand placebo to harness its beneficial effects, avoid nocebo or negative effects, and maximize the placebo response...
  69. ncbi Use of pharmaceuticals by inflammatory bowel disease patients: a population-based study
    C J Metge
    Faculty of Pharmacy, Manitoba Centre for Health Policy and Evaluation, Winnipeg, Canada
    Am J Gastroenterol 96:3348-55. 2001
    ..Furthermore, only 7.8% overall receive immunomodulatory medications, but this was independent of the decade of diagnosis...
  70. ncbi A prospective randomized comparison between small bowel enteroclysis and small bowel follow-through in Crohn's disease
    C N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Gastroenterology 113:390-8. 1997
    ..The aim was to perform a prospective randomized study at a single university medical center comparing SBE with SBFT in patients with Crohn's disease...
  71. ncbi Bone density in a population-based cohort of premenopausal adult women with early onset inflammatory bowel disease
    Charles N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 98:1094-100. 2003
    ....
  72. doi Parathyroid hormone is predictive of low bone mass in Canadian Aboriginal and White women
    Hope A Weiler
    Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Bone 42:498-504. 2008
    ..In conclusion, PTH is a better predictor of BMD than 25(OH)D in this population of Aboriginal and White women...
  73. doi Stress coping, distress, and health perceptions in inflammatory bowel disease and community controls
    Lesley A Graff
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:2959-69. 2009
    ..This study compares a community inflammatory bowel disease (IBD) sample of individuals with a matched non-IBD community sample of individuals on psychological functioning and health perceptions...
  74. doi The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders
    John R Walker
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 103:1989-97. 2008
    ..We assessed the prevalence of anxiety and mood disorders in a population-based IBD cohort...
  75. ncbi A population-based case control study of potential risk factors for IBD
    Charles N Bernstein
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 101:993-1002. 2006
    ..We aimed to pursue potential etiological clues to Crohn's disease (CD) and ulcerative colitis (UC) through a population-based case control survey study...
  76. doi Detecting colorectal cancer by 1H magnetic resonance spectroscopy of fecal extracts
    T Bezabeh
    Institute for Biodiagnostics, National Research Council, 435 Ellice Ave, Winnipeg, Manitoba, Canada
    NMR Biomed 22:593-600. 2009
    ....
  77. ncbi Does gastroenterology consultation change management of patients receiving hematopoietic stem cell transplantation?
    G Fallows
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Bone Marrow Transplant 28:289-94. 2001
    ..Since endoscopy was associated with a mortality of 1.8%, minimizing its use for the cases in which no impact is made, should be considered...
  78. ncbi Generational differences in the age at diagnosis with Ibd: genetic anticipation, bias, or temporal effects
    E M Faybush
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Gastroenterol 97:636-40. 2002
    ..We aimed to explore this issue using a population-based database...
  79. doi The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer
    Harminder Singh
    Internal Medicine and University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gastroenterology 139:1128-37. 2010
    ..There are limited data on mortality from colorectal cancer (CRC) among patients who have received colonoscopy examinations. We sought to determine CRC mortality among persons undergoing colonoscopies compared with the general population...
  80. doi Risk of cervical abnormalities in women with inflammatory bowel disease: a population-based nested case-control study
    Harminder Singh
    Internal Medicine, and the University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
    Gastroenterology 136:451-8. 2009
    ..We evaluated the risk of cervical abnormalities in women with inflammatory bowel disease (IBD) in a population-based, nested, case-control study...
  81. ncbi Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies
    Harminder Singh
    Department of Internal Medicine, Cancer Care Manitoba, University of Manitoba, Winnipeg
    JAMA 295:2366-73. 2006
    ..Limited evidence exists to guide the optimal frequency of repeat endoscopic examination for colorectal cancer screening after a negative colonoscopy...
  82. doi Long-term use of statins and risk of colorectal cancer: a population-based study
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:3015-23. 2009
    ..We conducted a population-based cohort study to determine the effect of long-term regular use of statins on the risk of colorectal cancer (CRC)...
  83. ncbi The epidemiology of inflammatory bowel disease in Canada: a population-based study
    Charles N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 101:1559-68. 2006
    ..The aim of this study was to estimate the incidence and prevalence of CD and UC in diverse regions of Canada and the overall burden of IBD in Canada...
  84. doi Predictors of colorectal cancer after negative colonoscopy: a population-based study
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 105:663-73; quiz 674. 2010
    ..There are no data on predictors of developing colorectal cancer (CRC) after a negative colonoscopy in usual clinical practice. We evaluated gender differences and predictors of CRC occurring after a negative colonoscopy...
  85. pmc High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    Roman Kotlowski
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 56:669-75. 2007
    ..One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls...
  86. ncbi Vitamin B12 malabsorption in patients with limited ileal resection
    Donald R Duerksen
    University of Manitoba, Winnipeg, Manitoba, Canada
    Nutrition 22:1210-3. 2006
    ..Patients with Crohn's disease who have terminal ileal resections are at risk for vitamin B12 malabsorption. Our aim was to determine whether the length of terminal ileum resected correlated with an abnormal Schilling test result...
  87. doi Epidemiology of immune-mediated inflammatory diseases: incidence, prevalence, natural history, and comorbidities
    Hani El-Gabalawy
    Arthritis Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    J Rheumatol Suppl 85:2-10. 2010
    ..Overall, the estimated prevalence of IMID in Western society is 5%-7%. This article provides an overview of studies of the incidence, prevalence, natural history, and comorbidities of IMID...
  88. pmc Predictors of serious complications associated with lower gastrointestinal endoscopy in a major city-wide health region
    Harminder Singh
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Can J Gastroenterol 24:425-30. 2010
    ..There are limited data regarding complications associated with colonoscopy and flexible sigmoidoscopy in usual clinical practice in Canada...
  89. ncbi Drug therapy for inflammatory bowel disease in pregnancy and the puerperium
    Dana C Moffatt
    University of Manitoba, Department of Internal Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Best Pract Res Clin Gastroenterol 21:835-47. 2007
    ..This review attempts to summarise the medical literature to date, as it pertains to the safety of medical therapy for IBD during pregnancy and the puerperium...
  90. pmc Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from Ileal Crohn's disease biopsy tissue
    Denis O Krause
    Department of Animal Science, University of Manitoba, Winnipeg, Canada
    J Bacteriol 193:583. 2011
    ..Its complete genome sequence reveals that it is most closely related to the human urinary tract pathogen E. coli CFT073, but it has a host of genes that are novel and to which no function has been ascribed...
  91. ncbi AGA technical review on osteoporosis in gastrointestinal diseases
    Charles N Bernstein
    Department of Internal Medicine and Inflammatory Bowel Disease Clinical and Research Centre University of Manitoba Winnipeg, Manitoba, Canada
    Gastroenterology 124:795-841. 2003
  92. doi Population-based controlled study of social support, self-perceived stress, activity and work issues, and access to health care in inflammatory bowel disease
    Linda Rogala
    University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 14:526-35. 2008
    ..In this cross-sectional substudy we compared IBD participants' levels of social support, self-perceived stress, disability, and access to healthcare with those of a matched community sample...
  93. ncbi Utilization of health-care resources by patients with IBD in Manitoba: a profile of time since diagnosis
    Teresa Longobardi
    University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and Department of Medicine, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 102:1683-91. 2007
    ..We tested the hypothesis of nonlinear longitudinal trends in health-care utilization by individuals with Crohn's disease (CD) and ulcerative colitis (UC) in Manitoba...
  94. doi Rate and predictors of early/missed colorectal cancers after colonoscopy in Manitoba: a population-based study
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 105:2588-96. 2010
    ..In this population-based study, we investigated the rate and predictors of CRCs diagnosed within 3 years of a colonoscopy...
  95. doi Body mass and composition affect bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study
    William D Leslie
    Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Inflamm Bowel Dis 15:39-46. 2009
    ..This prospective study was undertaken to clarify the role of body mass and composition as a determinant of bone mineral density (BMD) in recently diagnosed inflammatory bowel disease (IBD)...
  96. doi Colonoscopy and its complications across a Canadian regional health authority
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastrointest Endosc 69:665-71. 2009
    ..Defining the complication rate of endoscopy performed across an entire city will capture usual as opposed to referral center data...
  97. ncbi Beta 2-integrin/intercellular adhesion molecule (ICAM) expression in the normal human intestine
    C N Bernstein
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Clin Exp Immunol 106:160-9. 1996
    ..We raise the possibility that a second beta 2-integrin beta subunit may exist, and we report that ICAM-3 is expressed on endothelium, particularly in the adventitial layer...
  98. ncbi Viral hepatitis in a Canadian First Nations community
    G Y Minuk
    Department of Medicine, University of Manitoba, Winnipeg
    Can J Gastroenterol 17:593-6. 2003
    ....
  99. ncbi Who gets irritable bowel syndrome and does seeing a gastroenterologist affect its course?
    C N Bernstein
    Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, 804F 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4, Canada
    Can J Gastroenterol 15:5B-7B. 2001
    ..A structured gastroenterological consultation between the physician and patient may decrease the number of office visits for gastrointestinal-related problems...
  100. ncbi The relationship between inflammatory bowel disease and socioeconomic variables
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Am J Gastroenterol 96:2117-25. 2001
    ..IBD patients are at least as likely as the general population to be married...
  101. pmc An assessment of endoscopic and concomitant management of acute variceal bleeding at a tertiary care centre
    H Singh
    Section of Gastroenterology, University of Manitoba, 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Can J Gastroenterol 21:85-90. 2007
    ..Several therapies have been demonstrated to be beneficial in the management of acute variceal bleeding (AVB). The aim of the present study was to characterize the use of these therapies at a Canadian tertiary care centre...