F Beier

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span
    J R Gillespie
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Endocrinology 154:3702-18. 2013
  2. pmc An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis
    David D McErlain
    Department of Medical Biophysics Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada, N6A 3K7
    Arthritis Res Ther 14:R26. 2012
  3. pmc Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes
    Hanga Agoston
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    BMC Musculoskelet Disord 7:87. 2006
  4. pmc The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, ON, Canada
    BMC Mol Biol 7:30. 2006
  5. pmc Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development
    Claudine G James
    CIHR Group in Skeletal Development and Remodelling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    BMC Genomics 8:205. 2007
  6. pmc C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways
    Hanga Agoston
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    BMC Dev Biol 7:18. 2007
  7. pmc The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
    Veronica Ulici
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, N6A 5C1, Canada
    BMC Dev Biol 8:40. 2008
  8. pmc Src kinase inhibition promotes the chondrocyte phenotype
    Laura Bursell
    Department of Physiology and Pharmacology, Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Arthritis Res Ther 9:R105. 2007
  9. pmc Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
  10. pmc The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
    Ian D Welch
    Department of Animal Care and Veterinary Services, University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R14. 2009

Collaborators

Detail Information

Publications49

  1. doi request reprint GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span
    J R Gillespie
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Endocrinology 154:3702-18. 2013
    ..Our data suggest that skeletal-specific deletion of GSK-3β affects global metabolism and sensitizes male mice to developing type 2 diabetes. ..
  2. pmc An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis
    David D McErlain
    Department of Medical Biophysics Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada, N6A 3K7
    Arthritis Res Ther 14:R26. 2012
    ..The purpose of this study was to use dual-modality, preclinical imaging to monitor the initiation and progression of SBC occurring within an established rodent model of knee OA...
  3. pmc Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes
    Hanga Agoston
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    BMC Musculoskelet Disord 7:87. 2006
    ..We asked whether glucocorticoids could exert their activities by interfering with the expression of CNP or its downstream signaling components...
  4. pmc The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, ON, Canada
    BMC Mol Biol 7:30. 2006
    ..One member of this family, Activating Transcription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown...
  5. pmc Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development
    Claudine G James
    CIHR Group in Skeletal Development and Remodelling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    BMC Genomics 8:205. 2007
    ..Some targets of GC regulation in chondrogenesis are known, but the global effects of pharmacological GC doses on chondrocyte gene expression have not been comprehensively evaluated...
  6. pmc C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways
    Hanga Agoston
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    BMC Dev Biol 7:18. 2007
    ..C-type natriuretic peptide (CNP) has recently been identified as an important anabolic regulator of endochondral bone growth, but the molecular mechanisms mediating its effects are not completely understood...
  7. pmc The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
    Veronica Ulici
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, N6A 5C1, Canada
    BMC Dev Biol 8:40. 2008
    ..PI3K/Akt has been identified as a major regulator of cellular proliferation, differentiation and death in multiple cell types...
  8. pmc Src kinase inhibition promotes the chondrocyte phenotype
    Laura Bursell
    Department of Physiology and Pharmacology, Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Arthritis Res Ther 9:R105. 2007
    ..Strategies to block Src activity might therefore be useful both in tissue engineering of cartilage and in the maintenance of the chondrocyte phenotype in diseases such as osteoarthritis...
  9. pmc Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
    ..The time course of OA progression can be modulated through the use of forced mobilization...
  10. pmc The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
    Ian D Welch
    Department of Animal Care and Veterinary Services, University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R14. 2009
    ..In the present study, we examined the expression of a retinoid-regulated gene in murine models of OA...
  11. ncbi request reprint Cell-cycle control and the cartilage growth plate
    Frank Beier
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, and School of Dentistry, University of Western Ontario, London, Ontario, Canada
    J Cell Physiol 202:1-8. 2005
    ..Numerous recent studies have provided support for such a scenario and provide novel insights into the regulation and function of cell-cycle genes in chondrocytes. This review article summarizes recent progress in the field...
  12. doi request reprint Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression
    J R Gillespie
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Endocrinology 152:1755-66. 2011
    ..To our knowledge, this is the first tissue in which such a compensatory mechanism is described. Thus, our study provides important new insights into both skeletal development and the biology of GSK-3 proteins...
  13. ncbi request reprint The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia
    Frank Beier
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mol Endocrinol 16:2163-73. 2002
    ..In summary, our data suggest that stimulation of cell cycle gene expression and cell cycle progression by mutant PTH/PTHrP receptors contribute to the pathogenesis of JMC...
  14. doi request reprint Reduced chondrocyte proliferation, earlier cell cycle exit and increased apoptosis in neuronal nitric oxide synthase-deficient mice
    Q Yan
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Osteoarthritis Cartilage 20:144-51. 2012
    ..The objective of this study was to examine the effects of inactivation of neuronal nitric oxide synthase (nNOS) on cartilage development in mice...
  15. ncbi request reprint C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis
    Anita Woods
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Endocrinology 148:5030-41. 2007
    ..In summary, we demonstrate a novel role of CNP in promoting chondrogenesis by stimulating expression of molecules involved in cell adhesion molecules and glycosaminoglycan synthesis...
  16. ncbi request reprint Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
    ..To define the roles of transforming growth factor alpha (TGFalpha) in cartilage degradation...
  17. pmc Loss of ATRX in chondrocytes has minimal effects on skeletal development
    Lauren A Solomon
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 4:e7106. 2009
    ..Mutations in the human ATRX gene cause developmental defects, including skeletal deformities and dwarfism. ATRX encodes a chromatin remodeling protein, however the role of ATRX in skeletal development is currently unknown...
  18. pmc Regulation of gene expression by PI3K in mouse growth plate chondrocytes
    Veronica Ulici
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e8866. 2010
    ..In this current study we aimed to investigate targets of the PI3K signaling pathway in hypertrophic chondrocytes...
  19. doi request reprint Transcriptional regulators of chondrocyte hypertrophy
    Lauren A Solomon
    Department of Biochemistry, University of Western Ontario, London, Canada
    Birth Defects Res C Embryo Today 84:123-30. 2008
    ....
  20. ncbi request reprint Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
    ..The identification of Rgs genes as novel regulators of chondrogenesis will contribute to a better understanding of both normal cartilage development and the etiology of chondrodysplasias and osteoarthritis...
  21. pmc Genome-wide analyses of gene expression during mouse endochondral ossification
    Claudine G James
    CIHR Group in Skeletal Development and Remodelling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    PLoS ONE 5:e8693. 2010
    ..Comprehensive analyses of in vivo gene expression profiles during these processes are essential to obtain a complete understanding of the regulatory mechanisms involved...
  22. ncbi request reprint Genetic ablation of Rac1 in cartilage results in chondrodysplasia
    Guoyan Wang
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Dev Biol 306:612-23. 2007
    ..In summary, these data identify a novel, essential and tissue-specific role of Rac1 in skeletal development and demonstrate that Rac1 deficiency affects numerous regulatory pathways in cartilage...
  23. ncbi request reprint Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells
    Lee Anne Stanton
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Exp Cell Res 313:146-55. 2007
    ..We therefore suggest that p38 signaling regulates chondrocyte-perichondral cell communication during skeletal development, partially through increased Ihh signaling...
  24. ncbi request reprint Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1117:165-74. 2007
    ..Identified candidate genes including genes involved in chemokine, endothelin, and transforming growth factor-alpha signaling are discussed in the context of articular cartilage degeneration in early OA...
  25. ncbi request reprint RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation
    Guoyan Wang
    Department of Physiology and Pharmacology, Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 279:13205-14. 2004
    ..Finally, Y27632 treatment partially rescues the effects of RhoA overexpression. In summary, we identify the RhoA/ROCK signaling pathway as a novel and important regulator of chondrocyte proliferation and differentiation...
  26. doi request reprint Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
    Lab Invest 90:20-30. 2010
    ..These data suggest that TGFalpha is a strong stimulator of cartilage degradation and that Rho/ROCK and MEK/ERK signaling have critical roles in mediating these effects...
  27. pmc Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 16:5316-33. 2005
    ..Collectively, these analyses provide novel information on the temporal expression of molecules regulating endochondral bone development...
  28. doi request reprint Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth
    Qian Yan
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 62:2013-22. 2010
    ..This study was undertaken to examine the effects of inactivation of endothelial cell NOS (eNOS) on cartilage development in mice...
  29. doi request reprint Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes
    A Woods
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Osteoarthritis Cartilage 17:406-13. 2009
    ..We have previously shown that the Rho family of proteins and the actin cytoskeleton regulate both early and late chondrocyte differentiation...
  30. ncbi request reprint MAP kinases in chondrocyte differentiation
    Lee Anne Stanton
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Dev Biol 263:165-75. 2003
    ..These data are summarized and discussed here...
  31. ncbi request reprint RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner
    Anita Woods
    Department of Physiology and Pharmacology, The Canadian Institutes for Health Research CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1 Canada
    J Biol Chem 281:13134-40. 2006
    ..These data demonstrate that the effects of RhoA/ROCK signaling and actin polymerization inhibitors on chondrogenic gene expression are dependent on the cellular context...
  32. ncbi request reprint Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
    Guoyan Wang
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Bone Miner Res 20:1022-31. 2005
    ..These results identify Rac1 and Cdc42 pathways as novel regulators of cartilage development...
  33. ncbi request reprint Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions
    Anita Woods
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    J Cell Physiol 213:1-8. 2007
    ....
  34. pmc Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2
    Daphne Pala
    Department of Physiology and Pharmacology and Division of Oral Biology, Canadian Institute of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Biol Chem 283:9239-47. 2008
    ..Our results suggest a reduction in FAK/Src signaling is a critical feature permitting chondrogenic differentiation and that CCN2 operates downstream of this loss to promote chondrogenesis...
  35. ncbi request reprint Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis
    Anita Woods
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:23500-8. 2007
    ..Therefore, we demonstrate that Rac1 and Cdc42 are positive regulators of chondrogenesis, but act at least in part through different cellular and molecular mechanisms...
  36. pmc p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation
    Lee Anne Stanton
    CHIR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5C1
    Biochem J 378:53-62. 2004
    ..In summary, we have demonstrated a novel requirement for p38 signalling in hypertrophic differentiation of chondrocytes and identified myocyte enhancer factor 2C as an important regulator of chondrocyte gene expression...
  37. ncbi request reprint RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis
    Anita Woods
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 280:11626-34. 2005
    ..In conclusion, our data suggest that RhoA/ROCK signaling suppresses chondrogenesis through the control of Sox9 expression and actin organization...
  38. doi request reprint The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification
    Veronica Ulici
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5C1
    Bone 45:1133-45. 2009
    ..Bone mineral density (BMD) and bone mineral content (BMC) measured in the proximal tibia of 1-year-old mice were decreased in Akt1 KO mice, suggesting that the original delay in ossification might affect bone quality in older animals...
  39. ncbi request reprint Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography
    D D McErlain
    Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Canada
    Osteoarthritis Cartilage 16:458-69. 2008
    ..To non-invasively investigate the changes to epiphyseal bone occurring in a longitudinal pre-clinical model of osteoarthritis (OA) using in vivo micro-computed tomography (micro-CT)...
  40. pmc Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes
    Frank Beier
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Cell Biochem 110:573-80. 2010
    ....
  41. ncbi request reprint Identification of the putative collagen X gene from the pufferfish Fugu rubripes
    Anita Woods
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Gene 342:77-83. 2004
    ....
  42. ncbi request reprint p38 MAPK signaling during murine preimplantation development
    David R Natale
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5C1
    Dev Biol 268:76-88. 2004
    ..This study demonstrates that p38 MAPK activity is required to support development through the murine preimplantation interval...
  43. ncbi request reprint p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation
    Dalia Halawani
    Department of Physiology and Pharmacology, Canadian Institute of Health Research Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Oncogene 23:3726-31. 2004
    ..These observations indicate complex regulation of chondrosarcoma cell-cycle progression by p38 signaling, and suggest that components of p38 MAP kinase pathways may be effective targets in the treatment of these tumors...
  44. pmc Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein
    Kamal S Gill
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Cell Physiol 295:C38-49. 2008
    ..In summary, we identify a novel role for Rho-ROCK signaling in regulating chondrocyte spreading and demonstrate both cell- and matrix molecule-specific mechanisms controlling cell spreading...
  45. ncbi request reprint CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, University College London Royal Free Campus, London NW3 2PF, United Kingdom
    J Biol Chem 281:10715-26. 2006
    ..Thus in embryonic fibroblasts, CCN2 is a necessary cofactor required for TGFbeta to activate the adhesive FAK/Akt/phosphatidylinositol 3-kinase cascade, FAK/Akt-dependent genes, and adhesion to matrix...
  46. ncbi request reprint Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes
    Qin Ma
    Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610 0235, USA
    J Cell Biochem 101:477-87. 2007
    ..These data identify the Bcl-2 gene as a novel target of ATF-2 and CREB in growth plate chondrocytes...
  47. pmc Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification
    Cristina C Teixeira
    Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
    Dev Biol 319:171-8. 2008
    ..This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development...
  48. ncbi request reprint The role of activating transcription factor-2 in skeletal growth control
    Phyllis Luvalle
    Department of Anatomy and Cell Biology, University of Florida, Gainesville 32610, USA
    J Bone Joint Surg Am 85:133-6. 2003
  49. ncbi request reprint Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer
    Silvia Riemer
    Department of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    J Cell Biochem 86:688-99. 2002
    ..These results indicate the presence of a PTH/PTHrP responsive element in the human COL10A1 enhancer, which may be represented by multiple putative AP-1 sites located in this region...