T L Beattie

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Functional multimerization of the human telomerase reverse transcriptase
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 21:6151-60. 2001
  2. ncbi request reprint Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
  3. pmc Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1 Canada
    Mol Biol Cell 11:3329-40. 2000

Detail Information

Publications3

  1. pmc Functional multimerization of the human telomerase reverse transcriptase
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 21:6151-60. 2001
    ..These data suggest that the catalytic core of human telomerase may exist as a functionally cooperative dimer or multimer in vivo...
  2. ncbi request reprint Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
    ..Substitution of conserved amino acid residues in the reverse transcriptase domain of TP2 completely abolished telomerase activity. We suggest that TP2 and hTR might represent the minimal catalytic core of human telomerase...
  3. pmc Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1 Canada
    Mol Biol Cell 11:3329-40. 2000
    ..These results establish that the human telomerase RT possesses unique polymerization determinants that distinguish it from other RTs...