T L Beattie

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
    Nicholas S Y Ting
    Department of Biochemistry and Molecular Biology, Cancer Biology Research Group, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Nucleic Acids Res 33:2090-8. 2005
  2. pmc The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1
    Nicholas S Y Ting
    Department of Biochemistry and Molecular Biology and Department of Oncology, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive N W Calgary, AB T2N 4N1, Canada
    Nucleic Acids Res 37:6105-15. 2009
  3. pmc Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo
    Haley D M Wyatt
    Southern Alberta Cancer Research Institute and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 4:e7176. 2009
  4. pmc Functional multimerization of the human telomerase reverse transcriptase
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 21:6151-60. 2001
  5. ncbi request reprint Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
  6. pmc Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1 Canada
    Mol Biol Cell 11:3329-40. 2000

Collaborators

  • Susan P Lees-Miller
  • Nicholas S Y Ting
  • Haley D M Wyatt
  • Brant Pohorelic
  • Yaping Yu
  • Allison R Tsang
  • Deirdre A Lobb

Detail Information

Publications6

  1. pmc Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
    Nicholas S Y Ting
    Department of Biochemistry and Molecular Biology, Cancer Biology Research Group, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Nucleic Acids Res 33:2090-8. 2005
    ....
  2. pmc The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1
    Nicholas S Y Ting
    Department of Biochemistry and Molecular Biology and Department of Oncology, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive N W Calgary, AB T2N 4N1, Canada
    Nucleic Acids Res 37:6105-15. 2009
    ..These data are the first to report that hTR stimulates the kinase activity of DNA-PK toward a known telomere-associated protein, and may provide further insights into the function of DNA-PK at telomeres...
  3. pmc Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo
    Haley D M Wyatt
    Southern Alberta Cancer Research Institute and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 4:e7176. 2009
    ..A conserved glutamine residue in the TERT N-terminus is important for anchor site interactions in lower eukaryotes. The significance of this residue in higher eukaryotes, however, has not been investigated...
  4. pmc Functional multimerization of the human telomerase reverse transcriptase
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Biol 21:6151-60. 2001
    ..These data suggest that the catalytic core of human telomerase may exist as a functionally cooperative dimer or multimer in vivo...
  5. ncbi request reprint Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
    ..Substitution of conserved amino acid residues in the reverse transcriptase domain of TP2 completely abolished telomerase activity. We suggest that TP2 and hTR might represent the minimal catalytic core of human telomerase...
  6. pmc Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1 Canada
    Mol Biol Cell 11:3329-40. 2000
    ..These results establish that the human telomerase RT possesses unique polymerization determinants that distinguish it from other RTs...