Ryon M Bateman
Affiliation: University of British Columbia
- Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imagingRyon M Bateman
University of British Columbia, Critical Care Research Laboratories, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Colombia, Canada, V6Z 1Y6
J Biomed Opt 12:064005. 2007..In combination with multiphoton microscopy, quantum dots provide excellent in vivo imaging contrast of deep microvascular structures...
- Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanismJohn H Boyd
University of British Columbia Critical Care Research Laboratories, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Crit Care 12:R2. 2008..We investigated whether fibrinogen and fibrinogen degradation products, including D-dimer, could alter cardiomyocyte contractile function through interaction with ICAM-1 found on inflamed cardiomyocytes...
- Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemiaChiho Tokunaga
Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
Crit Care Med 35:1341-7. 2007..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...
- Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemiaRyon M Bateman
University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Am J Physiol Heart Circ Physiol 293:H448-56. 2007..HIF-1alpha and GLUT1 gene induction are related to a heterogeneous ICAM-1 expression and may be cardioprotective during the onset of septic injury...
- Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory responseJohn H Boyd
Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
Cardiovasc Res 72:384-93. 2006..We determined whether Toll-like receptors are expressed in cardiac tissue and whether stimulation with cognate ligands would result in a pro-inflammatory response and decreased cardiomyocyte contractility...
- Microvascular resuscitation as a therapeutic goal in severe sepsisRyon M Bateman
The James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
Crit Care 9:S27-32. 2005..Thus, attention must be paid to the microcirculation in patients with sepsis, and therapeutic strategies should be employed to resuscitate the microcirculation in order to avoid organ dysfunction and to reduce mortality...
- Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flowDaniel Goldman
Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
Am J Physiol Heart Circ Physiol 290:H2277-85. 2006..Thus heterogeneous stoppage of individual capillaries is a likely factor in pathological supply dependency...
- Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical modelDaniel Goldman
Dept of Mathematical Sciences, New Jersey Institute of Technology, Univ Heights, Newark, NJ 07102, USA
Am J Physiol Heart Circ Physiol 287:H2535-44. 2004..The model predicts that decreased FCD, increased fast flow, and increased Vo2 in sepsis expose skeletal muscle to significant regions of hypoxia, which could affect local cellular and organ function...
- Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscleRyon M Bateman
University of Western Ontario and the London Health Sciences Centre, Department of Medical Biophysics, London, ON, Canada
Crit Care Med 36:225-31. 2008..The objectives of this study were to determine whether sepsis-induced NO overproduction increased capillary stopped-flow and modulated tissue oxygen consumption in skeletal muscle...
- Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxideRyon M Bateman
Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
Crit Care 7:359-73. 2003..NO also regulates mitochondrial respiration. During sepsis, NO over-production mediates systemic hypotension and microvascular reactivity, and is seemingly protective of microvascular blood flow...
- Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsisChristopher G Ellis
Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
Am J Physiol Heart Circ Physiol 282:H156-64. 2002..Capillary O(2) extraction increased threefold (P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O(2) transport in early stage sepsis is likely the result of a microcirculatory dysfunction...