Ryon M Bateman

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging
    Ryon M Bateman
    University of British Columbia, Critical Care Research Laboratories, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Colombia, Canada, V6Z 1Y6
    J Biomed Opt 12:064005. 2007
  2. pmc Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 12:R2. 2008
  3. ncbi request reprint Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
    Chiho Tokunaga
    Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
    Crit Care Med 35:1341-7. 2007
  4. ncbi request reprint Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    Ryon M Bateman
    University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 293:H448-56. 2007
  5. ncbi request reprint Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
    John H Boyd
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
    Cardiovasc Res 72:384-93. 2006
  6. pmc Microvascular resuscitation as a therapeutic goal in severe sepsis
    Ryon M Bateman
    The James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Crit Care 9:S27-32. 2005
  7. ncbi request reprint Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow
    Daniel Goldman
    Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 290:H2277-85. 2006
  8. ncbi request reprint Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model
    Daniel Goldman
    Dept of Mathematical Sciences, New Jersey Institute of Technology, Univ Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 287:H2535-44. 2004
  9. ncbi request reprint Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle
    Ryon M Bateman
    University of Western Ontario and the London Health Sciences Centre, Department of Medical Biophysics, London, ON, Canada
    Crit Care Med 36:225-31. 2008
  10. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003

Detail Information

Publications11

  1. doi request reprint Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging
    Ryon M Bateman
    University of British Columbia, Critical Care Research Laboratories, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Colombia, Canada, V6Z 1Y6
    J Biomed Opt 12:064005. 2007
    ..In combination with multiphoton microscopy, quantum dots provide excellent in vivo imaging contrast of deep microvascular structures...
  2. pmc Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 12:R2. 2008
    ..We investigated whether fibrinogen and fibrinogen degradation products, including D-dimer, could alter cardiomyocyte contractile function through interaction with ICAM-1 found on inflamed cardiomyocytes...
  3. ncbi request reprint Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
    Chiho Tokunaga
    Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
    Crit Care Med 35:1341-7. 2007
    ..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...
  4. ncbi request reprint Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
    Ryon M Bateman
    University of British Columbia Critical Care Research Laboratories, Department of Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 293:H448-56. 2007
    ..HIF-1alpha and GLUT1 gene induction are related to a heterogeneous ICAM-1 expression and may be cardioprotective during the onset of septic injury...
  5. ncbi request reprint Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
    John H Boyd
    Critical Care Research Laboratories, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
    Cardiovasc Res 72:384-93. 2006
    ..We determined whether Toll-like receptors are expressed in cardiac tissue and whether stimulation with cognate ligands would result in a pro-inflammatory response and decreased cardiomyocyte contractility...
  6. pmc Microvascular resuscitation as a therapeutic goal in severe sepsis
    Ryon M Bateman
    The James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Crit Care 9:S27-32. 2005
    ..Thus, attention must be paid to the microcirculation in patients with sepsis, and therapeutic strategies should be employed to resuscitate the microcirculation in order to avoid organ dysfunction and to reduce mortality...
  7. ncbi request reprint Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow
    Daniel Goldman
    Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 290:H2277-85. 2006
    ..Thus heterogeneous stoppage of individual capillaries is a likely factor in pathological supply dependency...
  8. ncbi request reprint Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model
    Daniel Goldman
    Dept of Mathematical Sciences, New Jersey Institute of Technology, Univ Heights, Newark, NJ 07102, USA
    Am J Physiol Heart Circ Physiol 287:H2535-44. 2004
    ..The model predicts that decreased FCD, increased fast flow, and increased Vo2 in sepsis expose skeletal muscle to significant regions of hypoxia, which could affect local cellular and organ function...
  9. ncbi request reprint Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle
    Ryon M Bateman
    University of Western Ontario and the London Health Sciences Centre, Department of Medical Biophysics, London, ON, Canada
    Crit Care Med 36:225-31. 2008
    ..The objectives of this study were to determine whether sepsis-induced NO overproduction increased capillary stopped-flow and modulated tissue oxygen consumption in skeletal muscle...
  10. pmc Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide
    Ryon M Bateman
    Vascular Biology Program, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care 7:359-73. 2003
    ..NO also regulates mitochondrial respiration. During sepsis, NO over-production mediates systemic hypotension and microvascular reactivity, and is seemingly protective of microvascular blood flow...
  11. ncbi request reprint Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis
    Christopher G Ellis
    Vascular Biology Program, Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6B 1B8, Canada
    Am J Physiol Heart Circ Physiol 282:H156-64. 2002
    ..Capillary O(2) extraction increased threefold (P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O(2) transport in early stage sepsis is likely the result of a microcirculatory dysfunction...