- The interferon response inhibits HIV particle production by induction of TRIM22Stephen D Barr
Department of Medical Microbiology and Immunology, University of Alberta, Alberta Institute for Viral Immunology, Edmonton, Alberta, Canada
PLoS Pathog 4:e1000007. 2008..Mutational analyses of TRIM22 showed that the catalytic amino acids Cys15 and Cys18 of the RING domain are required for TRIM22 antiviral activity. These data disclose a pathway by which Type 1 interferons obstruct HIV replication...
- Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genomeStephen D Barr
University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Virol 79:12035-44. 2005..Further analysis indicated that ERVs in humans, mice, and rats showed similar distributions, suggesting purifying selection dictated their distributions as well...
- HIV integration site selection: targeting in macrophages and the effects of different routes of viral entryStephen D Barr
Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, 19104 6076, USA
Mol Ther 14:218-25. 2006..Analysis of additional published integration site sequences also indicated that the route of entry did not affect integration site selection for other viral envelopes as well...