C L Barr

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Gene for the serotonin transporter and ADHD: no association with two functional polymorphisms
    Karen G Wigg
    Department of Psychiatry, Cell and Molecular Division, The Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:566-70. 2006
  2. doi request reprint Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder
    Natalie L Bulgin
    Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Neuromolecular Med 10:343-55. 2008
  3. ncbi request reprint Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
  4. ncbi request reprint The norepinephrine transporter gene and attention-deficit hyperactivity disorder
    Cathy L Barr
    Department of Psychiatry and Division of Cellular and Molecular Biology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 114:255-9. 2002
  5. ncbi request reprint Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
  6. ncbi request reprint Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mol Psychiatry 6:334-7. 2001
  7. ncbi request reprint Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
    Mol Psychiatry 5:548-51. 2000
  8. ncbi request reprint Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
  9. doi request reprint Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
  10. ncbi request reprint Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems
    P Luca
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 12:776-85. 2007

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Gene for the serotonin transporter and ADHD: no association with two functional polymorphisms
    Karen G Wigg
    Department of Psychiatry, Cell and Molecular Division, The Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:566-70. 2006
    ..These polymorphisms were genotyped in 209 ADHD families identified through an affected proband. We did not find evidence for an association of these polymorphisms, or haplotypes of these polymorphisms, to ADHD in this sample...
  2. doi request reprint Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder
    Natalie L Bulgin
    Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Neuromolecular Med 10:343-55. 2008
    ....
  3. ncbi request reprint Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
    ..Further, we found no sex-specific relationship. Our results, therefore, do not support the previous evidence for this gene as a major factor contributing to depression...
  4. ncbi request reprint The norepinephrine transporter gene and attention-deficit hyperactivity disorder
    Cathy L Barr
    Department of Psychiatry and Division of Cellular and Molecular Biology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 114:255-9. 2002
    ..8%) was similar to that previously reported in a control sample (2.2%), it is unlikely that this variant is related to the ADHD phenotype. Our results do not support the NET1 gene as a major genetic susceptibility factor in ADHD...
  5. ncbi request reprint Linkage study of polymorphisms in the gene for myelin oligodendrocyte glycoprotein located on chromosome 6p and attention deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 105:250-4. 2001
    ..We did not observe biased transmission of the alleles at either polymorphism to ADHD probands or siblings. Our findings using this sample do not support the role of the MOG gene in ADHD...
  6. ncbi request reprint Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mol Psychiatry 6:334-7. 2001
    ..We conclude that the alleles at the polymorphisms tested in these two genes are not linked to the ADHD phenotype in this sample of families...
  7. ncbi request reprint Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
    Mol Psychiatry 5:548-51. 2000
    ..The number of informative transmissions for these two alleles was small, therefore it would be premature to make any conclusions from our study concerning the role of DRD5 in ADHD...
  8. ncbi request reprint Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
    ..These findings, while preliminary, identify association of ADHD to a gene that potentially plays a role in cell migration and axon growth...
  9. doi request reprint Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD)
    J Mill
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:866-73. 2009
    ....
  10. ncbi request reprint Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems
    P Luca
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 12:776-85. 2007
    ..Furthermore, the association of DRD1 with inattention, but not with RD, or the other reading and reading-related phenotypes analysed, suggests that DRD1 contributes uniquely to inattention, without overlap for reading ability...
  11. ncbi request reprint Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Canada
    Mol Psychiatry 5:405-9. 2000
    ..We observed biased transmission of the haplotypes of the alleles of these two polymorphisms. Our findings are suggestive of a role of this gene in ADHD...
  12. ncbi request reprint Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder
    J Lee
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Genes Brain Behav 7:53-60. 2008
    ..Based on our results and others, CHRNA4 may be involved in ADHD; however, its role in ADHD symptomatology remains to be clarified...
  13. ncbi request reprint Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder
    N Laurin
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 10:1117-25. 2005
    ..These findings support the proposed involvement of the calcyon gene in ADHD and implicate haplotype C1 as containing a risk allele...
  14. ncbi request reprint Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006
    ..The results in the present sample indicate that these nine genes are unlikely to be major susceptibility genes contributing to COMD...
  15. ncbi request reprint Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder
    K M Dorval
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 6:444-52. 2007
    ..Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait...
  16. ncbi request reprint Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Mol Psychiatry 10:861-7. 2005
    ..These results provide evidence that BDNF variants affect liability to juvenile-onset mood disorders, supported by data from two independent samples...
  17. ncbi request reprint Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Ontario, Canada
    Am J Med Genet 96:262-7. 2000
    ..We examined the haplotypes of three polymorphisms of the D4 receptor gene and observed biased transmission of two of these haplotypes. Our findings further support the role of the dopamine D4 gene in ADHD...
  18. ncbi request reprint Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 88:710-3. 1999
    ..A total of 77 nuclear families collected from Toronto were genotyped. We find no evidence for linkage of this polymorphism and ADHD in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:710-713, 1999...
  19. ncbi request reprint The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder
    Y Feng
    Department of Psychiatry, Cellular and Molecular Division, The Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 10:998-1005, 973. 2005
    ..Our findings continue to support SNAP25 in the susceptibility to ADHD...
  20. ncbi request reprint Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder
    J Strauss
    Centre for Addiction and Mental Health, University of Toronto, 250 College Str, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 131:16-9. 2004
    ....
  21. ncbi request reprint A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1
    C Tran
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 162:146-56. 2013
    ..The results of this study do not provide evidence for association between the putatively functional SNPs -3G/A and 1249G/T and RD...
  22. ncbi request reprint Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia
    G Zai
    Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
    Genes Brain Behav 4:2-9. 2005
    ..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene...
  23. ncbi request reprint 5'-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
    Am J Med Genet 105:84-90. 2001
    ..We conclude that these three polymorphisms are not related to the ADHD phenotype...
  24. pmc Association of the GABRD gene and childhood-onset mood disorders
    Y Feng
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 9:668-72. 2010
    ..These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding...
  25. ncbi request reprint Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region
    J Adams
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Mol Psychiatry 9:494-9. 2004
    ..There was no significant evidence of linkage between GRIN2A and these phenotypes. While the results were not significant in our sample, the previous association finding suggests that further study of this gene is warranted...
  26. ncbi request reprint Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
    Biol Psychiatry 49:333-9. 2001
    ..This association was later replicated in additional studies...
  27. ncbi request reprint Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder
    V L Misener
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mol Psychiatry 9:500-9. 2004
    ..DNA from 41 children was analysed, and no sequence variations were identified, indicating that the putative DRD1 risk variant for ADHD resides outside of the coding region of the gene...
  28. doi request reprint Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  29. ncbi request reprint Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families
    C Xu
    Department of Psychiatry, Division of Cellular and Molecular Biology, The Toronto Western Hospital, Toronto, Canada
    Am J Med Genet 105:159-62. 2001
    ..We found no evidence for linkage of the ADRA2A gene with ADHD, using the transmission disequilibrium test in this set of families...
  30. ncbi request reprint Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Am J Med Genet 96:114-7. 2000
    ..Our findings using this particular sample do not support the role of the dopamine D3 gene in ADHD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:114-117, 2000...
  31. ncbi request reprint Support for EKN1 as the susceptibility locus for dyslexia on 15q21
    K G Wigg
    Department of Psychiatry, Cell and Molecular Division, The Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
    Mol Psychiatry 9:1111-21. 2004
    ..Based on these findings, further studies of this gene in independent samples are now required to determine the relationship of this gene to dyslexia...
  32. ncbi request reprint Linkage study in families with posterior helical ear pits and Wiedemann-Beckwith syndrome
    C L Barr
    Department of Psychiatry, The Hospital for Sick Children, The Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet 104:120-6. 2001
    ..Alternatively, the PHEP phenotype may occur independently of WBS so that the association of WBS and PHEP in our pedigrees may, in fact, represent causal heterogeneity...
  33. ncbi request reprint Association of the ROBO1 gene with reading disabilities in a family-based analysis
    C Tran
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network Institute of Medical Science, University of Toronto
    Genes Brain Behav 13:430-8. 2014
    ..005 and P = 0.007). These results support previous associations between ROBO1 and RD, as well as correlation with low gene expression, suggesting a possible mechanism of risk conferred by this gene...
  34. ncbi request reprint Catechol-O-methyltransferase and Gilles de la Tourette syndrome
    C L Barr
    The Department of Psychiatry, Toronto Hospital Western Division, Toronto, Ontario, Canada
    Mol Psychiatry 4:492-5. 1999
    ..1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods. No significant evidence for linkage was found for the COMT gene and the TS/CMT, or OCD phenotypes in these pedigrees...
  35. ncbi request reprint Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder
    L Gomez
    Toronto Western Research Institute, University Health Network, Toronto, Canada
    Genes Brain Behav 13:535-42. 2014
    ..The results of this study indicate that KCNJ5 is associated with TS and ADHD in our samples, however, the functional variant(s) remain to be identified. ..
  36. ncbi request reprint Current status of genetic studies of Gilles de la Tourette syndrome
    C L Barr
    Department of Psychiatry, Toronto Hospital, Ontario
    Can J Psychiatry 43:351-7. 1998
    ..In this article, we review the evidence for the genetic basis of TS and the current status of genetic studies...
  37. ncbi request reprint Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene
    A H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Mol Psychiatry 8:156-66. 2003
    ....
  38. ncbi request reprint Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder
    Gwyneth Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:64-8. 2004
    ..334, P = 0.020). Further investigations combining genetic, pathological, and pharmacological strategies, are warranted...
  39. ncbi request reprint Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder
    Virginia L Misener
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ont, Canada
    Neuropsychobiology 50:231-4. 2004
    ..e. false-positive) result. These findings highlight the need for further investigations of this marker, in additional independent ADHD samples, in the future...
  40. ncbi request reprint Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder
    Nancy Laurin
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ont, Canada
    J Psychiatr Res 42:117-24. 2008
    ..005) and rs8098539A (P=0.035). These preliminary findings suggest a possible contribution of GNAL in the susceptibility to ADHD, with possible involvement of parent-of-origin effects...
  41. ncbi request reprint Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders
    Jennifer H Adams
    Department of Psychiatry, Cell and Molecular Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 132:90-5. 2005
    ..Based on these results, using these three polymorphisms, we do not find support for NTRK2 as a susceptibility gene for COMD...
  42. ncbi request reprint Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase
    Karen Wigg
    Department of Psychiatry, Toronto Western Hospital, Ont, Canada
    Am J Psychiatry 159:1046-8. 2002
    ..One recent study reported an association of an allele of the TaqI polymorphism located in the fifth intron of the gene for dopamine beta-hydroxylase (DBH). The authors' goal was to replicate this finding...
  43. ncbi request reprint Evidence for the gamma-amino-butyric acid type B receptor 1 (GABBR1) gene as a susceptibility factor in obsessive-compulsive disorder
    Gwyneth Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    Am J Med Genet B Neuropsychiatr Genet 134:25-9. 2005
    ..The observed trends suggest that further investigations of the role of the GABBR1 gene in OCD are warranted...
  44. ncbi request reprint Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder
    Jonghun Lee
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:976-81. 2007
    ..651, P = 0.008). These results should be interpreted cautiously, however, because of the low haplotype frequency. In light of the evidence for an involvement of BDNF in ADHD, further analysis of the BDNF gene in ADHD is warranted...
  45. doi request reprint Arginine vasopressin 1a receptor gene and maternal behavior: evidence of association and moderation
    R Bisceglia
    Department of Human Development and Applied Psychology, University of Toronto Toronto Western Research Institute, Toronto, ON, Canada
    Genes Brain Behav 11:262-8. 2012
    ..Mothers with two copies of the long RS3 alleles were less sensitive than mothers with one or zero copies of the long alleles. This association was strongest under conditions of high maternal early adversity...
  46. ncbi request reprint Genome scan for linkage to Gilles de la Tourette syndrome
    C L Barr
    Department of Psychiatry, Toronto Hospital Western Division, Toronto, Ontario, Canada
    Am J Med Genet 88:437-45. 1999
    ..Further support for linkage in these regions is required before linkage can be assumed...
  47. ncbi request reprint Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder
    Nancy Laurin
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:600-5. 2008
    ..Our results suggest that these six genes are unlikely to be susceptibility genes in the chromosome 5p13-q11 region and other genes should now be considered for priority study...
  48. ncbi request reprint No evidence for genetic association between DARPP-32 (PP1R1B) polymorphisms and attention deficit hyperactivity disorder
    Nancy Laurin
    Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:339-42. 2008
    ..In conclusion, albeit a key regulatory role in dopamine signaling, our data do not support a major contribution of the DARPP-32 gene in ADHD...
  49. doi request reprint Further genetic evidence implicates the vasopressin system in childhood-onset mood disorders
    Emma L Dempster
    Genetics and Development Division, Toronto Western Research Institute, Toronto ON, Canada
    Eur J Neurosci 30:1615-9. 2009
    ..The outcome of this study, combined with our previous association between COMD and AVPR1B, implicates genetic variation in vasopressinergic genes in mediating vulnerability to COMD...
  50. ncbi request reprint The gene for synapsin III and attention-deficit hyperactivity disorder
    Rohit Makkar
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Psychiatr Genet 17:109-12. 2007
    ..On the basis of the role of synapsin III in the modulation of neurotransmitter release, we tested this gene as a candidate contributing to the genetic susceptibility of attention deficit hyperactivity disorder...
  51. doi request reprint Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319
    Jillian M Couto
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 153:447-62. 2010
    ..Our data indicates that this putative regulatory region is a likely site of genetic variation contributing to RD in our sample, further narrowing the candidate region...
  52. ncbi request reprint Association of attention-deficit/hyperactivity disorder with a candidate region for reading disabilities on chromosome 6p
    Jillian M Couto
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada
    Biol Psychiatry 66:368-75. 2009
    ..RD has been previously associated with five genes in the region, particularly DCDC2 and KIAA0319...
  53. doi request reprint G72/G30 (DAOA) and juvenile-onset mood disorders
    Lissette Gomez
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:1007-12. 2009
    ....
  54. ncbi request reprint Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome
    Chun Xu
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 119:54-9. 2003
    ..We found no significant evidence for linkage using the transmission disequilibrium test for these two genes. Based on our families, we conclude that these genes are not major genetic factors contributing to the susceptibility to GTS...
  55. ncbi request reprint Linkage study between congenital cataracts and five crystallin loci
    Cathy L Barr
    Department of Psychiatry, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Am J Med Genet A 121:15-9. 2003
    ..Although LOD scores > 3.0 were not obtained, we found some support for linkage to four of the chromosomal regions examined, namely 2q33-35, 17q11.2-12, 21q22.3, and 22q11.2...
  56. doi request reprint Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders
    Virginia L Misener
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:653-9. 2009
    ..The results do not support the involvement of IL1B as a major factor in genetic risk for early-onset mood disorders...
  57. doi request reprint Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins
    Isabelle Ouellet-Morin
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:1442-9. 2008
    ..These findings indicate that the DAT1 gene contributes to ADHD symptoms in this sample and further suggest that the VNTR may not be the optimal polymorphism for study in all populations...
  58. ncbi request reprint Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)
    Yu Feng
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 139:1-6. 2005
    ..Our results therefore refute the possibility of the reported DraI variation or alleles of the VNTR as the functional variants contributing to the disorder...
  59. ncbi request reprint Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders
    Emma L Dempster
    Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Arch Gen Psychiatry 64:1189-95. 2007
    ..Arginine vasopressin (AVP) plays a crucial role in modulating the HPA axis under stress and does so through a G protein-coupled receptor, vasopressin V1b receptor (AVPR1b)...
  60. ncbi request reprint Inhibition of motor responses in siblings concordant and discordant for attention deficit hyperactivity disorder
    Russell J Schachar
    Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto M5N 2L1, Canada
    Am J Psychiatry 162:1076-82. 2005
    ..The authors sought to determine whether nonaffected siblings of ADHD probands have a motor response inhibition deficit and to assess concordance for this inhibition deficit in ADHD-concordant and ADHD-discordant sibling pairs...
  61. doi request reprint Association study of serotonin system genes in childhood-onset mood disorder
    Sajid A Shaikh
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    Psychiatr Genet 18:47-52. 2008
    ..The serotonin system has been implicated in neuropsychiatric disorders, including mood disorders...
  62. doi request reprint Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders
    Yu Feng
    Toronto Western Research Institute, University Health Network, Toronto, Ont, Canada M5T 2S8
    Am J Psychiatry 165:610-6. 2008
    ..The authors investigated NTRK3 as a susceptibility gene for childhood-onset mood disorders...
  63. ncbi request reprint Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia
    Gwyneth Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8
    Eur Neuropsychopharmacol 15:347-52. 2005
    ..310, P = 0.038) and a trend was observed between the genotype frequency (chi2 = 4.970, 2 df, P = 0.083) of SCZ individuals and controls. Further investigations of the role of GABBR1 in SCZ are warranted...
  64. ncbi request reprint GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families
    Yu Feng
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    Psychiatr Genet 17:347-50. 2007
    ..Further, we found no evidence of association when the results were analyzed in girls only (n=215). We, therefore, failed to replicate the previous association of this gene with mood disorders...
  65. ncbi request reprint Analysis of the dopamine beta hydroxylase gene in Gilles de la Tourette syndrome
    Fatih Ozbay
    Department of Child and Adolescent Psychiatry, Marmara University Faculty of Medicine, Istanbul, Turkey
    Am J Med Genet B Neuropsychiatr Genet 141:673-7. 2006
    ..These findings, in total, suggest that the DBH locus is unlikely to be a major gene influencing the susceptibility to DBH...
  66. ncbi request reprint Validating psychiatric endophenotypes: inhibitory control and attention deficit hyperactivity disorder
    Jennifer Crosbie
    Department of Psychiatry, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Torento, Canada M5G 1X8
    Neurosci Biobehav Rev 32:40-55. 2008
    ..The literature on motor response inhibition is reviewed to illustrate the validation process which is recommended in the selection of other candidate endophenotypes...
  67. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...