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Genomes and GenesSpecies | C BarrSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Current status of genetic studies of Gilles de la Tourette syndromeC L Barr
Department of Psychiatry, Toronto Hospital, Ontario
Can J Psychiatry 43:351-7. 1998..In this article, we review the evidence for the genetic basis of TS and the current status of genetic studies...- 5'-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorderC L Barr
Department of Psychiatry, The Toronto Western Hospital, Ontario, Canada
Am J Med Genet 105:84-90. 2001..We conclude that these three polymorphisms are not related to the ADHD phenotype... - Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorderC L Barr
Department of Psychiatry, The Toronto Hospital, Western Division, Ontario, Canada
Am J Med Genet 96:262-7. 2000..We examined the haplotypes of three polymorphisms of the D4 receptor gene and observed biased transmission of two of these haplotypes. Our findings further support the role of the dopamine D4 gene in ADHD... - Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorderC L Barr
Department of Psychiatry, The Toronto Hospital, Western Division, Canada
Mol Psychiatry 5:405-9. 2000..We observed biased transmission of the haplotypes of the alleles of these two polymorphisms. Our findings are suggestive of a role of this gene in ADHD... - Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorderC L Barr
Department of Psychiatry, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
Am J Med Genet 96:114-7. 2000..Our findings using this particular sample do not support the role of the dopamine D3 gene in ADHD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:114-117, 2000... - Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorderC L Barr
Department of Psychiatry, Toronto Hospital, Western Division, Toronto, Ontario, Canada
Am J Med Genet 88:710-3. 1999..A total of 77 nuclear families collected from Toronto were genotyped. We find no evidence for linkage of this polymorphism and ADHD in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:710-713, 1999... - Catechol-O-methyltransferase and Gilles de la Tourette syndromeC L Barr
The Department of Psychiatry, Toronto Hospital Western Division, Toronto, Ontario, Canada
Mol Psychiatry 4:492-5. 1999..1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods. No significant evidence for linkage was found for the COMT gene and the TS/CMT, or OCD phenotypes in these pedigrees... - Genome scan for linkage to Gilles de la Tourette syndromeC L Barr
Department of Psychiatry, Toronto Hospital Western Division, Toronto, Ontario, Canada
Am J Med Genet 88:437-45. 1999..Further support for linkage in these regions is required before linkage can be assumed... - Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sampleJ Strauss
Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Mol Psychiatry 10:861-7. 2005..These results provide evidence that BDNF variants affect liability to juvenile-onset mood disorders, supported by data from two independent samples... - Association study of CREB1 and childhood-onset mood disordersI Burcescu
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005..Further, we found no sex-specific relationship. Our results, therefore, do not support the previous evidence for this gene as a major factor contributing to depression... - Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorderN Laurin
Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Mol Psychiatry 10:1117-25. 2005..These findings support the proposed involvement of the calcyon gene in ADHD and implicate haplotype C1 as containing a risk allele... - Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian familiesI Burcescu
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 141:227-33. 2006..The results in the present sample indicate that these nine genes are unlikely to be major susceptibility genes contributing to COMD... - Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problemsP Luca
Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Mol Psychiatry 12:776-85. 2007..Furthermore, the association of DRD1 with inattention, but not with RD, or the other reading and reading-related phenotypes analysed, suggests that DRD1 contributes uniquely to inattention, without overlap for reading ability... - Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorderJ Lee
Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Genes Brain Behav 7:53-60. 2008..Based on our results and others, CHRNA4 may be involved in ADHD; however, its role in ADHD symptomatology remains to be clarified... - Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated regionD M Miranda
Department of Pharmacology of Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Am J Med Genet B Neuropsychiatr Genet 147:68-72. 2008..Thus, these two genes are unlikely to be the susceptibility genes contributing to GTS on 11q24... - No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disordersE L Dempster
Mol Psychiatry 12:1063-4. 2007 
Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implicationsMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 64:219-25. 2008..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes...- Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophreniaG Zai
Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
Genes Brain Behav 4:2-9. 2005..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene... - BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorderJ Strauss
Centre for Addiction and Mental Health, University of Toronto, ON M6S 3R4, Canada
Neuromolecular Med 5:181-92. 2004..41, df = 4, 58, p = 0.0035) were associated with more optimal performance on the memory tasks. This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes... - Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorderJ Strauss
Centre for Addiction and Mental Health, University of Toronto, 250 College Str, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 131:16-9. 2004.... - Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorderC L Barr
Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
Biol Psychiatry 49:333-9. 2001..This association was later replicated in additional studies... - Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder familiesC Xu
Department of Psychiatry, Division of Cellular and Molecular Biology, The Toronto Western Hospital, Toronto, Canada
Am J Med Genet 105:159-62. 2001..We found no evidence for linkage of the ADRA2A gene with ADHD, using the transmission disequilibrium test in this set of families... - Linkage study in families with posterior helical ear pits and Wiedemann-Beckwith syndromeC L Barr
Department of Psychiatry, The Hospital for Sick Children, The Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet 104:120-6. 2001..Alternatively, the PHEP phenotype may occur independently of WBS so that the association of WBS and PHEP in our pedigrees may, in fact, represent causal heterogeneity... - Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sampleJ M Scharf
Psychiatric Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 70:1495-6. 2008 - Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorderV L Misener
Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Mol Psychiatry 9:500-9. 2004..DNA from 41 children was analysed, and no sequence variations were identified, indicating that the putative DRD1 risk variant for ADHD resides outside of the coding region of the gene... - Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 regionJ Adams
Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Mol Psychiatry 9:494-9. 2004..There was no significant evidence of linkage between GRIN2A and these phenotypes. While the results were not significant in our sample, the previous association finding suggests that further study of this gene is warranted... - Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility regionP Paschou
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
Am J Hum Genet 75:545-60. 2004..In conclusion, our findings warrant the further investigation of 17q25 as a candidate susceptibility region for GTS... - Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorderK M Dorval
Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Genes Brain Behav 6:444-52. 2007..Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait... - No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorderN Laurin
Mol Psychiatry 12:226-9. 2007 - The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorderJ F Quist
Neurogentics Section, Centre for Addiction and Mental Health, Clarke Division, and Department of Psychiatry, University of Toronto, Canada
Mol Psychiatry 8:98-102. 2003..80, P = 0.03) to the affected child. Although preliminary, results from this study provide additional evidence that serotonin genes may be important risk factors for the development of ADHD... - The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorderY Feng
Department of Psychiatry, Cellular and Molecular Division, The Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Mol Psychiatry 10:998-1005, 973. 2005..Our findings continue to support SNAP25 in the susceptibility to ADHD... - Support for EKN1 as the susceptibility locus for dyslexia on 15q21K G Wigg
Department of Psychiatry, Cell and Molecular Division, The Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
Mol Psychiatry 9:1111-21. 2004..Based on these findings, further studies of this gene in independent samples are now required to determine the relationship of this gene to dyslexia... - Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta geneA H C Wong
Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
Mol Psychiatry 8:156-66. 2003....