Research Topics
Genomes and Genes | Alasdair M BarrSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathwayAlasdair M Barr
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, 828 West 10th Avenue, Vancouver, BC, Canada
Int J Neuropsychopharmacol 9:457-63. 2006..These results indicate that presynaptic proteins represent a potential molecular substrate for the effects of antipsychotic drugs on hippocampal synaptic connectivity...- A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophreniaWilliam J Panenka
Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada, V5Z 1L8
Schizophr Res 94:288-92. 2007..This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine... 
A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacyWilliam G Honer
BC Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC, Canada
J Psychiatry Neurosci 34:433-42. 2009..Better linkage between the components of translational research may improve the appropriate use of medications such as clozapine in psychiatric practice...- A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical testsAlasdair M Barr
Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
Neurosci Lett 405:111-5. 2006..These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects... - Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortexAlasdair M Barr
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
Alcohol Clin Exp Res 29:1915-20. 2005.... - The need for speed: an update on methamphetamine addictionAlasdair M Barr
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
J Psychiatry Neurosci 31:301-13. 2006..It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies... 
Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatmentAlasdair M Barr
Faculty of Medicine, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 100:252-60. 2008..While a number of theories have been proposed to account for such high rates of smoking, little is known about the subjective motivation for why schizophrenia patients smoke in comparison with those without the disease...- Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteinsAlasdair M Barr
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Eur J Neurosci 27:2568-74. 2008..However, it is unlikely that these behavioral differences may be accounted for by altered regional levels of presynaptic proteins... - The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in miceAlasdair M Barr
Department of Psychiatry, University of British Columbia, Vancouver, B C, Canada
Neuropharmacology 52:1114-23. 2007..These findings have relevance to a range of neuropsychiatric disorders that involve sensorimotor gating deficits, including schizophrenia... - Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in ratsAlasdair M Barr
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
Neuropharmacology 51:457-65. 2006..The absence of effect in isolation-reared rats may be due to the relatively small effect size of isolation rearing on PPI or dose of iloperidone... - Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes mazeAlasdair M Barr
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Behav Neurosci 121:1101-5. 2007..ApoER2 knockout mice also displayed altered use of specific search strategies and relationship of these strategies to errors made on the maze... - Role of estradiol withdrawal in 'anhedonic' sucrose consumption: a model of postpartum depressionAmanda D Green
Department of Psychology, Neuroscience Program and Brain Research Centre, The University of British Columbia, Vancouver, Canada
Physiol Behav 97:259-65. 2009..Together, these results suggest an important, though complex, role for gonadal hormones in the behavioral changes accompanying this model of depression... - A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal modelHeidi N Boyda
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Prog Neuropsychopharmacol Biol Psychiatry 34:945-54. 2010..Together, these findings indicate that acute administration of antipsychotic drugs has potent effects on metabolic regulation of glucose and insulin sensitivities, which may contribute to metabolic side-effects seen in humans... - Effects of sub-chronic clozapine and haloperidol administration on brain lipid levelsVilte E Barakauskas
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Prog Neuropsychopharmacol Biol Psychiatry 34:669-73. 2010..Our findings suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications... - Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatientsRic M Procyshyn
British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
J Clin Psychiatry 71:566-73. 2010.... - Predictors of starting to smoke cigarettes in patients with first episode psychosisGeoffrey N Smith
University of British Columbia, Vancouver, Canada
Schizophr Res 108:258-64. 2009..However, genetic, obstetric and early life conditions are risks for starting to smoke in the general population but their role in psychotic patients is unclear... - Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatmentRic M Procyshyn
Department of Research, Riverview Hospital, Port Coquitlam, BC, Canada
J Psychiatry Neurosci 32:331-8. 2007..The primary objective of this study was to determine whether an increase in serum lipids is associated with improvement in schizophrenia symptoms during steady state treatment with clozapine... - A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophreniaVilte E Barakauskas
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 35:1226-38. 2010..SNARE proteins and their interactions may be a novel target for the development of therapeutics... - Psychostimulant withdrawal as an inducing condition in animal models of depressionAlasdair M Barr
Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
Neurosci Biobehav Rev 29:675-706. 2005..Recent progress and limitations in the development of this model, as well as future directions for research, are evaluated and discussed... - Metabolic side-effects of the novel second-generation antipsychotic drugs asenapine and iloperidone: a comparison with olanzapineHeidi N Boyda
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 8:e53459. 2013..We therefore used preclinical models to evaluate the metabolic side-effects of glucose intolerance and insulin resistance with the novel SGAs asenapine and iloperidone for the first time. Olanzapine was used as a comparator... - Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington diseaseJeremy M Van Raamsdonk
Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children's and Women's Health, University of British Columbia, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
Exp Neurol 196:266-72. 2005..Overall, this work demonstrates the feasibility of experimental therapeutics in the YAC128 mouse model and suggests that experiments in these mice may be predictive for future human clinical trials... - Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activityMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 103:47-56. 2007.... - Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophreniaAlasdair M Barr
Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
Eur J Neurosci 20:303-7. 2004.... - Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophreniaWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
CNS Drugs 21:699-714. 2007..Trials need to be designed to investigate widely used approaches such as antipsychotic polypharmacy, where actual practice diverges from evidence-based guidelines... - Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim testsTamas Bartfai
Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:10470-5. 2004..These data further implicate brain and spinal cord galanin receptors as drug targets and provide an example of a systemically active compound based on a scaffold that mimics protein surfaces... - Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findingsWilliam J Panenka
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Drug Alcohol Depend 129:167-79. 2013..Treatment options include pharmacological, psychological or combination therapies. The present review summarizes the key findings in the literature spanning from molecular through to clinical effects... - Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female ratsHeidi N Boyda
Department of Anesthesiology and Pharmacology, University of British Columbia, Vancouver, BC
J Psychiatry Neurosci 37:407-15. 2012..However, use of the drug is commonly associated with a range of metabolic side effects, including glucose intolerance and insulin resistance. These symptoms have been accurately modelled in rodents... - Medication errors in psychiatry: a comprehensive reviewRic M Procyshyn
British Columbia Mental Health and Addictions Services Research Institute, Vancouver, British Columbia, Canada
CNS Drugs 24:595-609. 2010..Medication errors in psychiatry have been studied almost exclusively in the inpatient setting and thus little is known about the incidence and significance in outpatient and community settings... - A 'crash' course on psychostimulant withdrawal as a model of depressionAlasdair M Barr
Associate Professor, Dept of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Pharmacol Sci 23:475-82. 2002..Current advances and limitations in the development of this model, together with recent evidence that psychostimulant withdrawal in rodents can be used to screen for novel, rapidly acting antidepressant treatments, are discussed... - Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in ratsAlasdair M Barr
Department of Psychology, University of British Columbia, Vancouver, Canada
Psychopharmacology (Berl) 159:196-202. 2002..CONCLUSIONS: ECS was able to mitigate the anhedonic effects of d-amphetamine withdrawal, and provides additional support for the use of psychostimulant withdrawal as a model of depression... - Exposure to repeated, intermittent d-amphetamine induces sensitization of HPA axis to a subsequent stressorAlasdair M Barr
Department of Psychology, 2136 West Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neuropsychopharmacology 26:286-94. 2002.... - A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleusXiaoying Lu
Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:874-9. 2005.... - Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous systemJoanne Y T Leung
Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C V6T1Z3, Canada
Pharmacol Ther 135:113-22. 2012..The direct and indirect effects of antipsychotic drugs on the cardiovascular system and their possible mechanisms of action are discussed in this review, where both preclinical and clinical findings are integrated... - Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to ratsPavel Gershkovich
Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Eur Neuropsychopharmacol 20:545-52. 2010..Taken together, the results do not support the hypothesis that hypertriglyceridemia improves the effect of clozapine by altered pharmacokinetics of clozapine and norclozapine and their increased penetration across the BBB... - Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatographyMicheal Rosland
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Drug Dev Ind Pharm 33:1158-66. 2007..To develop and validate an HPLC method for the quantitation of clozapine and its metabolite, norclozapine in human plasma, rat plasma, and the various human plasma lipoprotein fractions... - Preclinical models of antipsychotic drug-induced metabolic side effectsHeidi N Boyda
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C, Canada, V6T 1Z3
Trends Pharmacol Sci 31:484-97. 2010..In this paper, we provide a major review of this important and growing field of preclinical study, and address crucial issues for future research... - Antipsychotic and psychostimulant drug combination therapy in attention deficit/hyperactivity and disruptive behavior disorders: a systematic review of efficacy and tolerabilityDavid Linton
British Columbia Mental Health and Addictions Research Institute, A3 938 W 28th Avenue, Vancouver, B C V5Z 4H4, Canada
Curr Psychiatry Rep 15:355. 2013..Further studies are necessary to confirm the efficacy and tolerability of the concurrent use of antipsychotics and psychostimulants in children and adolescents... - The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout miceAlasdair M Barr
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
Neuropsychopharmacology 29:221-8. 2004.... - Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowthJulia Mills
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V6T 123
J Neurosci 23:1638-48. 2003..Consequently, ILK inhibition resulted in an increase in the hyperphosphorylation of Tau, a substrate of GSK-3. Together these findings indicate that ILK is an important effector in NGF-mediated neurite outgrowth... - Pharmacological risk factors for delirium after cardiac surgery: a reviewLurdes Tse
Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C, Canada, V6T 1Z3
Curr Neuropharmacol 10:181-96. 2012..The objective of this review is to evaluate the literature on medications associated with delirium after cardiac surgery and potential prophylactic agents for preventing it... - Increased successive negative contrast in rats withdrawn from an escalating-dose schedule of D-amphetamineAlasdair M Barr
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Pharmacol Biochem Behav 71:293-9. 2002..This effect is interpreted as a consequence of the increased emotionality of withdrawn animals, and may be related to disruption of normal search behaviors... - High frequency of TNF alleles -238A and -376A in individuals from northern SardiniaSebastian A Wirz
The Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR307, La Jolla, CA 92037, USA
Cytokine 26:149-54. 2004.... - High levels of estradiol impair spatial performance in the Morris water maze and increase 'depressive-like' behaviors in the female meadow voleLiisa A M Galea
Department of Psychology and Neuroscience Program, The University of British Columbia, Vancouver, British Columbia, Canada
Physiol Behav 77:217-25. 2002..To our knowledge, this is the first demonstration in rodents indicating that estradiol-mediated changes in behavior in the FST is not indicative of subsequent performance in the Morris water maze... - Hippocampal complexin proteins and cognitive dysfunction in schizophreniaKen Sawada
Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
Arch Gen Psychiatry 62:263-72. 2005..CONCLUSIONS: The pathology of hippocampal complexin proteins might play an important role in schizophrenia, especially concerning cognitive disturbances...