P A Barber

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint MR molecular imaging of early endothelial activation in focal ischemia
    Philip A Barber
    Department of Clinical Neuroscience and the Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Alberta, Canada
    Ann Neurol 56:116-20. 2004
  2. pmc Magnetic resonance imaging of ischemia viability thresholds and the neurovascular unit
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Sensors (Basel) 13:6981-7003. 2013
  3. pmc Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia
    Philip A Barber
    Department of Clinical Neurosciences, Experimental Imaging Centre and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Canada
    BMC Neurosci 13:76. 2012
  4. pmc Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke
    Albert Y Jin
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    BMC Neurosci 11:12. 2010
  5. ncbi request reprint Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics, Room 153, 3330 Hospital Drive, Calgary, Edmonton, AB T2N 4N1 Canada
    Stroke 35:1720-5. 2004
  6. pmc Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
    P A Barber
    Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
    J Neurol Neurosurg Psychiatry 76:1528-33. 2005
  7. pmc The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies
    P A Barber
    Department of Clinical Neurosciences, Calgary Stroke Program, Seaman Family Magnetic Research Centre, NW, Calgary, Canada AB T2N 4N1
    J Neurol Neurosurg Psychiatry 75:1426-30. 2004
  8. ncbi request reprint Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics West, Room 153, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
    Neurosci Lett 388:54-9. 2005
  9. ncbi request reprint Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemia
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
    Stroke 32:84-8. 2001
  10. pmc Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
    BMC Neurol 1:1. 2001

Collaborators

Detail Information

Publications46

  1. ncbi request reprint MR molecular imaging of early endothelial activation in focal ischemia
    Philip A Barber
    Department of Clinical Neuroscience and the Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Alberta, Canada
    Ann Neurol 56:116-20. 2004
    ..The study suggests that the contrast agent Gd-DTPA-sLe(x) A can be used to visualize early endothelial activation after transient focal ischemia in vivo with MRI...
  2. pmc Magnetic resonance imaging of ischemia viability thresholds and the neurovascular unit
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Sensors (Basel) 13:6981-7003. 2013
    ....
  3. pmc Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia
    Philip A Barber
    Department of Clinical Neurosciences, Experimental Imaging Centre and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Canada
    BMC Neurosci 13:76. 2012
    ..Images were acquired starting at 2 or 24 hours after reperfusion over the ipsilateral and contralateral cortex before and for 3 hours after, MMPSense750 was injected...
  4. pmc Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke
    Albert Y Jin
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    BMC Neurosci 11:12. 2010
    ..In vivo assessment of BBB dysfunction was also investigated optically using intravital microscopy of the pial circulation following the injection of Fluorescein Isothiocyanate (FITC)-dextran (MW 2000 kDa)...
  5. ncbi request reprint Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics, Room 153, 3330 Hospital Drive, Calgary, Edmonton, AB T2N 4N1 Canada
    Stroke 35:1720-5. 2004
    ..The importance of mouse stroke models has increased with the development of genetically manipulated animals. We hypothesized that immediate postischemia hypothermia may attenuate ischemic brain injury in the mouse...
  6. pmc Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
    P A Barber
    Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
    J Neurol Neurosurg Psychiatry 76:1528-33. 2005
    ..Controversy exists about the optimal imaging technique in acute stroke. It was hypothesised that CT is comparable with DWI, when both are read systematically using quantitative scoring...
  7. pmc The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies
    P A Barber
    Department of Clinical Neurosciences, Calgary Stroke Program, Seaman Family Magnetic Research Centre, NW, Calgary, Canada AB T2N 4N1
    J Neurol Neurosurg Psychiatry 75:1426-30. 2004
    ..We assessed the sensitivity and specificity of the hyperdense middle cerebral artery (HMCA) and the "dot" sign using magnetic resonance angiography (MRA)...
  8. ncbi request reprint Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics West, Room 153, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
    Neurosci Lett 388:54-9. 2005
    ....
  9. ncbi request reprint Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemia
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
    Stroke 32:84-8. 2001
    ..CONCLUSIONS: The MCA dot sign is an early marker of thromboembolic occlusion of the distal MCA branches seen in the sylvian fissure and is associated with better outcome than the HMCA sign...
  10. pmc Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
    BMC Neurol 1:1. 2001
    ..Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia...
  11. ncbi request reprint Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator
    A M Demchuk
    Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Stroke 32:89-93. 2001
    ..We examined whether the emergent TCD TIBI classification correlated with stroke severity and outcome in patients treated with intravenously administered tPA (IV-tPA)...
  12. pmc Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Alta
    CMAJ 162:1589-93. 2000
    ..Areas for continued improvement include the door-to-needle time and broader education of the public about the symptoms of acute ischemic stroke...
  13. doi request reprint Development of a model of recurrent stroke consisting of a mild transient stroke followed by a second moderate stroke in rats
    M Qiao
    MR Technology, National Research Council Institute for Biodiagnostics West, Calgary, Alberta, Canada
    J Neurosci Methods 184:244-50. 2009
    ..Proximally, damage exceeds that of the first insult whereas distally the response is consistent with a tolerance to the second insult...
  14. pmc Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neurol Neurosurg Psychiatry 77:885-7. 2006
    ..To test the hypothesis that insular cortical ischaemia is associated with acute hypertension and hyperglycaemia...
  15. ncbi request reprint Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 56:1015-20. 2001
    ..Thrombolytic therapy for acute stroke (<3 hours) will not have a major impact on death and dependency unless it is accessible to more patients...
  16. pmc Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Alta
    CMAJ 162:1281-4. 2000
    ..The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy...
  17. ncbi request reprint Mild neurological symptoms despite middle cerebral artery occlusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
    Stroke 35:469-71. 2004
    ..Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy...
  18. ncbi request reprint The rise and fall of NMDA antagonists for ischemic stroke
    L Hoyte
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Curr Mol Med 4:131-6. 2004
    ..We also speculate that NMDA receptor antagonism may have hindered endogenous mechanisms for neuronal survival and neuroregeneration. It remains to be proven in human stroke whether NMDA receptor antagonism can be neuroprotective...
  19. doi request reprint Magnetic resonance molecular imaging of post-stroke neuroinflammation with a P-selectin targeted iron oxide nanoparticle
    A Y Jin
    Department of Clinical Neurosciences, the Experimental Imaging Centre, and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Alberta, Canada
    Contrast Media Mol Imaging 4:305-11. 2009
    ..MR imaging of P-selectin expression with a targeted iron oxide nanoparticle contrast agent may reveal early endothelial activation in stroke and other neuroinflammatory states...
  20. ncbi request reprint Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke
    J H Pexman
    Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 22:1534-42. 2001
    ..CONCLUSION: ASPECTS is a systematic, robust, and practical method that can be applied to different axial baselines. Clinician agreement is superior to that of the 1/3 MCA rule...
  21. doi request reprint Quantified T1 as an adjunct to apparent diffusion coefficient for early infarct detection: a high-field magnetic resonance study in a rat stroke model
    J Kaur
    Department of Clinical Neurosciences, Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Int J Stroke 4:159-68. 2009
    ..AIMS AND/OR HYPOTHESIS: Magnetic resonance imaging characteristics vary widely following ischemia and, at acute times, T1, T2 or apparent diffusion coefficient quantification may differentiate viable tissue from that destined to infarct...
  22. ncbi request reprint Reliability of assessing percentage of diffusion-perfusion mismatch
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta T2N 2T9, Canada
    Stroke 34:1681-3. 2003
    ..The present study sought to estimate the reliability of assessing the percentage of DWI-PWI mismatch...
  23. ncbi request reprint Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada
    Neurology 60:1525-7. 2003
    ..Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0)...
  24. ncbi request reprint Hyperacute post-thrombolysis hematoma by MRI
    A J Gagnon
    University of Calgary, Calgary Stroke Program, 1403 29 Street NW, Calgary, Alberta T2N 2T9, Canada
    Neurology 63:1534. 2004
  25. ncbi request reprint Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:507-11. 2005
    ..Intra-arterial thrombolysis has been reported as a potentially efficacious and safe treatment...
  26. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
    ..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach...
  27. ncbi request reprint Interobserver variation of ASPECTS in real time
    Shelagh B Coutts
    Seaman Family MR Centre, Calgary Health Region, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 35:e103-5. 2004
    ..We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point...
  28. ncbi request reprint Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry
    Imanuel Dzialowski
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
    Stroke 38:75-9. 2007
    ..We sought to study the relation between the type of hemorrhagic transformation on CT scans and functional outcome...
  29. ncbi request reprint Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo
    H S Sun
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada T2N 4N1
    Neuroscience 144:1509-15. 2007
    ..2(-/-) OGD group. These findings suggest that stimulation of endogenous cortical K(ATP) channels may provide a useful strategy for limiting the damage that results from cerebral ischemic stroke...
  30. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
    ..We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study...
  31. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
    ..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
  32. ncbi request reprint Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioning
    Lisa C Hoyte
    Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Canada
    Brain Res 1121:231-7. 2006
    ..The current study examines the effects of late phase ischemic preconditioning in a mouse model of middle cerebral artery occlusion (MCAO). Specific examination of the regional cerebral blood flow (rCBF) was conducted...
  33. ncbi request reprint Understanding and managing ischemic stroke
    P A Barber
    Department of Clinical Neurosciences, Seaman Family Magnetic Resonance Research Centre, University of Calgary, AB, Canada
    Can J Physiol Pharmacol 79:283-96. 2001
    ..This article provides an insight into the understanding of cerebral ischemia, together with current and future treatment strategies...
  34. ncbi request reprint Unexpected posthemorrhagic hydrocephalus in patients treated with rFVIIa
    S Subramaniam
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 67:1096. 2006
  35. ncbi request reprint Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarction
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 16:230-5. 2003
    ..As yet there are few guidelines to aid the selection of patients for aggressive interventional therapies, such as decompression hemicraniectomy and/or hypothermia...
  36. ncbi request reprint Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Ann Neurol 57:848-54. 2005
    ....
  37. doi request reprint Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
    Volker Puetz
    University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
    Int J Stroke 3:230-6. 2008
    ..In ischemic stroke, functional outcomes vary depending on site of intracranial occlusion. We tested the prognostic value of a semiquantitative computed tomography angiography-based clot burden score...
  38. ncbi request reprint Cerebral microhemorrhages in a patient with mycotic aneurysm: relevance of T2-GRE imaging in SBE
    Suresh Subramaniam
    Hotckiss Brain Institute, University of Calgary, 1403, 29th Street NW, Calgary, Alberta, Canada T2N2T9
    Neurology 67:1697. 2006
  39. ncbi request reprint Comparison of pre- and postcontrast 3D time-of-flight MR angiography for the evaluation of distal intracranial branch occlusions in acute ischemic stroke
    Janice J Yang
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 23:557-67. 2002
    ..We hypothesized that the use of contrast-enhanced MR angiography improves delineation of vessels with diminished or absent flow on precontrast MR angiograms...
  40. ncbi request reprint Biochemistry of ischemic stroke
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada
    Adv Neurol 92:151-64. 2003
  41. ncbi request reprint Bedside emergency transcranial Doppler diagnosis of severe carotid disease using orbital window examination
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Canada
    J Neuroimaging 15:138-43. 2005
    ..The authors sought to evaluate the TCD orbital window for predicting cervical ICA (cICA) stenosis in the setting of acute stroke and TIA...
  42. ncbi request reprint Hyperacute stroke: experience essential when reading unenhanced CT scans
    J H Warwick Pexman
    AJNR Am J Neuroradiol 25:516; author reply 516-8. 2004
  43. ncbi request reprint ASPECTS reading requires training and experience
    Shelagh B Coutts
    Stroke 34:e179; author reply e179. 2003
  44. ncbi request reprint MR DWI does not substitute for stroke severity scores in predicting stroke outcome
    Philip A Barber
    Neurology 66:1138-9. 2006
  45. ncbi request reprint Extent of hypoattenuation on CT angiography source images predicts functional outcome in patients with basilar artery occlusion
    Volker Puetz
    University of Technology Dresden, Department of Neurology, Dresden University Stroke Center, Fetscherstrasse 74, 01307 Dresden, Germany
    Stroke 39:2485-90. 2008
    ..We tested the validity of a novel CT score, the posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS)...
  46. ncbi request reprint Anterior spinal artery infarction at the cervicomedullary junction
    Teneille E Gofton
    Department of Clinical Neurosciences, University of Western Ontario, London Health Sciences Centre, London, ON, Canada
    Can J Neurol Sci 33:418-20. 2006