Research Topics
Species | P A BarberSummaryAffiliation: University of Calgary Country: Canada Publications
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Publications
Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermiaPhilip A Barber
Department of Clinical Neurosciences, Experimental Imaging Centre and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Canada
BMC Neurosci 13:76. 2012..Images were acquired starting at 2 or 24 hours after reperfusion over the ipsilateral and contralateral cortex before and for 3 hours after, MMPSense750 was injected...- Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of strokeAlbert Y Jin
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
BMC Neurosci 11:12. 2010..In vivo assessment of BBB dysfunction was also investigated optically using intravital microscopy of the pial circulation following the injection of Fluorescein Isothiocyanate (FITC)-dextran (MW 2000 kDa)... 
MR molecular imaging of early endothelial activation in focal ischemiaPhilip A Barber
Department of Clinical Neuroscience and the Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Alberta, Canada
Ann Neurol 56:116-20. 2004..The study suggests that the contrast agent Gd-DTPA-sLe(x) A can be used to visualize early endothelial activation after transient focal ischemia in vivo with MRI...- Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomesPhilip A Barber
Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics, Room 153, 3330 Hospital Drive, Calgary, Edmonton, AB T2N 4N1 Canada
Stroke 35:1720-5. 2004..The importance of mouse stroke models has increased with the development of genetically manipulated animals. We hypothesized that immediate postischemia hypothermia may attenuate ischemic brain injury in the mouse... - Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imagingP A Barber
Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
J Neurol Neurosurg Psychiatry 76:1528-33. 2005..Controversy exists about the optimal imaging technique in acute stroke. It was hypothesised that CT is comparable with DWI, when both are read systematically using quantitative scoring... - Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4TPhilip A Barber
Department of Clinical Neurosciences, University of Calgary, Institute for Biodiagnostics West, Room 153, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
Neurosci Lett 388:54-9. 2005.... - The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studiesP A Barber
Department of Clinical Neurosciences, Calgary Stroke Program, Seaman Family Magnetic Research Centre, NW, Calgary, Canada AB T2N 4N1
J Neurol Neurosurg Psychiatry 75:1426-30. 2004..We assessed the sensitivity and specificity of the hyperdense middle cerebral artery (HMCA) and the "dot" sign using magnetic resonance angiography (MRA)... - Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemiaP A Barber
Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
Stroke 32:84-8. 2001..CONCLUSIONS: The MCA dot sign is an early marker of thromboembolic occlusion of the distal MCA branches seen in the sylvian fissure and is associated with better outcome than the HMCA sign... - Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activatorA M Demchuk
Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Stroke 32:89-93. 2001..We examined whether the emergent TCD TIBI classification correlated with stroke severity and outcome in patients treated with intravenously administered tPA (IV-tPA)... 
Symptomatic hemorrhage after alteplase therapy not due to silent ischemiaM D Hill
Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
BMC Neurol 1:1. 2001..One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia...- Building a "brain attack" team to administer thrombolytic therapy for acute ischemic strokeM D Hill
Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Alta
CMAJ 162:1589-93. 2000..Areas for continued improvement include the door-to-needle time and broader education of the public about the symptoms of acute ischemic stroke... 
Development of a model of recurrent stroke consisting of a mild transient stroke followed by a second moderate stroke in ratsM Qiao
MR Technology, National Research Council Institute for Biodiagnostics West, Calgary, Alberta, Canada
J Neurosci Methods 184:244-50. 2009..Proximally, damage exceeds that of the first insult whereas distally the response is consistent with a tolerance to the second insult...- Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onsetJ A Pettersen
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
J Neurol Neurosurg Psychiatry 77:885-7. 2006..Several hours are required for sympathetic manifestations of insular ischaemia to evolve... - Why are stroke patients excluded from TPA therapy? An analysis of patient eligibilityP A Barber
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
Neurology 56:1015-20. 2001..Thrombolytic therapy for acute stroke (<3 hours) will not have a major impact on death and dependency unless it is accessible to more patients... - Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic strokeM D Hill
Department of Clinical Neurosciences, University of Calgary, Alta
CMAJ 162:1281-4. 2000..The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy... - Mild neurological symptoms despite middle cerebral artery occlusionShelagh B Coutts
Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
Stroke 35:469-71. 2004..Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy... - Magnetic resonance molecular imaging of post-stroke neuroinflammation with a P-selectin targeted iron oxide nanoparticleA Y Jin
Department of Clinical Neurosciences, the Experimental Imaging Centre, and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Alberta, Canada
Contrast Media Mol Imaging 4:305-11. 2009..MR imaging of P-selectin expression with a targeted iron oxide nanoparticle contrast agent may reveal early endothelial activation in stroke and other neuroinflammatory states... - Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute strokeJ H Pexman
Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
AJNR Am J Neuroradiol 22:1534-42. 2001..CONCLUSION: ASPECTS is a systematic, robust, and practical method that can be applied to different axial baselines. Clinician agreement is superior to that of the 1/3 MCA rule... - Quantified T1 as an adjunct to apparent diffusion coefficient for early infarct detection: a high-field magnetic resonance study in a rat stroke modelJ Kaur
Department of Clinical Neurosciences, Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
Int J Stroke 4:159-68. 2009..AIMS AND/OR HYPOTHESIS: Magnetic resonance imaging characteristics vary widely following ischemia and, at acute times, T1, T2 or apparent diffusion coefficient quantification may differentiate viable tissue from that destined to infarct... - Reliability of assessing percentage of diffusion-perfusion mismatchShelagh B Coutts
Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta T2N 2T9, Canada
Stroke 34:1681-3. 2003..The present study sought to estimate the reliability of assessing the percentage of DWI-PWI mismatch... - Hyperacute post-thrombolysis hematoma by MRIA J Gagnon
University of Calgary, Calgary Stroke Program, 1403-29 Street NW, Calgary, Alberta T2N 2T9, Canada
Neurology 63:1534. 2004 - Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experienceJ A Pettersen
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Can J Neurol Sci 32:507-11. 2005..All patients had residual monocular field defects. CONCLUSIONS: Our findings reveal a limited benefit for intra-arterial tPA compared to the rate of spontaneous improvement and conventional forms of therapy for retinal artery occlusion... - Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of strokeM D Hill
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada
Neurology 60:1525-7. 2003..Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0)... - The rise and fall of NMDA antagonists for ischemic strokeL Hoyte
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Curr Mol Med 4:131-6. 2004..We also speculate that NMDA receptor antagonism may have hindered endogenous mechanisms for neuronal survival and neuroregeneration. It remains to be proven in human stroke whether NMDA receptor antagonism can be neuroprotective... - Interobserver variation of ASPECTS in real timeShelagh B Coutts
Seaman Family MR Centre, Calgary Health Region, Foothills Hospital, Calgary, Alberta, Canada
Stroke 35:e103-5. 2004..We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point... - Acute intravenous--intra-arterial revascularization therapy for severe ischemic strokeMichael D Hill
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Stroke 33:279-82. 2002..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach... - Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registryImanuel Dzialowski
Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
Stroke 38:75-9. 2007..We sought to study the relation between the type of hemorrhagic transformation on CT scans and functional outcome... - Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivoH S Sun
Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada T2N 4N1
Neuroscience 144:1509-15. 2007..2(-/-) OGD group. These findings suggest that stimulation of endogenous cortical K(ATP) channels may provide a useful strategy for limiting the damage that results from cerebral ischemic stroke... - Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke StudyAndrew M Demchuk
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Cerebrovasc Dis 26:120-5. 2008..We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study... - Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioningLisa C Hoyte
Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Canada
Brain Res 1121:231-7. 2006..7+/-6.8% of contralateral (p=0.04). CONCLUSIONS: Improved rCBF is an important factor in the protection of IPC, during injurious MCAO in the mouse. Stringent monitoring of rCBF is required in future studies of IPC... - Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke StudyAndrew M Demchuk
Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
Stroke 36:2110-5. 2005..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study... - Unexpected posthemorrhagic hydrocephalus in patients treated with rFVIIaS Subramaniam
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 2T9
Neurology 67:1096. 2006 - Understanding and managing ischemic strokeP A Barber
Department of Clinical Neurosciences, Seaman Family Magnetic Resonance Research Centre, University of Calgary, AB, Canada
Can J Physiol Pharmacol 79:283-96. 2001..This article provides an insight into the understanding of cerebral ischemia, together with current and future treatment strategies... - Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden scoreVolker Puetz
University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
Int J Stroke 3:230-6. 2008..In ischemic stroke, functional outcomes vary depending on site of intracranial occlusion. We tested the prognostic value of a semiquantitative computed tomography angiography-based clot burden score... - Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imagingShelagh B Coutts
Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
Ann Neurol 57:848-54. 2005.... - Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarctionPhilip A Barber
Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Cerebrovasc Dis 16:230-5. 2003..These CT parameters require prospective validation before they should be considered reliable markers for decision-making... - Cerebral microhemorrhages in a patient with mycotic aneurysm: relevance of T2-GRE imaging in SBESuresh Subramaniam
Hotckiss Brain Institute, University of Calgary, 1403, 29th Street NW, Calgary, Alberta, Canada T2N2T9
Neurology 67:1697. 2006 - Comparison of pre- and postcontrast 3D time-of-flight MR angiography for the evaluation of distal intracranial branch occlusions in acute ischemic strokeJanice J Yang
Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region Calgary, Alberta, Canada
AJNR Am J Neuroradiol 23:557-67. 2002..In some patients, an improved understanding of acute ischemic stroke was obtained by viewing the pre- and postcontrast images. Postcontrast MR angiography should be included in the MR evaluation of acute stroke... - Biochemistry of ischemic strokePhilip A Barber
Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada
Adv Neurol 92:151-64. 2003 - Hyperacute stroke: experience essential when reading unenhanced CT scansJ H Warwick Pexman
AJNR Am J Neuroradiol 25:516; author reply 516-8. 2004 - MR DWI does not substitute for stroke severity scores in predicting stroke outcomePhilip A Barber
Neurology 66:1138-9. 2006 - Bedside emergency transcranial Doppler diagnosis of severe carotid disease using orbital window examinationMaher Saqqur
Department of Medicine (Neurology, University of Alberta, Canada
J Neuroimaging 15:138-43. 2005..When OA flow is anterograde, a low mean flow velocity or pulsatility index is also useful to identify cICA critical stenosis or occlusion... - ASPECTS reading requires training and experienceShelagh B Coutts
Stroke 34:e179; author reply e179. 2003 - Extent of hypoattenuation on CT angiography source images predicts functional outcome in patients with basilar artery occlusionVolker Puetz
University of Technology Dresden, Department of Neurology, Dresden University Stroke Center, Fetscherstrasse 74, 01307 Dresden, Germany
Stroke 39:2485-90. 2008..We tested the validity of a novel CT score, the posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS)... - Anterior spinal artery infarction at the cervicomedullary junctionTeneille E Gofton
Department of Clinical Neurosciences, University of Western Ontario, London Health Sciences Centre, London, ON, Canada
Can J Neurol Sci 33:418-20. 2006