Andrew J Baldwin

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture
    Andrew J Baldwin
    Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada
    Structure 19:1855-63. 2011
  2. doi request reprint αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Mol Biol 413:297-309. 2011
  3. doi request reprint Quaternary dynamics of αB-crystallin as a direct consequence of localised tertiary fluctuations in the C-terminus
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Mol Biol 413:310-20. 2011
  4. ncbi request reprint NMR spectroscopy brings invisible protein states into focus
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada
    Nat Chem Biol 5:808-14. 2009
  5. ncbi request reprint Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Am Chem Soc 134:15343-50. 2012
  6. doi request reprint 13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Am Chem Soc 132:10992-5. 2010
  7. doi request reprint An R(1ρ) expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada
    J Biomol NMR 55:211-8. 2013
  8. doi request reprint Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R(1ρ): an application to αB-crystallin
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada
    J Biomol NMR 53:1-12. 2012
  9. doi request reprint Measurement of methyl axis orientations in invisible, excited states of proteins by relaxation dispersion NMR spectroscopy
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Am Chem Soc 131:11939-48. 2009

Detail Information

Publications9

  1. doi request reprint The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture
    Andrew J Baldwin
    Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada
    Structure 19:1855-63. 2011
    ..The ensuing best-fit structures reveal the polyhedral architecture of αB-crystallin oligomers, and provide a rationale for their polydispersity and facile interconversion...
  2. doi request reprint αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Mol Biol 413:297-309. 2011
    ..This provides a new means for understanding the polydispersity of αB-crystallin and a framework for interrogating other heterogeneous protein assemblies...
  3. doi request reprint Quaternary dynamics of αB-crystallin as a direct consequence of localised tertiary fluctuations in the C-terminus
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Mol Biol 413:310-20. 2011
    ....
  4. ncbi request reprint NMR spectroscopy brings invisible protein states into focus
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada
    Nat Chem Biol 5:808-14. 2009
    ....
  5. ncbi request reprint Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Am Chem Soc 134:15343-50. 2012
    ..This work emphasizes the importance of using multiple methods in studies of supra-molecules, especially for highly dynamic ensembles where sample conditions can potentially affect the conformational properties observed...
  6. doi request reprint 13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Am Chem Soc 132:10992-5. 2010
    ..The methodology is applied to the gating residues of the T. acidiphilium proteasome that are shown to undergo extensive motion on the millisecond time scale...
  7. doi request reprint An R(1ρ) expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates
    Andrew J Baldwin
    Departments of Molecular Genetics, Biochemistry and Chemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada
    J Biomol NMR 55:211-8. 2013
    ....
  8. doi request reprint Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R(1ρ): an application to αB-crystallin
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada
    J Biomol NMR 53:1-12. 2012
    ....
  9. doi request reprint Measurement of methyl axis orientations in invisible, excited states of proteins by relaxation dispersion NMR spectroscopy
    Andrew J Baldwin
    Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Am Chem Soc 131:11939-48. 2009
    ..The approach allows the measurement of anisotropic restraints at methyl positions in excited states and complements previously developed experiments focusing on the protein backbone...